10 Best Otc Eye Drops For Infection of 2025

Tested and Reviewed: Top 10 Otc Eye Drops For Infection deals with expert ratings from 8.1 to a perfect 10

April 2026 Edition

Editor's Choice

9.7

Opcon-A

Opcon-A Allergy Eye Drops, Antihistamine and Redness Relief for Itchy, Red Eyes, Soothes Irritation from Pollen, Ragweed, Grass, Animal Hair and Dander Clinically Proven Formula, 0.5 Fl Oz (Pack of 2)

Editor's bottom line:

“This otc eye drops for infection is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

EYE DROPS FOR ALLERGIES AND EYE ITCHING: Opcon A eye drops combine an antihistamine with a redness reliever to help relieve itchy, red, irritated eyes. Temporary relief from itching & redness caused by pollen, ragweed, grass, animal hair & dander
RELIEF FOR ITCHY EYES : These allergy relief eye drops are clinically proven to provide effective relief of redness & itching caused by allergens. These allergy eye drops can be used up to four times a day to give temporary relief from symptoms
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected

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Picked by 397 people today

9.5

PATADAY

Pataday Twice Daily Relief, 0.17 Fl Oz

Main Highlights

EYE ALLERGY ITCH RELIEF: Works as an antihistamine to relieve itchy eyes in minutes
PROVIDES FAST SYMPTOM RELIEF: Hinders allergic reactions by limiting the release of chemicals that cause inflammation
EASY TO USE: One drop, use twice daily
LASTING RELIEF: Relief up to 8 hours
Contains doctor prescribed eye allergy itch relief ingredient

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9.5

Muro 128

Muro 128 Solution, Temporary Relief of Corneal Edema, Eye Care, Sodium Chloride Hypertonicity Ophthalmic Solution 5%, 0.5 Fl. Oz

Main Highlights

Muro 128 Sterile Ophthalmic 5% Solution provides a sterile eye wash solution
Directions: to 2 drops in affected eye(s) every 3 to 4 hours, or as directed by your doctor. Read enclosed insert for complete product information
Uses: Temporary relief of corneal edema
For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help your eyes feel moisturized & protected

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9.2

Zaditor

Zaditor Antihistamine Eye Drops, 5-mL

Main Highlights

Original Prescription strength
Up to 12 hour Itch Relief Works in Minutes
Antihstamine Eye Drops
For Ages 3 years and older

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9.0

TheraTears

TheraTears SteriLid Antimicrobial Eyelid Cleanser and Face Wash, for Eye Care, 2 Fl Oz

Main Highlights

Eyelid cleanser: TheraTears SteriLid eyelid cleanser and face wash gently cleanses eyelids and eye lashes to support eye care and comfort
Prescription-strength: Antimicrobial face spray with hypochlorous acid pH-balanced formula cleanses away dirt, oil, bacteria, and other eye irritants
Gentle on eyes: This hypochlorous acid spray for face and eyes is formulated to be gentle on eyelids, lashes, and the skin around the eyes
Ophthalmologist-created brand: The TheraTears eye drop formula was created by an ophthalmologist, following 18 years of research
Doctor-recommended brand: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

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8.8

Alcon

Alcon Zaditor Antihistamine Eye Drops, Twin Pack, 5-mL Each

Main Highlights

Fast-acting, long-lasting eye itch relief
The first over-the-counter eye drops that temporarily relieves itchy eyes for up to 12 hours with just one drop.
Original prescription-strength formula doesnt use a vasoconstrictor
Safe and effective for children aged 3 years and older*.

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8.6

Cassiel pet

Cassiel pet Eye Drops for Eye Infection Treatment, Soothe Infection Allergy, Relieve Dry Eyes & Red Eye，Eye Cleaner and Tear Stain Remover for Dogs and Cats | 10 ml 0.33 FL OZ (1 Bottle)

Main Highlights

Our formula contains various beneficial ingredients for dog & cat Eye Infection Treatment, Soothe Infection Allergy, Relieve Dry Eyes & Red EyeEye Cleaner And Tear Stain Remover such as Artifcial Musk, Gentian Tablets, Borneol,Aloe, chrysanthemum, Cassia Seed.
Product effectiveness: Under normal circumstances, significant improvement can be seen after three days of continuous use. If the condition is more complicated and serious, you can continue to use this product for your pet. The product ingredients are natural and mild, and the safety of your pet is guaranteed.
Daily Dosage and Frequency: 1. For initial use, apply 2 drops twice daily to your pet for 15 consecutive days. Starting on the 16th day, apply once daily. 2. Under normal circumstances, apply once daily. If the condition has recovered, apply once every two days.
Product safety: This product uses natural plant extracts, so the ingredients are non-irritating and can be used normally for your pets. The product is gentle and effective, and is very effective for pet recovery.
Effect after use: Using this product can keep your pet's eyes bright, moisturized and comfortable, avoiding various eye problems caused by the external environment, making your pet's daily life more pleasant.

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8.3

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

Main Highlights

Nano-droplet technology features delivery of the eye drop over the entire eye surface for fast dry eye relief
Preservative-Free Eye Drop Solution: Ideal for users with sensitive eyes providing fast hydration and tear evaporation protection
Long-Lasting Relief: Systane Complete PF eye drops help aqueous deficient, evaporative/lipid deficient dry eye
Safe for Use with Contact Lenses: Systane eye drops are safe for use with soft contact lenses
8 Hours of Dry Eye Relief: From doctor's reccomended #1 Brand
Systane COMPLETE PF Eye Drops contains two 10mL bottles to use as needed to relieve, protect, and to lubricate dry eyes

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8.1

Glenmark Therapeutics

Glenmark Therapeutics Olopatadine Eye Drops for Allergies, Redness Relief, Antihistamine Eye Drops, Allergy Relief from Pet Dander, Pollen, Grass, Ragweed, Works in Minutes, Olopatadine HCl 0.1%, 5ml

Main Highlights

EYE ALLERGY ITCH & REDNESS RELIEF: Works as an antihistamine and redness reliever to relieve itchy eyes in minutes
PROVIDES SYMPTOM RELIEF: Temporarily relieves itchy and red eyes due to pollen, ragweed, grass, animal hair and dander
TWICE DAILY RELIEF: Put 1 drop in the affected eye(s) twice daily
LASTING RELIEF: Relief up to 8 hours
Compare to the active ingredient of Pataday Twice Daily Relief

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8.1

Alaway

Alaway Antihistamine Eye Drops for Itchy Eyes, Fast-Acting, Up to 12-Hour Eye Itch Relief, Clinically Tested Prescription-Strength Formula, 0.34 Fl Oz

Main Highlights

Alaway Eye Itch Relief: Fast-acting antihistamine eye drops help relieve itchy eyes from pollen, ragweed, grass, pet hair, and dander. These allergy eye drops with ketotifen provide up to 12 hours of allergy relief.
Antihistamine Eye Drops: Clinically tested allergy eye itch medicine delivers fast-acting relief for itchy eyes. This prescription-strength eyedrops formula works at the source of eye itch symptoms.
Allergy Eye Care: Seasonal and all year allergy eyedrops provide fast relief from itchy eyes. This allergy medicine works in minutes at the source of eye itch symptoms. Perfect for on-the-go relief for adults and kids over 3.
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help your eyes feel healthy, moisturized, & protected

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Our Best Overall Choice

Best Choice

9.7

Opcon-A

Opcon-A Allergy Eye Drops, Antihistamine and Redness Relief for Itchy, Red Eyes, Soothes Irritation from Pollen, Ragweed, Grass, Animal Hair and Dander Clinically Proven Formula, 0.5 Fl Oz (Pack of 2)

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

EYE DROPS FOR ALLERGIES AND EYE ITCHING: Opcon A eye drops combine an antihistamine with a redness reliever to help relieve itchy, red, irritated eyes. Temporary relief from itching & redness caused by pollen, ragweed, grass, animal hair & dander
RELIEF FOR ITCHY EYES : These allergy relief eye drops are clinically proven to provide effective relief of redness & itching caused by allergens. These allergy eye drops can be used up to four times a day to give temporary relief from symptoms
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected

Show Price

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