10 Best Preservative Free Eye Drops For Dry Eyes of 2025

Tested and Reviewed: Top 10 Preservative Free Eye Drops For Dry Eyes deals with expert ratings from 8.1 to a perfect 10

May 2025 Edition

Editor's Choice

9.7

Save 21%

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

21% OffFree Shipping

Editor's bottom line:

“This preservative free eye drops for dry eyes is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

FAST-ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: Soothes and prevents further irritation
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

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Picked by 160 people today

9.5

Systane

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

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Main Highlights

Hydrates fast and provides long-lasting relief for dry eyes
Preservative free eye drops
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses
Extra moisturizing eye drops for sensitive eyes

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Best Value

9.5

Save 41%

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

41% OffFree Shipping

Main Highlights

Fast acting hydration for sensitive eyes
Preservative free tear evaporation protection
Nano droplets for better coverage

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9.2

Systane

Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

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Main Highlights

Preservative-Free Lubricant Eye Drops
Fast-Acting Hydration and lasting dry eye relief
Moisture rich formula eye drops for sensitive eyes
Tear evaporation protection for high-performance dry eye symptom relief that lasts

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9.0

Save 26%

Refresh

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

26% OffFree Shipping

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
Value size. 50 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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8.8

Refresh

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

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Main Highlights

ORIGINAL STRENGTH: Provides temporary relief for mild, occasional dry eye symptoms
FAST-ACTING: Instantly lubricates and moisturizes
PRESERVATIVE-FREE: Great for sensitive eyes
SOFT SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

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8.6

Biotrue

Biotrue Hydration Boost Eye Drops, Preservative Free, Soft Contact Lens Friendly for Irritated and Dry Eyes from Bausch + Lomb, Naturally Inspired, 0.33 FL OZ (10 mL)

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Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
CONTACT LENS FRIENDLY: Biotrue Hydration Boost Eye Drops can be applied while wearing soft contact lenses.
INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced.
EYE DROPS and MORE: Bausch and Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, and ointments to help your eyes feel moisturized and protected.

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8.3

Save 29%

iVIZIA

iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz Bottle

29% OffFree Shipping

Main Highlights

iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz bottle.
Unique Formulation: Hydrating polymers form a protective matrix, moisturizing Hyaluronic Acid holds up to 1000x its weight in moisture, and Trehalose (synthetic ingredient also found in desert plants).
Free of Irritating Preservatives: Sterile, safe for use with contact lenses
Patented ABAK Bottle: preservative-free, dispenses drop-by-drop, and does not stream. The ergonomic bottle is easy to open, easy to hold and squeeze.
iVIZIA We See a Better Way: for healthy, comfortable eyes

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8.1

Save 15%

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

15% OffFree Shipping

Main Highlights

TheraTears Dry Eye Therapy Lubricant Eye Drops, Preservative Free, provide immediate, long-lasting relief of dry eye symptoms
Discover TheraTears eye drops, one-of-a-kind silky hydration for dry eyes
TheraTears Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Preservative free for sensitive eyes; the single-use vials come in a foil pouch to ensure freshness
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 1 box of TheraTears Dry Eye Therapy Lubricant Drops, Preservative Free, 30 vials
FSA- and HSA-eligible product in the U.S.

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Our Best Overall Choice

Best Choice

9.7

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

21% OffFree Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

FAST-ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: Soothes and prevents further irritation
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

Show Price

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