10 Best Mthfr Testing Kit of 2025

Tested and Reviewed: Top 10 Mthfr Testing Kit deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

PlexusDX

Genetic Methylation Test Kit & MTHFR Testing Kit | 370+ DNA Reports Including MTHFR Gene Variants, COMT, Folate, B12, Riboflavin, Choline, Glucose, Keto Diet | Supplement & Diet Recommendations

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Editor's bottom line:

“This mthfr testing kit is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

WHAT YOU GET: DNA reports related to Methylation Genetics , AHCY, BHMT, CBS, MTHFS, MTHFD1, MTHFD1L, MTR, MTRR, Betaine, DHFR, DNMT3B, FOLH1, GNMT, MAT1A, SHMT1, TMYS, and more.
WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Cognitive Health, Hormone Balance, Detoxification, Antioxidants and more based on your unique DNA
HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for PEMT, Vitamin B12, Riboflavin, Homocysteine, Supplements, Diet and Lifestyle Recommendations
TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
CUSTOM MEAL PLANS: Discover which foods and meal plans you should be eating based on your genetics. Identify optimal intake of macros, vitamins, and minerals. Includes over 10,000 recipes.
ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.

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Picked by 397 people today

9.5

PlexusDX

Genetic Methylation Test Kit & MTHFR Testing Kit | 300+ DNA Reports Including MTHFR Gene Variants, COMT, BHMT, AHCY and Folate | Custom Supplement & Meal Plan Recommendations with 10,000 Recipes

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Main Highlights

WHAT YOU GET: DNA reports related to Methylation Genetics , AHCY, BHMT, CBS, MTHFS, MTHFD1, MTHFD1L, MTR, MTRR, Betaine, DHFR, DNMT3B, FOLH1, GNMT, MAT1A, SHMT1, and more.
WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Cognitive Health, Hormone Balance, Detoxification, Antioxidants and more based on your unique DNA
HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for PEMT, Vitamin B12, Riboflavin, Homocysteine, Supplements, Diet and Lifestyle Recommendations
TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
CUSTOM MEAL PLANS: Discover which foods and meal plans you should be eating based on your genetics. Identify optimal intake of macros, vitamins, and minerals. Includes over 10,000 recipes.
ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.

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9.5

empowerDX

empowerDX MTHFR Gene Test Kit, Methylation Test, Easy at-Home Test Detects Presence of 677 and 1298 MTHFR Gene Variants, Ages 2+, Fast Results Within 6 Days

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Main Highlights

TEST FOR VARIANTS OF MTHFR: Verify if you have a variant of the methylation gene; certain MTHFR gene variants may affect your ability to mentally thrive
WHAT IS MTHFR: The MTHFR gene helps folate work in your body, helps to regulate homocysteine (which can damage blood vessels when elevated), and plays a role in making dopamine, serotonin, and norepinephrine; variants of the MTHFR gene can be associated with mental health issues, depressed mood, fertility, anxious feelings, fetal development, and migraine headaches
EASY TO USE AT-HOME MTHFR TEST KIT: Requires an easy mouth swab for DNA test sample collection; Emerging research is studying the association between MTHFR gene variants and autism spectrum disorder, ADHD, autoimmune disease, Alzheimers disease, and much more
CERTIFIED LAB: empowerDX laboratories are certified by several different organizations and ensure that their methods and practices meet rigorous standards
SECURE & EASY TO READ RESULTS: MTHFR test results will be accessed privately through a secure online portal; a test guide will be provided on how to read and understand your results, which will reveal if there are any variations in the two MTHFR genetic markers

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9.2

MTHFR

MTHFR-Gene Methylation Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week, MTHFR C677T and MTHFR A1298C Gene Variants for Methylation Analysis. Results in 2-5 Days. Ages 0+

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Main Highlights

Get personalized supplement recommendations based on Ricardo Miranda's unique methylation protocol. He is widely recognized as a leading authority in methylation health and integrative genetics (video attached). With extensive experience coaching doctors nationwide and assisting thousands of patients, his expert guidance is tailored to your unique genetic profile, ensuring you benefit from proven, science-backed strategies for optimal health and wellness.
Comprehensive Mutation Analysis: Our test identifies every possible mutation in the MTHFR gene, providing you with precise information about your genetic makeup. Recognizing that navigating DNA results can be challenging, our dedicated specialists are just a phone call away, ready to assist you with any questions or concerns you may have.
Comprehensive Support: Get access to our expert team seven days a week through live phone support. Our knowledgeable specialists are ready to provide detailed explanations and answer your specific questions.
Simple, Non-Invasive Sampling: Our MTHFR gene test involves an easy-to-use cheek swab, designed for pain-free collection in the comfort of your home. This non-invasive method makes genetic testing straightforward and stress-free, ideal for individuals of any age, including toddlers and babies.
Targeted Efficacy: Our product is engineered to provide the most relevant insights for managing your methylation health effectively, promoting a focused approach to long-term wellness. This ensures that you receive the most practical and impactful recommendations tailored to your needs.
Reliable, Accurate, and Safe Results: Trust our MTHFR testing kit for its precision and thorough analysis, which focuses on the most impactful genetic information related to your methylation health. Our commitment to quality ensures that you receive dependable insights into your wellness. Your results are 100% secure with us. We uphold the strictest privacy standards and never share or sell your information to any third party. Our robust data protection protocols use encryption and are SOC2 compatible to ensure that your personal details remain confidential and secure.
When collecting a cheek swab from babies and toddlers, you can skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Just ensure the mouth is free of any food particles. Results in 2-5 business days from the day our lab receives your specimen.
Product ships in our original envelope packagingimages may vary slightly for display purposes, but the product inside remains the same.

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9.0

MTHFR

MTHFR+COMT Methylation Genes Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week. Includes C677T, A1298C & V158M Variants for Methylation and Wellness Analysis. Results in 2-5 Days. Ages 0+

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Main Highlights

Get personalized supplement suggestions and a wellness overview based on Ricardo Mirandas methylation methodology. He is widely recognized as a leading authority in methylation health and integrative genetics (video attached). With extensive experience coaching doctors nationwide and assisting thousands of patients, his expert guidance is tailored to your unique genetic profile, ensuring you benefit from proven, science-backed strategies for optimal health and wellness.
Targeted Genetic Insights: This test analyzes key variants in the MTHFR and COMT genes to provide a detailed view of your genetic profile. By focusing on these important pathways, the report offers clear information that can help you better understand your methylation and neurotransmitter-related genetics. Results are typically available 25 business days after our lab receives your specimen.
Comprehensive Support: Access our team seven days a week through live phone support. Our representatives are available to help with product information, guide you through the testing process, and assist with any questions related to your kit.
Simple and Convenient Testing: Collect your MTHFR + COMT sample at home with an easy, user-friendly process. This test includes analysis of both MTHFR and COMT genetic variants to provide a more complete view of your genetics related to these pathways. Adding COMT offers expanded informational insights alongside MTHFR for customers seeking a broader genetic overview.
Reliable and Confidential: Your MTHFR + COMT test is processed in a secure environment with strong privacy protections. We maintain strict confidentiality and safeguard your information through encrypted data handling and industry-standard security practices. Your results are 100% secure with us. We uphold the strictest privacy standards and never share or sell your information to any third party. Our robust data protection protocols use encryption and are SOC2 compatible to ensure that your personal details remain confidential and secure.
Clear and Supportive Guidance: Your report is designed to help you better understand your MTHFR and COMT genetic information. If you have questions about your results or the testing process, our team is available by phone to offer helpful assistance and customer support.
When collecting a cheek swab from babies and toddlers, you may skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Please ensure that the childs mouth does not contain any food particles before collecting the sample.
Product ships in our original envelope packaging. Images shown may vary slightly for display purposes, but the product inside remains the same.

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8.8

LIFEDNA

LifeDNA Methylation Genes Test Kit Includes MTHFR Analysis | Analyzes 13 Methylation Gene Variants (MTHFR, COMT, & VDR)

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Main Highlights

DISCOVER WHAT MAKES YOUR BODY UNIQUE - Stop guessing how your body processes nutrients, produces energy, and manages everyday stress. This DNA testing kit analyzes 13 methylation genes to uncover the specific variations that may be affecting your energy, nutrient absorption, and stress response; backed by 500+ peer-reviewed studies.
13 METHYLATION GENES ANALYZED - Most methylation test options check just MTHFR or a handful of variants. This panel covers MTHFR, COMT, MTR & MTRR, and 10 more critical genes, a more comprehensive picture of how your body processes B-vitamins, supports detox pathways, and regulates mood-related functions.
ACTIONABLE REPORTS, NOT RAW DATA - Go far beyond simple genetic reporting. This genetic testing kit delivers clear reports that translate complex methylation-genotype data about methylation into personalized insights and suggestions, so you know exactly what to explore next about your nutrition, energy, supplementation, and daily habits. Complimentary call with an expert included.
SIMPLE CHEEK SWAB, FAST RESULTS - No blood draws or doctor visits. Swab, seal, and mail it back in minutes. Receive your results in 3-5 weeks, not the 2-3 months other DNA tests can take. Everything you need is in the box
YOUR DNA DATA STAYS PRIVATE - Your genetic data is yours. Period. It is never sold to third parties, never shared with insurance companies, never accessed without your permission. You keep 100% ownership with full control, including the right to delete it anytime. Trusted by tens of thousands. This product is an informational wellness tool, not a substitute for professional healthcare guidance.

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8.6

MTHFR

COMT Gene Test Collection Kit Comes with Results Interpretation and Live Support 7 Days a Week - Cheek Swab - Results in 2-5 Days.

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Main Highlights

Includes results interpretation and LIVE SUPPORT via phone seven days a week. We offer real-time assistance to help you comprehend your results and their significance to you. Results in 2-5 business days from the day our lab receives your specimen.
Get personalized supplement recommendations based on Ricardo Miranda's unique methylation protocol. Widely recognized as The MTHFR Pioneer, he is a nationally recognized leading authority in methylation health and integrative genetics (video attached). With extensive experience coaching doctors nationwide and assisting thousands of patients, his expert guidance is tailored to your unique genetic profile, ensuring you benefit from proven, science-backed strategies for optimal health and wellness.
Our at-home genetic test kit is dedicated to analyzing the COMT gene, offering important insights through a straightforward cheek swab. Fast results.
The outcomes will indicate whether there are any variations in your COMT genetic marker. You can access the results via a secure online portal.
Dependable and Precise Outcomes: Have confidence in the excellence and precision of our COMT genetic testing kit. It delivers an in-depth examination of your COMT genetic data, enabling you to make informed decisions about your lifestyle.
When collecting a cheek swab from babies and toddlers, you can skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Just ensure the mouth is free of any food particles.
Simple, Non-Intrusive Collection: Our COMT gene test requires just an easy cheek swab, ensuring the process is pain-free and non-intrusive. You can gather your sample easily at home.
Product ships in our original envelope packagingimages may vary slightly for display purposes, but the product inside remains the same.

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8.3

AncestryDNA

AncestryDNA + Traits Genetic Test Kit: Personalized Genetic Traits, DNA Ethnicity Test, Origins & Ethnicities, Complete DNA Test, Ancestry Reports

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Main Highlights

TOP-SELLING CONSUMER DNA TEST: From your origins in over 3,600+ places around the world to the most connections to living relatives, no other DNA test kit delivers an experience as unique and interactive as AncestryDNA.
YOUR DATA, YOUR CONTROL: We give you full control over your genetic information. You decide what to share, and with whom.
DNA + TRAITS: Ever wondered where your freckles came from, or why you hate cilantro? AncestryDNA + Traits lets you discover 75+ genetic traits, allowing you to explore how your genes might have influenced a range of appearance, sensory, performance, nutrient, and other personal characteristics.
A FEW SIMPLE STEPS: Simply activate your DNA kit online and return your saliva sample in the prepaid package to our state-of-the-art lab. Your results will be available online in roughly six weeks.
ORIGINS AND INHERITANCE: AncestryDNA is the only DNA test that can show your origins results, DNA matches, and traits by each side of the family, without your parents taking a DNA test.

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8.1

SelfDecode

Genetic Methylation Test Kit | Methylation Pathway Including MTHFR, COMT, MTR, MTRR, CBS, BHMT Gene Variants | Personalized Recommendations to Optimize Methylation

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Main Highlights

WHAT YOU GET: A simple and painless at-home genetic test focused on key methylation-related genes, including MTHFR, COMT, CBS, MTR, MTRR, BHMT, MTHFD1, SHMT1, MAT1A, CHDH, AHCY, MTHFS, MTHFD1L, GNMT, DNMT3B, TYMS, DHFR, PEMT, FUT2, PDXK, TCN2, FOLH1, and CUBN. Receive personalized insights and actionable recommendations to support your methylation based on your unique DNA.
HOW DOES IT WORK? Simply open your kit and follow the included instructions to register. Collect your sample, then send it back using the prepaid return mailer provided. We will notify you via email, when your report is ready.
TARGETED INSIGHTS: The genetic methylation report decodes key gene variations affecting how your body detoxifies, repairs DNA, and balances hormones, empowering you with personalized insights to fine-tune your lifestyle and nutrition for better overall health.
ACTIONABLE RECOMMENDATIONS: Personalized recommendations to support optimal methylation covering supplements, diet, and lifestyle. Each recommendation is prioritized based on your unique DNA results and the strength of scientific evidence behind it, helping you focus on whats most likely to make a real difference.
ADVANCED DNA TESTING: The Methylation Pathway Report analyzes 30 SNPs (Genetic Variants) across 20+ key genes involved in this process, such as MTHFR, COMT, and PEMT, to reveal how your genetics influence detox, energy, and more.
PRIVACY & SECURITY: Your DNA is yours, and we keep it that way. All data is encrypted, anonymized, and remains fully under your control. We use HIPAA-compliant systems and advanced encryption to ensure your personal information stays secure at every step.

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8.1

tellmeGen

tellmeGen Advanced DNA Test Kit, Genetic Analysis on Health Predispositions, Ancestry, Traits, Nutrition and Fitness, Relative Connect and Lifetime Updates Included, 420+ Reports

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Main Highlights

ADVANCED GENETIC ANALYSIS. Access more than 420 comprehensive personalized reports, including over 200 focused on health and genetic risks with hereditary condition and disease susceptibility analysis. Explore insights into your ancestry, health, and traits in one test
DISCOVER YOUR ORIGINS AND CONNECT WITH FAMILY MEMBERS. With DNA Connect Family Finder, explore your ancestral roots, connect with relatives around the world who share your DNA, and build your family tree through our secure platform. Uncover maternal and paternal lineage, as well as percentage of Neanderthal DNA
FIND WHAT PERSONAL TRAITS you may possess from an increasingly comprehensive list such as eye clarity, skin pigmentation, sleep duration, cognitive ability, blood conditions, photic sneeze reflex, or the relationship between your genetics and your height, among many others. Decode your DNA to help make informed decisions
CONVENIENT AT-HOME TEST. Perform DNA test in 3 simple steps with a saliva sample, no blood or needles required. Activate your kit online, follow instructions, print out pre-paid label, ship, and receive your results in just 4-6 weeks. Unique email address required to register
PERSONALIZED AND PROFESSIONAL ASSISTANCE. Our team of genetics experts are available 24hrs a day, Monday to Friday, to help you interpret your results and answer any questions you may have, ensuring you get the most out of your genetic analysis

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Our Best Overall Choice

Best Choice

9.7

PlexusDX

Genetic Methylation Test Kit & MTHFR Testing Kit | 370+ DNA Reports Including MTHFR Gene Variants, COMT, Folate, B12, Riboflavin, Choline, Glucose, Keto Diet | Supplement & Diet Recommendations

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

WHAT YOU GET: DNA reports related to Methylation Genetics , AHCY, BHMT, CBS, MTHFS, MTHFD1, MTHFD1L, MTR, MTRR, Betaine, DHFR, DNMT3B, FOLH1, GNMT, MAT1A, SHMT1, TMYS, and more.
WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Cognitive Health, Hormone Balance, Detoxification, Antioxidants and more based on your unique DNA
HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for PEMT, Vitamin B12, Riboflavin, Homocysteine, Supplements, Diet and Lifestyle Recommendations
TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
CUSTOM MEAL PLANS: Discover which foods and meal plans you should be eating based on your genetics. Identify optimal intake of macros, vitamins, and minerals. Includes over 10,000 recipes.
ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.

Show Price

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