10 Best Osmotic Laxative Brands of 2025

Tested and Reviewed: Top 10 Osmotic Laxative Brands deals with expert ratings from 8.1 to a perfect 10

April 2026 Edition

Editor's Choice

9.7

Amazon Basic Care

Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Relieves Occasional Constipation, Unflavored, 1.68 pound (Pack of 1)

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Editor's bottom line:

“This osmotic laxative brands is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350; compare to MiraLAX active ingredient
CONSTIPATION RELIEF: Relieves occasional constipation/irregularity; generally produces a bowel movement in 1 to 3 days
DOCTOR RECOMMENDED ACTIVE INGREDIENT: Polyethylene Glycol 3350 is the Number One Doctor Recommended Laxative Active Ingredient (of U.S. physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)
SOFTENS THE STOOL: This laxative increases frequency of bowel movements and softens the stool
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage; grit free, sugar free and gluten free; for adults and children 17 years of age and older

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Picked by 397 people today

9.5

Amazon Basic Care

Amazon Basic Care ClearLax, Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Unflavored, 8.3 ounce (Pack of 1)

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Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350. Compare to MiraLAX active ingredient
OSMOTIC LAXATIVE: Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution acts as a laxative used to relieve occasional constipation/irregularity. The laxative generally produces a bowel movement in 1 to 3 days
RELIEF FOR IRREGULARITY: Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution increases frequency of bowel movements and softens the stool; relieves occasional constipation (irregularity).
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage. Grit free, sugar free and gluten free. For adults and children 17 years of age and older.
Polyethylene Glycol 3350 is the Doctor Recommended Laxative Active Ingredient (Of U.S. physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)

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9.5

Glenmark Therapeutics

Glenmark Therapeutics Polyethylene Glycol 3350 Powder, Osmotic Laxative, 45 Daily Doses, Softens Stool, Relieves Occasional Constipation, Powder for Solution, 26.9 Ounce

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Main Highlights

ORIGINAL PRESCRIPTION STRENGTH
OSMOTIC LAXATIVE: The active ingredient of this product is Polyethylene Glycol 3350, an osmotic laxative that relieves occasional constipation (irregularity) and softens the stool.
GET RELIEF: This laxative powder generally produces a bowel movement in 1 to 3 days.
DISSOLVES IN ANY BEVERAGE: This powder is unflavored, sugar free, and dissolves in any beverage.
USE AS DIRECTED: Fill to top of white section in cap which is marked to indicate the correct dose (17g), stir and fully dissolve powder in any 4 to 8 ounces of beverage (cold, hot or room temperature), then drink.

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9.2

Amazon Basic Care

Amazon Basic Care ClearLax, Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Unflavored, 1.11 pound (Pack of 1)

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Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350. Compare to MiraLAX active ingredient
OSMOTIC LAXATIVE: Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution acts as a laxative used to relieve occasional constipation/irregularity. The laxative generally produces a bowel movement in 1 to 3 days
RELIEF FOR IRREGULARITY: Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution increases frequency of bowel movements and softens the stool; relieves occasional constipation (irregularity).
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage. Grit free, sugar free and gluten free. For adults and children 17 years of age and older.
Polyethylene Glycol 3350 is the Doctor Recommended Laxative Active Ingredient (Of U.S. physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)

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9.0

MiraLAX

MiraLAX Laxative Powder, Gentle Constipation Relief for Adults, Stool Softener with PEG 3350, Nonstimulant Laxative, No Harsh Side Effects, Osmotic Laxative, 45 Dose

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Main Highlights

Works naturally with the water in your body: MiraLAX laxative powder gently unblocks your system by hydrating and softening your stool for occasional constipation relief
No harsh side effects: A laxative for constipation that doesn't cause gas, bloating, cramping, or sudden urgency
Nonstimulant: Cramp-free constipation relief for women and men that wont disrupt your day; works naturally with the water in your body
#1 doctor-recommended OTC laxative: Recommended by physicians, gastroenterologists, and pharmacists for safe and effective constipation relief for adults
Unflavored, grit-free powder: Dissolves completely in any hot or cold beverage for a simple, stress-free experience
Free from sugar, preservatives, and gluten: Dependable and gentle laxative for women and men

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8.8

CAMBER PHARMACEUTICALS, INC

Camber Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Relieves Occasional Constipation, Unflavored 119 gr.

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Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350; compare to NAtional Brand active ingredient
CONSTIPATION RELIEF: Relieves occasional constipation/irregularity; generally produces a bowel movement
SOFTENS THE STOOL: This laxative increases frequency of bowel movements and softens the stool

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8.6

CAMBER PHARMACEUTICALS, INC

Camber Polyethylene Glycol 3350 Powder, Osmotic Laxative, Relieves Occasional Constipation, Stool Softener (14 Daily Dose Sachet)

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Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350; compare to NAtional Brand active ingredient
CONSTIPATION RELIEF: Relieves occasional constipation/irregularity; generally produces a bowel movement
SOFTENS THE STOOL: This laxative increases frequency of bowel movements and softens the stool

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8.3

GoodSense

GoodSense Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Softens Stool, Relieves Occasional Constipation, 17.9 Ounce (Pack of 3)

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Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350. Compare to MiraLAX active ingredient
OSMOTIC LAXATIVE: GoodSense ClearLax Polyethylene Glycol 3350 Powder for Solution acts as a laxative used to relieve occasional constipation/irregularity. The laxative generally produces a bowel movement in 1 to 3 days
RELIEF FOR IRREGULARITY: GoodSense ClearLax Polyethylene Glycol 3350 Powder for Solution increases frequency of bowel movements and softens the stool; relieves occasional constipation (irregularity).
CONSTIPATION FROM GLP-1? Try GoodSense Polyethylene Glycol 3350 and continue on your weight loss journey. Use as directed.
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage Grit free, sugar free and gluten free; For adults and children 17 years of age and older
Polyethylene Glycol 3350 is the number 1 Doctor Recommended Laxative Active Ingredient (Of US physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)

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8.1

GoodSense

GoodSense Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Softens Stool, Relieves Occasional Constipation, 26.9 Ounce

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Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350. Compare to MiraLAX active ingredient
OSMOTIC LAXATIVE: GoodSense ClearLax Polyethylene Glycol 3350 Powder for Solution acts as a laxative used to relieve occasional constipation/irregularity. The laxative generally produces a bowel movement in 1 to 3 days
RELIEF FOR IRREGULARITY: GoodSense ClearLax Polyethylene Glycol 3350 Powder for Solution increases frequency of bowel movements and softens the stool; relieves occasional constipation (irregularity).
CONSTIPATION FROM GLP-1? Try GoodSense Polyethylene Glycol 3350 and continue on your weight loss journey. Use as directed.
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage Grit free, sugar free and gluten free; For adults and children 17 years of age and older
Polyethylene Glycol 3350 is the number 1 Doctor Recommended Laxative Active Ingredient (Of US physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)

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8.1

GoodSense

GoodSense ClearLax, Polyethylene Glycol 3350 Powder for Solution - Osmotic Laxative for Constipation Relief, Unflavored, 8.3 oz

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Main Highlights

Effective Constipation Relief: Provides relief from occasional constipation by softening stool and increasing bowel movements.
Osmotic Laxative: Contains Polyethylene Glycol 3350 for gentle and effective relief. Supports regular bowel movements.
Unflavored and Grit-Free: Dissolves easily in any beverage without altering the taste or texture. Sugar-free and gluten-free making this suitable for those with dietary restrictions.
Relief for Irregularity: Powder works by increasing the amount of water in the intestinal tract to stimulate bowel movements.
Instructions: See product label for full usage instructions. Use as directed.

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Our Best Overall Choice

Best Choice

9.7

Amazon Basic Care

Amazon Basic Care ClearLax Polyethylene Glycol 3350 Powder for Solution, Osmotic Laxative, Relieves Occasional Constipation, Unflavored, 1.68 pound (Pack of 1)

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ACTIVE INGREDIENT: The active ingredient of this osmotic laxative is Polyethylene Glycol 3350; compare to MiraLAX active ingredient
CONSTIPATION RELIEF: Relieves occasional constipation/irregularity; generally produces a bowel movement in 1 to 3 days
DOCTOR RECOMMENDED ACTIVE INGREDIENT: Polyethylene Glycol 3350 is the Number One Doctor Recommended Laxative Active Ingredient (of U.S. physicians surveyed by an independent market research firm, excluding Therapeutic Fiber and Stool Softeners)
SOFTENS THE STOOL: This laxative increases frequency of bowel movements and softens the stool
UNFLAVORED POWDER: Unflavored laxative powder dissolves in any beverage; grit free, sugar free and gluten free; for adults and children 17 years of age and older

Show Price

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