10 Best Oxymetazoline Hcl Nasal Spray of 2025

Tested and Reviewed: Top 10 Oxymetazoline Hcl Nasal Spray deals with expert ratings from 8.1 to a perfect 10

June 2026 Edition

Editor's Choice

9.7

Amazon Basic Care

Amazon Basic Care Maximum Strength 12 Hour Nasal Spray, Oxymetazoline HCl Solution, Sinus Pressure Relief, Cold and Allergy Medicine, Decongestant, 1 fl oz (Pack of 1)

Editor's bottom line:

“This oxymetazoline hcl nasal spray is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: This nasal spray contains oxymetazoline hydrochloride 0.05%, a nasal decongestant. Compare to the active ingredient in Afrin Original.
PURPOSE: This nasal spray temporarily relieves nasal congestion, sinus congestion and pressure due to the common cold, hay fever and upper respiratory allergies.
12 HOUR RELIEF: Amazon Basic Care Maximum Strength Nasal Spray provides fast, powerful congestion relief for allergies and colds for up to 12 hours.
FAST CONGESTION RELIEF: Provides fast and powerful nasal congestion relief for allergies and colds.
FAST-ACTING NASAL DECONGESTANT clears stuffy nose due to upper respiratory allergies and the common cold.

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Picked by 397 people today

9.5

MAJOR

MAJOR Maximum Strength Nasal Decongestant Spray, Oxymetazoline HCl 0.05% Pump Mist, Non-Drowsy Nasal Spray, up to 12-Hour Relief from Nasal Congestion, Colds, and Allergies 1 Fl. Oz. (3-Pack)

Main Highlights

NASAL DECONGESTANT SPRAY Contains 0.05% Oxymetazoline HCl to temporarily relieve nasal congestion from the common cold, hay fever, or upper respiratory allergies. Provides up to 12 hours of relief with a convenient nasal spray pump mist.
HELPS RELIEVE SINUS PRESSURE This nasal spray decongestant is formulated to temporarily reduce sinus pressure and swollen nasal membranes. Suitable for adults and children ages 6 to under 12, with adult supervision.
NON-DROWSY, NO DRIP NASAL SPRAY Quality non-drowsy, no-drip formula that wont run from the nose or down the throat. Designed for comfortable use to alleviate nasal congestion, cold, and allergy symptoms.
HOW TO USE - Shake well before use. 23 sprays per nostril every 1012 hours. Do not exceed 2 doses in 24 hours or for more than 3 days. Children under 6: Ask a doctor.
MAJOR PHARMACEUTICALS - At Major Pharmaceuticals, we believe wellness should be accessible to everyone. We pride ourselves on our legacy of delivering affordable, high-quality OTC and vitamin supplements, trusted by healthcare professionals and pharmacies across 50+ therapeutic categories.

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Best Value

9.5

Save 3%

Amazon Basic Care

Amazon Basic Care Maximum Strength 12 Hour Nasal Spray, Oxymetazoline HCl Solution, Congestion Relief, Cold and Allergy Medicine, Decongestant, 1 Fl Oz (Pack of 2)

3% Off

Main Highlights

The information below is per-pack only
ACTIVE INGREDIENT: This nasal spray contains oxymetazoline hydrochloride 0.05%, a nasal decongestant. Compare to the active ingredient in Afrin Original.
PURPOSE: This nasal spray temporarily relieves nasal congestion, sinus congestion and pressure due to the common cold, hay fever and upper respiratory allergies.
12 HOUR RELIEF: Amazon Basic Care Maximum Strength Nasal Spray provides fast, powerful congestion relief for allergies and colds for up to 12 hours.
FAST CONGESTION RELIEF: Provides fast and powerful nasal congestion relief for allergies and colds.
FAST-ACTING NASAL DECONGESTANT clears stuffy nose due to upper respiratory allergies and the common cold.

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9.2

Amazon Basic Care

Amazon Basic Care No Drip Nasal Spray, 12 Hour Maximum Strength Nasal Decongestant, Oxymetazoline HCl, Fast-Acting Sinus Pressure Relief, 1 fl oz (Pack of 1)

Main Highlights

ACTIVE INGREDIENT: This nasal spray contains oxymetazoline HCl, the #1 doctor recommended adult nasal spray active ingredient (of U.S. physicians surveyed by an independent market research firm). Compare to the active ingredient in Afrin No Drip.
SOOTHING 12 HOUR MAXIMUM STRENGTH RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides 12 hours of maximum strength nasal congestion relief due to the common cold, hay fever and upper respiratory allergies.
FAST NASAL CONGESTION RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides fast and powerful relief for colds and allergies. Temporarily relieves sinus congestion and pressure.
NASAL RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides temporary nasal congestion relief by shrinking swollen nasal membranes so you can breathe more freely.
NO DRIP NASAL SPRAY: This cold and allergy relief nasal spray won't drip down your nose or throat. Nasal decongestant pump mist. This product is gluten free.

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9.0

MAJOR

MAJOR Maximum Strength Nasal Decongestant Spray, Oxymetazoline HCl 0.05% Pump Mist, Non-Drowsy Nasal Spray, up to 12-Hour Relief from Nasal Congestion, Colds, and Allergies 1 Fl. Oz. (12-Pack)

Main Highlights

NASAL DECONGESTANT SPRAY Contains 0.05% Oxymetazoline HCl to temporarily relieve nasal congestion from the common cold, hay fever, or upper respiratory allergies. Provides up to 12 hours of relief with a convenient nasal spray pump mist.
HELPS RELIEVE SINUS PRESSURE This nasal spray decongestant is formulated to temporarily reduce sinus pressure and swollen nasal membranes. Suitable for adults and children ages 6 to under 12, with adult supervision.
NON-DROWSY, NO DRIP NASAL SPRAY Quality non-drowsy, no-drip formula that wont run from the nose or down the throat. Designed for comfortable use to alleviate nasal congestion, cold, and allergy symptoms.
HOW TO USE - Shake well before use. 23 sprays per nostril every 1012 hours. Do not exceed 2 doses in 24 hours or for more than 3 days. Children under 6: Ask a doctor.
MAJOR PHARMACEUTICALS - At Major Pharmaceuticals, we believe wellness should be accessible to everyone. We pride ourselves on our legacy of delivering affordable, high-quality OTC and vitamin supplements, trusted by healthcare professionals and pharmacies across 50+ therapeutic categories.

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8.8

berkley jensen

Berkley Jensen No Drip Severe Congestion Nasal Spray - Maximum Strength Decongestant with Oxymetazoline HCl & Menthol - Pump Mist Applicator, No Steroid, 12 Hour Relief, 1 Fl Oz (Pack of 3)

Main Highlights

POWERFUL CONGESTION RELIEF: Our nasal spray decongestant offers fast and powerful relief from nasal congestion and sinus pressure due to Allergies and Colds, providing a rapid solution to alleviate breathing discomfort
MESS-FREE APPLICATION: With a no-drip mist pump applicator, this nose spray decongestant delivers effective relief without the inconvenience of the solution dripping down from the nose or throat
LASTING EFFECTS: Our sinus spray contains 0.05% oxymetazoline HCl and menthol, which provide 12 hours of relief from sinus congestion throughout your day-to-day routine
SUPERB VALUE: Each package contains three 1 fl. oz. bottles of our nasal spray congestion relief for adults, allowing you to keep one at home for your household and bring one in your purse when out and about
QUALITY MANUFACTURING: We are committed to supplying premium wellness products to all our clients, with our decongestants for adults made in a facility that complies with strict quality protocols
MAXIMUM STRENGTH FORMULA: Contains 0.05% Oxymetazoline HCl with Menthol, the number one doctor recommended adult nasal spray active ingredient for severe congestion relief
NO STEROID FORMULA: This nasal decongestant spray provides effective relief without steroids, using a pump mist applicator for easy and controlled application

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8.6

Amazon Basic Care

Amazon Basic Care No Drip Severe 12 Hour Nasal Decongestant Pump Mist, Maximum Strength Plus Menthol, Allergy Relief, 1 fl oz (Pack of 1)

Main Highlights

ACTIVE INGREDIENT: This nasal spray contains oxymetazoline HCl, a nasal decongestant and the doctor recommended adult nasal spray active ingredient (source: IQVIA physicians survey 2019), which compares to the active ingredient in Afrin No Drip. Offers maximum strength nasal congestion relief.
12 HOUR, MAXIMUM STRENGTH RELIEF: Amazon Basic Care Severe Congestion Nasal Spray, Oxymetazoline HCl provides 12 hours of maximum strength nasal congestion relief due to the common cold, hay fever and upper respiratory allergies.
FAST NASAL CONGESTION RELIEF: Amazon Basic Care Severe Congestion Nasal Spray, Oxymetazoline HCl provides fast and powerful relief for colds and allergies. Temporarily relieves sinus congestion and pressure.
NASAL RELIEF: Amazon Basic Care Severe Congestion Nasal Spray, Oxymetazoline HCl provides temporary nasal congestion relief by shrinking swollen nasal membranes so you can breathe more freely.
NO DRIP NASAL SPRAY: This cold and allergy relief nasal spray won't drip down your nose or throat. Severe congestion formula pump mist. Safety Sealed. This product is gluten free. Contains Menthol.

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8.3

ASSURED

(12 pack) Nasal Relief Spray, 12 hour Pump Mist (Oxymetazoline HCL) 0.5 fl oz

Main Highlights

Family Care Nasal Relief
Twelve bottles per order.

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8.1

Amazon Basic Care

Amazon Basic Care No Drip Nasal_Spray, 12 Hour Nasal Decongestant, Pump Mist, Oxymetazoline HCl, Cold and Allergy Nasal Spray, 1 fl oz (Pack of 2)

Main Highlights

The information below is per-pack only
ACTIVE INGREDIENT: This nasal spray contains oxymetazoline HCl, the #1 doctor recommended adult nasal spray active ingredient (of U.S. physicians surveyed by an independent market research firm). Compare to the active ingredient in Afrin No Drip.
SOOTHING 12 HOUR MAXIMUM STRENGTH RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides 12 hours of maximum strength nasal congestion relief due to the common cold, hay fever and upper respiratory allergies.
FAST NASAL CONGESTION RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides fast and powerful relief for colds and allergies. Temporarily relieves sinus congestion and pressure.
NASAL RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides temporary nasal congestion relief by shrinking swollen nasal membranes so you can breathe more freely.
NO DRIP NASAL SPRAY: This cold and allergy relief nasal spray won't drip down your nose or throat. Nasal decongestant pump mist. This product is gluten free.

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8.1

Family Care

FamilyCare Nasal Relief Spray, Pump Mist, Anti-drip, Severe Congestion, (Oxymetazoline HCI) 12 Hours, 3 Pack

Main Highlights

12 hour nasal relief
severe congestion
compare to afrin severe congestion
pump mist
anti-drip

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Our Best Overall Choice

Best Choice

9.7

Amazon Basic Care

Amazon Basic Care Maximum Strength 12 Hour Nasal Spray, Oxymetazoline HCl Solution, Sinus Pressure Relief, Cold and Allergy Medicine, Decongestant, 1 fl oz (Pack of 1)

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: This nasal spray contains oxymetazoline hydrochloride 0.05%, a nasal decongestant. Compare to the active ingredient in Afrin Original.
PURPOSE: This nasal spray temporarily relieves nasal congestion, sinus congestion and pressure due to the common cold, hay fever and upper respiratory allergies.
12 HOUR RELIEF: Amazon Basic Care Maximum Strength Nasal Spray provides fast, powerful congestion relief for allergies and colds for up to 12 hours.
FAST CONGESTION RELIEF: Provides fast and powerful nasal congestion relief for allergies and colds.
FAST-ACTING NASAL DECONGESTANT clears stuffy nose due to upper respiratory allergies and the common cold.

Show Price

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