10 Best Spider Killer of 2025

Tested and Reviewed: Top 10 Spider Killer deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Ortho

Ortho Home Defense Insect Killer for Indoor and Perimeter2 with Comfort Wand, Controls Ants, Roaches, Spiders and More, 1.33 gal

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Editor's bottom line:

“This spider killer is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Ortho Home Defense Insect Killer for Indoor & Perimeter2 kills the toughest home-invading insects, including ants, cockroaches, spiders, fleas, ticks, scorpions, earwigs, silverfish and periodical cicadas (as listed)
This insect killer spray provides a long-lasting bug barrier of up to 12 month protection against ants, roaches and spiders indoors on non-porous surfaces
Use this pest control spray indoors in kitchens and bathrooms or around doors and windows, and outdoors to the perimeter of foundations, patios, decks, garages or wherever insects are a recurring problem
Apply this bug killer anytime as a preventative treatment or after you see evidence of insect activity
This 1.33 gal. container of Ortho Home Defense Insect Killer for Indoor & Perimeter2 comes with a battery-powered Comfort Wand, which delivers a continuous spray for easy application

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Picked by 397 people today

9.5

Ortho

Ortho Home Defense Max Indoor Insect Barrier with Extended Reach Comfort Wand, Kills Ants, Roaches, Spiders, Fleas and Ticks, 1 gal.

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Main Highlights

Start killing ants, roaches, spiders, fleas and ticks with Ortho Home Defense Max Indoor Insect Barrier
This insect control spray kills listed bugs and protects your home for 365 days against ants, roaches and spiders indoors on nonporous surfaces
Use this indoor insect spray in kitchens, bathrooms and basements, and around doors and windows; apply outdoors to foundations to create a barrier around your home
Create an insect barrier anytime as a preventative treatment or after you see evidence of insect activity
Apply Ortho Home Defense Max Indoor Insect Barrier using the Extended Reach Comfort Wand, which lets you spray without bending

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9.5

Wet & Forget

Wet & Forget Miss Muffet's Revenge Spider Killer Indoor and Outdoor Spider Control, 64 OZ. Ready to Use, Gray Bottle, (803064)

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Main Highlights

Kills spiders and creates a barrier inside and outside the home to keep them away for up to 12 months with just one application
Attached sprayer for quick and easy application with a spray range of up to 10 feet for those hard to reach places
Treat all areas were spiders are found, spray until wet but not soaking and for long lasting results leave spray undisturbed
Apply in calm weather where rain is not expected for 24hrs and allow to dry completely before entering treated area
Miss Muffet's Revenge has unlimited shelf life, is ready to use, and especially formulated for all spiders except Black Widow and Brown Recluse

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9.2

HOT SHOT

Hot Shot Ant, Roach & Spider Killer, Kills Insects Indoors and Outdoors, Kills Roaches and Listed Ants on Contact, Insecticide Spray, 17.5 Ounce (Crisp Linen)

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Main Highlights

FAST KNOCKDOWN: Kills listed insects on contact* and keeps killing up to 3 months.**
KILLS INSECTS INDOORS: Hot Shot Ant, Roach & Spider Killer kills ants, cockroaches, spiders, fleas, silverfish, firebrats, crickets, Asian ladybeetles, carpet beetles, waterbugs, palmetto bugs and stink bugs indoors.
KILLS INSECTS OUTDOORS: This product kills ants, cockroaches, spiders, fleas, crickets, Asian ladybeetles, stink bugs, palmetto bugs and waterbugs outdoors.
CRISP LINEN SCENT: Use Hot Shot Ant, Roach & Spider Killer to kill insects while leaving behind a crisp linen scent.
NO OILY RESIDUE: Spray surface until damp; this product leaves no oily residue behind.

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9.0

HOT SHOT

Hot Shot Spider & Scorpion Killer (Aerosol), Kills Large Spiders and Scorpions in Seconds, Including Black Widow, Brown Recluse and Wolf Spiders, 16 Ounces

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Main Highlights

KILLS IN SECONDS: The fast-acting formula kills spiders, scorpions and other listed insects in seconds
KILLS FOR UP TO 4 MONTHS: Keeps killing ants (excluding harvester, pharaoh and fire ants), cockroaches and crickets for up to 4 months
KILLS BLACK WIDOW SPIDERS: Also kills black widow spiders as they hatch
UP TO 5-FT TARGETED SPRAY: Broad spray pattern ensures full coverage of treatment area
NO-MESS FORMULA: The water-based formula is non-staining and leaves no oily residue or lingering odor

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8.8

Terro

TERRO T2302 Spider, Ant, Roach, and Other Insects Killer Aerosol Spray – 2 Pack

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Main Highlights

2 spray bottles
Kills spiders (including Black widow, brown recluse and hobo spiders), ants, cockroaches, crickets, scorpions, and other insects
Kills on contact
Can be used indoors and outdoors

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8.6

Mighty Mint

Mighty Mint Peppermint Oil Spider Repellent Spray – Indoor & Outdoor Bug Control for Spiders and Insects – Plant-Based, Extra-Strong Formula - 16 oz

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Main Highlights

PET-FRIENDLY & FAMILY-SAFE FORMULA Mighty Mint is a top pick for pet parents looking for a natural pest control solution. Safe to use around dogs, cats, and kids when applied as directedno harsh fumes or dangerous chemicals, just powerful peppermint protection you can trust.
POWERFUL PLANT-BASED PEST CONTROL Formulated with extra-concentrated peppermint oil and geraniol, this spray quicky repels and kills spiders using a proven formula.
EFFECTIVE INDOOR & OUTDOOR USE Designed for versatile application on baseboards, entryways, patios, and other areas. Helps repel insects from kitchens, bathrooms, living spaces, and morewithout staining surfaces.
FRESH MINTY SCENT WITH LONG-LASTING EFFECT Infused with pure peppermint oil, this formula leaves a crisp, clean aroma that lingers without overwhelming. Free from synthetic fragrances and common allergens, making it a gentle option for scent-sensitive households.
READY-TO-USE 16 OZ SPRAY FOR TARGETED APPLICATION Perfect for quick treatments in high-traffic areas, this 16 oz bottle delivers fast, focused pest control against spiders, ants, and other common insects. Pre-mixed and easy to usejust spray and go for natural protection wherever its needed most.

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8.3

Terro

TERRO Spider & Insect Trap T3206-10 - Pack of 10 Insect Traps

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Main Highlights

Use these cockroach traps folded to conceal insects from view, or lay flat for a larger catch area
Traps and kills spiders, ants, cockroaches, crickets, and other crawling insects using sticky and glue traps
EASY-TO-USE roach sticky traps can be used flat or folded
GLUE TRAPS FOR ROACHES can be used around the home against baseboards, in corners, behind doors, or underneath furniture
Kills the Big 3 Effectively capture dangerous spiders, including brown recluse, black widow, and hobo spiders with these brown recluse spider traps

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8.1

HARRIS

Harris Spider Killer, Liquid Spray with Odorless and Non-Staining Formula (32oz, 2-Pack)

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Main Highlights

Odorless Formula - Odorless and non-staining formula will not cause damage to fabrics when used according to label directions
EPA Registered - Registered with the Environmental Protection Agency (No. 3-11) for indoor residential use
Kills a Variety of Insects - Also effective for ants, roaches, asian lady beetles, crickets, silverfish & more
For Indoor/Outdoor Use - The spray can use used indoors and outdoors as long as it is applied according to label directions
Kills Spiders When Spray Dries - The spray will kill once completely dried

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Our Best Overall Choice

Best Choice

9.7

Ortho

Ortho Home Defense Insect Killer for Indoor and Perimeter2 with Comfort Wand, Controls Ants, Roaches, Spiders and More, 1.33 gal

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Ortho Home Defense Insect Killer for Indoor & Perimeter2 kills the toughest home-invading insects, including ants, cockroaches, spiders, fleas, ticks, scorpions, earwigs, silverfish and periodical cicadas (as listed)
This insect killer spray provides a long-lasting bug barrier of up to 12 month protection against ants, roaches and spiders indoors on non-porous surfaces
Use this pest control spray indoors in kitchens and bathrooms or around doors and windows, and outdoors to the perimeter of foundations, patios, decks, garages or wherever insects are a recurring problem
Apply this bug killer anytime as a preventative treatment or after you see evidence of insect activity
This 1.33 gal. container of Ortho Home Defense Insect Killer for Indoor & Perimeter2 comes with a battery-powered Comfort Wand, which delivers a continuous spray for easy application

Show Price

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