10 Best Osmotic Laxatives of 2025

Tested and Reviewed: Top 10 Osmotic Laxatives deals with expert ratings from 8.1 to a perfect 10

May 2026 Edition

Editor's Choice

9.7

Amazon Basic Care

Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Relieves Occasional Constipation, Unflavored, 1.68 pound (Pack of 1)

Editor's bottom line:

“This osmotic laxatives is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350; compare to MiraLAX active ingredient
CONSTIPATION RELIEF: Relieves occasional constipation/irregularity; generally produces a bowel movement in 1 to 3 days
DOCTOR RECOMMENDED ACTIVE INGREDIENT: Polyethylene Glycol 3350 is the Number One Doctor Recommended Laxative Active Ingredient (of U.S. physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)
SOFTENS THE STOOL: This laxative increases frequency of bowel movements and softens the stool
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage; grit free, sugar free and gluten free; for adults and children 17 years of age and older

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Picked by 397 people today

9.5

Amazon Basic Care

Amazon Basic Care ClearLax, Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Unflavored, 8.3 ounce (Pack of 1)

Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350. Compare to MiraLAX active ingredient
OSMOTIC LAXATIVE: Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution acts as a laxative used to relieve occasional constipation/irregularity. The laxative generally produces a bowel movement in 1 to 3 days
RELIEF FOR IRREGULARITY: Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution increases frequency of bowel movements and softens the stool; relieves occasional constipation (irregularity).
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage. Grit free, sugar free and gluten free. For adults and children 17 years of age and older.
Polyethylene Glycol 3350 is the Doctor Recommended Laxative Active Ingredient (Of U.S. physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)

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9.5

MiraLAX

MiraLAX Laxative Powder, Gentle Constipation Relief for Adults, Stool Softener with PEG 3350, Nonstimulant Laxative, No Harsh Side Effects, Osmotic Laxative, 45 Dose

Main Highlights

Works naturally with the water in your body: MiraLAX laxative powder gently unblocks your system by hydrating and softening your stool for occasional constipation relief
No harsh side effects: A laxative for constipation that doesn't cause gas, bloating, cramping, or sudden urgency
Nonstimulant: Cramp-free constipation relief for women and men that wont disrupt your day; works naturally with the water in your body
#1 doctor-recommended OTC laxative: Recommended by physicians, gastroenterologists, and pharmacists for safe and effective constipation relief for adults
Unflavored, grit-free powder: Dissolves completely in any hot or cold beverage for a simple, stress-free experience
Free from sugar, preservatives, and gluten: Dependable and gentle laxative for women and men

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9.2

Glenmark Therapeutics

Glenmark Therapeutics Polyethylene Glycol 3350 Powder, Osmotic Laxative, 45 Daily Doses, Softens Stool, Relieves Occasional Constipation, Powder for Solution, 26.9 Ounce

Main Highlights

ORIGINAL PRESCRIPTION STRENGTH
OSMOTIC LAXATIVE: The active ingredient of this product is Polyethylene Glycol 3350, an osmotic laxative that relieves occasional constipation (irregularity) and softens the stool.
GET RELIEF: This laxative powder generally produces a bowel movement in 1 to 3 days.
DISSOLVES IN ANY BEVERAGE: This powder is unflavored, sugar free, and dissolves in any beverage.
USE AS DIRECTED: Fill to top of white section in cap which is marked to indicate the correct dose (17g), stir and fully dissolve powder in any 4 to 8 ounces of beverage (cold, hot or room temperature), then drink.

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9.0

Amazon Basic Care

Amazon Basic Care ClearLax, Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Unflavored, 1.11 pound (Pack of 1)

Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350. Compare to MiraLAX active ingredient
OSMOTIC LAXATIVE: Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution acts as a laxative used to relieve occasional constipation/irregularity. The laxative generally produces a bowel movement in 1 to 3 days
RELIEF FOR IRREGULARITY: Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution increases frequency of bowel movements and softens the stool; relieves occasional constipation (irregularity).
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage. Grit free, sugar free and gluten free. For adults and children 17 years of age and older.
Polyethylene Glycol 3350 is the Doctor Recommended Laxative Active Ingredient (Of U.S. physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)

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8.8

MiraLAX

MiraLAX Laxative Powder, Gentle Constipation Relief for Adults, Stool Softener with PEG 3350, Nonstimulant Laxative, No Harsh Side Effects, Includes Stirrer, 14 Dose

Main Highlights

Works naturally with the water in your body: Hydrates, softens, and eases your stool providing gentle and effective occasional constipation relief for women and men
Nonstimulant laxative: A gentle laxative for women and men with no harsh side effects, unblock your system without bloating, cramping, or sudden urgencies
#1 doctor-recommended OTC laxative: Recommended by physicians, gastroenterologists, and pharmacists for safe and effective constipation relief for adults
Convenient stirrers: Includes stirrers for effortless mixing, just fill cap to indicated line, mix, and drink in any hot or cold beverage. MiraLAX Laxative will provide relief in 1-3 days
Unflavored, grit-free powder: Dissolves completely in any hot or cold drink for a simple, stress-free experience
Free from: Sugar, preservatives, and gluten, a reliable stool softener choice

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8.6

Dulcolax

Dulcolax Stimulant Laxative Tablets, Predictable & Effective Constipation Relief, Relieves Straining & Bloating, Bisacodyl 5 mg, 50 Count

Main Highlights

Includes: One (1) 50-count box of Dulcolax stimulant laxative comfort-coated tablets
Dependable constipation relief: Dulcolax tablets reactivate your natural gut rhythm* for effective morning constipation relief
Works fast: Dulcolax provides constipation relief in as little as six to 12 hours, starting with just one tablet
Effective active ingredient: Dulcolax stimulant laxative tablets are made with bisacodyl, which helps increase movement in the intestines
On-the-go relief: Pack these overnight laxative pills in your travel essentials to help you get back to being regular when stress and overindulgence slow you down
Doctor recommended: Dulcolax is the No. 1 doctor-recommended brand among OTC stimulant laxative brands
Predictable relief: Provides predictable relief of hard, dry stools caused by occasional constipation and irregularity

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8.3

Dulcolax

Dulcolax Stimulant Laxative Tablets, Predictable & Effective Constipation Relief, Relieves Straining & Bloating, Bisacodyl 5 mg, 100 Count

Main Highlights

INCLUDES: One (1) 100-count box of Dulcolax stimulant laxative comfort-coated tablets
DEPENDABLE CONSTIPATION RELIEF: Dulcolax tablets reactivate your natural gut rhythm for effective morning constipation relief
WORKS FAST: Dulcolax provides constipation relief in as little as six to 12 hours, starting with just one tablet
EFFECTIVE ACTIVE INGREDIENT Dulcolax stimulant laxative tablets are made with bisacodyl, which helps increase movement in the intestines
ON-THE-GO RELIEF: Pack these overnight laxative pills in your travel essentials to help you get back to being regular when stress and overindulgence slow you down
DOCTOR RECOMMENDED: Dulcolax is the doctor-recommended brand among OTC stimulant laxative brands
PREDICTABLE RELIEF: Provides predictable relief of hard, dry stools caused by occasional constipation and irregularity

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8.1

CAMBER PHARMACEUTICALS, INC

Camber Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Relieves Occasional Constipation, Unflavored 119 gr.

Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350; compare to NAtional Brand active ingredient
CONSTIPATION RELIEF: Relieves occasional constipation/irregularity; generally produces a bowel movement
SOFTENS THE STOOL: This laxative increases frequency of bowel movements and softens the stool

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8.1

GoodSense

GoodSense Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Softens Stool, Relieves Occasional Constipation, 26.9 Ounce

Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350. Compare to MiraLAX active ingredient
OSMOTIC LAXATIVE: GoodSense ClearLax Polyethylene Glycol 3350 Powder for Solution acts as a laxative used to relieve occasional constipation/irregularity. The laxative generally produces a bowel movement in 1 to 3 days
RELIEF FOR IRREGULARITY: GoodSense ClearLax Polyethylene Glycol 3350 Powder for Solution increases frequency of bowel movements and softens the stool; relieves occasional constipation (irregularity).
CONSTIPATION FROM GLP-1? Try GoodSense Polyethylene Glycol 3350 and continue on your weight loss journey. Use as directed.
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage Grit free, sugar free and gluten free; For adults and children 17 years of age and older
Polyethylene Glycol 3350 is the number 1 Doctor Recommended Laxative Active Ingredient (Of US physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)

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Our Best Overall Choice

Best Choice

9.7

Amazon Basic Care

Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Relieves Occasional Constipation, Unflavored, 1.68 pound (Pack of 1)

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350; compare to MiraLAX active ingredient
CONSTIPATION RELIEF: Relieves occasional constipation/irregularity; generally produces a bowel movement in 1 to 3 days
DOCTOR RECOMMENDED ACTIVE INGREDIENT: Polyethylene Glycol 3350 is the Number One Doctor Recommended Laxative Active Ingredient (of U.S. physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)
SOFTENS THE STOOL: This laxative increases frequency of bowel movements and softens the stool
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage; grit free, sugar free and gluten free; for adults and children 17 years of age and older

Show Price

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