10 Best Sinus Medicine of 2025

Tested and Reviewed: Top 10 Sinus Medicine deals with expert ratings from 8.1 to a perfect 10

May 2025 Edition

Editor's Choice

9.7

Save 14%

Vicks

Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

14% OffFree Shipping

Editor's bottom line:

“This sinus medicine is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details

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Picked by 206 people today

9.5

Save 25%

GenCare

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

25% OffFree Shipping

Main Highlights

ULTIMATE SINUS RELIEF - Experience maximum strength nasal decongestion and sinus pressure relief from indoor or outdoor allergies or common cold symptoms. 10 mg of Phenylephrine HCl helps alleviate pressure in your nose, sinus, ears, and throat.
BREATHE EASIER - Lowering sinus pressure and eliminating congestion can help you breathe better and deeper during the day or night. This over the counter decongestant can help with common symptoms like runny nose or blocked nasal passages.
NON DROWSY FORMULA - GenCare Nasal Decongestion can be taken any time of day including the morning or daytime. Many decongestant treatments are only suitable for nighttime use and are therefore limited for active adults and kids who need relief all day long.
BULK SAVINGS BOTTLE - Stop worrying about constant refills with our value savings 300 tablet family size bottle. This is the perfect size for families or people who suffer from chronic congestion due to allergies or seasonal illness.
100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 300 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of nasal decongestion customers...Click Add-to-Cart Today

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Best Value

9.5

Save 28%

Tylenol

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

28% OffFree Shipping

Main Highlights

24-count of Tylenol Sinus Severe Daytime Medicine Caplets for non-drowsy relief of symptoms due to the common cold, flu, hay fever or other respiratory allergies such as mucus and sinus congestion
Pain reliever, fever reducer, decongestant and expectorant medicine temporarily relieves minor aches and pains as well as symptoms of chest congestion, nasal congestion, sinus headache and pressure
Each caplet contains 325 milligrams of acetaminophen to reduce fever and pain; 5 milligrams of nasal decongestant phenylephrine HCl to help clear nasal passages; and 200 milligrams of the expectorant guaifenesin to help make coughs more productive
The non-drowsy formula of this sinus decongestant medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and passages, and thinning bronchial secretions to help make coughs more productive
From the #1 doctor recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

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9.2

Save 26%

Sudafed

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

26% OffFree Shipping

Main Highlights

20-count of Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Medicine Tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
Each multi-pack contains 20 tablets of nasal decongestant, with 12 Daytime and 8 Nighttime tablets for powerful symptom relief throughout the day and while you sleep
Each daytime and nighttime dose contains 10 milligrams of the nasal decongestant phenylephrine HCl per tablet and each nighttime dose also contains 25 milligrams per tablet of the antihistamine diphenhydramine HCl
Both formulas help relieve sinus pressure and sinus congestion, and nasal congestion due to the common cold, hay fever, or upper respiratory allergies. Nighttime tablets also relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose
From the #1 pharmacist recommended brand among oral OTC decongestants, this maximum-strength formula can be used by adults and children 12 years and older for powerful symptom relief

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9.0

Vicks

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

Free Shipping

Main Highlights

Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, sinus pain, chest congestion and mucus!
Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it thins and loosens mucus, reduces pressure in the sinuses, and relieves sinus pain!
The powerful, non-drowsy nasal decongestant medicine, expectorant, and pain reliever help to provide all in one relief for your sinus symptoms!
HSA and FSA eligible, Check with your provider for more details
This product is not formulated with an antihistimine allergy medicine and is not intended to treat runny nose, itchy & watery eyes, or sneezing

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8.8

Save 16%

Tylenol

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

16% OffFree Shipping

Main Highlights

24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

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8.6

Save 15%

Sudafed

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

15% OffFree Shipping

Main Highlights

DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan

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8.3

Save 22%

Mucinex

Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

22% OffFree Shipping

Main Highlights

MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion.
#1 TRUSTED COLD AND COUGH BRAND: #1 Cold and Cough brand doctors trust*
PAIN RELIEVER: Contains Acetaminophen which relieves minor aches and pains
EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion
NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure
USAGE: Use as directed; For ages 12+ years

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Our Best Overall Choice

Best Choice

9.7

Vicks

Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

14% OffFree Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details

Show Price

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