10 Best Medicine For Headache of 2025

Tested and Reviewed: Top 10 Medicine For Headache deals with expert ratings from 8.1 to a perfect 10

May 2025 Edition

Editor's Choice

9.7

Save 28%

Excedrin

Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief - 100 Count

28% OffFree Shipping

Editor's bottom line:

“This medicine for headache is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

One bottle of 100 caplets of Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief
Aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress
Delivers muscle ache, shoulder and neck pain relief
Combines acetaminophen with caffeine to temporarily relieve pain caused by headaches and muscle aches
Contains a trusted formula that combines a pain reliever and an amplifier
Effectively relieves tension-type headaches in convenient caplet form

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Picked by 196 people today

9.5

Save 25%

Tylenol

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

25% OffFree Shipping

Main Highlights

100-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction

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9.5

Save 29%

Excedrin

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 24 count

29% OffFree Shipping

Main Highlights

One bottle of 24 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
Migraine medicine that delivers effective migraine headache pain relief
Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
Delivers a powerful triple action formula with two pain fighters and an amplifier
Migraine relief medicine available in convenient caplet form
For some, these Excedrin Migraine caplets relieve migraine pain in 30 minutes
HSA and FSA eligible product

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9.2

Save 22%

Goody's

Goody's Pain Relief Powders, Extra Strength Headache Powder, 50 ct (Pack of 1)

22% OffFree Shipping

Main Highlights

Goody's Extra Strength Headache Powder temporarily relieves minor aches and pains due to headaches, minor arthritis pain, colds, backaches, muscle aches, toothaches and menstrual cramps
Powder formula works fast to relieve pain
Contains 260 mg Acetaminophen, 520 mg Aspirin (NSAID) and 32.5 mg Caffeine
Convenient, on-the-go stick packs for relief anytime or anywhere
Contains 1 box of Goody's Extra Strength Headache Powder, 50 stick powders; for use by adults and children 12 years and older

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9.0

Amazon Basic Care

Amazon Basic Care Headache Relief Geltabs, 80 Count

Free Shipping

Main Highlights

ACTIVE INGREDIENTS: This product contains acetaminophen 250 mg, aspirin 250 mg (NSAID, nonsteroidal anti-inflammatory drug) and caffeine 65 mg; compare to the active ingredients in Excedrin Extra Strength Geltabs
PAIN RELIEF: Amazon Basic Care Extra Strength Headache Relief Geltabs offer headache and arthritis pain relief; also provides pain relief for toothaches, muscular aches and premenstrual and menstrual cramps
EXTRA STRENGTH: When you need something strong to temporarily reduce pain, these extra strength geltabs will help you feel better so you don't miss out on life's special moments
PAIN RELIEVER AND PAIN RELIEVER AID: Extra Strength Headache Relief Geltabs combine acetaminophen 250 mg, aspirin 250 mg (NSAID, nonsteroidal anti-inflammatory drug) and caffeine 65 mg to help relieve minor aches and pains when you need it the most
GLUTEN FREE: These pain relief pills are gluten free

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Best Value

8.8

Save 31%

Tylenol

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

31% OffFree Shipping

Main Highlights

24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

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8.6

Advil

Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 100 Coated Tablets

Free Shipping

Main Highlights

One bottle of 100 Advil Pain Reliever and Fever Reducer Coated Tablets, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief
Advil ibuprofen pain reliever and fever reducer for adults provides longer lasting relief than Tylenol Extra Strength, targets pain at the sight of inflammation, and new packaging features 20 percent less plastic to keep nearly 5,000 pounds of plastic out of landfills
Headache medicine, back pain medicine, joint pain medicine or minor arthritis pain reliever that also provides menstrual pain relief, as well as relief of muscle aches or aches and pains from the common cold
Coated Advil tablets are easy to swallow pain relievers, providing relief that lasts for up to 6 hours
Headache pain relief, period pain relief, back pain medication and fever medicine for adults and children 12 years and older
Take these ibuprofen tablets as directed, taking one tablet every 4 to 6 hours while symptoms persist, or two tablets if pain or fever does not respond to one tablet
HSA and FSA eligible product

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8.3

GenCare

GenCare - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg & Caffeine 65 mg (200 Caplets) Best Value Bulk Extra Strength for Head, Migraine, Joint Pain & Body Ache Relief Medicine

Free Shipping

Main Highlights

EXTRA STRENGTH RELIEF - Reach for GenCare extra strength Tension Headache Relief when suffering from mild to severe headaches, migraines, tension pain and muscle aches. Our full head and body pain remedy includes Acetaminophen (500 mg) pain reliever and Caffeine (65 mg) for focus and energy.
DUAL ACTION - The potent dual action pain relief pill isn't just for mild to severe headaches. It provides fast and effective relief for sore muscles, tooth aches, back aches, neck pain, arthritis and joint pain. Compare to generic Excedrin Tension Headache active ingredients.
MENTAL FOCUS - Caffeine can help quickly restore energy levels and focus so you can get over the pain and back to being productive and at your best. This product contains as much caffeine as a cup of coffee so avoid taking this before bed or at night.
FAMILY VALUE SIZE - Save big compared to big box retailers and your local pharmacy with our 200 caplet bulk savings bottle. Directions: Adults and children 12 and older take 2 caplets every 6 hours as needed with water. For children under 12, ask a doctor before use.
100% SATISFACTION GUARANTEE - Enjoy fast and effective headache and muscle ache relief! GenCare backs up each bulk savings bottle of Tension Headache Relief with our 100% Customer Satisfaction Guarantee. Join thousands of satisfied customers.

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8.1

Save 9%

Tylenol

Tylenol Extra Strength Caplets with 500 mg Acetaminophen, Pain Reliever and Fever Reducer for Headache, Backache, Toothache & Minor Arthritis Pain Relief, 100 Count

9% OffFree Shipping

Main Highlights

100-count value size bottle of Tylenol Extra Strength Caplets with 500 mg of acetaminophen, a known pain reliever and fever reducer, to provide temporary relief of minor aches and pains and reduce fever
Each extra strength Tylenol pain relief caplet contains 500 mg of acetaminophen for strong and effective pain relief, and has an excellent safety profile when used as directed
Use 500 mg acetaminophen caplets as a fever reducer and to help provide relief of common pain symptoms including headache, backache, toothache, menstrual cramps, and pain caused by the common cold
This extra strength acetaminophen pain reliever can be used by adults and children who are 12 years and older. To use, take two acetaminophen caplets every six hours while symptoms last and do not take more than six caplets in 24 hours
From the doctor recommended brand for pain relief and fever reduction, experience relief from minor aches and pains with Tylenol Extra Strength Caplets with 500 mg Acetaminophen

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8.1

Excedrin

Excedrin Game Over for Headaches Limited Edition Extra Strength Pain Relief Caplets for Headache Relief, Temporarily Relieves Minor Aches and Pains Due to Headache – 200 Count

Free Shipping

Main Highlights

One bottle of 200 Excedrin Game Over for Headaches Limited Edition Extra Strength Pain Relief Caplets
Extra strength pain reliever works fast to relieve gaming-related headaches stemming from muscular tension, visual overload and the nonstop blitz of bleeps and blips
Excedrin Extra Strength works in 3 ways to relieve headaches: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
Pain medicine for adults that is clinically proven to provide temporary headache relief, and it temporarily relieves pain associated with colds, menstrual cramps, toothaches, muscular aches and arthritis
Excedrin Extra Strength caplets contain two pain relievers and a pain relieving aid for enhanced effect
Headache pain reliever available in caplet form for convenient pain management
For some, headache relief can start in 15 minutes
HSA and FSA eligible product

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Our Best Overall Choice

Best Choice

9.7

Excedrin

Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief - 100 Count

28% OffFree Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

One bottle of 100 caplets of Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief
Aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress
Delivers muscle ache, shoulder and neck pain relief
Combines acetaminophen with caffeine to temporarily relieve pain caused by headaches and muscle aches
Contains a trusted formula that combines a pain reliever and an amplifier
Effectively relieves tension-type headaches in convenient caplet form

Show Price

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