10 Best Mthfr Gene Test of 2025

Tested and Reviewed: Top 10 Mthfr Gene Test deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Triquetra Health

Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)

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Editor's bottom line:

“This mthfr gene test is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

BIOLOGICALLY ACTIVE FORM OF FOLATE (1 mg or 1000 mcg) : L-Methylfolate is the biological active form of Folate. It immediately absorbs into bloodstream and requires no processing by the body. The 1 mg dose is ideal to address daily Folate nutritional needs.*
ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.*
ENHANCED SUBLINGUAL ABSORPTION, CHERRY FLAVOR: The liquid sublingual form of L-methylfolate immediately absorbs directly into the bloodstream with higher overall absorption.*
SUPPORTS HEALTHY METHYLATION: The L Methyl Folate form of Folate is essential for healthy methylation especially for those with MTHFR gene.*
PREGNANCY, BRAIN, MOOD, ENERGY SUPPORT, CARDIOVASCULAR: 1 mg of Methylfolate supports healthy baby development during pregnancy. It is also essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.* Methylfolate also supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.*

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Picked by 397 people today

9.5

PlexusDX

Genetic Methylation Test Kit & MTHFR Testing Kit | 300+ DNA Reports Including MTHFR Gene Variants, COMT, BHMT, AHCY and Folate | Custom Supplement & Meal Plan Recommendations with 10,000 Recipes

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Main Highlights

WHAT YOU GET: DNA reports related to Methylation Genetics , AHCY, BHMT, CBS, MTHFS, MTHFD1, MTHFD1L, MTR, MTRR, Betaine, DHFR, DNMT3B, FOLH1, GNMT, MAT1A, SHMT1, and more.
WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Cognitive Health, Hormone Balance, Detoxification, Antioxidants and more based on your unique DNA
HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for PEMT, Vitamin B12, Riboflavin, Homocysteine, Supplements, Diet and Lifestyle Recommendations
TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
CUSTOM MEAL PLANS: Discover which foods and meal plans you should be eating based on your genetics. Identify optimal intake of macros, vitamins, and minerals. Includes over 10,000 recipes.
ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.

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9.5

empowerDX

empowerDX MTHFR Gene Test Kit, Methylation Test, Easy at-Home Test Detects Presence of 677 and 1298 MTHFR Gene Variants, Ages 2+, Fast Results Within 6 Days

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Main Highlights

TEST FOR VARIANTS OF MTHFR: Verify if you have a variant of the methylation gene; certain MTHFR gene variants may affect your ability to mentally thrive
WHAT IS MTHFR: The MTHFR gene helps folate work in your body, helps to regulate homocysteine (which can damage blood vessels when elevated), and plays a role in making dopamine, serotonin, and norepinephrine; variants of the MTHFR gene can be associated with mental health issues, depressed mood, fertility, anxious feelings, fetal development, and migraine headaches
EASY TO USE AT-HOME MTHFR TEST KIT: Requires an easy mouth swab for DNA test sample collection; Emerging research is studying the association between MTHFR gene variants and autism spectrum disorder, ADHD, autoimmune disease, Alzheimers disease, and much more
CERTIFIED LAB: empowerDX laboratories are certified by several different organizations and ensure that their methods and practices meet rigorous standards
SECURE & EASY TO READ RESULTS: MTHFR test results will be accessed privately through a secure online portal; a test guide will be provided on how to read and understand your results, which will reveal if there are any variations in the two MTHFR genetic markers

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9.2

MTHFR

MTHFR-Gene Methylation Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week, MTHFR C677T and MTHFR A1298C Gene Variants for Methylation Analysis. Results in 2-5 Days. Ages 0+

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Main Highlights

Get personalized supplement recommendations based on Ricardo Miranda's unique methylation protocol. He is widely recognized as a leading authority in methylation health and integrative genetics (video attached). With extensive experience coaching doctors nationwide and assisting thousands of patients, his expert guidance is tailored to your unique genetic profile, ensuring you benefit from proven, science-backed strategies for optimal health and wellness.
Comprehensive Mutation Analysis: Our test identifies every possible mutation in the MTHFR gene, providing you with precise information about your genetic makeup. Recognizing that navigating DNA results can be challenging, our dedicated specialists are just a phone call away, ready to assist you with any questions or concerns you may have.
Comprehensive Support: Get access to our expert team seven days a week through live phone support. Our knowledgeable specialists are ready to provide detailed explanations and answer your specific questions.
Simple, Non-Invasive Sampling: Our MTHFR gene test involves an easy-to-use cheek swab, designed for pain-free collection in the comfort of your home. This non-invasive method makes genetic testing straightforward and stress-free, ideal for individuals of any age, including toddlers and babies.
Targeted Efficacy: Our product is engineered to provide the most relevant insights for managing your methylation health effectively, promoting a focused approach to long-term wellness. This ensures that you receive the most practical and impactful recommendations tailored to your needs.
Reliable, Accurate, and Safe Results: Trust our MTHFR testing kit for its precision and thorough analysis, which focuses on the most impactful genetic information related to your methylation health. Our commitment to quality ensures that you receive dependable insights into your wellness. Your results are 100% secure with us. We uphold the strictest privacy standards and never share or sell your information to any third party. Our robust data protection protocols use encryption and are SOC2 compatible to ensure that your personal details remain confidential and secure.
When collecting a cheek swab from babies and toddlers, you can skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Just ensure the mouth is free of any food particles. Results in 2-5 business days from the day our lab receives your specimen.
Product ships in our original envelope packagingimages may vary slightly for display purposes, but the product inside remains the same.

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9.0

MTHFR

MTHFR+COMT Methylation Genes Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week. Includes C677T, A1298C & V158M Variants for Methylation and Wellness Analysis. Results in 2-5 Days. Ages 0+

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Main Highlights

Get personalized supplement suggestions and a wellness overview based on Ricardo Mirandas methylation methodology. He is widely recognized as a leading authority in methylation health and integrative genetics (video attached). With extensive experience coaching doctors nationwide and assisting thousands of patients, his expert guidance is tailored to your unique genetic profile, ensuring you benefit from proven, science-backed strategies for optimal health and wellness.
Targeted Genetic Insights: This test analyzes key variants in the MTHFR and COMT genes to provide a detailed view of your genetic profile. By focusing on these important pathways, the report offers clear information that can help you better understand your methylation and neurotransmitter-related genetics. Results are typically available 25 business days after our lab receives your specimen.
Comprehensive Support: Access our team seven days a week through live phone support. Our representatives are available to help with product information, guide you through the testing process, and assist with any questions related to your kit.
Simple and Convenient Testing: Collect your MTHFR + COMT sample at home with an easy, user-friendly process. This test includes analysis of both MTHFR and COMT genetic variants to provide a more complete view of your genetics related to these pathways. Adding COMT offers expanded informational insights alongside MTHFR for customers seeking a broader genetic overview.
Reliable and Confidential: Your MTHFR + COMT test is processed in a secure environment with strong privacy protections. We maintain strict confidentiality and safeguard your information through encrypted data handling and industry-standard security practices. Your results are 100% secure with us. We uphold the strictest privacy standards and never share or sell your information to any third party. Our robust data protection protocols use encryption and are SOC2 compatible to ensure that your personal details remain confidential and secure.
Clear and Supportive Guidance: Your report is designed to help you better understand your MTHFR and COMT genetic information. If you have questions about your results or the testing process, our team is available by phone to offer helpful assistance and customer support.
When collecting a cheek swab from babies and toddlers, you may skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Please ensure that the childs mouth does not contain any food particles before collecting the sample.
Product ships in our original envelope packaging. Images shown may vary slightly for display purposes, but the product inside remains the same.

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8.8

MTHFR

COMT Gene Test Collection Kit Comes with Results Interpretation and Live Support 7 Days a Week - Cheek Swab - Results in 2-5 Days.

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Main Highlights

Includes results interpretation and LIVE SUPPORT via phone seven days a week. We offer real-time assistance to help you comprehend your results and their significance to you. Results in 2-5 business days from the day our lab receives your specimen.
Get personalized supplement recommendations based on Ricardo Miranda's unique methylation protocol. Widely recognized as The MTHFR Pioneer, he is a nationally recognized leading authority in methylation health and integrative genetics (video attached). With extensive experience coaching doctors nationwide and assisting thousands of patients, his expert guidance is tailored to your unique genetic profile, ensuring you benefit from proven, science-backed strategies for optimal health and wellness.
Our at-home genetic test kit is dedicated to analyzing the COMT gene, offering important insights through a straightforward cheek swab. Fast results.
The outcomes will indicate whether there are any variations in your COMT genetic marker. You can access the results via a secure online portal.
Dependable and Precise Outcomes: Have confidence in the excellence and precision of our COMT genetic testing kit. It delivers an in-depth examination of your COMT genetic data, enabling you to make informed decisions about your lifestyle.
When collecting a cheek swab from babies and toddlers, you can skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Just ensure the mouth is free of any food particles.
Simple, Non-Intrusive Collection: Our COMT gene test requires just an easy cheek swab, ensuring the process is pain-free and non-intrusive. You can gather your sample easily at home.
Product ships in our original envelope packagingimages may vary slightly for display purposes, but the product inside remains the same.

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8.6

AffinityDNA

AffinityDNA Folate Metabolism DNA Test | MTHFR C677T Gene | at Home Cheek Swab Sample Collection Kit | Results in 10-15 Working Days from AffinityDNA

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Main Highlights

The Folate Metabolism Test test is a science-based DNA test helps to determine if a person is at higher risk for issues like elevated homocysteine, which is linked to a greater risk of cardiovascular diseases, and may have trouble properly metabolizing folic acid.
Simply take the easy, at-home test and in just 10-15 working days you will receive a comprehensive genetic report from the laboratory that gives you recommendations - based on your unique DNA
The Folate Metabolism test can shed new light on your risk of folate deficiency, cardiovascular health, pregnancy and foetal development, personalized nutrition, neurological and mental health, our DNA test kit can provide you with the answers you need.
The Folate Metabolism test analyses the MTHFR C677T gene, known to influence several important health aspects, particularly related to folate metabolism and homocysteine levels. Please see the images for an extract of an example report.

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8.3

LIFEDNA

LifeDNA Methylation Genes Test Kit Includes MTHFR Analysis | Analyzes 13 Methylation Gene Variants (MTHFR, COMT, & VDR)

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Main Highlights

DISCOVER WHAT MAKES YOUR BODY UNIQUE - Stop guessing how your body processes nutrients, produces energy, and manages everyday stress. This DNA testing kit analyzes 13 methylation genes to uncover the specific variations that may be affecting your energy, nutrient absorption, and stress response; backed by 500+ peer-reviewed studies.
13 METHYLATION GENES ANALYZED - Most methylation test options check just MTHFR or a handful of variants. This panel covers MTHFR, COMT, MTR & MTRR, and 10 more critical genes, a more comprehensive picture of how your body processes B-vitamins, supports detox pathways, and regulates mood-related functions.
ACTIONABLE REPORTS, NOT RAW DATA - Go far beyond simple genetic reporting. This genetic testing kit delivers clear reports that translate complex methylation-genotype data about methylation into personalized insights and suggestions, so you know exactly what to explore next about your nutrition, energy, supplementation, and daily habits. Complimentary call with an expert included.
SIMPLE CHEEK SWAB, FAST RESULTS - No blood draws or doctor visits. Swab, seal, and mail it back in minutes. Receive your results in 3-5 weeks, not the 2-3 months other DNA tests can take. Everything you need is in the box
YOUR DNA DATA STAYS PRIVATE - Your genetic data is yours. Period. It is never sold to third parties, never shared with insurance companies, never accessed without your permission. You keep 100% ownership with full control, including the right to delete it anytime. Trusted by tens of thousands. This product is an informational wellness tool, not a substitute for professional healthcare guidance.

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8.1

LIFEDNA

Methylation Gene Test MTHFR COMT VDR Analysis 3-Pack Kit for Families - 12 Methylation Genes Variants

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Main Highlights

DISCOVER WHAT MAKES YOUR BODY UNIQUE - Stop guessing how your body processes nutrients, produces energy, and manages everyday stress. This DNA testing kit analyzes 13 methylation genes to uncover the specific variations that may be affecting your energy, nutrient absorption, and stress response; backed by 500+ peer-reviewed studies.
13 METHYLATION GENES ANALYZED - Most methylation test options check just MTHFR or a handful of variants. This panel covers MTHFR, COMT, MTR & MTRR, and 10 more critical genes, a more comprehensive picture of how your body processes B-vitamins, supports detox pathways, and regulates mood-related functions.
ACTIONABLE REPORTS, NOT RAW DATA - Go far beyond simple genetic reporting. This genetic testing kit delivers clear reports that translate complex methylation-genotype data about methylation into personalized insights and suggestions, so you know exactly what to explore next about your nutrition, energy, supplementation, and daily habits. Complimentary call with expert included.
SIMPLE CHEEK SWAB, FAST RESULTS - No blood draws or doctor visits. Swab, seal, and mail it back in minutes. Receive your results in 3-5 weeks, not the 2-3 months other DNA tests can take. Everything you need is in the box
YOUR DNA DATA STAYS PRIVATE - Your genetic data is yours. Period. It is never sold to third parties, never shared with insurance companies, never accessed without your permission. You keep 100% ownership with full control, including the right to delete it anytime. Trusted by tens of thousands. This product is an informational wellness tool, not a substitute for professional healthcare guidance.

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8.1

LIFEDNA

LifeDNA 13 Methylation Genes Test Complete Wellness Analysis | Over 120 Traits for Nutrition, Fitness, Vitamins, Sleep, Skincare Reports

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Main Highlights

YOUR METHYLATION TEST PLUS 135+ WELLNESS INSIGHTS - Dont settle for a methylation-only snapshot. This DNA testing kit analyzes 13 methylation genes and expands into 135+ personalized insights across nutrition, vitamins, fitness, sleep, skincare, and cognition, so wellness challenges get real answers.
13 METHYLATION GENES ANALYZED - Most methylation test options check just MTHFR or a handful of variants. This panel covers MTHFR, COMT, MTR & MTRR, and 10 more, a complete picture of how your body processes B-vitamins, supports detox pathways, and regulates mood-related functions.
8 COMPREHENSIVE WELLNESS REPORTS - Nutrition. Vitamins. Fitness. Sleep. Skincare. Cognition and more. Eight detailed reports built from your DNA, each one shaped by your DNA, not generic advice. Your DNA, your roadmap. Complimentary call with expert included.
SIMPLE CHEEK SWAB, FAST RESULTS - No blood draws or doctor visits. Swab, seal, and mail it back in minutes. Receive your results in 3-5 weeks, not the 2-3 months other DNA tests can take. Everything you need is in the box.
YOUR DNA DATA STAYS PRIVATE - Your genetic data is yours. Period. It is never sold to third parties, never shared with insurance companies, never accessed without your permission. You keep 100% ownership with full control, including the right to delete it anytime. Trusted by tens of thousands. This product is an informational wellness tool, not a substitute for professional healthcare guidance.
EXPERT PRIVATE CALL: Review your test results with one of our LifeDNA experts. Schedule a call with our staff. We are here to assist.

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Our Best Overall Choice

Best Choice

9.7

Triquetra Health

Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

BIOLOGICALLY ACTIVE FORM OF FOLATE (1 mg or 1000 mcg) : L-Methylfolate is the biological active form of Folate. It immediately absorbs into bloodstream and requires no processing by the body. The 1 mg dose is ideal to address daily Folate nutritional needs.*
ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.*
ENHANCED SUBLINGUAL ABSORPTION, CHERRY FLAVOR: The liquid sublingual form of L-methylfolate immediately absorbs directly into the bloodstream with higher overall absorption.*
SUPPORTS HEALTHY METHYLATION: The L Methyl Folate form of Folate is essential for healthy methylation especially for those with MTHFR gene.*
PREGNANCY, BRAIN, MOOD, ENERGY SUPPORT, CARDIOVASCULAR: 1 mg of Methylfolate supports healthy baby development during pregnancy. It is also essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.* Methylfolate also supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.*

Show Price

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