10 Best Melatonin B6 5mg of 2025

Tested and Reviewed: Top 10 Melatonin B6 5mg deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

XYMOGEN

XYMOGEN Melatonin CR - 5 mg Melatonin Extended Release Tablets - Sleep Cycle & Circadian Rhythm Support - Vegetarian, Dairy-Free & Non-GMO - 90 Tablets

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Editor's bottom line:

“This melatonin b6 5mg is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Melatonin Sleep Support: XYMOGEN Melatonin CR supports healthy sleep patterns, circadian rhythm balance, and nighttime rest through controlled-release delivery*
Nighttime Wellness Support: Melatonin provides antioxidant activity and supports immune system nutrition during nighttime recovery*
Controlled-Release Formula: Designed to release melatonin gradually over time to support sleep onset and sleep maintenance throughout the night*
Allergen-Conscious Purity: This supplement is free from gluten, GMOs, dairy, soy, corn, peanuts, egg, and shellfish to fit seamlessly into a variety of dietary lifestyles
XYMOGEN champions integrative health, empowering people and healthcare professionals with evidence-based formulations

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Picked by 397 people today

9.5

Bronson

Bronson Melatonin 5mg Fast Dissolve Peppermint Tablets with Vitamin B6 - Promotes Relaxation, 360 Vegetarian Chewable Lozenges

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Main Highlights

Melatonin is a hormone naturally produced in our bodies that supports healthy sleep cycles, but its balance can easily be disrupted. Bronsons Melatonin 5 MG Peppermint Lozenges act quickly and help promote a healthy night of rest.*
Regulate Sleep Patterns: Bronsons Melatonin 5 MG Fast Acting Peppermint Lozenges help to establish normal sleep patterns and provide you a more restful/relaxing night. Research has shown that a better night of sleep can lead to improved performance and focus.
Fast Acting Lozenges: Bronsons great tasting peppermint formula provides fast acting results that are absorbed quickly and can be taken at any time. Additionally, Melatonin 5 MG Fast Acting Peppermint includes Vitamin B6 to support melatonin production.*
Trusted Since 1960: The pioneers of Bronson Vitamins were a group of pharmacists who witnessed the benefits of vitamins and mineral supplementation firsthand with their patients. Bronson Vitamins have been consistently mentioned by top medical professionals since our inception in 1960.

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9.5

Vitacost Brand

Vitacost Melatonin Time Release 5 mg Plus B6-100 Tablets

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Main Highlights

Provides natural support for healthy sleep.*
Helps circadian rhythyms normalize after jet lag.*
Supports healthy sleep in the elderly.*
Promotes a more refreshed sleep.*
Has a variety of antioxidant activities shown to be more powerful than vitamin E and vitamin C.*

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9.2

Bronson

Bronson Melatonin 5mg Fast Dissolve Orange Flavor Tablets with Vitamin B6 - Promotes Relaxation, 360 Vegetarian Chewable Lozenges

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Main Highlights

Melatonin is a hormone naturally produced in our bodies that supports healthy sleep cycles, but its balance can easily be disrupted. Bronsons melatonin 5 mg orange lozenges act quickly and help promote a healthy night of rest.*
Regulate sleep patterns: Bronsons melatonin 5 mg fast acting orange lozenges help to establish normal sleep patterns and provide you a more restful/relaxing night. A better night of sleep can lead to improved performance and focus.
Fast acting lozenge: Bronsons great tasting orange formula provides fast acting results that are absorbed quickly and can be taken at any time. Additionally, melatonin 5 mg fast acting orange includes vitamin B6 to support melatonin production.*
Trusted since 1960: The pioneers of Bronson Vitamins were a group of pharmacists who witnessed the benefits of vitamins and mineral supplementation firsthand with their patients. Bronson Vitamins have been consistently mentioned by top medical professionals since our inception in 1960.

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9.0

MASON NATURAL

Mason Natural Melatonin 5 mg with B6 & Calcium, Natural Sleep Aid, Supports Restful Sleep, 60 Tablets

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Main Highlights

NATURAL SLEEP SUPPORT: Designed to be taken before bed & may help support deep, restful sleep, especially for individuals with occasional sleeplessness
DUAL ACTION FORMULA: Contains melatonin with vitamin B6 & calcium, which may help support a normal & consistent sleep cycle for better overall rest
SLEEP & WELLNESS BENEFITS: Melatonin may help support deep sleep & a balanced sleep cycle, as well as assist in maintaining normal blood pressure levels during sleep
CLEAN INGREDIENTS: Guaranteed no added yeast, milk, egg, fish, corn, crustacean shellfish, tree nuts, peanuts, or wheat No artificial fragrance, colors, flavors, or preservatives Soy-free
TRUSTED FOR OVER 50 YEARS: Mason Natural has produced quality vitamin supplements for over five decades, adhering to cGMPs (current Good Manufacturing Practices) and US guidelines with rigorous testing & inspections

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8.8

Bronson

Bronson Melatonin 5mg Fast Dissolve Cherry Flavor Tablets with Vitamin B6 - Nighttime Sleep Aid - Promotes Relaxation, 360 Vegetarian Chewable Lozenges

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Main Highlights

Fall Asleep Faster, Stay Asleep: Melatonin is naturally produced by our bodies to manage sleep cycles, but its balance can be easily disrupted. Melatonin helps you fall asleep faster, stay asleep longer, and wake up feeling refreshed.
Regulate Sleep Patterns: Bronson's Melatonin helps to establish normal sleep patterns and give you a more restful and relaxing sleep and in turn, better overall health. Research shows that better sleep can lead to improved performance and focus.
Fast, Dissolve Tablets: Bronson's unique fast dissolve cherry formula enables faster absorption that can be taken anytime, anywhere.
Trusted Since 1960: The pioneers of Bronson Vitamins were a group of pharmacists who witnessed the benefits of vitamins and mineral supplementation firsthand with their patients. Bronson Vitamins have been consistently mentioned by top medical professionals since our inception in 1960.

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8.6

Nature Made

Nature Made Melatonin 5mg Tablets Extra Strength, 100% Drug Free Sleep Aid for Adults, 90 Tablets, 90 Day Supply

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Main Highlights

Occasional use sleep support supplement: Contains one 90 count bottle of Nature Made 5 mg melatonin tablets for a 90-day supply of sleep supplements for adults
Adults take one of these 5mg Melatonin sleep supplements one hour before bedtime with water; do not exceed 2 tablets daily
Melatonin is a hormone found naturally in the body that helps to regulate sleep and wake cycles
These Nature Made Melatonin Tablets are 100% drug free, gluten free, non habit forming, and have no color added, no artificial flavors, and no preservatives
Each Nature Made 5 mg Melatonin Tablet helps you fall asleep faster and supports restful sleep
United States Pharmacopeia (USP) Verified; #1 Pharmacist Recommended Vitamin & Supplement Brand*
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

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8.3

NusaPure

NusaPure Melatonin with Vitamin B6 & Calcium - Suitable for Vegetarian/Vegan, Non-GMO - 5 mg - 60 Tablets

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Main Highlights

Melatonin + Vitamin B6 5 mg 60 Tablets Vegetarian/Vegan, Non-GMO
60 veggie Capsules for a 60-Day Supply. Vegan/Vegetarian, Non-Gmo
The supplement is suitable for vegetarians and does not contain common allergens such as gluten, soy, wheat, milk, eggs, fish, shellfish, tree nuts, or sesame. However, it is produced in a facility that processes allergens.
Our formulations are crafted with quality ingredients and care
Manufactured in the USA in a cGMP registered facility with high standards

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8.1

KAL

KAL Melatonin 5 mg Supplement for Adults - Sleep Aid & Rest Support, Fast Release Lozenges, Melatonin 5mg & Vitamin B6 10mg for Men & Women, Promotes Calm, Vegetarian - 60 Count

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Main Highlights

MELATONIN SUPPLEMENT - Each fast-acting lozenge is packed with 5mg melatonin and 10mg vitamin B6, designed to help with occasional sleeplessness and support calming relaxation
SLEEP AID & REST SUPPORT - The only thing that makes a long day feel longer is getting little to no rest the night before. KAL has developed our delicious and nutrient rich Melatonin for rest support
LEMON FLAVOR - Our delicious vegetarian/vegan formula features a natural lemon flavor that will make taking melatonin feel like a treat
SUGGESTED USE - Don't like swallowing pills? Pop one lozenge as needed into your mouth and let it dissolve to release the powerful ingredients. Use only as directed; store in a cool, dry place
KAL QUALITY - Our dissolvable melatonin lozenges are made in our GMP-certified facility and tested in our own state-of-the-art lab in Utah to ensure the highest standards

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8.1

Natrol

Natrol Melatonin 5mg Fast Dissolve Tablets, Sleep Support Supplements for Adults, Strawberry Flavor, 200 Tablets, Up to 200 Day Supply

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Main Highlights

FALL ASLEEP FASTER: Natrol Melatonin 5mg tablets promote falling asleep in as little as 15 minutes (1)
SLEEP SUPPORT: These melatonin chewables help you stay asleep longer through melatonin dissolvable tablets so you wake up refreshed and ready to take on the day ahead (1)
100% DRUG-FREE: Enjoy sleep support with our non-habit forming, 100% drug-free melatonin dissolvable tablets
DELICIOUS TASTING MELATONIN NATROL TABLETS: Fast Dissolve chewable melatonin tablets for adults feature a delicious strawberry flavor and require no water to swallow, making them easy and delicious to take
CONVENIENT FOR BUSY LIFESTYLES: As America's #1drug-free sleep aid brand, take these chewable melatonin 5mg tablets 30 minutes before bedtime for restful sleep support (1,2)

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Our Best Overall Choice

Best Choice

9.7

XYMOGEN

XYMOGEN Melatonin CR - 5 mg Melatonin Extended Release Tablets - Sleep Cycle & Circadian Rhythm Support - Vegetarian, Dairy-Free & Non-GMO - 90 Tablets

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Melatonin Sleep Support: XYMOGEN Melatonin CR supports healthy sleep patterns, circadian rhythm balance, and nighttime rest through controlled-release delivery*
Nighttime Wellness Support: Melatonin provides antioxidant activity and supports immune system nutrition during nighttime recovery*
Controlled-Release Formula: Designed to release melatonin gradually over time to support sleep onset and sleep maintenance throughout the night*
Allergen-Conscious Purity: This supplement is free from gluten, GMOs, dairy, soy, corn, peanuts, egg, and shellfish to fit seamlessly into a variety of dietary lifestyles
XYMOGEN champions integrative health, empowering people and healthcare professionals with evidence-based formulations

Show Price

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