10 Best Mucus Relief of 2025

Tested and Reviewed: Top 10 Mucus Relief deals with expert ratings from 8.1 to a perfect 10

July 2025 Edition

Editor's Choice

9.7

WELMATE

WELMATE Mucus Relief | Guaifenesin 1200 Mg Maximum Strength | 100 Count Extended-Release Bi-Layer Tablets

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Editor's bottom line:

“This mucus relief is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Active Ingredient: Guaifenesin 1200mg is an expectorant that helps reduce chest congestion caused by colds, infections or irritants. Compare to the active ingredient in Muci-nex.
Immediate & Extended Relief: Our mucus relief tablet has a unique bi-layer that offers immediate relief via the first layer, and the second layers continues working for up to 12 hours.
Relieves Chest Congestion: Thins and loosens mucus to alleviate chest congestion caused by excess phlegm making your cough more productive.
Breathe easier by taking Guaifenesin 1200mg at the first sign of symptoms. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.
Proudly Made: Safe for adults and children 12 years of age and older. Take 1 tablet with a full glass of water every 12 hours. Do not exceed 2 tablets over a 24 hour period.

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Picked by 221 people today

9.5

Save 27%

Mucinex

Mucinex 12 Hour 1200mg Maximum Strength Guaifenesin Chest Congestion & Mucus Relief, Guaifenesin Expectorant Aids Mucus Removal, Chest Decongestant for Adults, Dr Recommended, 42ct Tablets

27% OffFree Shipping

Main Highlights

EXCESS MUCUS RELIEF: Maximum Strength Mucinex 12hr extended-release tablets pack a powerful punch with 1200 mg guaifenesin expectorant, providing you with long-lasting chest congestion relief
AIDS EXCESS MUCUS REMOVAL: Maximum strength chest congestion relief; Mucinex 12hr lasts up to 12 hours and provides relief for your chest congestion and makes cough more productive
EXPECTORANTS FOR ADULTS: Mucinex helps clear lungs by thinning & loosening mucus; Say goodbye to excess mucus, say hello to chest congestion relief
EXTENDED RELEASE GUAIFENESIN: Experience long-lasting excess mucus relief with Mucinex's 12hr maximum strength extended-release 1200 mg guaifenesin bi-layer tablets with immediate & extended release
TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended OTC Expectorant**; Get the brand that doctors trust and recommend
COLD AND FLU MEDICINE FOR ADULTS: For powerful cough, cold, and flu multi-symptom relief, check out our range of Mucinex Fast-Max cold and flu medicines; Beat cold and flu symptoms with confidence
FSA & HSA Eligible: Save Up to 30% - Cover out-of-pocket expenses with pre-tax dollars (Product eligibility may vary by plan; Check with your benefits administrator to determine which expenses are eligible before you shop)
QUALITY YOU CAN TRUST: Mucinex uses carbomer that is manufactured without the use of benzene
*IQVIA using ProVoice Survey, August 2023; **U.S. News & World Report/Pharmacy Times 2023-2024

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9.5

Guardian

Guardian Mucus Relief 12 Hour (70 Count) Extended Release Guaifenesin, 1200mg Maximum Strength, Chest Congestion Expectorant Tablets (70 Count Bottle (Pack of 1))

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Main Highlights

Whether it's the spring or fall allergy season Guardian Mucus Relief has you covered. Guardian Mucus Relief MAXIMUM STRENGTH Relieves Chest Congestion
Thins and loosens Mucus, Makes Coughs more productive
Convenient Packaging- Tired of fumbling with blister packs? - Get 70 tablets in a bottle - For chronic users the bottle pack is more convenient - no mess and no fuss of removing each pill from the blister pack
Extended Release. Gets to work right away and each pill lasts 12 hours. BLUE DYE FREE
1200mg 70 Count BOTTLE. EXTENDED RELEASE Maximum Strength -Made in USA

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9.2

Guardian

Guardian Mucus Relief, 600mg Guaifenesin 12 Hour Extended Release, Chest Congestion Expectorant (100 Count Bottle)

Free Shipping

Main Highlights

Relieves Chest Congestion
Thins and loosens Mucus
Makes Coughs more productive
Extended Release. Gets to work right away and each pill lasts 12 hours
600mg EXTENDED RELEASE - Made in USA

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Best Value

9.0

Save 41%

GenCare

GenCare Mucus Relief Expectorant Guaifenesin 400 mg 200 Tablets Value Pack - Fast Acting Thinning of Mucus for Colds, Chest Congestion, Flu, Coughing and Allergies

41% OffFree Shipping

Main Highlights

FAST RELIEF - GenCare mucus relief Guaifenesin is an expectorant that helps loosen and thin mucus in your throat so you can breathe easier through your nose and mouth while expelling mucus and phlegm.
FIGHTS COLDS - Combat chest congestion, mucus and bronchial secretions caused by the common cold and flu. This product is not for children under 12 years of age.
EASY SWALLOW TABLETS - Avoid foul tasting cough syrups and liquids that need to be taken every couple of hours for lasting effects. Easy to swallow to provide fast and sustained mucus relief during the day and night.
BULK SAVINGS - You and your family will always have cough and congestion relief on hand. Save money with the same active ingredient as Mucinex and Robitussin Mucus + Chest Congestion at a fraction of the price.
100% SATISFACTION GUARANTEE - Our 100% Customer Satisfaction Guarantee. Join thousands of satisfied customers and families...Click Add-to-Cart to order Today!

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8.8

Save 31%

Safrel

Safrel Pharma Mucus Relief Guaifenesin 400 mg - Fast Acting Expectorant, Thins and Loosens Mucus, Relieves Chest Congestion, Cough, Cold and Flu | Compare to Mucinex Tablets (200 Count (Pack of 1))

31% OffFree Shipping

Main Highlights

Effective Mucus Relief: Safrels Mucus Relief provides fast and effective mucus removal with Guaifenesin 400mg, helping clear your airways for easier breathing. Get quick relief from chest congestion and mucus buildup.
Clear Mucus from Throat: Safrel Mucus Relief DM works to clear mucus from the throat, relieving congestion and discomfort. It helps soothe your throat while targeting chest congestion for better breathing and comfort.
Cough and Mucus Relief: Get dual-action relief with Cough Relief and Mucus Relief 400mg. Our cough pills effectively relieve coughing while loosening mucus in the chest, so you can breathe freely and feel better quickly.
Cold and Flu Medicine: Safrel Mucus Relief Tablets are perfect for alleviating cold flu symptoms, including excess mucus and congestion. Use our formula to mucus clear and feel refreshed during cold or flu season.
Effective Throat Relief: Safrels Cough Tablets are formulated with the best meds to dry up mucus and act as a throat mucus remover. Feel comfortable and clear with every breath, even during cold or flu seasons.

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8.6

HEALTH LFE

HEALTH LFE Mucus Relief Guaifenesin Caplets 400 mg, Immediate Release Fast Acting Expectorant, Thin and Loosens Mucus, Relieves Chest Congestion, Cough, Cold and Flu (Medium, 200 Count)

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Main Highlights

ACTIVE INGREDIENT: The active ingredient in this product is Guaifenesin, an expectorant that helps reduce chest congestion caused by colds, infections or irritants. Clinically proven to provide powerful relief for your toughest chest congestion.
FAST ACTING: HealthLife Guaifenesin is a fast-acting expectorant helps loosen and thin mucus. Take 1 tablet every 4 hours with water.
EASY TO SWALLOW: Our 400 mg tablets are small in size making it easier to swallow to promote clearer breathing by providing continuous relief through out the day and night. Enjoy cough mucus relief with tablets that can be used by those with allergies, colds, infections, and flu bugs.
VALUE PACK SAVINGS: Did you know, with HealthLife Guaifenesin of 60 count value pack can save you significant amount of money with the same active ingredient Leading Brands..
MADE IN USA: A Non-Drowsy Immediate Release Formula carefully manufactured in USA to gurantee 100% satisfaction.

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8.3

Amazon Basic Care

Amazon Basic Care Maximum Strength Mucus DM, Expectorant and Cough Suppressant, 14 Tablets

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Main Highlights

ACTIVE INGREDIENTS: Amazon Basic Care Maximum Strength Mucus Relief DM tablets contain dextromethorphan HBr and guaifenesin; compare to the active ingredients in Maximum Strength Mucinex DM
MAXIMUM STRENGTH: 1200 mg of guaifenesin and 60 mg of dextromethorphan HBr team up to take on your toughest cold
EFFECTIVE: Amazon Basic Care Maximum Strength Mucus-DM clears your chest congestion and eases the intensity of coughing
COUGH SUPPRESSANT: This 12-hour cough medicine contains dextromethorphan HBr for cough relief; it relieves the impulse to cough to help you get to sleep
COUGH EXPECTORANT: Contains guaifenesin to help loosen phlegm so you can cough up that bothersome mucus; makes coughs more productive

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8.1

HealthA2Z

HealthA2Z® Mucus Relief | Guaifenesin 400mg | No Benzene | Immediate Release | Expectorant (60 Counts)

Free Shipping

Main Highlights

Cough & Cold Relief

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Our Best Overall Choice

Best Choice

9.7

WELMATE

WELMATE Mucus Relief | Guaifenesin 1200 Mg Maximum Strength | 100 Count Extended-Release Bi-Layer Tablets

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Active Ingredient: Guaifenesin 1200mg is an expectorant that helps reduce chest congestion caused by colds, infections or irritants. Compare to the active ingredient in Muci-nex.
Immediate & Extended Relief: Our mucus relief tablet has a unique bi-layer that offers immediate relief via the first layer, and the second layers continues working for up to 12 hours.
Relieves Chest Congestion: Thins and loosens mucus to alleviate chest congestion caused by excess phlegm making your cough more productive.
Breathe easier by taking Guaifenesin 1200mg at the first sign of symptoms. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.
Proudly Made: Safe for adults and children 12 years of age and older. Take 1 tablet with a full glass of water every 12 hours. Do not exceed 2 tablets over a 24 hour period.

Show Price

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