10 Best Methylfolate Supplement of 2025

Tested and Reviewed: Top 10 Methylfolate Supplement deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Nutricost

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO (Methylated Folate)

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Editor's bottom line:

“This methylfolate supplement is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

120 Capsules MethylFolate (120 Servings)
1,000mcg MethylFolate Per Serving
Vegetarian Capsules
Non-GMO & Gluten Free & 3rd Party Tested
Made in an NSF Certified, GMP Compliant, FDA Registered Facility.

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Picked by 397 people today

9.5

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

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Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

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9.5

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

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Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

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9.2

NOW Foods

NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets

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Main Highlights

CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
Packaged in the USA by a family owned and operated company since 1968

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9.0

THORNE

THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg

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Main Highlights

Healthy Methylation: Provides essential nutritional support in the form of bioactive, methylated folate (vitamin B9) to support the body's methylation cycle*
Cognitive Support: Enhances the production of key neurotransmitters like serotonin, melatonin, dopamine, and other natural brain chemicals that regulate brain function and mood*
Nerves & Circulation: Supports healthy blood vessel and nerve function, and supports healthy fetal brain development during pregnancy*
4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

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8.8

Jarrow Formulas

Jarrow Formulas Methyl B-12 & Methyl Folate, Bioactive Vitamin B9 & Vitamin B12 Supplement, Supports Cellular Energy Production, Healthy Brain Function & Metabolism, 100 Chewable Tablets, 100 Servings

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Main Highlights

Cellular Energy Metabolism and Cardiovascular support supplement: Contains one 100 count bottle of Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg Chewable Tablets for a 100-day supply.
Offers a unique combination of B Vitamins in easy-to-take, lemon-flavored chewable tablets to support cellular energy metabolism, neurotransmitter synthesis and cardiovascular health.
Dietary supplement with Methyl B12, Methyl Folate and Pyridoxal-5-Phosphate (P-5-P), the active forms of Vitamins B-12, B9 and B6.
Suggested Use: Adults, take one chewable tablet once a day or as directed by your qualified healthcare professional.
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.

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8.6

Carlyle

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free Supplement | Methyl Folate, 5-MTHF | by Opti-Folate

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Main Highlights

L-METHYLFOLATE: A metabolically active form of Folic Acid, also known as Folate or B-9 Vitamin!
COMPLETE FORMULA: Quick-release capsules deliver 25,000 mcg Folate (15 mg L-METHYLFOLATE)
ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living.
CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
NATURALLY FREE OF: Gluten, Wheat, Yeast, Lactose, Soy, Artificial Flavor, Preservatives and Non-GMO

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8.3

Life Extension

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

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Main Highlights

Get a brain boost Stay proactive about your brain health and support optimal cognitive function with this folate supplement. This 1700 mcg vitamin B formula helps maintain healthy cognitionespecially as you age.
Pump up the heart health This 5-MTHF supplement is a cardiovascular health superstar! Folate helps maintain already-normal homocysteine levels, an important cardiovascular health marker. Folate is a great way to keep heart health in check.
Metabolically active form 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folates 5-MTHF form.
Ingredients matter We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USAand a Certificate of Analysis is available for every one.
Live your healthiest life We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. Thats why so many of our formulas feature specific ingredients and amounts based on scientific studies.

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8.1

Double Wood Supplements

Methylfolate 1,000mcg, 120 Capsules (Third Party Tested Methyl Folate Supplement) Methylated Folate is a More Active Form of Folate Than Folic Acid (Non-GMO, Vegan Safe) by Double Wood

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Main Highlights

MORE ACTIVE FORM OF FOLATE: Recent research suggests that Methylfolate is a more active form of folate when compared to Folic Acid. Folic Acid is the synthetic form of Folate
METABOLICALLY ACTIVE 5-MTHF (OPTIMIZED FOLATE): Methylfolate is the biological and active form of Folate. It is more immediately absorbed into the bloodstream and requires little processing by the body
METHYLFOLATE vs METHYL B12: Methylfolate (known as B9) and Methyl B12 are the active forms of Folate and B12 and are readily used by the body compared to non-methylated forms of the same vitamins
ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood's Methylfolate is manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients. Plus,it is vegetarian, Non-GMO and gluten-free
WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

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8.1

Horbäach

Horbäach Methyl Folate Supplement | 1000 mcg | 200 Capsules | 5-MTHF | Folic Acid | Non-GMO, Gluten Free Methylfolate

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Main Highlights

ESSENTIAL NUTRIENT: Methyl Folate is the active, more bioavailable form of the B-Vitamin Folic Acid
CONVENIENT FORM: Delivers 1000 mcg of this important nutrient in Quick-Release capsules
EXPERTLY CRAFTED: Specially formulated supplement derived from high-quality sourcing standards
HORBAACH MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Lactose, Soy, Artificial Color & Flavoring & NON-GMO

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Our Best Overall Choice

Best Choice

9.7

Nutricost

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO (Methylated Folate)

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

120 Capsules MethylFolate (120 Servings)
1,000mcg MethylFolate Per Serving
Vegetarian Capsules
Non-GMO & Gluten Free & 3rd Party Tested
Made in an NSF Certified, GMP Compliant, FDA Registered Facility.

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