10 Best Proteolytic Enzymes Supplements of 2025

Tested and Reviewed: Top 10 Proteolytic Enzymes Supplements deals with expert ratings from 8.1 to a perfect 10

June 2025 Edition

Editor's Choice

9.7

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NOW Foods

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

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Editor's bottom line:

“This proteolytic enzymes supplements is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Packaged in the USA by a family owned and operated company since 1968

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Picked by 198 people today

9.5

Save 15%

Piping Rock

Piping Rock Proteolytic Enzymes Supplement | 120 Capsules | Broad Spectrum Complex | Vegetarian, Non-GMO, Gluten Free

15% OffFree Shipping

Main Highlights

Superior quality at the best value
Designed to support your lifestyle goals
Devoted to Purity, Potency and Safety!
Non-GMO and Gluten Free
Laboratory Tested, using Trusted Ingredients

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9.5

Save 37%

Natural Factors

Natural Factors - Zymactive Proteolytic Enzyme Double Strength, Supports a Healthy Inflammatory Response to Help Muscle and Joint Function, Gluten Free, Non-GMO, 30 Enteric Coated Tablets

37% OffFree Shipping

Main Highlights

POTENT PROTEOLYTIC ENZYMES: Enteric coated double strength tablets to support joint and muscle inflammation.
NATURAL ENZYME SUPPORT: Zymactive is an advanced formula that provides systemic enzyme support for the body's natural healthy inflammatory response and immune system
LOCAL, ORGANIC, AND NON-GMO: Because Natural Factors Farms are certified organic, we don't pollute the earth with pesticides and chemical fertilizers. We grow true species non-hybridized, non-GMO seeds, including many open-pollinated varieties. Growing locally also helps reduce the carbon emissions from overseas transportation, and keep jobs in the community.
JUST THE RIGHT SIZE: We believe we need to be big enough to do it right. We are one of the only nutritional companies to have our own organic farms, our own extraction, encapsulation, and production facilities, our own labs and research facilities. We are also one of the few branded manufacturers of nutraceuticals in North America to have our own soft gel encapsulation facility.
WHERE GREAT HEALTH BEGINS: Today, Natural Factors is one of the largest manufacturers of nutritional products in North America. But our origins reach back to the 1950s, and right from day one, we've always been fully committed to making products right. We are not a public company with shareholders to impress. Instead, we care about impressing you.

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9.2

Carlyle

Carlyle Proteolytic Enzymes | 300 Capsules | Systemic Broad Spectrum Supplement | Vegetarian, Non-GMO & Gluten Free Formula

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Main Highlights

PROTEOLYTIC ENZYMES: Can be found naturally in certain foods like papaya and pineapple
BROAD SPECTRUM: Features an Advanced Enzyme Complex with Premium Turmeric Curcumin for added support
ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Artificial Flavor, Sweetener, Preservatives & Non-GMO

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9.0

NOW Foods

NOW Foods Supplements, Bromelain (Natural Proteolytic Enzyme) 2,400 GDU/g - 500 mg, Natural Proteolytic Enzyme*, 120 Veg Capsules

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Main Highlights

Bromelain is a proteolytic enzyme derived from the stem of the pineapple plant that has protein-digesting properties*
When taken with food, bromelain can help to support healthy digestion; when taken between meals, it may help to support joint comfort and may help to relieve temporary soreness that is associated with muscle overuse*
Bromelain is designed by nature to support proper gastrointestinal function and may also help to promote the comfort of muscles and joints*
Take 1 capsule 1 to 2 times daily, with or between meals
Packaged in the USA by a family owned and operated company since 1968.

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8.8

Doctor's BEST

Doctors Best Proteolytic Enzymes, Broad Spectrum Proteolytic Enzyme Formulation, Non-GMO, Vegetarian 90 Delayed Release Veggie Caps

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Doctors Best

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8.6

Wonder Laboratories

Wonder Laboratories Proteolytic Enzymes | Bromelain Papain Pancreatin Trypsin 550 mg Total with Standardized Amylase, Lipase, and Protease, 300 Tablets

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Main Highlights

Nutritionally Supports Your Body's Natural Response to Inflammation, Immune Function, and Supports Digestive and Intestinal Health*
Contains Bromelain, Lipase, Trypsin, Papain, Pancreatin, Chymotrypsin, Protease, and Amylase
Bromelain and Proteolytic Enzymes to help support the breakdown of proteins in digestion, immune function, and other vital processes.*
Amylase Lipase Bromelain Digestive Enzymes Organic Sources to provide you with a well formulated digestive enzyme
MADE IN USA - Manufactured and packaged in the USA by a family owned and operated company since 1962.

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8.3

AMVILAB

Amvilab - Proteolytic Enzymes - Trypsin & Chymotrypsin - Reduces Edema & Inflammation From Tissue Injury - Supports Digestive, Tissue & Immune Health - Recovery Boost - Dietary Supplement -60 Capsules

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Main Highlights

PROTEOLYTIC ENZYMES - Amvilabs Systemic Proteolytic Enzymes contain a combination of Trypsin & Chymotrypsin to improve joint and muscle health by helping important metabolic pathways. This supplement helps support protein metabolism pathway, immune system health, a healthy circulatory function, and more.
BOOST IMMUNE SYSTEM HEALTH - Backed by scientific evidence, our Systemic Proteolytic Enzymes boost the immune system by helping clear the debris and bad proteins that cause inflammation in the body. This supplement helps keep you robust and resilient.
REDUCES INFLAMMATION & PAIN - Ingredients like Trypsin and Chymotrypsin work on micro-wounds to clear debris, acting as a pro-healing supplement. Countering inflammation and reducing edema in accidental injuries, this supplement is perfect for after surgical and orthopedic injuries, and burns.
IMPROVES CIRCULATION & DIGESTION - Systemic Proteolytic Enzymes for inflammation help to initiate tissue repair, remove dead cells, and reduce blockages in vessels, allowing healthy tissues to grow. Acting as a natural detox and digestive ally, this supplement breaks down harmful substances and food, supporting a cleaner, healthier gut and body.
QUALITY ASSURED - This premium blend of Proteolytic Enzymes supplements are GMP certified, Gluten Free, Non-GMO and are made in the USA. Take 2 capsules 3 times daily for maximum benefits. Dont wait any longer to take control of your health and well-being, start your journey to elevate your wellness.

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8.1

WellnessOne

WellnessOne ProOneZyme Digestive Enzymes Supplements - Systemic Proteolytic Enzymes for Digestion, Gut Health, Gas Relief & Bloating - Contains Bromelain, Nattokinase, Protease & More - 90 Capsules

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Main Highlights

- Break down complex foods with ease. Our proprietary systemic enzymes blend includes protease, bromelain, nattokinase, seaprose-s, papain, and more to help digest proteins, fats, dairy, gluten, and carbs.
- Say goodbye to discomfort! Our enzymes help break down food completely, minimizing gas and bloating for a more comfortable digestive experience. Take 3 capsules daily at the beginning of a meal.
- Our proprietary systemic enzymes work throughout your entire digestive system, regardless of varying pH levels. This means faster relief from gas, bloating, and indigestion for maximum digestive comfort.
- Get the most out of your meals! Our digestive enzymes for women and men help break down proteins, fiber, and carbohydrates, promoting better nutrient absorption and supporting overall digestive health.
& - A healthy gut is key to overall well-being! Our enzymes promote a balanced gut microbiome, potentially enhancing your body's natural defenses.
- ProOneZyme is formulated by vitamin experts using high-quality, Non-GMO ingredients. Manufactured in a GMP-certified facility for your peace of mind. We prioritize customer satisfaction, so feel free to reach out if you have any questions!

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8.1

HEAL-N-SOOTHE

HEAL-N-SOOTHE Proteolytic Enzymes - Natural Joint Support Supplement - Unique Blend of Bromelain, Papain, Boswellia, and Turmeric - 90 Count

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Main Highlights

Proteolytic Systemic Enzyme Joint Support System - Heal-n-Soothe contains a blend of Proteolytic Enzymes, Turmeric Extract, Bromelain, Boswellia Extract, Papain, Rutin, Mojave Yucca Root, Devil's Claw, Citrus Bioflavonoids, Alpha Lipoic Acid and Ginger supplement
Scientifically formulated - Heal-n-Soothe is All-Natural & Vegetarian. No Gluten, No GMOs, No Added Sugars, No Dairy, and No Fillers or Binders.
Supports Healthy Immune System - High potency preteolytic enzyme blend that is scientifcally shown to support a healthy immune system

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Our Best Overall Choice

Best Choice

9.7

NOW Foods

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

51% OffFree Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Packaged in the USA by a family owned and operated company since 1968

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Doctor's Best 3000 GDU Bromelain Proteolytic Digestive Enzymes Supplements, Supports Healthy Digestion, Joint Health, Nutrient Absorption, 500 mg,Capsule, 90 Count(Pack of 1)

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California Gold Nutrition Proteolytic Enzymes, 90 Delayed Release Veggie Capsules

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Potent Nattokinase 4000 FU Serrapeptase 240000 SPU Lumbrokinase 2000 FU Supplement - Proteolytic Enzymes Capsules for Energy Support, Digestion, Detox, Cognition & Gut Health for Men & Women

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HerbaMe Proteolytic Enzymes Supplement with Serrapeptase - Devils Claw, 90 Capsules, Promotes Joints Relief, Muscle and Tissue Health with Lasting Mobility, Athletes Post Workout Recovery Support

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VITÄLZYM Digestive Enzymes for Gut Health | Proteolytic Systemic Multi Enzymes with Serrapeptase for Women and Men | Helps Increase Blood Flow and Maintain Digestive Health (90 Capsules)

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