10 Best Meds For Back Pain of 2025

Tested and Reviewed: Top 10 Meds For Back Pain deals with expert ratings from 8.1 to a perfect 10

September 2025 Edition

Editor's Choice

9.7

Aleve

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

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Editor's bottom line:

“This meds for back pain is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
Comes in small, easy-to-swallow tablets; use as directed

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Picked by 347 people today

9.5

ThermaCare

ThermaCare Advanced Back & Hip Therapy Adhesive HeatWraps, Disposable Heat Therapy Patches, Heat Pads for Instant Muscle & Herniated Disc Pain Relief, HSA/FSA Eligible & Approved, L/XL, 10 Count

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Main Highlights

Back Pain HeatWraps: These air activated HeatWraps provide up to 16 hours of pain relief. Set Includes 10 Lower Back wraps (L/XL Size)
Advanced Design: Single use wraps that are thin enough to be worn discreetly. Heat cell placement that stays close to your skin; Designed to adapt to your movements and easy readjustment
Effective Pain Relief: Wraps provide heat where you need it; Drug free, discreet and portable, so you can use them anywhere; Targets: Body Aches, Pains, & Arthritis
Therapeutic Heat: Our patented technology produces real heat to help your body rebuild damaged tissue & accelerate healing.
Real Heat, Real Healing: Heat therapy helps to ease muscle pain, reduce soreness, and loosen tight muscles by blocking pain signals & improving circulation & flexibility

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9.5

Advil

Advil Dual Action Back Pain Caplets Delivers 125mg Ibuprofen and 250mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count

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Main Highlights

144-ct of Advil Dual Action Back Pain Caplets, 125mg Ibuprofen and 250mg Acetaminophen, Provide 8 Hours of Back Pain Relief.
Pain relief pills fight back pain 2 ways; acetaminophen blocks pain signals and ibuprofen targets pain caused by inflammation.
Each caplet contains acetaminophen and ibuprofen for back pain relief; back pain medication also provides headache, toothache, menstrual cramp, muscle pain and lower back pain relief.
Ibuprofen and acetaminophen caplets that provide back pain relief for 8 hours.
Pain pills that relieve pain in two ways, providing powerful relief with a lower maximum daily dose of each medication - the perfect addition to your college dorm room essentials.
Advil is a top selling over the counter pain reliever, providing safe and effective pain relief when used as directed for more than 35 years.

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9.2

Bayer

Bayer Extra Strength 500mg Aspirin Plus Caffeine for Powerful Pain Relief, 200 Coated Caplets

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Main Highlights

Aspirin Plus Caffeine: This pain medicine for adults and children over 12 contains 500mg aspirin, as well as 32.5mg caffeine to help boost the pain-relieving effects of aspirin
Powerful Pain Reliever: Dual action formula containing aspirin and caffeine for a pain relief booster provides fast relief at the site of pain, when taken as directed
Targeted Back and Body Relief: Bayer Back and Body Extra Strength Aspirin provides fast, proven relief of backache and muscle aches and pains
Free From: Each coated pain medicine tablet is free of sodium and is coated to make it easier for swallowing
125 Years of Relief: Bayer Aspirin has been a leading aspirin brand in pain relief

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9.0

Save 24%

MagniLife

MagniLife Leg & Back Pain Relief, Fast-Acting Pain Relief, Naturally Soothe Burning, Tingling and Stabbing Pains, Symptomatic or Preventative, 125 Quick-Dissolve Tablets

24% OffFree Shipping

Main Highlights

NATURAL PAIN RELIEF - Constant pain in your lower body can be distracting and debilitating. Get relief today with this pain reliever developed to specifically target pain symptoms in the lower back, buttocks and legs.
ALL-NATURAL INGREDIENTS - Naturally derived quick dissolve tablets contain active ingredients to help deliver fast-acting, serious relief when you need it most.
SYMPTOMATIC OR PREVENTATIVE - Our quick-dissolve tablets may be used to treat pain immediately or to prevent symptoms and have no known side effects so you can take them 2 to 3 times a day and go back to business as usual.
SAFE, PLANT-DERIVED BLEND - A great benefit of our tablets is they can be taken with other OTC or prescription medications. A safe option for someone who is currently taking medication or wants to avoid medicines that can be harsh on the body.
TRUSTED BRAND WITH YOU IN MIND - MagniLife has been a trusted business for over 20 years. All of our products are developed and manufactured in our state-of-the art facilities. Made with highly qualified formulators to ensure excellence in quality and consistency, we ensure top quality products and are dedicated to providing products that help to improve quality of life. Start your journey to a healthy lifestyle today!

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8.8

Save 25%

Tylenol

Tylenol 8 Hour Muscle Aches & Pain, 650 mg Extended-Release Acetaminophen Tablets for Muscle and Joint Pain, Bi-Layer Design for Quick and Long Lasting Relief, 100 Count

25% OffFree Shipping

Main Highlights

100 Count bottle of Tylenol 8 Hour Muscle Aches & Pains Acetaminophen Tablets to provide temporary relief of minor aches and pains such as muscle aches, joint pain, back pain, headache, toothache, the common cold, and menstrual cramps
Each extended-release tablet contains 650 mg of acetaminophen and features two unique layers - the first is fast-acting and the second is long-lasting - for effective minor joint, minor arthritis and muscle pain that works as hard as you do
This oral pain reliever medicine reduces fever and helps alleviate minor aches and pains, so you can take control of your joint and muscle pain and take back your day with pain relief that works as hard as you do
These pain relief tablets can be used by adults and children who are 12 years and older to relieve minor muscle aches and pain for up to 8 hours. When used as directed, these pain relief tablets have an excellent safety profile
Experience fast-acting, effective relief and alleviate muscle, joint, knee and arthritis aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction

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8.6

Amazon Basic Care

Amazon Basic Care Back and Muscle Pain, Naproxen Sodium Tablets 220 mg, Pain Reliever and Fever Reducer, For Backache, Muscular Aches, Minor Arthritis Pain, Headache and More, 90 Count

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Main Highlights

ACTIVE INGREDIENT: Amazon Basic Care Back and Muscle Pain contains the active ingredient naproxen sodium 220, a nonsteroidal anti-inflammatory drug (NSAID) and pain reliever/fever reducer. Compare to the active ingredient in Aleve Back and Muscle Pain.
BACK and MUSCLE: Count on up to 12 hours of relief with one dose of Amazon Basic Care Back and Muscle Pain Naproxen Sodium Tablets, 220 mg, a pain reliever and fever reducer for temporary relief of minor back and muscle aches and pains.
MINOR ACHES and PAINS: Amazon Basic Care Back and Muscle Pain Naproxen Sodium Tablets, 220 mg also alleviates: backache, muscular aches, minor pain of arthritis, menstrual cramps, headache, toothache, the common cold and temporarily reduces fever.
12 HOURS: A pain reliever and fever reducer with the strength to last 12 hours means stopping less often to take more doses.
ADULTS and ADOLESCENTS: This product contains naproxen sodium 220 mg, a pain reliever and fever reducer for use in adults and children age 12 years and older.

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8.3

Save 33%

Doans

Doans Extra Strength Pain Reliever Caplets, 24 Count

33% OffFree Shipping

Main Highlights

Provides extra strength pain relief for aching back
Doan's pills have been relieving back pain for millions of backache sufferers for generations
Doan's active ingredients target the muscles of the back and ease the pain

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8.1

Save 25%

Salonpas

Salonpas Pain Relieving Patch, LARGE, 6 Count, for Back, Neck, Shoulder, Knee Pain and Muscle Soreness, 8 Hour Pain Relief

25% OffFree Shipping

Main Highlights

PAIN RELIEVING PATCH: Effective for large pain areas, these comfortable & convenient topical patches have 3 powerful pain fighters that work at the site of pain. Analgesics include camphor, menthol & methyl salicylate.
VERSATILE COMFORT: With rounded corners & flexible fabric, application is easy & the patches bend with your movements. The patches stay where you need them & are easy to remove.
TARGETED RELIEF: Provides temporary relief of pain associated with sore back, neck, wrist, ankle, hip, shoulder, knee & elbow. Help alleviate muscle soreness, backache, joint pain & sprains.
LONG-LASTING: For penetrating, mess-free & targeted relief, apply spray or patch to manage pain in specific areas. Salonpas pain relieving patches & sprays offer pain relief for up to 8 hours.
SOOTHE YOUR PAIN: With pain relief patches, sprays, creams, gels & liquids, Salonpas is here to help you get through your day with discreet, easy-to-use, topical pain relief for temporary relief of aches & pains.

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Best Value

8.1

Save 55%

Percogesic

Percogesic Backache Relief Pain Reliever, Maximum Strength, 48 Tablets

55% OffFree Shipping

Main Highlights

Percogesic Backache Relief is a fast acting formula soothes your backaches away and available without prescription
Magnesium salicylate, the key ingredient in Percogesic Backache Relief, is a nonsteroidal anti inflammatory drug (NSAID) that reduces back and muscular aches
Effective analgesic with enhanced pain relief
Easy to swallow coated tablets
Pharmacist recommended

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Our Best Overall Choice

Best Choice

9.7

Aleve

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
Comes in small, easy-to-swallow tablets; use as directed

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