10 Best Saccharomyces Boulardii of 2025

Tested and Reviewed: Top 10 Saccharomyces Boulardii deals with expert ratings from 8.1 to a perfect 10

April 2026 Edition

Editor's Choice

9.7

Triquetra Health

Organic Saccharomyces Boulardii - 10 Billion CFU - Clinically Validated CNCM I-1079 Probiotic Strain - Gut, Digestion & Healthy Bowel Support - First Organic Form of S. Boulardii Probiotic - 60 Count

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Editor's bottom line:

“This saccharomyces boulardii is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ORGANIC SACCHAROMYCES BOULARDII - PREMIUM PROBIOTIC STRAIN: Our organic-certified Saccharomyces boulardii probiotics feature the clinically validated CNCM I-1079 strain, recognized for its ability to support gut health and digestive balance. This trusted strain has been used worldwide to promote a healthy microbiome and maintain optimal gut function.*
FAST-ACTING S. BOULARDII PROBIOTIC FOR GUT & MICROBIOME SUPPORT: Ideal for those experiencing occasional digestive discomfort or looking to maintain healthy gut flora after antibiotic use, S. boulardii probiotics offer prompt support. This resilient yeast probiotic helps restore digestive balance and promote optimal gut function when you need it most.*
DESIGNED TO THRIVE IN HARSH CONDITIONS: Our Saccharomyces boulardii withstands stomach acid and bile, so it arrives in your gut ready to help maintain digestive balance. Its a reliable choice for promoting gut healtheven alongside antibiotic use.*
SUPPORTS GUT HEALTH & MICROBIOME BALANCE: Our S. boulardii probiotic helps maintain a healthy microbial balance, fostering an environment where beneficial microbes can thrive. Its the ideal choice for those looking to support digestive wellness and long-term gut health.*
CONVENIENT & SHELF-STABLE PROBIOTIC: No refrigeration required! Saccharomyces boulardii probiotics are shelf-stable, making them perfect for travel or busy lifestyles. Enjoy reliable gut support whenever and wherever you need it.*
CERTIFIED ORGANIC, CLEAN, AND TESTED FOR QUALITY: Made with USDA-certified organic Saccharomyces boulardii, this product is vegan, GMO-free, and free from additives. Produced in a cGMP-certified facility and third-party tested for safety, you can trust its purity and effectiveness.*

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Picked by 397 people today

9.5

Pure Therapro Rx

Saccharomyces Boulardii Probiotics 10 Billion CFU Made in USA | No Fillers Patented Strain: Lynside CNCM I-3799 Probiotics for Men and Women | Pure TheraPro Rx, Pharma Grade 120 Count

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Main Highlights

: Saccharomyces is a patented & clinically studied strain that has been used for its regulatory effect on the intestinal flora, helping to maintain normal balance in the intestine.
: We strive for optimal health. That's why our Saccharomyces Boulardii probiotics do not contain fillers, excipients, flow agents, or the additive magnesium stearate, which is believed to inhibit nutrient absorption. We don't use questionable ingredients and do our due diligence to find authentic versions/forms of nutrients. Our probiotic capsules are non-GMO and gluten-free.
: Our patented Saccharomyces strain (CNCM I-3799) is stable at body temperature (98.6°F) for survival in gastric acids. It's also stable at room temperature for 24 months. We use a proprietary process of less-aggressive drying at a controlled temperature and lower vacuum to preserve complete probiotic yeast cells, delaying the Saccharomyces aging process.
:Pure TheraPro Rx Saccharomyces probiotic capsules deliver a minimum of 10 billion colony-forming units per daily serving (250mg per capsule). These probiotics supplement capsules quickly achieve high concentrations in the GI tract, then clear within 3-5 days after discontinuing use. Take 1 to 2 capsules daily in the morning or as directed by a healthcare provider.
: Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.

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9.5

Jarrow Formulas

Jarrow Formulas Saccharomyces Boulardii + MOS Probiotics for Digestive Health and Intestinal Tract Support - 5 Billion CFU Per Serving - 90 Delayed Release Caps - Probiotic + Prebiotic - 90 Servings

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Main Highlights

One (1) 90 count bottle of Jarrow Formulas Saccharomyces Boulardii Probiotics+ MOS Gut Health Supplements Veggie Capsules for a 90-day supply
Digestion supplement with 5 billion CFU of Saccharomyces boulardii, a probiotic yeast clinically shown to benefit individuals in greater need for intestinal support*
Probiotics for gut health include MOS, a prebiotic that feeds the beneficial bacteria in the gut*
Suggested Use: Adults take 1 capsule once a day with water, or as directed by your qualified healthcare professional. May be taken with food or on an empty stomach
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.

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9.2

NOW Foods

NOW Supplements, Saccharomyces Boulardii, 5 Billion CFU Probiotic, 60 Veg Capsules

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Main Highlights

PROBIOTIC 5 BILLION CFU: Supports a healthy balance of intestinal flora*
USEFUL WHEN TRAVELING*: For occasional diarrhea*
REFRIGERATION RECOMMENDED: Refrigerate as soon as item is delivered to maintain shelf life through the 2-year best by date listed on bottom of bottle.
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Packaged in the USA by a family owned and operated company since 1968

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9.0

NOW Foods

NOW Foods Supplements, Saccharomyces Boulardii, 5 Billion CFU Probiotic, 120 Veg Capsules

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Main Highlights

PROBIOTIC 5 BILLION CFU: Supports a healthy balance of intestinal flora
USEFUL WHEN TRAVELING: For occasional diarrhea
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Non-GMO, Vegan/Vegetarian, Nut Free, Gluten Free, Dairy Free, Egg Free, Keto Friendly, Kosher, Halal
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
Packaged in the USA by a family owned and operated company since 1968.
During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

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8.8

Natural Foundation Supplements

Saccharomyces Boulardii Probiotic Supplement 240 Tablets 3 Billion CFU Probiotics for Men & Women Supports Intestinal Digestive & Gut Health (240, Saccharomyces Boulardii)

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Main Highlights

DIGESTIVE HEALTH - Saccharomyces boulardii probiotics promotes healthy gut function & immune system. It also supports occasional constipation, diarrhea, gas & bloating
BACKED BY SCIENCE - Our team of research scientists collect data from credible studies to formulate the optimal probiotic dosage, providing our customers with the best daily support
3RD PARTY TESTED - We ensure that all products are tested for safety, potency and identity. We use a leading independent laboratory to carry out all testing for your peace of mind

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8.6

Pure Therapro Rx

Saccharomyces Boulardii Probiotics 10 Billion CFU - Made in USA | No Fillers, Patented Strain: Lynside CNCM I-3799 Probiotics for Men and Women | Pure TheraPro Rx - 60 Capsules

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Main Highlights

: Saccharomyces is a patented & clinically studied strain that has been used for its regulatory effect on the intestinal flora, helping to maintain normal balance in the intestine.
: We strive for optimal health. That's why our Saccharomyces Boulardii probiotics do not contain fillers, excipients, flow agents, or the additive magnesium stearate, which is believed to inhibit nutrient absorption. We don't use questionable ingredients and do our due diligence to find authentic versions/forms of nutrients. Our probiotic capsules are non-GMO and gluten-free.
: Our patented Saccharomyces strain (CNCM I-3799) is stable at body temperature (98.6°F) for survival in gastric acids. It's also stable at room temperature for 24 months when stored properly. We use a proprietary process of less-aggressive drying at a controlled temperature and lower vacuum to preserve complete probiotic yeast cells, delaying the Saccharomyces aging process.
: Pure TheraPro Rx Saccharomyces probiotic capsules deliver a minimum of 10 billion colony-forming units per daily serving (250mg per capsule). These probiotics supplement capsules quickly achieve high concentrations in the GI tract, then clear within 3-5 days after discontinuing use. Take two (2) capsules one to two times daily, or as directed by a healthcare practitioner. If detox symptoms occur, lower the dose to ¼ capsule and slowly increase to the full dose. Can be taken with or without food. Please Note: Capsules may be opened and mixed into water, juice, or apple sauce. Consume immediately after mixing. Do not heat.
: Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.

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8.3

Jarrow Formulas

Jarrow Formulas Saccharomyces Boulardii + MOS Probiotics for Digestive Health and Intestinal Tract Support - 5 Billion CFU Per Serving - 180 Delayed Release Caps - Probiotic + Prebiotic - 180 Servings

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Main Highlights

Probiotic and Prebiotic: Saccharomyces Boulardii probiotic yeast helps support and maintain intestinal microflora, and restore normal intestinal microflora when possible disruptions occur, such as during travel or from intake of certain medications (1)
MOS: MOS is a prebiotic that feeds the beneficial bacteria in the gut(1)
5 Billion CFU: Delivers a minimum of 5 billion viable cells (under recommended storage conditions and within Best Used Before date); Take these veggie probiotic capsules 1 or 2 times per day with water, or as directed by a healthcare professional
Allergy-Friendly Formula Made with non-GMO ingredients, this vegan and gluten-free dietary supplement has no wheat, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts or sesame making it suitable for vegans and vegetarians
Probiotic yeast that survives stomach acid and colonizes the intestinal tract
MOS: Unfriendly bacteria binding site decoy
One of the best substantiated probiotics

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8.1

Pure Therapro Rx

Saccharomyces Boulardii Probiotics 10 Billion CFU - Made in USA | No Fillers, Patented Strain: Lynside CNCM I-3799 Probiotics for Men and Women | Pure TheraPro Rx - 240 Capsules

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Main Highlights

: Saccharomyces is a patented & clinically studied strain that has been used for its regulatory effect on the intestinal flora, helping to maintain normal balance in the intestine.
: We strive for optimal health. That's why our Saccharomyces Boulardii probiotics do not contain fillers, excipients, flow agents, or the additive magnesium stearate, which is believed to inhibit nutrient absorption. We don't use questionable ingredients and do our due diligence to find authentic versions/forms of nutrients. Our probiotic capsules are non-GMO and gluten-free.
: Our patented Saccharomyces strain (CNCM I-3799) is stable at body temperature (98.6°F) for survival in gastric acids. It's also stable at room temperature for 24 months. We use a proprietary process of less-aggressive drying at a controlled temperature and lower vacuum to preserve complete probiotic yeast cells, delaying the Saccharomyces aging process.
: Pure TheraPro Rx Saccharomyces probiotic capsules deliver a minimum of 10 billion colony-forming units per daily serving (250mg per capsule). These probiotics supplement capsules quickly achieve high concentrations in the GI tract, then clear within 3-5 days after discontinuing use. Take 1 to 2 capsules daily in the morning or as directed by a healthcare provider.
: Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.

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8.1

Seeking Health

Seeking Health Saccharomyces Boulardii - Gentle Digestive Support for Healthy Bowel Movements* - Supports a Good GI Tract Environment & Microbiome While Traveling* - Gluten & Dairy-Free - 60 Capsules

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Main Highlights

Supports healthy digestion, intestinal absorption, and bowel tone
Supports a healthy population and balance of good gastrointestinal tract bacteria
Supports gut microbiome health during travel
Great for Travel & Busy Days: These shelf-stable, acid-resistant and temperature-tolerant probiotic capsules require no refrigeration and can be taken anywhere, making them perfect for travel, busy families, or anyone with an on-the-go lifestyle
Optimizing Healthy Living: From research to packaging, Seeking Health prioritizes quality and safety at every step of the production process to provide health support you can trust

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Our Best Overall Choice

Best Choice

9.7

Triquetra Health

Organic Saccharomyces Boulardii - 10 Billion CFU - Clinically Validated CNCM I-1079 Probiotic Strain - Gut, Digestion & Healthy Bowel Support - First Organic Form of S. Boulardii Probiotic - 60 Count

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ORGANIC SACCHAROMYCES BOULARDII - PREMIUM PROBIOTIC STRAIN: Our organic-certified Saccharomyces boulardii probiotics feature the clinically validated CNCM I-1079 strain, recognized for its ability to support gut health and digestive balance. This trusted strain has been used worldwide to promote a healthy microbiome and maintain optimal gut function.*
FAST-ACTING S. BOULARDII PROBIOTIC FOR GUT & MICROBIOME SUPPORT: Ideal for those experiencing occasional digestive discomfort or looking to maintain healthy gut flora after antibiotic use, S. boulardii probiotics offer prompt support. This resilient yeast probiotic helps restore digestive balance and promote optimal gut function when you need it most.*
DESIGNED TO THRIVE IN HARSH CONDITIONS: Our Saccharomyces boulardii withstands stomach acid and bile, so it arrives in your gut ready to help maintain digestive balance. Its a reliable choice for promoting gut healtheven alongside antibiotic use.*
SUPPORTS GUT HEALTH & MICROBIOME BALANCE: Our S. boulardii probiotic helps maintain a healthy microbial balance, fostering an environment where beneficial microbes can thrive. Its the ideal choice for those looking to support digestive wellness and long-term gut health.*
CONVENIENT & SHELF-STABLE PROBIOTIC: No refrigeration required! Saccharomyces boulardii probiotics are shelf-stable, making them perfect for travel or busy lifestyles. Enjoy reliable gut support whenever and wherever you need it.*
CERTIFIED ORGANIC, CLEAN, AND TESTED FOR QUALITY: Made with USDA-certified organic Saccharomyces boulardii, this product is vegan, GMO-free, and free from additives. Produced in a cGMP-certified facility and third-party tested for safety, you can trust its purity and effectiveness.*

Show Price

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