10 Best Xlear Nasal Spray 12 Hour of 2025

Tested and Reviewed: Top 10 Xlear Nasal Spray 12 Hour deals with expert ratings from 8.1 to a perfect 10

May 2026 Edition

Editor's Choice

9.7

Beekeeper's Naturals

Kids' Saline Nasal Mist by Beekeeper's Naturals, Clears Stuff Noses, Nasal Spray for Kids 1+ w/ Saline, Aloe & Propolis, 3 fl oz

Editor's bottom line:

“This xlear nasal spray 12 hour is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

KIDS SALINE NASAL MIST SPRAY: Each calming nasal mist spray helps clear nasal congestion while gently soothing and moisturizing the nasal passages.
FORMULATED WITH DOCTORS: Formulated with doctors, our Kids Propolis Saline Nasal Mist features a potent dose of propolis and aloe leaf extract to soothe and moisturize irritated and congested noses for easy breathing all year round.
GENTLE CARE FOR LITTLE ONES 1+ & EASY TO USE: We have formulated this product for gentle yet effective clearing and moisturizing of nasal passages without any of the burning or stinging of an OTC nasal spray.
SAFE FOR DAILY USE: Free of phenylephrine, our clean formula is non-habit forming, drug-free, and safe for daily use.
EFFICACY COMES FIRST: We arent just creating cleaner alternatives to the traditional medicine cabinet. Beekeepers' Naturals merges modern science with natural medicine to create natural remedies that actually work. Doctor formulated and backed by rigor.

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Picked by 397 people today

9.5

Xlear

Xlear 12-Hour Nasal Decongestant Spray, Natural Saline Nasal Spray with Xylitol and Oxymetazoline, Instant Sinus Pressure and Congestion Relief for Kids and Adults 0.5 fl oz (Pack of 1)

Main Highlights

INSTANT RELIEF. Includes oxymetazoline for instant relief from even the most extreme congestion and sinus pressure.
INCLUDES XYLITOL. The addition of xylitol cleans, moisturizes, and protects delicate sinus tissues.
12-HOUR RELIEF. Patented formula provides a full 12 hours of relief without drowsiness or dryness.
EASY-TO-USE PUMP SPRAY. Metered pump sprayer ensures precise dosing every time.
NATURAL INGREDIENTS. Over 99% natural formula containing just 4 ingredients means you know exactly whats going up your nose.

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9.5

Xlear

Xlear 12-Hour Natural Saline Nasal Decongestant Spray with Xylitol and Oxymetazoline, Instant Sinus Pressure and Congestion Relief for Kids and Adults 0.5 fl oz (Pack of 3)

Main Highlights

INSTANT RELIEF. Includes oxymetazoline for instant relief from even the most extreme congestion and sinus pressure.
INCLUDES XYLITOL. The addition of xylitol cleans, moisturizes, and protects delicate sinus tissues.
12-HOUR RELIEF. Patented formula provides a full 12 hours of relief without drowsiness or dryness.
EASY-TO-USE PUMP SPRAY. Metered pump sprayer ensures precise dosing every time.
NATURAL INGREDIENTS. Over 99% natural formula containing just 4 ingredients means you know exactly whats going up your nose.

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9.2

Xlear

Xlear 12-Hour Natural Saline Nasal Decongestant Spray with Xylitol and Oxymetazoline, Instant Sinus Pressure and Congestion Relief for Kids and Adults 0.5 fl oz (Pack of 2)

Main Highlights

INSTANT RELIEF. Includes oxymetazoline for instant relief from even the most extreme congestion and sinus pressure.
INCLUDES XYLITOL. The addition of xylitol cleans, moisturizes, and protects delicate sinus tissues.
12-HOUR RELIEF. Patented formula provides a full 12 hours of relief without drowsiness or dryness.
EASY-TO-USE PUMP SPRAY. Metered pump sprayer ensures precise dosing every time.
NATURAL INGREDIENTS. Over 99% natural formula containing just 4 ingredients means you know exactly whats going up your nose.

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Best Value

9.0

Save 38%

Xlear

Xlear Natural Nasal Spray with Xylitol, 1.5 fl oz (Pack of 12)

38% Off

Main Highlights

NATURAL SALINE SOLUTION & NASAL RINSE: Our nasal saline spray will gently clean and moisturize the sinus tissues. Unlike other normal saline nasal sprays our spray can also decongest the sinuses by targeting the primary causes of nasal congestion. Our nose spray will help reduce tissue swelling from pollen, pollution, contaminants, and other irritants.
SAFE NASAL RINSE & SPRAY: Our all-natural nasal cleaner is safe for kids, non-addictive, Non-GMO Project Verified and is effective without the use of steroids, drugs, or chemicals. It is the ideal daily sinus medicine that will reduce swelling and open your airways. Using our saline nose spray before bed may reduce snoring.
IMPROVED FORMULA WITH XYLITOL: Our patented saline nasal spray solution may reduce tissue inflammation and naturally open airways. Xylitol's powerful oral and upper respiratory health benefits come from its unique five-carbon structure. Xylitol may help reduce swelling and allergy symptoms by reducing contaminant adhesion on your nasal tissue.
EASY TO USE DIRECTIONS: Clear the nasal passageway by gently blowing your nose before using Xlear. Prime the pump by holding the sinus rinse bottle upright and pumping one or more times until the saline solution is dispensed. Insert nozzle into nostril and depress pump completely while breathing in through your nose. Spray each nostril 2-4 times and use at least twice daily.
WASH AWAY POLLUTANTS: Our natural saline nasal spray can wash away pollutants and help to bring sinus relief. Use our sinus spray daily to protect and keep your nasal passages clean. Each 1.5 oz bottle delivers approx. 240 fine mist Sprays so you can find fast and quick relief.

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8.8

Xlear

Xlear Natural Xylitol Nasal Spray, Regular and Travel Size 12-Hour Nasal Decongestant Bundle, 1.5 fl oz & 0.5 fl oz (Pack of 2)

Main Highlights

NATURAL SALINE SOLUTION & NASAL RINSE: Our xylitol nasal spray will gently clean and moisturize the sinus tissues. Xlear 12-Hour Nasal decongestant spray includes oxymetazoline for instant relief from even the most extreme congestion and sinus pressure. Unlike other normal saline nasal sprays, Xlear spray targets the primary causes of nasal congestion. Our nose spray will help reduce tissue swelling from pollen, pollution, contaminants and all other irritants.
12-HOUR RELIEF. Patented formula provides a full 12 hours of relief without drowsiness or dryness.
IMPROVED FORMULA WITH XYLITOL: Our patented saline nasal spray solution naturally opens airways. Xylitol's powerful oral and upper respiratory health benefits come from its unique five-carbon structure. Xylitol helps to reduce swelling and allergy symptoms by reducing contaminant adhesion on you nasal tissue.
EASY TO USE DIRECTIONS: Gently blow your nose to clear nasal passages before use. Hold the bottle upright and prime the pump until the saline sprays. Insert the nozzle into each nostril, fully depress the pump while breathing in, and spray 24 times per nostril. Use at least twice daily. Use the regular formula for daily nasal care. Use the 12-hour formula for temporary relief from congestion due to colds, allergies, or sinusitis. It also soothes and moisturizes.
WASH AWAY POLLUTANTS: Our natural saline nasal spray can wash away pollutants and help to bring sinus relief. Use our sinus spray daily to protect and keep your nasal passages clean. Each 1.5 oz bottle delivers approx. 240 fine mist Sprays so you can find fast and quick relief.

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8.6

Save 34%

Flonase

Flonase Sensimist Allergy Relief Nasal Spray - Non-Drowsy 24HR Long Lasting Allergy Relief with Fine, Scent-Free Mist - 240 Sprays Total (2 Bottles of 120 Sprays Each)

34% Off

Main Highlights

Contains two bottles of Flonase Sensimist, each bottle has 120 sprays to provide 240 sprays total; for optimal results, blow your nose before spraying
Start feeling better the same day; most users experience relief within 8 hours, with maximum benet after 3 to 4 days of daily use
From the #1 doctor recommended allergy brand (1), Flonase Sensimist provides full prescription strength relief from allergy symptoms caused by pollen, mold, dust mites, and pet dander
Relieves 6 allergy symptoms including nasal congestion, which single-ingredient oral antihistamines dont treat, and itchy, watery eyes (2) which other nasal sprays arent indicated to treat
Flonase Sensimist is scent-free and uses a bottle designed to deliver a ne mist that users barely feel
Each bottle should last 4 weeks, so one pack provides almost 2 months of symptom relief; be sure to read the instructions so you get the correct dose
Flonase Sensimist is FSA/HSA eligible to help maximize those healthcare benefits
Great for Spring and Fall seasonal allergy relief, but it works year-round (after 6 months of daily use (2 months for kids) ask doctor if you can keep using)

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8.3

Dristan

Dristan 12-Hour Nasal Spray, 0.5 Fl Oz (Pack of 3)

Main Highlights

Product of Dristan
Pack of 3

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8.1

4-Way

4Way Fast Acting Nasal Spray for Adults and Children 12+, Sinus Congestion Relief and Nasal Congestion Relief Nasal Spray - 1 Fl Oz Spray Bottle

Main Highlights

Health Care
Nasal Care
nasal-moisturizers
Fast Relief of: Nasal Congestion, Swollen Nasal Membranes, Sinus Congestion, and Sinus Pressure.

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8.1

Save 7%

Afrin

Afrin Saline Nasal Spray, 100% Drug Free, Saline Solution, Daily Care Nasal Spray for Everyday Congestion and Dry Nose, Easy Mist, 4.5 OZ

7% Off

Main Highlights

100% Drug-Free Everyday Congestion Relief: Saline Nasal Spray clears out irritants, allergens, and mucus from nasal passages to help decongest stuffy noses
Moisturizes & Hydrates: Nasal Saline Rinse that gently hydrates and soothes dry nasal passages.
Daily Comfort: Drug-free Saline Nasal Spray that is safe for daily use; perfect for adults, kids, and babies 6 months of age or older. Use as directed.
Clear Your Sinuses: Nasal saline spray that helps clear your sinuses from everyday nasal congestion with drug-free relief
Easy Mist: Saline Mist with a one-way flow technology designed to keep the product within the bottle, no mess no stress.

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Our Best Overall Choice

Best Choice

9.7

Beekeeper's Naturals

Kids' Saline Nasal Mist by Beekeeper's Naturals, Clears Stuff Noses, Nasal Spray for Kids 1+ w/ Saline, Aloe & Propolis, 3 fl oz

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

KIDS SALINE NASAL MIST SPRAY: Each calming nasal mist spray helps clear nasal congestion while gently soothing and moisturizing the nasal passages.
FORMULATED WITH DOCTORS: Formulated with doctors, our Kids Propolis Saline Nasal Mist features a potent dose of propolis and aloe leaf extract to soothe and moisturize irritated and congested noses for easy breathing all year round.
GENTLE CARE FOR LITTLE ONES 1+ & EASY TO USE: We have formulated this product for gentle yet effective clearing and moisturizing of nasal passages without any of the burning or stinging of an OTC nasal spray.
SAFE FOR DAILY USE: Free of phenylephrine, our clean formula is non-habit forming, drug-free, and safe for daily use.
EFFICACY COMES FIRST: We arent just creating cleaner alternatives to the traditional medicine cabinet. Beekeepers' Naturals merges modern science with natural medicine to create natural remedies that actually work. Doctor formulated and backed by rigor.

Show Price

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