10 Best Otc For Acid Reflux of 2025

Tested and Reviewed: Top 10 Otc For Acid Reflux deals with expert ratings from 8.1 to a perfect 10

April 2025 Edition

Editor's Choice

9.7

Amazon Basic Care

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

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Editor's bottom line:

“This otc for acid reflux is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC
TREATS FREQUENT HEARTBURN: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week
ACID REDUCER: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
HEARTBURN TIPS: Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.
Product may be manufactured in India or Israel

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Picked by 273 people today

9.5

HealthCareAisle

HealthCareAisle Omeprazole 20 mg - 42 Delayed-Release Tablets - Acid Reducer, Treats Frequent Heartburn

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Main Highlights

Effective heartburn medicine: Omeprazole is an acid reducer that treats frequent heartburn (occurring 2 or more days a week)
Stop heartburn at the source: Our Omeprazole tablets inhibit the proton pumps in the stomach from producing excess acid
All-day heartburn relief: Take one tablet daily to treat heartburn for up to 24 hours; use as directed for 14 days; do not take for more than 14 days or more often than every 4 months unless directed by a doctor
Not for immediate relief: May take 1 to 4 days for full effect; see package label for warnings and other important information

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9.5

Prilosec

Prilosec OTC, Omeprazole Delayed Release 20mg, Acid Reducer, Treats Frequent Heartburn for 24 Hour Relief, All Day, All Night*, 20mg, 14 Tablets

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Main Highlights

TREATS FREQUENT HEARTBURN: Heartburn medicine for those who experience heartburn flare ups 2+ times a week
With 1 PRILOSEC OTC PILL in the morning, BLOCK HEARTBURN. ALL DAY. ALL NIGHT.*
PREVENT EXCESS ACID PRODUCTION for heartburn relief that lasts for 24 HOURS.* Starts working on DAY 1*
CONTAINS ACTIVE INGREDIENT OMEPRAZOLE delayed-release 20mg, an acid reducer that provides long-lasting, heartburn relief*
FSA and HSA eligible

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Best Value

9.2

Save 29%

Curist

Curist Famotidine 20mg Bulk Pack (300 Count Tablets) Acid Reflux Medicine for Heartburn Relief - OTC Maximum Strength Stomach Acid Reducer - Anti Acid Relief Tablets for Indigestion Heartburn Relief

29% OffFree Shipping

Main Highlights

EFFECTIVE ACID REFLUX RELIEF: Experience quick heartburn relief and say good bye to acid reflux symptoms such as indigestion & sour belly with our acid controller famotidine 20mg. Provides quick acid relief when heartburn strikes!
MAXIMUM STRENGTH OTC & LASTING PROTECTION: Our acid reflux medicine forms a protective barrier against excess stomach acid, helping to prevent heartburn and provide lasting stomach acid relief. Works longer than chewable antacids for acid reflux. Maximum strength over-the-counter famotidine tablets.
PREVENT MEAL-INDUCED HEARTBURN & STOMACH ACID: This acid reflux medicine is designed for easy ingestion, making it convenient for individuals seeking effective relief from acid reflux caused by specific foods & beverages when on-the-go.
HEARTBURN MEDICATION VALUE PACK: Each bottle contains 300 Famotidine 20mg tablets, ensuring you have an ample amount of heart burn or acid reflux medicine on hand whenever symptoms arise, saving you time and money with famotidine 20mg bulk.
A TRUSTED ACID REFLUX MEDICINE: A known acid reducer, our OTC Famotidine 20mg tablets offer a reliable solution for managing acid reflux symptoms. Our tablets contain the highest dosage of active ingredient available OTC, stronger than famotidine 10mg.

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9.0

HealthCareAisle

HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)

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Main Highlights

EFFECTIVE HEARTBURN RELIEF: Omeprazole acid reducer capsule that treats frequent heartburn occurring 2 or more days a week.
14-DAY ACID REFLUX MEDICINE:Take one Omeprazole capsule daily for heartburn relief up to 24 hours. May take 1-4 days for full effect. See package label for warnings and other important information.
COMPARABLE TO THE NATIONAL BRAND: Has the same active ingredient as Prilosec OTC*
STOP HEARTBURN AT THE SOURCE: Our Omeprazole 20mg capsules inbibit the proton pumps in the stomach from producing excess acid, acting as an acid reducer.
Directions: use as directed for 14 days; do not take for more than 14 days or more often than every 4 months unless directed by your healthcare provider

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8.8

Complete Natural Products

Acid Reflux Complete 8oz - Natural Organic Liquid Heartburn, GERD, & Amish Reflux Relief Remedy & Medicine

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Main Highlights

MADE WITH ORGANIC and KOSHER INGREDIENTS: The whole Acid Reflux Treatment is Certified USDA Organic and OU Kosher. Ingredients you can count on being healthy for you.
TASTES GREAT & EASY TO TAKE! As a liquid, this time tested Organic Amish Acid Reflux Remedy is absorbed far better than any pill or capsule would be. It is an all Natural and healthy medicine, with ingredients like Aloe, Ginger, Garlic, & Vanilla.
GET RESULTS: Stops Acid Reflux, Heartburn, GERD, and Prevents Acid Indigestion and Sour Stomach.
PILLOW OR WEDGE NOT REQUIRED! Acid Reflux Complete absorbs quicker at a higher percentage because it is a liquid.
MADE IN THE USA: Complete Natural Products formulates, manufactures, and bottles everything! You are getting an amazing Heartburn Remedy straight from the source.

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8.6

Save 7%

Ohm

Ohm Omeprazole Tablets, Delayed-Release Tablets, 20mg Acid Reducer, 42 Tablets

7% OffFree Shipping

Main Highlights

Treats FREQUENT Heartburn!
Stomach Acid Reducer
Delayed-Release Tablets
Three 14-Day Courses of Treatment

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8.3

Zegerid OTC

Zegerid OTC, Omeprazole 20mg and Sodium Bicarbonate, Heartburn Medicine, Acid Reducer, PPI, 24hr All Day Protection, 1 Pack 42 Capsules

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Main Highlights

CLINICALLY PROVEN - Zegerid OTC is clinically proven to treat frequent heartburn
THE ONLY OTC PPI WITH TWO ACTIVE INGREDIENTS: Omeprazole provides powerful heartburn relief. Plus, Sodium Bicarbonate ensures your body can absorb it properly.
JUST ONE PILL A DAY - Zegerid OTC proton pump inhibitor medication treats frequent heartburn.
24 HOURS / ZERO HEARTBURN
Use as directed for 14 days for treating frequent heartburn. As with all PPIs, may take 1-4 days for full effect, although some people might get complete relief within 24 hours.

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8.1

REFLUX GOURMET

REFLUX GOURMET Natural Heartburn Acid Reflux Relief Support Supplement for GERD, LPR, Indigestion, Aid for Intermittent Fasting, Alginate Therapy, Made in The USA, Vanilla Caramel

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Main Highlights

STOPPING REFLUX - Reflux Gourmet was founded by two physicians with over 40 years of combined specialized experience on the forefront of caring for people suffering with reflux, and a celebrity chef who knows what it feels like to do the suffering. Our all-natural supplement for heartburn relief was innovated by these unique experts to work safely and effectively - and taste delicious!
WHY WE CREATED OUR RESCUE PRODUCTS - We at Reflux Gourmet wanted to create a safe all-natural option for those suffering from reflux. If you have ever found yourself researching terms like natural acid reflux relief, natural heartburn relief, GERD relief, or LPR relief we hope our Vanilla Caramel Rescue and Mint Chocolate Rescue provide the answer youve been looking for. Let us rescue you from reflux.
ALGINATE THERAPY - Alginate, safely used in the food industry for over 100 years, is derived from seaweed. Once our formula is taken, the alginate forms a protective coating in the throat, esophagus, and stomach that helps relieve or prevent manifestations of reflux. When the alginate reaches the stomach, it forms a protective gel-like raft that floats on the top of the stomach contents. This raft blocks off the esophagus, physically preventing the reflux of stomach contents into the esophagus.
100% ALL-NATURAL - The only alginate therapy made with 100% all-natural ingredients that is Glycerin FREE, Potassium FREE, and Paraben FREE. Made from start to finish in Northern California. Made entirely from all-natural ingredients considered safe for children and during pregnancy. No known side effects.
WHEN TO TAKE - General directions for use: Take one teaspoon (5 ml), or more as needed or as directed by your physician, after meals and before bed.
INTERMITTENT FASTING - Alginates are also widely used to relieve hunger pains associated with intermittent fasting in order to promote weight loss.

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Our Best Overall Choice

Best Choice

9.7

Amazon Basic Care

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC
TREATS FREQUENT HEARTBURN: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week
ACID REDUCER: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
HEARTBURN TIPS: Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.
Product may be manufactured in India or Israel

Show Price

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