10 Best Methylated Folate of 2025

Tested and Reviewed: Top 10 Methylated Folate deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Nutricost

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO (Methylated Folate)

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Editor's bottom line:

“This methylated folate is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

120 Capsules MethylFolate (120 Servings)
1,000mcg MethylFolate Per Serving
Vegetarian Capsules
Non-GMO & Gluten Free & 3rd Party Tested
Made in an NSF Certified, GMP Compliant, FDA Registered Facility.

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Picked by 397 people today

9.5

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

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Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

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9.5

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

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Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

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9.2

NOW Foods

NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets

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Main Highlights

CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
Packaged in the USA by a family owned and operated company since 1968

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9.0

THORNE

THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg

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Main Highlights

Healthy Methylation: Provides essential nutritional support in the form of bioactive, methylated folate (vitamin B9) to support the body's methylation cycle*
Cognitive Support: Enhances the production of key neurotransmitters like serotonin, melatonin, dopamine, and other natural brain chemicals that regulate brain function and mood*
Nerves & Circulation: Supports healthy blood vessel and nerve function, and supports healthy fetal brain development during pregnancy*
4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

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8.8

Life Extension

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

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Main Highlights

Get a brain boost Stay proactive about your brain health and support optimal cognitive function with this folate supplement. This 1700 mcg vitamin B formula helps maintain healthy cognitionespecially as you age.
Pump up the heart health This 5-MTHF supplement is a cardiovascular health superstar! Folate helps maintain already-normal homocysteine levels, an important cardiovascular health marker. Folate is a great way to keep heart health in check.
Metabolically active form 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folates 5-MTHF form.
Ingredients matter We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USAand a Certificate of Analysis is available for every one.
Live your healthiest life We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. Thats why so many of our formulas feature specific ingredients and amounts based on scientific studies.

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8.6

Jarrow Formulas

Jarrow Formulas Methyl B-12 & Methyl Folate, Bioactive Vitamin B9 & Vitamin B12 Supplement, Supports Cellular Energy Production, Healthy Brain Function & Metabolism, 100 Chewable Tablets, 100 Servings

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Main Highlights

Bioactive B Vitamins: Jarrow Methyl B-12 & Methylfolate provides methylcobalamin (methyl B-12) and methyl folate, which are the biologically active forms of B9 & B12 vitamins, plus pyridoxal-5-phosphate (P5P), the coenzyme form of vitamin B6
Full-Body Benefits: This Jarrow Formulas methylated B12 and B9 supplement combines the active forms of these vitamins to support cellular energy production, healthy brain function, DNA and neurotransmitter synthesis, and amino acid metabolism(1)
Homocysteine Metabolism: Methyl B-12 and methyl folate in this B12 and folate supplement facilitate metabolism of homocysteine into methionine, while P5P supports amino acid metabolism, including pathways involved in cysteine production (1)
Convenient Chewable Tablet: Each naturally fruit-flavored chewable tablet delivers 2.5 mg vitamin B6, 680 mcg DFE folate, and methyl B12 1000mcg; our B9 & B12 vegan formula has no wheat, gluten, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts or sesame
Superior Nutrition and Formulation: The goal of Jarrow B12 is to promote optimal health with high-quality, effective, affordable and superior formulation of vitamin B12 supplements; our customers can be assured purity and value

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8.3

365 by Whole Foods Market

365 by Whole Foods Market, Methyl Folate, 100 Count

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Main Highlights

100 count methyl folate supplement
Active form of folate for optimal absorption
Supports cellular health
Easy-to-swallow capsules
Quality tested for potency
Made in USA

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8.1

Micro Ingredients

Micro Ingredients L Methylfolate 15mg, 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil

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Main Highlights

Micro Ingredients offers a highly bioavailable 3-in-1 L-Methylfolate softgel formula made with coconut oil for enhanced absorption, delivering active folate as 5-MTHF (25mg DFE containing 15mg L-Methylfolate) per serving with Vitamin B6 and Methyl B12.
L-Methylfolate is the active form of folate, combined with methylated B12 (1,000mcg as methylcobalamin) and Vitamin B6 (as pyridoxine HCl) in a powerful active formula to support efficient nutrient utilization.
Each pouch includes 240 softgels, with 2 softgels per serving, providing a 120-day supply of advanced B vitamin replenishment over time.
Enjoy complementary 3-in-1 support with a complex of key B vitamins that work together to promote mood, heart, energy, and brain health for both men and women.
Premium non-GMO methylfolate supplement. Made without soy, dairy, and gluten. Ingredients must pass a 3rd party lab test to ensure our product is safe, pure, and potent.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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8.1

Jarrow Formulas

Jarrow Formulas Extra Strength Methyl Folate 400 mcg, Dietary Supplement for Cardiovascular and Neurologic Health Support, 60 Veggie Capsules, 60 Day Supply

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Main Highlights

Cardiovascular and Neurologic Health support methylfolate supplement: One 60 count bottle of Jarrow Formulas Extra Strength Methyl Folate 400 mcg Veggie Capsules for a 60-day supply
Dietary supplement with 400 mcg of Methyl Folate (5-MTHF, methylated folate), a biologically active form of Vitamin B9 to support cardiovascular health, proper cell division and neurologic health(1)
This methyl folate supplement features Quatrefolic methyl folate
Suggested Use: Adults, add to your wellness regimen by taking one capsule by mouth once a day with or without food, or as directed by your qualified healthcare professional; major allergen-free
Disclaimer: (1) These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

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Our Best Overall Choice

Best Choice

9.7

Nutricost

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO (Methylated Folate)

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

120 Capsules MethylFolate (120 Servings)
1,000mcg MethylFolate Per Serving
Vegetarian Capsules
Non-GMO & Gluten Free & 3rd Party Tested
Made in an NSF Certified, GMP Compliant, FDA Registered Facility.

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