10 Best Oral Mouth Sore Treatment of 2025

Tested and Reviewed: Top 10 Oral Mouth Sore Treatment deals with expert ratings from 8.1 to a perfect 10

May 2025 Edition

Editor's Choice

9.7

Save 34%

Orajel

Orajel Nonseptic Mouth Sore Rinse 16oz, Soothing Mint Flavor, Provides Pain Relief, Promotes Healing, 3-Pack

34% OffFree Shipping

Editor's bottom line:

“This oral mouth sore treatment is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

PAIN RELIEF: Orajel Mouthwash helps to provide you with temporary pain relief from your mouth sores and irritation.
PROMOTES HEALING: Specially formulated to help kill bacillus in your mouth and promote healing so you can feel better.
FOR ALL MOUTH SORES: From canker sores, to cheek bites, gum irritation, and sores from dentures or braces- Orajel Mouth Sore Rinse can help alleviate your pain from the comfort of your home.
MINT FLAVOR mouthwash, 16oz
#1 Oral Pain Reliever Brand for Adults

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Picked by 312 people today

9.5

Save 13%

Canker-X

Canker-X Mouth Sore Gel, Fast Pain Relief & Healing for Canker Sores, Cheek Bites and Oral Abrasions, Oral Pain Relief Gel, Benzocaine-Free and Alcohol-Free, Adults and Kids 6+ Years, 0.28 fl oz

13% OffFree Shipping

Main Highlights

FAST PAIN RELIEF & HEALING GEL: Canker-X canker sore treatment gel provides fast, long-lasting oral pain relief from canker sores, abrasions and more without any burning or numbing sensation. Clinically tested formula with NO Benzocaine and NO alcohol
MOUTH SORES TREATMENT: Canker-X soothes canker sores, cheek bites, mouth sores and mouth abrasions often caused by braces and dentures. The alcohol-free and benzocaine-free oral pain relief gel promotes healing and relieves pain
SOOTHES, HYDRATES & PROTECTS: The unique and clinically tested Canker-X gel formula contains Polyvinylpyrrolidone (PVP) which forms a micro-thin protective coating over a mouth sore to block irritants like food & drinks, and relieves discomfort for up to 6 hours
HOW TO USE: Use the extended nozzle to easily apply the gel on even hard-to-reach mouth sores. You can also apply gel with a clean finger or cotton swab. Wait 2 mins for the protective barrier to form. For best results, avoid eating/drinking for 1 hour
SAFE & EFFECTIVE: Clinically tested, Canker-X Gel is an effective canker sore treatment for both children (6+ years) and adults. Key ingredients are Aloe Vera to soothe, Sodium Hyaluronate to hydrate and Polyvinylpyrrolidone (PVP). Use as needed

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9.5

PHS Brands

Prevention Mouth Sore Mouthwash | Alcohol Free | Canker Sore Treatment, 16 fl oz (Pack of 1)

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Main Highlights

Effective Mouth Sore Treatment: Specially designed for canker sores, ulcers, and irritation caused by braces, burns or minor injuries, this mouth rinse provides fast, soothing relief while supporting healing and oral comfort. Ideal for managing sensitive oral tissue and protecting against further irritation.
Alcohol-Free & Gentle Formula: Formulated with hydrogen peroxide, sodium citrate, zinc, and glycerin that work together to provide effective pain relief and protect irritated areas in the mouth, lips, and throat. Made without alcohol, fluoride, or dyes, making it safe for short term daily use and sensitive oral care
Long-Lasting Freshness: Infused with natural menthol and peppermint oil, this refreshing healing mouthwash offers 12 hours of fresh breath while relieving discomfort from mouth sores, ulcers, gum disease and other oral issues.
Safe and Easy to Use: This canker sore mouthwash is safe for adults and children aged 2 and older. With early and consistent use, it helps prevent oral discomfort while supporting a healthy, balanced oral environment. For best results, rinse 3-5 times daily or as needed to relieve pain, promote healing, and protect against future irritations.
Hydrating & Restorative Care: Rehydrates and moisturizes the oral cavity, ensuring a comfortable experience while serving as an effective mouth sore treatment. Helps to prevent canker sores inside the mouth, dry mouth, and general irritation

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9.2

Zilactin

Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1

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Main Highlights

Broad-Spectrum Formula: Provides immediate, long lasting oral pain relief of canker sores, mouth sores and gum irritation
Fast, Long-Lasting Relief: Contains a proprietary blend of ingredients including 10% Benzocaine for immediate, long lasting, oral pain relief
Bioadhesive Technology: Provides up to 6 hours of durable protection and relief so you can eat and drink pain free
Feel It. Heal It: Initial sting, followed by long lasting relief and recovery
Made in USA: Assures quality and reliability in every application

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9.0

Save 27%

DenTek

DenTek Canker Relief Sore Patch Relieves Canker Pain, 6 Count (Pack of 1)

27% OffFree Shipping

Main Highlights

DenTek Canker Relief Advanced Canker Sore Patches help provide relief from canker sore pain and help protect from irritants while promoting healing
Clinically tested to reduce canker sore pain and help relieve the pain from small oral wounds and irritation from braces and oral ulcers
Flexible and ultrathin patches contain Vitamin E and help provide comfort
Easy to use just apply the patch to sore/wound, hold in place and patch will adhere
Contains 1 box of DenTek Canker Relief Canker Sore Patch, 6 count
FSA- and HSA-eligible product in the U.S.

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8.8

Oral-B

Oral-B Mouth Sore Mouthwash Special Care Oral Rinse, Hydrogen Peroxide Mouthwash, 16 fl oz, Mouthwash Alcohol Free

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Main Highlights

1. UNIQUE ORAL CARE: Oral-B special care rinse is crafted to meet your unique oral care needs, including hydrogen peroxide mouthwash.
2. DENTIST FORMULATED: Specially formulated for Mouth Sores, including: Canker Sores, Cheek Bites, Braces & Denture Irritations, Oral & Gum Irritations
3. CLEANSING ACTION: Cleanses oral wounds.
4. TRUSTED INGREDIENTS: No added alcohol, artificial dyes, parabens, gluten, sodium lauryl Sulfate (SLS). This mouthwash is also alcohol free mouthwash.
5. TRUSTED BRAND: The brand trusted by dentists AND consumers worldwide now brings you the Oral-B special care rinse collection.

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8.6

Rite Aid

Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief - .5 fl oz, Benzocaine 20% | Pain Relief Medications & Treatments | Canker Sore and Tooth Pain Relief for Adults | Mouth Sores Treatment

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Main Highlights

MOUTH SORE TREATMENT: Rite Aid Max Strength Oral Liquid Anesthetic Benzocaine 20% pain relieving liquid temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief from pain associated with toothaches, gum pain, canker sores, and dentures/braces. Compare Rite Aid to the leading national brand and get the same reliable mouth pain relief you can count on.
MAXIMUM STRENGTH: Formulated with 20% Benzocaine, Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief offers the maximum amount of pain relief and aims to temporarily relief the mouth and tooth pain that ails you, so you can live pain free.
ADULTS AND CHILDREN 2 YEARS AND UP: Apply to affected area using applicator tip. Use up to 4 times daily or as directed by a doctor. Children under 12 years of age should be supervised in the use of this product. Children under 2 years of age do not use.
TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.

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8.3

Save 7%

Colgate

Colgate Peroxyl Antiseptic Mouth Sore Rinse, Alcohol Free, 1.5% Hydrogen Peroxide, Mild Mint, 8.4 Fl Oz (Pack of 1)

7% OffFree Shipping

Main Highlights

Mouth rinse cleanses and promotes healing of minor oral wounds
Antiseptic rinse helps promote healing of: oral sores, irritations, mouth burns
Oxygenating action removes oral debris to facilitate healing
Soothes minor gum inflammation from dental procedures, dentures and orthodontic appliances
1.5% hydrogen peroxide, alcohol free formula

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8.1

Save 23%

Orajel

Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand

23% OffFree Shipping

Main Highlights

INSTANT PAIN RELIEF: Orajel Mouth Sore Gel contains 20% Benzocaine to relieve pain from canker sores, mouth sores, cold sores and other mouth irritations
SOOTHING RELIEF: Maximum strength gel uses menthol to soothe irritated and sore gums quickly, where you need it most
PROTECTION: Our unique, fast acting, formula contains an astringent to help protect sores from irritation, including irritation from dentures or braces, as well as canker sores
EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.
From the #1 Oral Pain Reliever Brand for Adults

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8.1

CUROXEN

CUROXEN Mouth Sore Relief, Made with All-Natural Ingredients Including Olive Oil, Calendula, Beeswax, Clove Essential Oil, and Cinnamon Oil, Gluten-Free - 0.42 oz

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Main Highlights

WITH CALENDULA: Calendula is derived from the flower petals of the pot marigold and has been used for medicinal purposes throughout history. *An independent accredited laboratory (non-human/non-animal) study measured the amount of germs killed in one hour. CUROXEN killed 99.9% of the germs tested: E.coli, S.aureas, P.aeruginosa, E.faecalis, and MRSA. Claims based on traditional homeopathic practice and laboratory testing, not accepted clinical medical evidence. Not FDA evaluated.
ALL-NATURAL INGREDIENTS: Our ointment formula consists of ultra-pure oxygenated olive oil, calendula, clove essential oil which combined create an effective oral care product., We added cinnamon essential oil for an improved taste. It uses all-natural ingredients with no added artificial thickeners. It may liquefy when over 77 degrees Fahrenheit. If a thicker product is preferred, refrigerate for 10 minutes.
ADVANCED FORMULA: CUROXEN does NOT contain any artificial chemicals. This mouth care cream is manufactured under strict Good Manufacturing Practices per U.S. Food and Drug Administration (FDA) guidelines.
DIRECTIONS FOR USE: This topical gel is for adults and children over 12 years of age. Cut the tip of the tube and apply ointment liberally to the affected area as needed. Don't use if the tube is cut before opening. CUROXEN can be used on children 2 to 12 years old with adult supervision after consulting a healthcare professional. Children under 2 should not use CUROXEN.
ABOUT US: At OrganiCare, we aim to create all-natural OTC healthcare products and first aid supplies. We want to dispel the notion that all-natural products are not as effective as their chemical-laden counterparts.

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Our Best Overall Choice

Best Choice

9.7

Orajel

Orajel Nonseptic Mouth Sore Rinse 16oz, Soothing Mint Flavor, Provides Pain Relief, Promotes Healing, 3-Pack

34% OffFree Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

PAIN RELIEF: Orajel Mouthwash helps to provide you with temporary pain relief from your mouth sores and irritation.
PROMOTES HEALING: Specially formulated to help kill bacillus in your mouth and promote healing so you can feel better.
FOR ALL MOUTH SORES: From canker sores, to cheek bites, gum irritation, and sores from dentures or braces- Orajel Mouth Sore Rinse can help alleviate your pain from the comfort of your home.
MINT FLAVOR mouthwash, 16oz
#1 Oral Pain Reliever Brand for Adults

Show Price

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