10 Best Single Use Eye Drops of 2025

Tested and Reviewed: Top 10 Single Use Eye Drops deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Refresh

Refresh Plus Lubricant Eye Drops, Preservative Free, Single Use Containers, 30 Count

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Editor's bottom line:

“This single use eye drops is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
On-the-go single use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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Picked by 397 people today

9.5

Refresh

REFRESH PLUS Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 70 Single-Use Containers

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Main Highlights

LASTING RELIEF: Original strength lubricating formula soothes mild symptoms of eye dryness
PRESERVATIVE-FREE: Made with zero preservatives to relieve mild symptoms of dry eyes including burning, irritation, and discomfort
FAST ACTING: Instantly moisturizes and lubricates
RELIABLE PROTECTION: Active ingredients provide lasting lubrication for dry eyes
GENTLE: Safe to use as often as needed. Great for dry, sensitive eyes
VALUE SIZE: 70 on-the-go, single-use vials
CAN BE USED AFTER LASIK OR OTHER EYE SURGERIES: Follow your eye doctor's instructions if you are using REFRESH PLUS after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.

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9.5

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

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Main Highlights

Dry eye relief without preservatives for sensitive eyes: TheraTears preservative-free lubricating eye drops in single-use vials provide immediate, long-lasting relief from dry eye symptoms
Instant hydration: TheraTears eye drops restore eyes natural balance and deliver fast hydration relief for dry eyes, because hydration is as essential for eye health as it is for the rest of the body
Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

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9.2

Refresh

Refresh Classic Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 30 Count (Pack of 1)

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Main Highlights

Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Preservative free formula
Great for sensitive eyes
On the go single use vials
The selling brand in preservative free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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9.0

TheraTears

TheraTears Extra Dry Eye Therapy Preservative-Free Lubricating Eye Drops for Dry Eyes, 30 Single-Use Vials

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Main Highlights

Dry eye relief without preservatives for sensitive eyes: TheraTears EXTRA preservative-free lubricating eye drops provide immediate relief from dry eye symptoms; formula provides EXTRAordinary relief and provides up to 12 hours of hydrating comfort
Instant hydration: TheraTears EXTRA eye drops restore eyes natural balance and deliver fast hydration relief for dry eyes, because hydration is essential for dry eye health
Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

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8.8

Systane

Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)

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Main Highlights

#1 Dr Recommended Brand of Artificial Tears*
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief
Reduces both the signs and symptoms of dry eye
Single-Use Convenience. Store at room temperature

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8.6

Refresh

REFRESH OPTIVE Preservative-Free Artificial Tears Lubricant Eye Drops, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

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Main Highlights

PRESERVATIVE-FREE: Specifically formulated without preservatives to quickly relieve dry, sensitive eyes
DUAL-ACTION FORMULA: Quickly lubricates and hydrates
SOOTHING: Delivers soothing hydration directly to your eye
RELIABLE PROTECTION: Active ingredients provide lasting lubrication for dry eyes
VALUE SIZE: 60 on-the-go, single-use vials
RECOMMENDED: Can be used for post-LASIK dryness. Follow your eye doctor's instructions if you are using REFRESH OPTIVE after an eye surgery (e.g., LASIK) to relieve dryness and discomfort
GENTLE: Safe to use as often as needed

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8.3

LUMIFY

LUMIFY Preservative Free Eye Drops for Red Eyes, Redness Reliever for Sensitive Eye, Brighter and Whiter Looking Eyes, Works in 1 Minute & Lasts Up to 8 Hours, 20 Single-Use Vials

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Main Highlights

EYE DROPS FOR RED EYES: From the eye care experts at Bausch + Lomb, LUMIFY Preservative Free Eye Drops help restore your eyes natural whiteness & reveal your eyes' natural radiance. These red eye drops work within 1 minute & last up to 8 hours
PRESERVATIVE FREE EYE DROPS: Compared to other redness relief eye drops, LUMIFY is the only OTC eye drop to contain low-dose brimonidine that selectively targets redness & helps lower risk of certain side effects seen with other OTC redness relievers when used as directed
PRESERVATIVE FREE REDNESS RELIEVER: The LUMIFY eye drops do not contain bleach or dyes. 95% showed significant redness reduction in 1 minute. They are the first and only preservative free redness reliever eye drops and are formulated to be gentle on sensitive eyes
AMAZING LOOKING EYES: We understand how important eyes are and despite all eye creams, mascara, eyeliners, and eyeshadows, you wont look your best with red eyes. Our redness relief eye drops help eyes look brighter and whiter to help restore their natural glow
DEVELOPED BY EYE CARE EXPERTS: For over 150 years, the experts at Bausch + Lomb have focused on innovation & quality in eye care products, from contact lenses and solutions to eye drops for allergies and eye itching, ointments, eye vitamins, and more

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8.1

Biotrue

Biotrue Hydration Boost, Preservative-Free Eye Drops for Dry Eyes, Instantly Moisturizes, Rehydrates, Contact Lens Friendly, Refresh & Relieve Eye Irritation, 30 Single-Use Vials (Pack of 1 )

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Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost for Dry Eyes are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
Convenient, single dose vials
BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced for comfort.
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help your eyes feel moisturized and protected.

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8.1

Soothe

Soothe Preservative-Free Lubricant Eye Drops, Dry Eye Relief, Moisturizing, for Fast Relief & Gentle Enough for Sensitive Eyes and LASIK Dryness, Single-Use Vials, 30 Count

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Main Highlights

EYE DROPS FOR DRY EYES: Use Soothe Lubricant Eye Drops to help moisturize & refresh dry eyes for long-lasting relief & comfort. Fast-acting dry eye therapy formulated to relieve dryness of the eye & help prevent irritation
PRESERVATIVE FREE EYE DROPS: These tear replacement dry eye drops are clinically proven to help relieve dry and irritated eye symptoms. Soothe lubricating eye drops are gentle enough for sensitive eyes and are recommended for LASIK dryness
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected

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Our Best Overall Choice

Best Choice

9.7

Refresh

Refresh Plus Lubricant Eye Drops, Preservative Free, Single Use Containers, 30 Count

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
On-the-go single use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

Show Price

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