10 Best Synbiotic Supplements of 2025

Tested and Reviewed: Top 10 Synbiotic Supplements deals with expert ratings from 8.1 to a perfect 10

September 2025 Edition

Editor's Choice

9.7

Ritual

Ritual Synbiotic+ Probiotic, Prebiotic, Postbiotic, 3-in-1 Formula for Gut and Digestive Health, Regularity, Bloat, Immune Support, Vegan Delayed-Released Capsule, Women and Men, 30 Day

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Editor's bottom line:

“This synbiotic supplements is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

SYNBIOTIC+ 3-IN-1 FORMULA: with prebiotics, probiotics and postbiotics to support a balanced gut microbiome. Our formula is Made Traceable with 11b CFUs with two of the world's most clinically studied probiotic strains. Our visible supply chain tells you what you're putting into your body where it comes from and why. Plus it's designed to thrive with our delayed-release capsule to help reach the colon (not the stomach), an ideal place for probiotics to survive and grow.*
MADE TRACEABLE: Our world-class scientists scoured the globe for high quality ingredients. Prebiotics PreforPro from Georgia - targets undesirable bacteria and supports growth of beneficial gut bacteria; Probiotics BB-12(Bifidobacterium anamalis ssp. lactis) and LGG (Lactobacillus rhamnosus) from Denmark - provide live microorganisms that contribute to a healthy gut microflora; Postbiotics Butyrate (as Tributyrin) from Spain- for major energy source for the cells that line the colon.*
SMART CAPSULE: Our innovative nested capsule is designed to thrive with it's delayed-release technology to help the probiotics to reach the colon (not the stomach), an ideal place for probiotics to survive and grow.* Plus we added a minty tab to every bottle so taking your daily gut support can be a more enjoyable experience.* All bottled up in a moisture-controlled technology to protect the probiotic strain. No Refrigeration Needed.
DIGESTIVE AND IMMUNITY SUPPORT: Our cutting edge approach to digestive support includes probiotic strains to support healthy regularity and relief of occasional discomforts such as mild and occasional bloating, gas, and diarrhea; postbiotic to supports gut barrier function; prebiotics designed to target undesirable bacteria in the gut and support the growth of beneficial gut bacteria; and probiotics to help support immune health. Its estimated that 70% of the immune system is located in the gut.*
THIRD PARTY TESTED: Each batch of Synbiotic+ is tested for identity, purity, strength, and composition, so we can be sure that whats on the label is whats in the capsules. We also complete third-party testing to ensure our products are compliant with regulations and guidelines for heavy metals, microbes, and major allergens and to help assure the quality and safety of our products.
OUR HAPPINESS GUARANTEE: We want you to love your Ritual products! If youre not completely satisfied with your order, simply reach out to us directly for friendly support. While Amazons return policy may not allow for returns, we are happy to offer you a full refund or exchange within 30 days. Just click on "Contact Seller" on your orders page, and well take care of you!

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Picked by 172 people today

9.5

Seed

Seed DS-01 Daily Synbiotic - Prebiotic and Probiotic for Women & Men - Digestive Health, Gut Health, Immune Support, Bloating & Constipation Relief - Vegan & Shelf-Stable - 60 Capsules (30-Day Supply)

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Main Highlights

2-in-1 Prebiotic + Probiotic: Seed DS-01 Daily Synbiotic is formulated with 24 clinically and scientifically studied probiotic strains and a patented, plant-based prebiotic outer capsule to deliver benefits in and beyond the gut. 53.6 Billion AFU.
Whole-Body Benefits: In addition to bloating relief and improved regularity, DS-01 is formulated for digestive and whole-body benefits, including gut health, digestive health, gut barrier integrity, immune support, skin health, and hearth health.
Engineered to Survive: Seeds patented capsule-in-capsule ViaCap delivery technology protects probiotics through digestion to ensure the full probiotic dose reaches the colon. DS-01 is shelf-stable and no refrigeration is required.
Getting Started: If it's your first time taking DS-01, or its been more than a week since your last dose, take 1 capsule daily for three days before moving on to 2 capsules daily. You may notice mild gastrointestinal discomfort or changes in digestion. Any discomfort typically resolves in 1-2 weeks.
Customer Support: DS-01 goes through extensive third party testing for safety and quality. If you have questions about DS-01, or aren't satisfied with your purchase, reach out to us directly and we'd be happy to help.

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9.5

Klaire Labs

Klaire Labs SFI Health Ther-Biotic Synbiotic 50 Billion CFU Daily Probiotics for Women & Men - Pre and Probiotic with Low-FODMAP Certified Prebiotic, 7 Probiotics for Sensitive Stomachs (30 Capsules)

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Main Highlights

Pro + Prebiotic For Gut Health & Immune Support - Ther-Biotic Synbiotic pre and probiotics for women and men offers comprehensive support for healthy digestion, respiratory function, and immune health.*
Supports the Microbiome & Digestive Comfort - Synbiotic daily probiotic nutritional supplements may help reduce occasional constipation, diarrhea, gas, and bloating in as little as seven days. Results may vary.*
Clinically Studied Probiotics and A Low-FODMAP Certified Prebiotic - Research shows that probiotics may offer a more profound effect on GI ecology when combined with a prebiotic. This formula includes seven probiotics for digestive health and Sunfiber; a low-FODMAP certified prebiotic.*
50 Billion CFU, No Refrigeration Required - Delayed-release capsule technology delivers live probiotics where they're needed most. This digestive supplement also uses patented packaging to protect the live bacteria at room temperature through the expiry date. No refrigeration needed.*
Klaire Labs is Now SFI Health - Klaire Labs has been part of the SFI Health family for many years leading the way in efficacy, safety, quality, and trusted by healthcare practitioners. While we might be changing the way things look, rest assured that our formulations and pre and probiotic supplement lines remain the same.

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9.2

Bio.me

Synbiotic - 3-in-1 Prebiotics and Probiotics for Digestive Health & Immune Support, Men & Womens Probiotics and Prebiotics - Non-GMO Pre Pro Post Biotics for Women & Men - Vegan - 60 Capsules

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Main Highlights

PROBIOTICS AND PREBIOTICS FOR DIGESTIVE HEALTH: Our daily synbiotic is a 3-in-1 formula that meets the essential gut health needs of both men and women, containing probiotics for men digestive health and probiotics for women digestive health.
GUT HEALTH SUPPLEMENTS: Featuring probiotics and prebiotics that aid in the production of digestive enzymes, our daily use probiotic blend maintains good gut bacteria diversity, supports digestion and helps provide bloating relief.
ADVANCED FORMULA FOR GUT HEALTH: Our probiotic prebiotic capsules combine multiple strains of probiotics that fortify the growth and diversity of good gut bacteria. Our formula is an essential blend of men's and women's probiotics for gut health.
IMMUNE SUPPORT AND BLOATING RELIEF: Our clinically-proven postbiotic not only enhances immune function but also offers bloating relief for men and women, acting as a powerful antioxidant protector. Immune supporting benefits begin to work within 2 hours of taking.
PURITY AND QUALITY: As a premium gut health supplement, our biome focused formula is non-GMO, third-party tested, and combines both prebiotics and probiotics for women and men, ensuring clean ingredients for your digestive wellness.

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9.0

Alaya Naturals

Alaya Naturals Advanced Synbiotic - Probiotic + Prebiotic - 14 Billion CFU Delayed Release Probiotic Supplement with Prebiotics from Sunfiber®, and L-glutamine for Gut Lining Integrity - 60 Capsules

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Main Highlights

OPTIMAL PREBIOTIC/PROBIOTIC BLEND: 14 Billion CFU of 7 Probiotic strains, 300mg of prebiotic fiber from Sunfiber , and L-glutamine, an amino acid that supports gut lining.
7 CAREFULLY SELECTED HUMAN RESIDENT STRAINS: Our blend includes Lactobacillus Plantarum 6595, Bifidobacterium lactis BI-04, Lactobacillus reuteri, Lactobacillus paracasei, Lactobacillus salivarius, Bifidobacterium breve and Bifidobacterium longum BI-05.
DELAYED RELEASE CAPSULES: Probiotics are only effective if they can survive the trip into our bodies. Our blend is encapsulated in delayed release capsules for maximum survivability through your digestive tract.

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8.8

Peak Performance

Synbiotic = Prebiotic + Probiotic + Postbiotic 3-in-1 Supplement with Clinically Tested Ingredients. Pre And Probiotics Plus Important Tributyrin Postbiotics For Gut. Vegan Capsules For Women + Men

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Main Highlights

Dont be fooled! Not all prebiotics or probiotic supplements cover all bases. Peak Performance Synbiotic is a Prebiotic + Probiotic + Postbiotic 3-in-1 capsule supplement specifically designed for allround digestive, gut, gastrointestinal health, as well as immune health.* Made with a Prebiotic Complex, Soil-Based Probiotic Blend and clinically tested CoreBiome Tributyrin 55% Extract.
Prebiotics- Xylooligosaccharides(XOS) (from PreticX) is a new prebiotic XOS (xylooligosaccharide) that has been clinically shown to increase bifidobacteria in the colon and aid in healthy digestion.
Probiotics - Soil-Based Blend (Bacillus subtilis, Bacillus coagulans, and Bacillus coagulans). Naturally found in the earth and have a longer and more stable shelf-life. Research shows they appear to survive the first part of their journey through the stomach and small intestine.
Postbiotics - CoreBiome Tributyrin 55% Extract - Backed by clinical studies, supports immune health by promoting a healthy microbiome, supports balanced flora, helps support gut and digestive health and intestinal walls.
Over 1 Million Customers + 1-for-1 Donation To Vitamin Angels. Peak Performance is celebrating over 1 Million customers and we are also very proud of our 1-for-1 donation match program. For every unit you purchase, through our partnership with the nonprofit Vitamin Angels, we will supply a child at risk of malnutrition with vitamins for 1 year! To date, we've supplied over 1 Million children with life changing Vitamins- So thank you for helping us continue this great cause!

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8.6

Seed

Seed 14 Day Gut Reset - Prebiotic and Probiotic for Women & Men - Digestive Health, Gut Health, Rapid Gut Recovery, Bloating & Constipation Relief - Vegan & Shelf-Stable - 28 Capsules (14-Day Supply)

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Main Highlights

Rapid Gut Relief: Seed 14 Day Gut Reset is clinically validated to restore healthy gut function within 14 days. 14 Day Gut Reset uses Seed's proprietary DS-01 formulation, including 24 clinically and scientifically studied probiotic strains and a patented, plant-based prebiotic outer capsule.
For Acute Gut Disruption: Travel, stress, lack of quality sleep, certain prescriptions, physical inactivity, environmental stressors, and poor diet can cause gastrointenal issues. Seed's 14 Day Gut Reset replenishes beneficial bacteria in and strengthens the gut barrier within 14 days.
Engineered to Survive: Seeds patented capsule-in-capsule ViaCap delivery technology protects probiotics through digestion to ensure the full probiotic dose reaches the colon. 14 Day Gut Reset is shelf-stable and no refrigeration is required.
Getting Started: Take 2 capsules daily for two weeks. For ongoing whole body benefits like immune support, skin health, and heart health, consider continuing with Seed DS-01 Daily Synbiotic after completing 14 Day Gut Reset. Visit the Seed store on Amazon for more information.
Customer Support: 14 Day Gut Reset goes through extensive third party testing for safety and quality. If you have questions about 14 Day Gut Reset, or aren't satisfied with your purchase, reach out to us directly and we'd be happy to help.

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8.3

Peak Performance

Organic Synbiotic = Prebiotics + Probiotics + Postbiotics 3-in-1 Supplement for Women, Men, & Kids. Pre, Pro, & Post Biotics Liquid Drops for Gut + Microbiome Balance. Made in USA, Vegan, Zero Sugar

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Main Highlights

Dont be fooled! Not all prebiotic or probiotic supplements cover all bases. Peak Performance USDA Organic Liquid Drops Synbiotic is a Prebiotic + Probiotic + Postbiotic 3-in-1 supplement specifically designed for digestive, gut, gastrointestinal health, as well as immune health.*
1) Prebiotics - Organic Inulin nourishes gut bacteria for digestion and gut health. 2) Probiotics - Bacillus coagulans Unique IS-2 supports gut balance, digestion, and immune support. 3) Postbiotics - Lactobacillus sakei proBio65 maintains gut flora, digestion, and immune support.
Powerful Yet Gentle - Zero Sugar, No Bitter Taste - Our customers enjoy our natural tasting formula without any bitter taste. Simply mix these drops in tea, juice, milk, or even water and you wont even taste it!
Vegan, Allergy Free - Free of unnecessary fillers, Soy, Milk, Egg, Shellfish, Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives. Manufactured Under The Highest Quality GMP Regulations and USA Standards.
Over 1,000,000 Customers + 1-for-1 Donation To Vitamin Angels. Peak Performance is celebrating over 1,000,000 customers and we are also very proud of our 1-for-1 donation match program. For every unit you purchase, through our partnership with the nonprofit Vitamin Angels, we will supply a child at risk of malnutrition with vitamins for 1 year! To date, we've supplied over 1 Million children with life changing Vitamins - So thank you for helping us continue this great cause!

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8.1

MAV NUTRITION

Prebiotics and Probiotics for Women & Men | Pre and Probiotics for Gut Health & Bloating Relief | Synbiotic with 20 Billion CFU Lactobacillus & Bifidobacterium | Shelf-Stable | Vegetarian | 60 Ct.

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Main Highlights

PROBIOTIC AND PREBIOTIC CAPSULES: Probiotics are beneficial bacteria that help maintain a healthy balance in your gut. Prebiotics act as food for probiotics, to help them grow and thrive. A synbiotic combines probiotics and prebiotics to optimize gut health.*
SUPPORT HEALTHY DIGESTION: With a high 20 billion CFU in every serving of prebiotic and probiotic, our high-quality probiotic prebiotic supplement is the well-rounded digestion aid to rebalance and support your digestive tract.*
REDUCES BLOATING: MAV Nutritions Pre and Probiotics for women & men contain the most potent probiotic strains to promote regularity and digestive health. Lactobacillus Acidophilus & Bifidobacterium Bifidum are well-studied for supporting bloating relief for women and men.*
MADE FOR YOUR MICROBIOME: A balanced microbiome is key to overall digestive and immune health. Pro-Pres symbiotic blend of pro and prebiotics for women & men can help maintain a healthy balance of gut microbiota.*
NO REFRIGERATION NEEDED: Our daily synbiotic Probiotic and Prebiotic for women & men is formulated Non-GMO, Vegetarian, Gluten-Free, and manufactured in a GMP certified facility. It is third-party tested to meet the highest possible standards.

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8.1

NaturaLife Labs A Higher Standard

Probiotics 70 Billion CFU – 15 Probiotic strains + Organic Prebiotic+ Postbiotic 3-in-1 Complete – Promotes Healthy Digestive & Immune Function –Gas, Bloating, Constipation Support – for Men & Women

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Main Highlights

3-IN-1 70 Billion Probiotic+, Prebiotic+, Postbiotic+. Carefully formulated by experts
We deliver a unique and potent formula of 70 Billion CFU Active Cultures with 15 diverse strains, organic prebiotic blend and postbiotic blend.
Our 3-in-1 probiotic supplement uses delayed release & PH sensitive capsule technology and patented guard acid protection system. Our bottle provides premier shelf stable technology - no refrigeration required.
Third-Party Tested: Each batch is tested for purity and quality to guarantee safety and efficacy. Manufactured in the USA in a GMP-certified facility to ensure purity, potency, and quality.

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Our Best Overall Choice

Best Choice

9.7

Ritual

Ritual Synbiotic+ Probiotic, Prebiotic, Postbiotic, 3-in-1 Formula for Gut and Digestive Health, Regularity, Bloat, Immune Support, Vegan Delayed-Released Capsule, Women and Men, 30 Day

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

SYNBIOTIC+ 3-IN-1 FORMULA: with prebiotics, probiotics and postbiotics to support a balanced gut microbiome. Our formula is Made Traceable with 11b CFUs with two of the world's most clinically studied probiotic strains. Our visible supply chain tells you what you're putting into your body where it comes from and why. Plus it's designed to thrive with our delayed-release capsule to help reach the colon (not the stomach), an ideal place for probiotics to survive and grow.*
MADE TRACEABLE: Our world-class scientists scoured the globe for high quality ingredients. Prebiotics PreforPro from Georgia - targets undesirable bacteria and supports growth of beneficial gut bacteria; Probiotics BB-12(Bifidobacterium anamalis ssp. lactis) and LGG (Lactobacillus rhamnosus) from Denmark - provide live microorganisms that contribute to a healthy gut microflora; Postbiotics Butyrate (as Tributyrin) from Spain- for major energy source for the cells that line the colon.*
SMART CAPSULE: Our innovative nested capsule is designed to thrive with it's delayed-release technology to help the probiotics to reach the colon (not the stomach), an ideal place for probiotics to survive and grow.* Plus we added a minty tab to every bottle so taking your daily gut support can be a more enjoyable experience.* All bottled up in a moisture-controlled technology to protect the probiotic strain. No Refrigeration Needed.
DIGESTIVE AND IMMUNITY SUPPORT: Our cutting edge approach to digestive support includes probiotic strains to support healthy regularity and relief of occasional discomforts such as mild and occasional bloating, gas, and diarrhea; postbiotic to supports gut barrier function; prebiotics designed to target undesirable bacteria in the gut and support the growth of beneficial gut bacteria; and probiotics to help support immune health. Its estimated that 70% of the immune system is located in the gut.*
THIRD PARTY TESTED: Each batch of Synbiotic+ is tested for identity, purity, strength, and composition, so we can be sure that whats on the label is whats in the capsules. We also complete third-party testing to ensure our products are compliant with regulations and guidelines for heavy metals, microbes, and major allergens and to help assure the quality and safety of our products.
OUR HAPPINESS GUARANTEE: We want you to love your Ritual products! If youre not completely satisfied with your order, simply reach out to us directly for friendly support. While Amazons return policy may not allow for returns, we are happy to offer you a full refund or exchange within 30 days. Just click on "Contact Seller" on your orders page, and well take care of you!

Show Price

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