10 Best Over The Counter Hydrocortisone Cream of 2025

Tested and Reviewed: Top 10 Over The Counter Hydrocortisone Cream deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Amazon Basic Care

Amazon Basic Care Maximum Strength Anti-Itch Cream, Hydrocortisone 1 Percent Intensive Healing Formula, 1 ounce (Pack of 1)

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Editor's bottom line:

“This over the counter hydrocortisone cream is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: The active ingredient in this anti-itch cream is hydrocortisone 1 percent; compare to the active ingredient in Cortizone 10 Intensive Healing Formula
MAXIMUM STRENGTH RELIEF: Hydrocortisone is the number one doctor recommended anti-Itch active Ingredient (of U.S. physicians surveyed by an independent market research firm)
POWERFUL MEDICINE, FAST RELIEF: Great for relieving itching associated with skin irritation, rashes, inflammation, redness, insect bites, eczema, psoriasis and poison ivy, oak and sumac
LASTS UP TO 10 HOURS when used as directed; ultra creamy, maximum strength hydrocortisone formula helps heal problem skin; safe for sensitive skin; for adults and children age 2 years of age and older
INTENSIVE HEALING FORMULA calms, nourishes and hydrates; clinically proven to moisturize for up to 24 hours; features antioxidants, chamomile and Vitamins A, C and E

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Picked by 397 people today

9.5

Amazon Basic Care

Amazon Basic Care Hydrocortisone 1% Anti-Itch Cream, White, 2 Ounce (Pack of 1)

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Main Highlights

ACTIVE INGREDIENT: Amazon Basic Care Maximum Strength Hydrocortisone 1 Percent Anti-Itch Cream contains vitamins A, D and E plus aloe, with the active ingredient hydrocortisone 1 percent; compare to Cortizone 10 Plus Maximum Strength active ingredient
HYDROCORTISONE CREAM: Amazon Basic Care Maximum Strength Hydrocortisone 1 Percent Anti-Itch Cream contains the number one doctor recommended anti-itch active ingredient (of U.S. physicians surveyed by an independent market research firm)
PLUS 10 SOOTHING MOISTURIZERS: Our hydrocortisone cream is enriched with vitamins A, D and E plus aloe to soothe and moisturize while relieving itch fast
FOR FAST, POWERFUL RELIEF of itches and rashes due to: eczema; psoriasis; seborrheic dermatitis; poison ivy, oak, and sumac; insect bites; external genital and anal itching; soaps; detergents; cosmetics; jewelry
KEEP ANTI-ITCH CREAM in your first aid kit and medicine cabinet to make sure you are able to fight itch fast with ultra-moisturizing relief for skin redness, irritation, rashes, inflammation, eczema and psoriasis

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9.5

CeraVe

CeraVe 1% Hydrocortisone Anti-Itch Cream, Fragrance-Free Relief for Eczema-Prone & Dry Skin, 1 Ounce

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Main Highlights

[ MAXIMUM STRENGTH ] 1% Hydrocortisone, the maximum strength Hydrocortisone Cream without a prescription, to provide temporary itch relief from extra dry skin, eczema-prone skin, as well as relief for minor skin irritations and rashes.
[ HYDRATING ITCH RELIEF CREAM ] With Hyaluronic Acid to help retain skins natural moisture and Niacinamide to help calm skin.
[ GENTLE ON SKIN ] Holds National Eczema Association (NEA) Seal of Acceptance. Fragrance free, non-irritating, and non-comedogenic.
[ 3 ESSENTIAL CERAMIDES ] Ceramides make up 50% of the lipids in the skin barrier. CeraVe products are formulated with three essential ceramides (1; 3; 6-II) to help restore & maintain the skins natural barrier.
[ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more. This product is non-sealed. FSA Eligible & HSA Eligible

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9.2

Globe

Globe Hydrocortisone Maximum Strength Cream 1% w/Aloe, 16 oz, Anti-Itch Cream for Redness, Swelling, Itching, Rash, Bug/Mosquito Bites, Eczema, Hemorrhoids & More, 16 oz Jar

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Main Highlights

MAXIMUM STRENGTH FORMULA: Globe Hydrocortisone Cream 1% with Aloe combines powerful hydrocortisone with soothing aloe for rapid relief from itching, redness, and irritation. Ideal for eczema, psoriasis, insect bites, and more.
FAST ITCH RELIEF: Provides fast relief from skin irritation, rashes, redness, and bug bites. Helps with poison ivy, oak, sumac, and other skin conditions. Perfect for easing symptoms of dermatitis and reducing swelling.
ESSENTIAL FOR HOME & TRAVEL: Keep this hydrocortisone cream in your home, car, or travel kit. Cleanse the affected area with mild soap and apply up to 4 times daily for immediate alleviation from itching and redness.
PHARMACIST RECOMMENDED: Hydrocortisone is highly effective in easing symptoms of eczema, psoriasis, and dermatitis, particularly itching, redness, and discomfort. Safe to use for insect bites and rashes caused by poison ivy and oak, offering reliable alleviation from irritated skin.
PREMIUM QUALITY MANUFACTURING: Manufactured in USFDA-audited facilities, Globe products meet the highest pharmaceutical standards. Compare to leading name brand ingredients for cost-effective, reliable relief.
QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Trifecta Pharmaceuticals USA is a family business based in sunny Fort Lauderdale, Florida USA.

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9.0

Globe Pharmacy

(3 Pack) Globe Hydrocortisone Maximum Strength Cream 1% w/Aloe, Anti-Itch Cream for Redness, Swelling, Itching, Rash, Bug/Mosquito Bites, Eczema, Hemorrhoids & More

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Main Highlights

WHATS INSIDE: Globe brand Maximum Strength Hydrocortisone Cream combines the effectiveness of hydrocortisone 1% with the soothing, moisturizing and healing properties of aloe vera.
FAST EFFECTIVE RELIEF: Provides Fast Effective Relief of skin Irritation and Rashes; Inflammation and Redness; Insect Bites; Poison Ivy, Oak, and Sumac. Itch & Rash Relief For Eczema, Psoriasis, Seborrheic Dermatitis.
FRONT LINE ANTI-ITCH: What you need to know: Hydrocortisone cream is a safe and effective home remedy and useful in any home, car or camping first aid kit. For use in adults and children 12 years and older, cleanse the affected area with mild soap and warm water, pat dry and apply the cream not more than 3-4 times a day.
PHARMACISTS RECOMMENDED: Our pharmacist says: Eczema, psoriasis and other forms of dermatitis can be highly irritating and distressing to sufferers. Hydrocortisone is known to be effective in easing the symptoms of these conditions, particularly itching, redness and discomfort. Insect bites and rashes caused by poison oak and poison ivy can also be safely treated with Globe brand hydrocortisone cream.
AMAZING DEAL: Anti-Itch Cream 3 x 1 oz Tubes for the price of 1 of the Leading Name Brand..
QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Trifecta Pharmaceuticals USA is located in Fort Lauderdale, Florida. All Globe Health Products are Manufactured at US Audited Facilities.

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8.8

KIRKLAND

Kirkland Signature Hydrocortisone 1% Plus Anti-Itch Cream, 8 Ounces (Pack of 4)

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Main Highlights

4 Tubes, 2 Ounces Each
Kirkland Signature Hydrocortisone 1% Plus contains the active ingredient hydrocortisone 1% enriched with aloe plus vitamins A and E

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8.6

Aveeno

Aveeno Maximum Strength 1% Hydrocortisone Anti-Itch Cream, Triple Oat, Aloe & Vitamin E For Itch Relief From Eczema, Psoriasis, Insect Bites, Poison Ivy, Oak & Sumac & Detergents, 1 oz, 2 Pack

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Main Highlights

1-ounce tube of Maximum-Strength Aveeno 1% Hydrocortisone Anti-Itch Cream is fragrance-free, non-comedogenic and formulated to provide longer-lasting relief for itchy skin
This dye-free, maximum-strength hydrocortisone itch relief cream with triple oat is designed to effectively relieve itch and help soothe skin irritations
The anti-itch cream is specially formulated with triple oat, skin-soothing Aloe, and nourishing Vitamin E for longer-lasting relief from minor skin irritations and rashes
Use maximum strength 1% hydrocortisone cream on skin affected by eczema, psoriasis, insect bites, poison ivy, oak, or sumac, soaps, detergents, cosmetics, or jewelry for temporary itch relief
From the dermatologist-recommended skincare brand for over 70 years, Aveeno uses the goodness of nature and the power of science to keep skin healthy looking and feeling balanced

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8.3

Aveeno

Aveeno Maximum Strength 1% Hydrocortisone Anti-Itch Cream, Triple Oat, Aloe & Vitamin E for Itch Relief from Eczema, Psoriasis, Insect Bites, Poison Ivy, Oak & Sumac & Detergents, 1 oz

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Main Highlights

1-ounce tube of Maximum-Strength Aveeno 1% Hydrocortisone Anti-Itch Cream is fragrance-free, non-comedogenic and formulated to provide longer-lasting relief for itchy skin
This dye-free, maximum-strength hydrocortisone itch relief cream with triple oat is designed to effectively relieve itch and help soothe skin irritations
The anti-itch cream is specially formulated with triple oat, skin-soothing Aloe, and nourishing Vitamin E for longer-lasting relief from minor skin irritations and rashes
Use maximum strength 1% hydrocortisone cream on skin affected by eczema, psoriasis, insect bites, poison ivy, oak, or sumac, soaps, detergents, cosmetics, or jewelry for temporary itch relief
From the dermatologist-recommended skincare brand for over 70 years, Aveeno uses the goodness of nature and the power of science to keep skin healthy looking and feeling balanced

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8.1

Trifecta Pharmaceuticals USA

(3 Pack) Globe Hydrocortisone Maximum Strength Transparent Ointment 1%,1 oz, Anti-Itch Topical Ointment for Redness, Swelling, Itching, Rash, Bug/Mosquito Bites, Eczema, Hemorrhoids & More

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Main Highlights

WHATS INSIDE: Globe brand Maximum Strength Hydrocortisone Ointment Maximum Strength Ointment that locks in moisture while hydrocortisone relieves the itch.
FAST EFFECTIVE RELIEF: Provides Fast Effective Relief of skin Irritation and Rashes; Inflammation and Redness; Insect Bites; Poison Ivy, Oak, and Sumac. Itch & Rash Relief For Eczema, Psoriasis, Seborrheic Dermatitis
FRONT LINE ANTI-ITCH: What you need to know: Hydrocortisone ointment is a safe and effective home remedy and useful in any home, car or camping first aid kit. For use in adults and children 12 years and older, cleanse the affected area with mild soap and warm water, pat dry and apply the cream not more than 3-4 times a day.
PHARMACISTS RECOMMENDED: Our pharmacist says: Eczema, psoriasis and other forms of dermatitis can be highly irritating and distressing to sufferers. Hydrocortisone is known to be effective in easing the symptoms of these conditions, particularly itching, redness and discomfort. Insect bites and rashes caused by poison oak and poison ivy can also be safely treated with Globe brand hydrocortisone ointment.
AMAZING DEAL: Anti-Itch Ointment 3 x 1 oz Tubes for the price of 1 of the leading Name Brand.
WATER-RESISTANT FORMULA: Globe Hydrocortisone 1% Anti Itch Ointment locks in moisture and helps keep the affected area clean while relieving the itch. Maximum Strength Globe Hydrocortisone Ointment helps relieve itch associated with minor skin irritations and rashes due to insect bites, psoriasis, poison ivy and more.
QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Trifecta Pharmaceuticals USA is located in Fort Lauderdale, Florida. All Globe Health Products are Manufactured at US Audited Facilities.

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8.1

Aquaphor

Aquaphor Children's Itch Relief Ointment, 1% Hydrocortisone Anti Itch Ointment for Skin Irritation, Insect Bites, Psoriasis, Skin Rashes Eczema & Poison Ivy, Fragrance Free, 1 Oz Tube, Pack of 2

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Main Highlights

CHILDREN'S ITCH RELIEF OINTMENT: Aquaphor Children's Itch Relief Ointment is suitable for children ages 2 and up
INSTANT RELIEF: Delivers up to 12 hours of significant itch relief and helps provide instant soothing itch relief for eczema flares, skin irritation, rashes and psoriasis
OUTDOOR IRRITATION RELIEF: Anti itch ointment can also be used to help soothe and relieve itchiness from outdoor causes such as insect bites and poison ivy
FORMULATED WITHOUT: Features 1% hydrocortisone anti-itch ointment and is fragrance free, paraben free, and hypoallergenic, making it ideal for childrens skin care
INCLUDES: Two 1 ounce tubes of Aquaphor Children's Itch Relief Ointment, 1% Hydrocortisone Anti-Itch Ointment

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Our Best Overall Choice

Best Choice

9.7

Amazon Basic Care

Amazon Basic Care Maximum Strength Anti-Itch Cream, Hydrocortisone 1 Percent Intensive Healing Formula, 1 ounce (Pack of 1)

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: The active ingredient in this anti-itch cream is hydrocortisone 1 percent; compare to the active ingredient in Cortizone 10 Intensive Healing Formula
MAXIMUM STRENGTH RELIEF: Hydrocortisone is the number one doctor recommended anti-Itch active Ingredient (of U.S. physicians surveyed by an independent market research firm)
POWERFUL MEDICINE, FAST RELIEF: Great for relieving itching associated with skin irritation, rashes, inflammation, redness, insect bites, eczema, psoriasis and poison ivy, oak and sumac
LASTS UP TO 10 HOURS when used as directed; ultra creamy, maximum strength hydrocortisone formula helps heal problem skin; safe for sensitive skin; for adults and children age 2 years of age and older
INTENSIVE HEALING FORMULA calms, nourishes and hydrates; clinically proven to moisturize for up to 24 hours; features antioxidants, chamomile and Vitamins A, C and E

Show Price

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