10 Best Preservative Free Artificial Tears of 2026

Tested and Reviewed: Top 10 Preservative Free Artificial Tears deals with expert ratings from 8.1 to a perfect 10

June 2026 Edition

Editor's Choice

9.7

Save 8%

Refresh

REFRESH TEARS PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

8% Off

Editor's bottom line:

“This preservative free artificial tears is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ORIGINAL STRENGTH: Provides temporary relief for mild, occasional dry eye symptoms
FAST ACTING: Instantly lubricates and moisturizes
PRESERVATIVE-FREE: Made with zero preservatives to relieve mild symptoms of dry eyes including irritation, and discomfort
SOOTHING: Great for dry, sensitive eyes
SOFT-SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
GENTLE: Safe to use as often as needed
RELIABLE PROTECTION: Active ingredients provide lasting lubrication for dry eyes

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Picked by 397 people today

9.5

Systane

Systane, Complete Preservative Free Dry Eye Drops, Contains Propylene Glycol 0.6%, Multi-Dose Lubricating Eye Drops for Irritation and Dryness, Hydrating and Soothing, 0.3 Fl Oz, 2 Count

Main Highlights

Advanced Relief for Dry, Irritated Eyes: Systane COMPLETE Preservative-Free Lubricant Eye Drops provide soothing relief for all types of dry eye, including aqueous-deficient, evaporative, and mixed dry eye. Helps relieve discomfort due to environmental exposure such as sun and wind
Lasting Relief from One Drop: Formulated with Propylene Glycol (0.6%), it provides up to 8 hours of dry eye relief. Systane COMPLETE Preservative-Free helps relieve common dry eye symptoms like sore, watery, stinging, burning, tired, dry, and irritated eyes. For mild to moderate dry eye sufferers who want dependable hydration
Advanced Nano-Droplet Technology: Nano-droplet technology features the rapid delivery of this soothing drop over the entire eye surfaceresulting in better coverage vs Systane Balance. It provides fast hydration, evaporation protection and long-lasting dry eye relief
Easy Dosing: The multi-dose bottle, with its ergonomic design for easy drop administration. Instill 12 drops as needed throughout your day. With just one drop, Systane COMPLETE Preservative-Free provides 8 hours of dry eye symptom relief in a preservative-free formula ideal, for sensitive eyes
Trusted Brand, Convenient Design: Systane is a trusted name in eye care, recommended by eye care professionals for reliable dry eye relief. The multi-dose easy-application bottle offers on-the-go hydration, keeping eyes refreshed and moisturized wherever your day takes you

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9.5

Refresh

Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free,Value Size, 0.01 Fl Oz Single-Use Containers, 70 Count

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes

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Best Value

9.2

Save 41%

Systane

Systane Ultra Preservative Free Lubricant Eye Drops, 0.34 fl oz, Fast-Acting Dry Eye Relief from Irritation & Dryness, Hydrating Eye Drops for Extended Protection, Multi-Dose Bottle

41% Off

Main Highlights

Fast-Acting Dry Eye Relief for Dry, Irritated Eyes: Systane ULTRA Preservative-Free Lubricant Eye Drops provide rapid hydration and lasting relief for dry eyes caused by irritants like screen time, air quality, low humidity, or seasonal changes. Designed for occasional or mild dry eye sufferers
Targets the Aqueous Layer: Formulated with Polyethylene Glycol 400 and Propylene Glycol, our moisturizing eye drops for dry eyes help hydrate and protect the ocular surface by replenishing the aqueous (water) layer of the tear film to deliver fast-acting and long-lasting dry eye relief throughout the day
Gentle Preservative-Free Formula: Suitable for sensitive eyes, the preservative-free formula of Systane ULTRA Preservative-Free Lubricating Eye Drops helps soothe eye dryness without preservatives. Helps relieve discomfort to the eye caused by wind, dust, or extended screen exposure, making it suitable for everyday use
Convenient & Hygienic Application: Available in an easy-to-use multi-dose bottle providing a sterile, travel-friendly option for on-the-go dry eye relief. A great addition to your daily eye care routine, instill 12 drops as needed throughout the day. These lubricating eye drops help restore comfort, whether you're at your desk or on the go
Trusted Brand, Convenient Design: Systane is a trusted name in eye care, recommended by eye care professionals for reliable dry eye relief. The multi-dose easy-application bottle offers on-the-go hydration, keeping eyes refreshed and moisturized wherever your day takes you

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9.0

Save 15%

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

15% Off

Main Highlights

Dry eye relief without preservatives for sensitive eyes: TheraTears preservative-free lubricating eye drops in single-use vials provide immediate, long-lasting relief from dry eye symptoms
Instant hydration: TheraTears eye drops restore eyes natural balance and deliver fast hydration relief for dry eyes, because hydration is as essential for eye health as it is for the rest of the body
Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

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8.8

Save 20%

Refresh

Refresh OPTIVE MEGA-3 PF Lubricant Eye Drops Preservative-Free Artificial Tears, 0.33 fl oz (10mL)

20% Off

Main Highlights

FAST ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: One drop provides 10+ hours of dry eye relief (results may vary) (Data on file, AbbVie, Inc. REF-136415)
UNIQUE FORMULA: Enhanced with antioxidants and plant-based flaxseed oil (inactive ingredients), which contains omega-3s
SOFT-SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
PRESERVATIVE-FREE: Gentle and safe to use as often as needed
SOOTHING: Great for dry, sensitive eyes
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
TRUSTED: #1 doctor recommended for preservative-free artificial tears from the brand with over 35 years of experience
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense, depending on your plan

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8.6

Save 28%

Systane

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief, 0.34 fl oz, Twin Pack (Pack of 2)

28% Off

Main Highlights

Hydrates fast and provides long-lasting relief for dry eyes
Preservative free eye drops
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses
Extra moisturizing eye drops for sensitive eyes
Ideal for postsurgical patients, e.g. post-lasik or post cataract surgery with dry eye symptoms

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8.3

Save 31%

Alcon

ALCON Systane Hydration Preservative-Free Lubricant Eye Drops, Transparent, 0.6 Fl Oz, 30 Count

31% Off

Main Highlights

Hydrates fast and provides long-lasting relief.
#1 Doctor & pharmacist Recommended brand
Preservative free
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses

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8.1

TheraTears

TheraTears Dry Eye Therapy Eye Drops for Dry Eyes, 1.0 Fl Oz

Main Highlights

Immediate dry eye relief: TheraTears Lubricating Eye Drops provide immediate, long-lasting relief from dry eye symptoms such as burning, grittiness, and irritation
Instant hydration: TheraTears Dry Eye Therapy eye drops restore eyes natural balance and deliver fast hydration relief for dry eyes; relieving irritated and itchy eyes
Unique Formula: TheraTears eye drops formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The hydrating TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended* brand, created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details; *ProVoice Survey data collected 9/1/23-8/31/24

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8.1

Refresh

Refresh Optive Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 60 Count

Main Highlights

Dual-action formula lubricates and hydrates
Relieves mild symptoms of eye dryness
Works fast by delivering soothing moisture
Preservative-free for sensitive eyes
Value size: 60 on-the go, single-use vials

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Our Best Overall Choice

Best Choice

9.7

Refresh

REFRESH TEARS PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

8% Off

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ORIGINAL STRENGTH: Provides temporary relief for mild, occasional dry eye symptoms
FAST ACTING: Instantly lubricates and moisturizes
PRESERVATIVE-FREE: Made with zero preservatives to relieve mild symptoms of dry eyes including irritation, and discomfort
SOOTHING: Great for dry, sensitive eyes
SOFT-SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
GENTLE: Safe to use as often as needed
RELIABLE PROTECTION: Active ingredients provide lasting lubrication for dry eyes

Show Price

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