10 Best Otc Eczema Cream of 2025

Tested and Reviewed: Top 10 Otc Eczema Cream deals with expert ratings from 8.1 to a perfect 10

October 2025 Edition

Editor's Choice

9.7

Eucerin

Eucerin Eczema Relief Body Cream, Eczema Cream with Colloidal Oatmeal, Ceramide-3 and Licorice Root Extract, 14 Oz Tube

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Editor's bottom line:

“This otc eczema cream is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

24-Hour Hydration: Eucerin Eczema Relief Body Cream delivers 24-hour hydration and is formulated with Colloidal Oatmeal, Ceramide-3 and Licorice Root Extract
Free Of: This Eucerin eczema relief cream is fast-absorbing and is fragrance free, dye free and steroid free
Appropriate For: Eucerin Eczema Relief Body Cream is appropriate for use on adults, children and babies 3 months and older
Stay Flare Free: In a clinical study, with daily use of this Eucerin eczema cream, 4 out of 5 children remained flare-free for 6 months*
Trusted Eczema Care: Eucerin is the #1 Best Selling Eczema Relief Brand**
Includes one (1) 14 ounce tube of Eucerin Eczema Relief Body Cream with Colloidal Oatmeal

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Picked by 157 people today

9.5

Save 16%

La Roche-Posay

La Roche-Posay Lipikar Soothing Relief Eczema Cream, Face and Body Lotion For Eczema and Sensitive, Dry Skin, Moisturizer with Colloidal Oatmeal to Relieve Irritation

16% OffFree Shipping

Main Highlights

Soothing eczema cream for targeted areas on body, face, and hands is clinically shown to relieve itchy, irritated skin
This steroid and antibiotic free eczema cream helps visibly reduce the signs of eczema. Accepted by the National Eczema Association. Suitable for children 3 years and up. From the #1 Body Care Brand in European Pharmacies
Recommended for Eczema-prone skin, dry, itchy and irritated skin, as well as sensitive skin. Steroid free and antibiotic free eczema cream
Visibly reduces signs of eczema and provides long lasting relief. Helps relieve itching and irritation. Soothing, non-greasy cream texture
Formulated with 1% Colloidal Oatmeal: helps soothe and relieve minor skin irritation and itching due to eczema and rashes. Shea Butter to help restore the skin's hydrolipidic film and help skin feel soothed

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9.5

Eucerin

Eucerin Eczema Relief Cream, Full Body Lotion, Moisturizing Eczema Cream with Colloidal Oatmeal (Skin Protectant) and Ceramide 3, 8 Oz Tube

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Main Highlights

24 Hour Hydration: Eucerin Eczema Relief Body Cream delivers 24 hour hydration, and is formulated with colloidal oatmeal, Ceramide-3, and Licorice Root Extract
Free Of: This Eucerin eczema relief cream is fast-absorbing, and is fragrance free, dye free, and steroid free
Great For: Eucerin Eczema Relief Body Cream skin care for eczema is appropriate for use on adults, children and babies 3 months and older
Stay Flare Free: In a clinical study, with daily use of this Eucerin eczema cream, 4 out of 5 children remained flare-free for 6 months*
Trusted Eczema Care: Eucerin is the #1 Best Selling Eczema Relief Brand**
Includes one (1) 8 ounce tube of Eucerin Eczema Relief Body Cream

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Best Value

9.2

Save 27%

Exederm

Exederm Flare Control Cream for Eczema & Dermatitis, 2oz

27% Off

Main Highlights

Helps Relieve Flare-Ups: Exederm eczema cream temporarily relieves itching associated with minor irritations, rashes & inflamed skin due to atopic eczema, psoriasis, seborrheic dermatitis, and contact dermatitis from soaps, detergents or cosmetics*
Maximum Strength Without a Prescription: Our hydrocortisone cream helps provide quick relief from itchy, irritated skin without needing a prescription. The maximum strength formula helps soothe flare-ups. Fast-acting results for lasting itch relief*
Skin Loving Ingredients: Our cream is formulated for ultra sensitive skin. Contains Hydrocortisone Acetate USP 1% with skin-soothing ingredients like glycerin & caprylic triglyceride to help nourish skin. Suitable for adults & children over 2 years
Daily Use for Healthier Skin: Apply to the affected area not more than 3 to 4 times daily. Avoid contact with eyes. This anti itch cream is paraben-free, and contains no gluten, fragrances, dyes, SLS, SLES, propylene glycol or cocamidopropyl
Why Exederm for Eczema Relief? Our philosophy is simple - avoid irritants that trigger eczema. Exederm is a simple and sensible approach for anyone with eczema, dermatitis and dry or sensitive skin - without using unnecessary chemicals*

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9.0

LMNOOP

LMNOOP Eczema Cream, Maximum Strength Treatment Ointment for Rash, Psoriasis, Dermatitis, Urticaria, Jock Itch, Fungal Infection, Anti-Itch, Relief for Sensitive, Irritated Skin 1.76oz

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Main Highlights

Widely usedLMNOOP Eczema Therapy Cream helps heal eczema, rosacea and more, stops itch from rashes and contact dermatitis, ane soothes inflamed skin and removes bacteria without irritating or damaging the raw skin. It also intensely moisturizes to help strengthen skins natural moisture barrier, helping to retain natural moisture and restore skin's protective function.
Functional EfficacyLMNOOP Eczema Therapy Cream is clinically proven to help relieve and soothe the common symptoms of eczema, including itchiness, the appearance of redness, dryness and irritation, and can be absorbed quickly once applied on the skin.
Applicable peopleAll ingredients of LMNOOP Eczema Therapy Cream are naturally non-irritating so it can be safely used for babies, children, adolescents, adults, the elderly and other people. This Ointment for Eczema is suitable for all skin including dry skin, sensitive skin, oily skin, acne-prone, and more. Cann't not be used for pregnant women.
Natural IngredientsLMNOOP Eczema Therapy Cream Inactive ingredients includes essence extracted from dictamnus dasycarpus root, bassia scoparia fruit, cnidium monnieri fruit, sophora flavescens root and more. The active ingredients includes menthol (antifungal and skin protectant). The medicinal properties are mild, natural and easy to be absorbed by the skin without worrying about the risk of antibiotic resistance and hormone dependence.
Satisfaction GuaranteeFrom the date of purchase, LMNOOP Eczema Therapy Cream provide a 365-day money-back guarantee. If you have any questions, please contact us, we will provide you with professional services within 24 hours to solve any problems you encounter.

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8.8

Save 5%

CeraVe

CeraVe 1% Hydrocortisone Anti-Itch Cream, Fragrance-Free Relief for Eczema-Prone & Dry Skin, 1 Ounce

5% OffFree Shipping

Main Highlights

[ MAXIMUM STRENGTH ] 1% Hydrocortisone, the maximum strength Hydrocortisone Cream without a prescription, to provide temporary itch relief from extra dry skin, eczema-prone skin, as well as relief for minor skin irritations and rashes.
[ HYDRATING ITCH RELIEF CREAM ] With Hyaluronic Acid to help retain skins natural moisture and Niacinamide to help calm skin.
[ GENTLE ON SKIN ] Holds National Eczema Association (NEA) Seal of Acceptance. Fragrance free, non-irritating, and non-comedogenic.
[ 3 ESSENTIAL CERAMIDES ] Ceramides make up 50% of the lipids in the skin barrier. CeraVe products are formulated with three essential ceramides (1; 3; 6-II) to help restore & maintain the skins natural barrier.
[ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more. This product is non-sealed. FSA Eligible & HSA Eligible

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8.6

Cortizone-10

Cortizone-10 Maximum Strength Intensive Healing Itch Relief Cream, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Bug Bites, Rash, Eczema, Psoriasis, Poison Ivy, Oak, Sumac & More, 2 oz

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Main Highlights

INCLUDES: One (1) 2 oz. tube of Cortizone-10 Maximum Strength* Intensive Healing Itch Relief Cream (*Among topical anti-itch OTCs)
RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
MOISTURIZES & RESTORES: Includes 10 moisturizers, plus vitamins A, C, and E to nourish skin and help restore skin's moisture barrier
ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
FAST ACTING: Relieves itch in five minutes with 24-hour moisture that's gentle on skin, fragrance free, and dye free
DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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8.3

Cortizone-10

Cortizone-10 Maximum Strength Intensive Healing Itch Relief Lotion for Eczema, 1% Hydrocortisone, Fast-Acting, Anti-Itch Cream for Minor Skin Irritations, Rashes and Inflammation Due to Eczema, 3.5 oz

Free Shipping

Main Highlights

INCLUDES: One (1) 3.5 oz. tube of Cortizone-10 Maximum Strength* Intensive Healing Itch Relief Lotion for Eczema (*Among topical anti-itch OTCs)
RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, rashes, and inflammation due to eczema, psoriasis, seborrheic dermatitis, and more
MOISTURIZES & RESTORES: Dermatologist-tested formula with seven moisturizers, plus a vitamin and botanical complex made specifically for eczema and itchy dry skin
ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
FAST ACTING: Relieves itch in five minutes with 24-hour moisturization that's gentle on skin, fragrance free, and dye free
DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

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8.1

Save 18%

Eucerin

Eucerin Eczema Relief Cream - Full Body Daily Lotion for Eczema-Prone Skin - 5 oz. Tube

18% OffFree Shipping

Main Highlights

24 Hour Hydration: Eucerin Eczema Relief Body Cream delivers 24 hour hydration, and is formulated with colloidal oatmeal, Ceramide-3, and Licorice Root Extract
Free Of: This Eucerin eczema relief cream is fast-absorbing, and is fragrance free, dye free, and steroid free
Great For: Eucerin Eczema Relief Body Cream skin care for eczema is appropriate for use on adults, children and babies 3 months and older
Stay Flare Free: In a clinical study, with daily use of this Eucerin eczema cream, 4 out of 5 children remained flare-free for 6 months*
Trusted Eczema Care: Eucerin is the #1 Best Selling Eczema Relief Brand**
Includes one (1) 5 ounce tube of Eucerin Eczema Relief Body Cream

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8.1

Save 21%

Gold Bond

Gold Bond Medicated Eczema Relief Hand Cream, 3 oz., Skin Protectant Cream With 2% Colloidal Oatmeal

21% OffFree Shipping

Main Highlights

Includes one (1) 3-oz. Gold Bond Eczema Relief Medicated Hand Cream
Gold Bond Eczema Cream relieves itching, dryness, scaling, roughness and redness associated with eczema
Made with 2% colloidal oatmeal, seven moisturizers, and three vitamins to soothe skin and relieve itching
Gold Bond Eczema Relief Medicated Hand Cream has been tested by dermatologists and is hypoallergenic
Gold Bond Eczema Relief Medicated Hand Cream has been accepted by the National Eczema Association
Create a TerraCycle account and start recycling your empty Gold Bond packaging

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Our Best Overall Choice

Best Choice

9.7

Eucerin

Eucerin Eczema Relief Body Cream, Eczema Cream with Colloidal Oatmeal, Ceramide-3 and Licorice Root Extract, 14 Oz Tube

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

24-Hour Hydration: Eucerin Eczema Relief Body Cream delivers 24-hour hydration and is formulated with Colloidal Oatmeal, Ceramide-3 and Licorice Root Extract
Free Of: This Eucerin eczema relief cream is fast-absorbing and is fragrance free, dye free and steroid free
Appropriate For: Eucerin Eczema Relief Body Cream is appropriate for use on adults, children and babies 3 months and older
Stay Flare Free: In a clinical study, with daily use of this Eucerin eczema cream, 4 out of 5 children remained flare-free for 6 months*
Trusted Eczema Care: Eucerin is the #1 Best Selling Eczema Relief Brand**
Includes one (1) 14 ounce tube of Eucerin Eczema Relief Body Cream with Colloidal Oatmeal

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