10 Best Phlegm Cough Medicine of 2025

Tested and Reviewed: Top 10 Phlegm Cough Medicine deals with expert ratings from 8.1 to a perfect 10

April 2025 Edition

Editor's Choice

9.7

Save 24%

Mucinex

Mucinex 12 Hour 1200mg Maximum Strength Guaifenesin Chest Congestion & Mucus Relief, Guaifenesin Expectorant Aids Mucus Removal, Chest Decongestant for Adults, Dr Recommended, 42ct Tablets

24% OffFree Shipping

Editor's bottom line:

“This phlegm cough medicine is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

EXCESS MUCUS RELIEF: Maximum Strength Mucinex 12hr extended-release tablets pack a powerful punch with 1200 mg guaifenesin expectorant, providing you with long-lasting chest congestion relief
AIDS EXCESS MUCUS REMOVAL: Maximum strength chest congestion relief; Mucinex 12hr lasts up to 12 hours and provides relief for your chest congestion and makes cough more productive
EXPECTORANTS FOR ADULTS: Mucinex helps clear lungs by thinning & loosening mucus; Say goodbye to excess mucus, say hello to chest congestion relief
EXTENDED RELEASE GUAIFENESIN: Experience long-lasting excess mucus relief with Mucinex's 12hr maximum strength extended-release 1200 mg guaifenesin bi-layer tablets with immediate & extended release
TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended OTC Expectorant**; Get the brand that doctors trust and recommend
COLD AND FLU MEDICINE FOR ADULTS: For powerful cough, cold, and flu multi-symptom relief, check out our range of Mucinex Fast-Max cold and flu medicines; Beat cold and flu symptoms with confidence
FSA & HSA Eligible: Save Up to 30% - Cover out-of-pocket expenses with pre-tax dollars (Product eligibility may vary by plan; Check with your benefits administrator to determine which expenses are eligible before you shop)
QUALITY YOU CAN TRUST: Mucinex uses carbomer that is manufactured without the use of benzene
*IQVIA using ProVoice Survey, August 2023; **U.S. News & World Report/Pharmacy Times 2023-2024

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Picked by 285 people today

9.5

Save 6%

Robitussin

Robitussin Adult Maximum Strength Cough Plus Chest Congestion DM Max, Cough Suppressant and Expectorant, Raspberry Flavor, 8 Fl Oz x 2

6% OffFree Shipping

Main Highlights

Two 8 fl oz bottles of Robitussin Adult Maximum Strength Cough Plus Chest Congestion DM Max, Cough Suppressant and Expectorant, Raspberry Flavor
Relief for cough and an expectorant for relief of chest congestion
Maximum-strength cough relief formula with expectorant that thins and loosens mucus for productive coughs
Raspberry flavored, daytime cough medicine delivers fast, effective cough relief
Cough suppressant and liquid expectorant suitable for adults and children 12 years and over
HSA and FSA eligible product

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9.5

Save 22%

Mucinex

Mucinex DM Max Liquid Cough & Cold Medicine For Adults, Cold And Flu Medicine for Excess Mucus Relief, Guaifenesin & Dextromethorphan Expectorant & Decongestant for Adults, Dr Recommended, 6.0 Fl Oz

22% OffFree Shipping

Main Highlights

COUGH COLD AND FLU MEDICINE FOR ADULTS: Mucinex DM Max expectorant & cough suppressant packs a powerful 1..2.. punch with dextromethorphan and Guaifenesin 400mg extended release, providing you with long-lasting relief from mucus congestion and cough.
EXCESS MUCUS RELIEF: Maxium strength multi-symptom relief. Mucinex DM Max is clinically proven to last up to 4hrs and provide relief for chest congestion and make coughs more productive.
EXPECTORANTS AND DECONGESTANTS FOR ADULTS: Mucinex DM Max helps clear lungs of excess mucus and phlegm to help make every day a breath of fresh air. Say goodbye to chest congestion and cough, say hello to excess mucus relief!
EXTENDED RELEASE GUAIFENESIN: Experience 4hr relief with Mucinex DM Max extended-release 400mg guaifenesin and 20mg dextromethorphan HBr in an easier to swallow liquid format.
TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended Brand. Don't be fooled by cheap imitations get the brand that doctors trust and recommend!
COLD MEDICINE FOR ADULTS: When you need a powerful cough and cold medicine that's formulated for adults, Mucinex DM is the name to trust. Beat cold and flu symptoms with confidence.
*IQVIA using ProVoice Survey, December 2022 U.S. News & World Report/Pharmacy Times 2023-2024

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9.2

Save 6%

Robitussin

Robitussin Adult Maximum Strength Cough + Chest Congestion DM Max (8 fl. oz. Bottle), Cough Suppressant & Expectorant, Raspberry Flavor

6% OffFree Shipping

Main Highlights

Maximum-strength formula with expectorant that thins and loosens mucus for productive coughs
Raspberry flavored, daytime cough medicine delivers fast, effective cough relief
Suitable for adults and children 12 years and over

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9.0

Save 22%

Boiron

Boiron Chestal Pellets for Cough and Mucus Relief, Nasal or Chest Congestion, and Sore Throat Relief - 2 Count (160 Pellets)

22% OffFree Shipping

Main Highlights

ON-THE-GO COUGH & MUCUS RELIEF: Chestal Cough & Mucus Pellets relieve dry coughs and minor throat irritations that can occur with a cold, and also loosen mucus to make coughs more productive.* Ideal for busy people on the move, these pellets in compact and portable tubes are convenient to take at home or on the go.
CONVENIENT MELTAWAY PELLETS: Get cough relief anywhere, anytime. Chestal Cough & Mucus Pellets dissolve easily in the mouth without water, chewing, or swallowing.
HELP YOUR FAMILY THE NATURAL WAY: This homeopathic cough and cold medicine is non-drowsy and can be taken day or night. It has no known interactions with other medications, herbs, or supplements and contains no artificial sweeteners, flavors, colors, or preservatives.
A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are manufactured to meet the highest standards of cGMP and HPUS for purity and quality.
BUY WITH YOUR HSA/FSA: Many of your favorite Boiron medicines are now eligible for reimbursement. Look for our logo designating products that can be paid for with your Health Savings Account or Flexible Savings Account.

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8.8

Save 10%

ALKA-SELTZER PLUS

Alka-Seltzer Plus Maximum Strength Cough, Mucus & Congestion Powermax Liquid Gels, Fast and Effective Chest Congestion Relief, Cough Suppressant, For Adults and Children 12 Years and Older 24 Count

10% OffFree Shipping

Main Highlights

Alka-Seltzer Plus Maximum Strength Cough, Mucus & Congestion Powermax Liquid Gels provide relief from cough, mucus, and congestion. *Use as directed.
Provides powerful maximum multi-symptom relief from nasal congestion, headache, chest congestion, body ache, sore throat, sinus pressure, congestion and fever
Fast and effective coughing medicine for adults so you can get back to your busy life
Each cough, mucus, and congestion relief box contains: 24 Liquid gels, 1 dose (2 Liquid gels)
The cough suppressant ingredient (Dextromethorphan Hbr) helps to relieve cough and Expectorant (Guaifenesin) in this medicine helps loosen phlegm (mucus) and make coughs more productive.
HSA/FSA Eligible -- Check your plan for coverage.

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8.6

TUKOL

TUKOL Max Action Severe Congestion & Cough Medicine for Adults – Expectorant Cough Syrup, DM Cough Syrup, Dry Cough Cold and Sore Throat Medicine, Chest Decongestant,12+ Years, 6 Fl Oz

Free Shipping

Main Highlights

[ MULTI-SYMPTOM RELIEF FOR SEVERE COLD AND COUGH ]: Tukol Max Action offers a powerful solution to relieve cough, nasal, and chest congestion, making it easier to breathe and alleviating discomfort so you can continue your day without interruptions
[ POWERFUL EXPECTORANT AND COUGH SUPPRESSANT ]: Helps thin mucus and relieve chest congestion, making it easier to expel, while also calming persistent coughs for fast, effective relief
[ NON-DROWSY FORMULA FOR DAYTIME RELIEF ]: Designed for daytime use, this non-drowsy cough syrup targets multiple cold symptoms like cough, nasal, and chest congestion, allowing you to stay productive while feeling better
[ ACTIVE INGREDIENTS FOR MAXIMUM RELIEF ]: Contains Dextromethorphan HBr to suppress cough and Guaifenesin to loosen mucus, providing fast, targeted relief from cold and cough symptoms
[ EASY DOSAGE FOR ADULTS ]: For adults and children 12 years and older, take 20 mL every 4 hours as needed. Do not exceed 6 doses in 24 hours. Use the provided measuring cup for accurate dosage and fast relief from cough and congestion

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8.3

Amazon Basic Care

Amazon Basic Care Maximum Strength Mucus DM, Expectorant and Cough Suppressant, 14 Tablets

Free Shipping

Main Highlights

ACTIVE INGREDIENTS: Amazon Basic Care Maximum Strength Mucus Relief DM tablets contain dextromethorphan HBr and guaifenesin; compare to the active ingredients in Maximum Strength Mucinex DM
MAXIMUM STRENGTH: 1200 mg of guaifenesin and 60 mg of dextromethorphan HBr team up to take on your toughest cold
EFFECTIVE: Amazon Basic Care Maximum Strength Mucus-DM clears your chest congestion and eases the intensity of coughing
COUGH SUPPRESSANT: This 12-hour cough medicine contains dextromethorphan HBr for cough relief; it relieves the impulse to cough to help you get to sleep
COUGH EXPECTORANT: Contains guaifenesin to help loosen phlegm so you can cough up that bothersome mucus; makes coughs more productive

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8.1

HealthA2Z

HealthA2Z® Mucus Relief DM | Dextromethorphan HBr 20mg | Guaifenesin 400mg | No Benzene | Cough, Immediate Release, Uncoated (50 Count (Pack of 1))

Free Shipping

Main Highlights

HealthA2Z Mucus Relief DM | Dextromethorphan HBr 20mg | Guaifenesin 400mg | Cough, Immediate Release, Uncoated

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Our Best Overall Choice

Best Choice

9.7

Mucinex

Mucinex 12 Hour 1200mg Maximum Strength Guaifenesin Chest Congestion & Mucus Relief, Guaifenesin Expectorant Aids Mucus Removal, Chest Decongestant for Adults, Dr Recommended, 42ct Tablets

24% OffFree Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

EXCESS MUCUS RELIEF: Maximum Strength Mucinex 12hr extended-release tablets pack a powerful punch with 1200 mg guaifenesin expectorant, providing you with long-lasting chest congestion relief
AIDS EXCESS MUCUS REMOVAL: Maximum strength chest congestion relief; Mucinex 12hr lasts up to 12 hours and provides relief for your chest congestion and makes cough more productive
EXPECTORANTS FOR ADULTS: Mucinex helps clear lungs by thinning & loosening mucus; Say goodbye to excess mucus, say hello to chest congestion relief
EXTENDED RELEASE GUAIFENESIN: Experience long-lasting excess mucus relief with Mucinex's 12hr maximum strength extended-release 1200 mg guaifenesin bi-layer tablets with immediate & extended release
TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended OTC Expectorant**; Get the brand that doctors trust and recommend
COLD AND FLU MEDICINE FOR ADULTS: For powerful cough, cold, and flu multi-symptom relief, check out our range of Mucinex Fast-Max cold and flu medicines; Beat cold and flu symptoms with confidence
FSA & HSA Eligible: Save Up to 30% - Cover out-of-pocket expenses with pre-tax dollars (Product eligibility may vary by plan; Check with your benefits administrator to determine which expenses are eligible before you shop)
QUALITY YOU CAN TRUST: Mucinex uses carbomer that is manufactured without the use of benzene
*IQVIA using ProVoice Survey, August 2023; **U.S. News & World Report/Pharmacy Times 2023-2024

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