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10 Best Nighttime Gel Eye Drops of 2025

Tested and Reviewed: Top 10 Nighttime Gel Eye Drops deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

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1

Editor's Choice

9.7

Systane Nighttime Lubricant Eye Ointment 3.5g Tube

Systane

Systane Nighttime Lubricant Eye Ointment 3.5g Tube

Editor's bottom line:

“This nighttime gel eye drops is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*
Provides nighttime relief of dry eye symptoms
Ointment soothes and protects against dry, irritated eyes
Forms long-lasting, protective layer on eyes while you sleep
Safe, preservative-free formula

Picked by 397 people today

2

9.5

Systane Lubricant Eye Gel Drops, 10-mL (Packaging May Vary)

Systane

Systane Lubricant Eye Gel Drops, 10-mL (Packaging May Vary)

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*
Thicker eye drop formulation that creates a protective shield over your eyes.
Convenience of a drop with a protection of a gel.
For the temporary relief of burning and irritation due to dryness of the eye
NOTE: PRODUCT PACKAGING MAY VARY

3

9.5

iVIZIA Eye Gel for Nighttime Dry Eyes, Preservative-Free, 30 Single-use vials

iVIZIA

iVIZIA Eye Gel for Nighttime Dry Eyes, Preservative-Free, 30 Single-use vials

Main Highlights

Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve dry eye symptoms.
Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for dry eye or nighttime use.
iVIZIA We See a Better Way: for healthy, comfortable eyes

4

9.2

TheraTears Liquid Gel Nighttime Lubricating Eye Drops for Dry Eyes, Single-Use Vials, 30 Count

TheraTears

TheraTears Liquid Gel Nighttime Lubricating Eye Drops for Dry Eyes, Single-Use Vials, 30 Count

Main Highlights

Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms, 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
Instant hydration: TheraTears eye drops restore eyes natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

5

9.0

Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile

Refresh

Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile

Main Highlights

Extended relief plus protection for dry, irritated eyes
Our most comprehensive gel formula
Anytime relief, day or night
Feels like a drop but works like a gel for lasting comfort
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
#1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

6

8.8

Soothe Preservative-Free Lubricant Eye Ointment, Nighttime Relief for Severe Dry & Irritated Eyes, Gentle for Sensitive Eyes, 0.12 Fl Oz

Soothe

Soothe Preservative-Free Lubricant Eye Ointment, Nighttime Relief for Severe Dry & Irritated Eyes, Gentle for Sensitive Eyes, 0.12 Fl Oz

Main Highlights

EYE OINTMENT FOR DRY EYES AT NIGHT: Use Soothe Lubricant Eye Ointment to help moisturize & refresh severe dry eyes overnight for long-lasting relief & comfort. Soothing nighttime dry eye relief formula to help relieve dryness & prevent irritation
SEVERE DRY EYE RELIEF: This dry eye ointment contains two lubricants to help relieve dry and irritated eye symptoms. Soothe ointment is gentle enough for sensitive eyes and can be used as often as needed, but stop use and ask a doctor if condition worsens or persists more than 72 hours. Remove contact lenses before using
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected

7

8.6

TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)

TheraTears

TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)

Main Highlights

Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms which may be better for people with sensitive eyes, with 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
Instant hydration: TheraTears eye drops restore eyes natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

8

8.3

Genteal Tears Gel Drops, 8 ml

Genteal

Genteal Tears Gel Drops, 8 ml

Main Highlights

Product Type:Medication
Item Package Dimension:1.75 " L X1.25 " W X3.88 " H X
Item Package Quantity:1
Country Of Origin: United States

9

8.1

Allergan Refresh Liquigel Size .5oz Allergan Refresh Liquigel For Moderate To Severe Dry Eye

Refresh

Allergan Refresh Liquigel Size .5oz Allergan Refresh Liquigel For Moderate To Severe Dry Eye

Main Highlights

Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

10

8.1

Genteal Tears Night-Time Ointment 3.5g Clear 0.12 Fl Oz

Genteal

Genteal Tears Night-Time Ointment 3.5g Clear 0.12 Fl Oz

Main Highlights

Severe Dry Eye Symptom Relief
Long-Lasting Nighttime Relief
Nighttime Protection: Apply before bed for dry eye relief
Moisturizes and lubricates eyes
Protects against further eye irritation

Our Best Overall Choice

9.7

Systane Nighttime Lubricant Eye Ointment 3.5g Tube

Systane

Systane Nighttime Lubricant Eye Ointment 3.5g Tube

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*
Provides nighttime relief of dry eye symptoms
Ointment soothes and protects against dry, irritated eyes
Forms long-lasting, protective layer on eyes while you sleep
Safe, preservative-free formula

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Systane Nighttime Lubricant Eye Ointment 3.5g Tube

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