10 Best Methylated Vitamins Men of 2025

Tested and Reviewed: Top 10 Methylated Vitamins Men deals with expert ratings from 8.1 to a perfect 10

July 2025 Edition

Editor's Choice

9.7

10X Health System

10X Health Optimize Methylated Multivitamin for Men & Women - 34 in 1 Formula with 800 mcg of Vitamin B12, Vitamin E, 5-MTHF, B Complex, NAC, Magnesium & Zinc Multivitamins - 90 Capsules

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Editor's bottom line:

“This methylated vitamins men is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Targeted Nutritional Support: 10x Optimize methylated multivitamins offer the ultimate multivitamin and mineral formula to address genetic deficits in your methylation pathway. This impacts your overall wellness and supports optimal health.
Essential Methylated Nutrients: This includes crucial methylated vitamins like 5-MTHF (methylated folic acid), methylated B12, riboflavin (B2), and pyridoxine (B6). This multivitamin-methylated formula supports your body's natural methylation processes.
Vital Minerals for Balance: Formulated with optimized minerals such as magnesium and zinc, 10X Optimize multivitamins for women and men help to maintain essential mineral balance and support the immune system, energy production, and cognitive function.
Additional Methylation Support: Contains NAC (N-acetyl L-cysteine), a powerful amino acid known for its excellent support of the methylation pathway. NAC helps boost your body's ability to boost antioxidant levels and promote cellular health.
Quality and Safety Focused: The 10X Optimize methylated multivitamin from 10X Health System is proudly made in the USA using premium, carefully sourced ingredients. Each batch undergoes rigorous quality and purity testing, ensuring your wellness.

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Picked by 281 people today

9.5

Inessa

Inessa Methylated Multivitamin for Men and Women - Advanced Natural Daily Mens Multivitamins with CoQ10 100mg, Vitamins D3, K2, A, B Complex Vitamins, Folic Acid & Zinc - 60 Vegan Tablets

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Main Highlights

[Feel Like You, But Better] You want to thrive, not just survive. You want best, not just better, health. So meet the cutting-edge multivitamin supplement designed with your optimal wellness in mind. This magical multivitamin with K2 and vitamin D3 is productivity powerhouse that keeps you feeling fresh and focused, all-day-long.
[Daily Wellness, Simplified] - Why take multiple supplements to get everything you need? This one-a-day wonder has 25 ingredients in highly bioavailable doses crammed into every dose. Its one of the only multivitamins that works like an antioxidant complex, B-complex, CoQ10, vitamin D3 and vitamin K2 supplement in one.
[Vegan Society Approved] Eating clean? We hear you. This women's and mens vegan multivitamin is also allergen, gluten and dairy free. But dont just take our word for it. We batch test our multivitamin supplement for purity and it contains no unnecessary additives, chemicals, flavorings or color.
[Fights Fatigue] Micronutrient deficiencies can impact your vitality, and even healthy diets may not give you everything you need for boundless energy. But with relevant doses of CoQ10, B-complex vitamins, D3, iodine and more, this women's and mens multivitamin will put the natural spring back into your step.
[Nature's Nourishment] - Embrace a natural approach to wellness with our gluten-free, vegan multivitamin. Crafted for modern men like you, it champions your dietary choices while enriching your health journey. Make every day a step toward a healthier, happier you!

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9.5

Pure Therapro Rx

Methyl Multi Without Iron Methylated Multivitamin for Men & Women, 60-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 120 Caps

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Main Highlights

: Discussed on The Joe Rogan Experience with Gary Brecka, Methyl Multi without Iron is a vegan-friendly, hypoallergenic, and meticulously-researched multivitamin and multimineral supplement made from high-quality ingredients with zero fillers. Our comprehensive formulation promotes healthy cognitive function and supports antioxidant protection and detoxication. Methyl Multi is the ultimate multivitamin to support total-body wellness and optimum vitality.
: When supplementing, absorption is key! Methyl Multi without Iron is formulated with Quatrefolic Folate (5-MTHF), Albion TRAACS mineral chelates, and other micronutrients in their pre-methylated and coenzyme forms for optimal absorption and bioavailability, all together in DRcaps acid resistant vegetable capsules.
: Millions of Americans have MTHFR and/or COMT mutations, making it difficult for their bodies to process key vitamins like B12 and Folate. Methyl Multi without Iron contains pre-methylated forms of B12 and Folate for increased bioavailability, which can help to support healthy metabolism, energy release from food, detoxification, and nervous system function.
? For those extremely sensitive or new to methylated vitamins, we recommend gradually increasing the amount you are taking so your body can adapt. A small percentage of customers can experience a temporary detoxification / Herxheimer response. Symptoms may include: headache, lethargy, skin rash / hives, respiratory symptoms (cough, sore throat). These are temporary and a sign that the supplement is working. However if your body detoxes too quickly at one time it can overload your detox pathways! Its imperative to lower the amount you are taking for a few days and work your way up slowly to the full dose LOW & SLOW
: Pure TheraPro Rx Methyl Multi without Iron contain no fillers such as rice flour, cornstarch, or wood pulp fibers. Our manufacturing facility adheres to strict NSF/cGMP guidelines. Consumer safety and satisfaction are our highest priority, which is why our products undergo rigorous third-party testing and screening to ensure product purity and potency.
: Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.

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9.2

Power By Naturals

Power By Naturals Methyl Multi One - Iron-Free Methylated Multivitamin with Quatrefolic 5-MTHF, Active B12, P5P, CoQ10 & Zinc for MTHFR Support - Energy & Focus Formula - 60 Capsules (2-Month Supply)

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Main Highlights

EXPERIENCE THE POWER OF METHYL MULTI ONE: Our high-potency methylated multivitamin for men and women, offering a comprehensive blend of 27 vitamins and minerals, including methylated b complex, ADK, C and E in highly bioavailable forms. Packed with CoQ10, 5-MTHF, and ALA for antioxidant support, this formula is designed for easy absorption. It's your balanced, convenient, and economical one-a-day solution for adults.
UNLOCK ESSENTIAL MTHFR SUPPORT: Our methylated multivitamin is here to elevate your mineral intake, especially if you have gene variants. With body-ready active forms like bioactive Folate, Methyl B12/B6, and enzymatic cofactors, it optimizes methylation, promoting overall well-being and balance.
ALL -IN-ONE DAILY VEGAN MULTIVITAMIN: Get complete daily nutrition in just one capsule. Our convenient, balanced one-a-day multivitamin supports overall wellness, including bone, heart, eye, and metabolic health. Packed with ADK, methyl folate, active B12, CoQ10, and essential vitamins/minerals, including amino acids and B vitamins, it ensures your body gets everything it needs every day.
NATURAL VARIATIONS EXPLAINED: Some bioactive vitamins may have a noticeable scent due to oxidation, and you might see product speckles from chelated minerals that aid absorptionboth are normal occurrences. We avoid artificial additives to preserve the product's natural characteristics. Store it in a sealed, dry space at a cool room temperature or refrigerate to minimize scent due to oxidation.
USA-MADE EXCELLENCE: Our USA-made products feature premium ingredients, crafted in a top-tier NSF/GMP facility for safety. Our multivitamin is gluten-free, GMO-free, Vegan-Friendly, and additive-free, showing our dedication to your well-being and smart nutrition choices. Experience the confidence that comes with American-made quality.

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9.0

Nextdia

Methylated Multivitamin for Men Gummies, BCAA Amino Acids, Zinc, Vitamin A C D3 E K2 B6 B12 Biotin Calcium, Magnesium, Lycopene, Digestive Enzymes - Energy Muscle Immunity - Sugar Free, Vegan, 60 Cts

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Main Highlights

Complete Multivitamins for Men: Even if you adhere to a balanced diet, you will likely still benefit from NEXTDIA daily men's multivitamin to bridge any nutritional gaps. Packed with 35 essential vitamins & minerals: Vitamin A C D3 K2 E, methylated folate & B12, B-complex, calcium, magnesium, zinc copper iodine potassium, digestive enzymes, and essential amino acids. GUMMIEJEL gummy-filled technology enhance nutrient stability and absorption, you'll enjoy taking men multivitamin gummies daily.
Energy, Immune & Mood: All 8 B vitaminsthiamin, B2, B3, B5, B6, biotin, folate and methyl B12PLUS vitamin C, D3, Zinc. Featuring the active forms of B6 (pyridoxal-5'-phosphate), folate (5-MTHF) and B12 (methylcobalamin), ideal for those with the MTHFR gene and more bioavailable than standard folic acid or B vitamins. The powerhouse trio of organic vitamin C, lichen-sourced D3, zinc for immune support. Men vitamins gummies fill nutritional gaps to support immunity, energy and mood.
Contains All 9 Essential Amino Acids: EAAs and Branched Chain Amino Acids (BCAAs) are building blocks the body cannot produce on its own and received through our diets. Our men's methylated multivitamin includes the 3 BCAAs (L-leucine, L-isoleucine & L-Valine) and 6 additional EAAs (L-Lysine HCL, L-Threonine, L-Phenylalanine, L-Histidine, L-Tryptophan, L-Methionine). These amino acids support muscle health, reduce fatigue, and brain function, providing sustained energy and go harder and further.
Strengthen Bones, Teeth & Muscle: Calcium citrate is better absorbed and gentler on the stomach than calcium carbonate. Mens vitamins multivitamin formulated with vitamin D3 (from VEGAN lichen) to enhance calcium absorption, Vitamin K2 as MK7 to direct calcium to the bones. Magnesium further supports calcium absorption by aiding its transport across cell membranes. Together, calcium, D3, K2, and Magnesium work synergistically to promote healthy bones, teeth & muscle function.
Sugar-Free, Vegan & Made in the USA: These vegan multivitamin gummies are sweetened with monk fruit and allulose which are low-carb sugar substitutes AND a good option if you don't tolerate sugar alcohols like erythritol or xylitol. Proudly made in the USA, 3rd party tested to ensure completely Non-GMO with NO preservatives, gluten, wheat, nuts, dairy, eggs, shellfish, soy, and gelatin. If you have any questions, feel free to reach outyour satisfaction is our top priority!

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Best Value

8.8

Save 34%

SmartyPants

SmartyPants Multivitamin for Men, Gummies: Omega 3 Fish Oil (EPA/DHA), Methylfolate, CoQ10, Vitamin D3, C, Vitamin B12, B6, A, K & Zinc for Immune Support, Biotin, 180 Gummies (30 Day Supply)

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Main Highlights

PACKAGING MAY VARY - Fresh New Look, Same Trusted Quality
PREMIUM, SCIENCE-BACKED GUMMY MULTIVITAMIN FOR MEN: SmartyPants Men's Multi & Omegas is specifically formulated to help fill nutritional gaps in the average diet
BETTER NUTRIENT SOURCES: We include bioavailable forms of high-quality nutrients that are easy for your body to absorb like methylated folate, vitamin B12 as methylcobalamin, D3, and zinc citrate
CERTIFIED CLEAN, THIRD PARTY TESTED FORMULA: Our men's vitamins are a Clean Label Project Purity Award Winner! Subjected to strict testing for 200+ contaminants and chemicals, so you can be sure you're choosing high quality vitamins you can trust
DELICIOUS TASTE & NON-GMO: Lemon Crème, Blueberry, and Blackberry Flavors with Other Natural Flavors. Adult men take 6 gummies daily. May be taken with or without food

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8.6

Double Wood Supplements

Methylated Multivitamin (Methylated and Activated Vitamins Only - B Complex with Trimethylglycine (TMG) and Methylfolate)(Non-GMO, Gluten Free MTHFR Supplement) 120 Capsules by Double Wood

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Main Highlights

METHYLATED FORMS OF VITAMINS: Double Wood's Methylated Multivitamin contains only methylated / activated forms of vitamins that are already usable by the body and do not need to be further converted in order to be bioavailable
METHYLATED B COMPLEX: Contains the Methylated / Activated Coenzyme form of Vitamin B2 (R-5-P), Vitamin B6 (P-5P) and Vitamin B12 (Methylcobalamin and Dibencozide)(Methyl B12)
SIX TOTAL METHYLATED VITAMINS: Contains trimethylglycine and calcium L-5-methyltetrahydrofolate (MTHFR multivitamin) to help support healthy folic acid levels and control homocysteine levels in the body. It is important to use methylated folic acid since standard folic acid is inert in the body and cannot be processed further by many people
CAN COMBINE WITH A NORMAL MULTIVITAMIN: Double Wood's Methylated Multivitamin can be combined with a regular multivitamin for those looking to also supplement with inactive vitamins or vitamins such as Magnesium and Vitamin D
WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

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8.3

Micro Ingredients

Pure Methylated Multivitamin for Men & Women | 240 Capsules with Vitamins C, D, B12, Thiamin, Folate + Magnesium, Zinc, & More | High Absorption | Bioactive Vitamin & Mineral Complex | Filler Free

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Main Highlights

Micro Ingredients offers a Pure Methylated Multivitamin Complex. 19-in-1 support with high absorption bioactive forms. 240 capsules that feature raw, active ingredients with no fillers.
Each serving provides active methylated vitamins like fat-soluble vitamin C (ascorbyl palmitate), A (retinyl palmitate), D3 (cholecalciferol), E (d- alpha tocopherol), thiamin HCl, riboflavin (R5P), niacin (niacinamide), B6 (P5P), folate, B12 (methylcobalamin), biotin, and pantothenic acid.
An advanced multivitamin combined with key minerals for promoting various health benefits that include energy, cellular, heart, immune, and brain support for men and women.
Enjoy only active ingredients that use high bioavailable methylated vitamins and minerals for efficiently refilling key nutritional gaps over time.
Premium non-GMO multivitamins supplement. Made without fillers, soy, dairy, wheat, gluten, fish, shellfish, peanuts, and tree nuts. Ingredients must pass our 3rd party lab tests to ensure a product that is safe, pure, and potent.

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8.1

NUTRAHARMONY

Methylated Multivitamin - B-Complex with Methylfolate & B12 - for Men & Women - 9-in-1 MTHFR Supplement with TMG - for Energy, Brain & Mood - Vegan, Lab Tested - Made in USA - 120 Capsules, One/Day

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Main Highlights

9-in-1 Methylated Multivitamin power through your day with 9 essential methylation support vitamins B2, B6, B9, B12, C, D3, E, K2 & Trimethylglycine packed into a single, easy-to-take capsule. Methylated B Complex designed to deliver your daily nutritional needs, this formula features activated, bioavailable vitamin forms that fuel your wellness journey helping you thrive with just one capsule a day.
Active & Bioavailable Vitamins supercharge your body with L-Methylfolate the most bioavailable form of Folate to maintain optimal levels and enhance critical methylation processes. Feel the boost of potent Vitamin B12 Methylcobalamin for all-day energy, paired with activated Vitamins B2 and B6 to power your metabolism, support radiant skin, and strengthen your nervous system.
Methylation, Brain & Energy Support supports natural energy & vitality, helps reduce the feeling of fatigue with essential Methylated B Complex that aid healthy folate levels, balanced homocysteine, and the methylation process. Includes key vitamins to support cognitive function, sharpness, and a balanced mood for a calm, focused lifestyle.
Made in USA With Globally Sourced Ingredients our methylated multivitamin supplement is proudly manufactured in the USA under strict quality control standards. Non-GMO, DYE-free, No Gluten & Soy-Free, and GMP-certified, methylated multivitamin for men & women are produced with the most potent ingredients for maximum efficacy & purity in every batch.
Trustworthy Service at NUTRAHARMONY, we are committed to providing only premium-quality supplements, including our carefully crafted Methylated B Complex vitamins. Our exceptional customer service ensures that your satisfaction is our top priority, making your wellness journey as seamless and trustworthy as possible.

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8.1

Save 22%

Igennus Healthcare Nutrition

Igennus Methylated Men's Multivitamin, MTHFR Supplement with Active B-Vitamins, 21 Highly Bioavailable Nutrients, Multivitamin for Sustained Release, Clean Label, Non-GMO & Halal 60 Tablets

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Main Highlights

METHYLATED & ACTIVE FORMS - each nutrient form has been carefully selected to optimize the journey from supplement to cell. Includes methylated B-vitamins, chelated minerals and gentle zinc (new label, same advanced formula, you may receive either label)*
SLOW-RELEASE FORMULA: blood nutrient levels are optimized with bioactive vitamin forms & slow-release formula. Take 1 tablet twice per day as a split dose
MULTIVITAMIN FOR MEN: 22 high-potency nutrients including bioactive B-complex, chelated minerals and antioxidant complex enhanced with lycopene; iron-free
MORE OF WHAT YOU NEED, LESS OF WHAT YOU DON'T - our nutritionists have formulated a comprehensive multivitamin for men, topping up nutrients often lacking in everyday diets, without unnecessary extras*
PURE & CLEAN: lab-verified ingredients; UK GMP manufactured; vegan; no silicon dioxide or magnesium stearate; fully recyclable packaging; easy-to-swallow oval tablets

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Our Best Overall Choice

Best Choice

9.7

10X Health System

10X Health Optimize Methylated Multivitamin for Men & Women - 34 in 1 Formula with 800 mcg of Vitamin B12, Vitamin E, 5-MTHF, B Complex, NAC, Magnesium & Zinc Multivitamins - 90 Capsules

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Targeted Nutritional Support: 10x Optimize methylated multivitamins offer the ultimate multivitamin and mineral formula to address genetic deficits in your methylation pathway. This impacts your overall wellness and supports optimal health.
Essential Methylated Nutrients: This includes crucial methylated vitamins like 5-MTHF (methylated folic acid), methylated B12, riboflavin (B2), and pyridoxine (B6). This multivitamin-methylated formula supports your body's natural methylation processes.
Vital Minerals for Balance: Formulated with optimized minerals such as magnesium and zinc, 10X Optimize multivitamins for women and men help to maintain essential mineral balance and support the immune system, energy production, and cognitive function.
Additional Methylation Support: Contains NAC (N-acetyl L-cysteine), a powerful amino acid known for its excellent support of the methylation pathway. NAC helps boost your body's ability to boost antioxidant levels and promote cellular health.
Quality and Safety Focused: The 10X Optimize methylated multivitamin from 10X Health System is proudly made in the USA using premium, carefully sourced ingredients. Each batch undergoes rigorous quality and purity testing, ensuring your wellness.

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