10 Best Leather Safe Enzyme Cleaner of 2025

Tested and Reviewed: Top 10 Leather Safe Enzyme Cleaner deals with expert ratings from 8.1 to a perfect 10

May 2026 Edition

Editor's Choice

9.7

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

Editor's bottom line:

“This leather safe enzyme cleaner is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen enzyme cleaner for dog urine
Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen enzyme cleaner for dog urine
Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx

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Picked by 397 people today

9.5

Leather Honey

Leather Honey Leather Cleaner: Non-Toxic Leather Care Made in the USA Since 1968. Deep Cleans Leather, Faux & Vinyl - Couches, Car Seats, Purses, Tack, Shoes & Bags. Safe Any Colors & White Leather

Main Highlights

NON TOXIC, GENTLE CLEANER: Our proven, rejuvenating formula is a powerful, fragrance-free cleaner ideal for all your leather goods (except suede). EPA Safer Choice certified
CLEAN ALL TYPES OF LEATHER: Quickly and gently removes dirt, oil, tough stains and grime from car seats, truck seats, upholstery, furniture, handbags, purses, shoes, accessories, saddles, and tack. Effectively cleans leather of all colors, including white leather. Safe for exotic leather, faux, vinyl
SAFE FOR YOU, SAFE FOR LEATHER: Made with non-toxic, high-quality ingredients that makes your leather last longer. Safe for people, pets & your leather
TEST & APPLY: Apply leather cleaner with a lint-free cloth. No need to scrub or rub simply wipe down and allow it to dry. Spot test on each leather item first. Not for use on suede
AMERICAN MADE SINCE 1968: Our premium leather care formulas have had a cult following among leather experts, retailers and high-end car and furniture makers and enthusiasts for over 50 years.

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9.5

Rocco & Roxie Supply Co.

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

Main Highlights

Eliminates Stains, Odors, & Residue: If its gross, its gone; from blowouts, urine, vomit, and other organic spills; Rocco & Roxie stain & odor eliminator has a subtle Meyer lemon scent that quickly dissipates, leaving your space feeling fresher
Every Surface, Every Time: Our fast-acting carpet stain remover spray formula works great on floors, furniture, clothing, pet bedding, litter boxes, travel crates, hamster cages, cars, campers, and anywhere else major accidents happen
Minerals & Enzymes: The key is getting to the problem deep-down, so we added a mineral-based odor neutralizer to our bio-enzymatic formula; upon contact with tough stains & odors, this pet enzyme cleaner feasts on ammonia crystals and organic matter
Gentle & Safe Carpet Spray: Safe to use around pets and children, when used as directed; chlorine-free, color-safe with no hazardous propellants; Certified Safe for all carpets with the Seal of Approval by the trusted Carpet and Rug Institute (CRI)
Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this pet odor eliminator and stain remover, contact us; we are determined to make it right

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9.2

Absolutely Clean

Amazing Leather Cleaner/Conditioner/Deodorizer | Powerful, Natural Enzyme Cleaner | USA Made | Great for Leather & Vinyl, Furniture, Boots, Purses, Clothing & More Removes Stains Spray & Wipe (16oz)

Main Highlights

"POWERFUL NATURAL ENZYMES: Our leather cleaner for furniture formula uses powerful natural enzymes and plant-based surfactants as cleaning agents to help remove any stains and odors from your leather surfaces. Our fume-free formula provides for a gentle but powerful all-around cleaning experience, leaving your leather looking clean and refreshed."
"FAST, EFFECTIVE, & EASY TO USE: Simply spray the cleaner on leather conditioner for furniture, and then use a damp sponge or soft brush to apply it in a circular motion until the dirt is gone! Wipe down the surface to remove excess soap. Its that easy."
"GREAT FOR ALL LEATHER: You can also use this leather cleaner and conditioner for furniture on car seats, accessories, like boots and purses. Our powerful enzyme formula not only cleans but also conditions your leather by helping to prevent cracks and peels, and nourishes by keeping it soft, supple, and clean. Also works great for spot treatments and as a stain remover."
"VETERINARIAN APPROVED: Our vet-approved enzyme formula is made without the use of harsh chemicals or noxious fumes, making for a gentle yet powerful cleaning solution for removing the toughest stains and eliminating the most stubborn odors."
"MADE IN THE USA: Absolutely Clean is a small, family owned-and-operated company based in Colorado. We make our products at home in the USA. We believe in providing an exceptional cleaning experience for our customers by providing high-quality products. No matter what your cleaning needs are, Absolutely Clean has the product for you!"

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9.0

Griot's Garage

Griot's Garage Odor Neutralizing Leather Cleaner for Car Seats, Dashboard, Door Panels, Eliminates Unwanted Smells, 10971, 22oz

Main Highlights

DEEP CLEAN AND ODOR REMOVAL: This powerful car leather cleaner penetrates deep into the grain to lift dirt, stains, and unwanted smells, restoring your leather or vinyl to a fresh, clean, and like-new condition
SAFE AND EFFECTIVE: The pH-balanced formula of this auto leather cleaner is tough on stains but gentle enough for use on aniline and pigmented leather; Made in the USA
ELIMINATES TOUGH ODORS: Unlike other cleaners that just mask smells, our leather odor remover neutralizes unpleasant odors at the source for long-lasting freshness
VERSATILE FOR ALL SURFACES: Ideal for leather and vinyl seats, dashes, door panels, and more, this genuine leather cleaner lifts dirt and grime while restoring the natural look of your car interior with a clean and refreshed finish
EASY-TO-USE LEATHER INTERIOR CAR CLEANER: Simply spray and wipe to quickly lift dirt, grime, and stains from leather and vinyl surfaces

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8.8

Leather Honey

Leather Honey Leather Cleaner Spray: UV Protectant, Non-Toxic & Made in the USA Since 1968. Cleans & Protects Leather, Faux & Vinyl - Couches, Car Seats, Purses, Shoes, Bags & Tack. Safe for Any Color

Main Highlights

NON-TOXIC, POWERFUL LEATHER CLEANER + UV PROTECTANT: The same reliable formula in a convenient spray + UV protectant. Our proven, rejuvenating formula is a powerful, fragrance-free leather cleaner ideal for all your leather goods, plus vinyl, faux leather, vegan leather, plastic and rubber. (Not for suede.)
CLEAN AND PROTECT ALL TYPES OF LEATHER, RUBBER, VINYL AND PLASTIC: Quickly and gently removes dirt, oil, tough stains and grime. Use as a car seat cleaner, for truck seats, upholstery, purses, shoes, accessories, saddles & tack. Safe for exotic leather, faux, vinyl & leather of all colors, including white leather.
ADVANCED UV PROTECTANT: UV protection is crucial for leather items exposed to the sun's harmful rays. Our 16oz leather cleaner spray keeps your leather in new condition & provides powerful protection against sun damage, which can fade, crack and dry leather.
SAFE FOR YOU, SAFE FOR LEATHER: Our 16 oz spray cleaner is PH balanced and made with non-toxic, high-quality ingredients that make leather last longer. Free of PFAS forever chemicals and safe for people, pets & your leather.
AMERICAN MADE SINCE 1968: Our premium leather care formulas have had a cult following among leather experts, retailers and high-end car and furniture makers and enthusiasts for over 50 years.

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8.6

P & S PROFESSIONAL DETAIL PRODUCTS

P & S PROFESSIONAL DETAIL PRODUCTS Terminator Enzyme Spot & Stain Remover – Professional Upholstery & Carpet Cleaner, Eliminates Grease, Dirt, Protein-Based Stains, Fresh Scent - 16 Oz.

Main Highlights

QUICKLY ATTACKS GREASE, OIL, DIRT AND FOOD RELATED SPOTS AND STAINS. The ideal upholstery cleaner!
EFFECTIVE ENZYME CLEANER That Penetrates, Cleans, and Deodorizes In One Application. Makes for a perfect car seat cleaner or car carpet cleaner.
PRE-TREAT SPOTS & STAINS On Carpet And Upholstery Prior To Shampooing
FRESH
RENNY DOYLE DOUBLE BLACK COLLECTION: Master Level Professional Detailing Products From P&S - Family Owned & Operated For Over 50 Years!

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8.3

Chemical Guys

Chemical Guys Leather Cleaner and Conditioner Kit - Car Cleaner and Conditioner, Safely Cleans & Conditions Leather Car Interiors, Furniture, Shoes, Boots, Bags, Apparel & More, 2 Bottles (16 oz Each)

Main Highlights

COMPLETE LEATHER CARE KIT (SPI_109_16) - This Chemical Guys kit includes Cleaner and Conditioner, two 16 oz bottles that work together to clean, restore, and protect leather in cars, homes, and more
CLEANS AND CONDITIONS - Chemical Guys interior cleaner for leather that lifts dirt and grime while the Conditioner nourishes and restores leather suppleness, leaving interior surfaces soft, smooth, refreshed
VERSATILE USE - This car leather cleaner and conditioner kit is designed for automotive interiors and equally effective on leather furniture, apparel, shoes, boots, jackets, handbags, and other everyday leather goods
SAFE & EFFECTIVE CAR LEATHER CONDITIONER AND CLEANER- pH-balanced formulas are safe for all natural, synthetic, and sealed leathers; gentle cleaning power helps prevent cracks, fading, and drying while preserving the original finish
EASY TWO-STEP SYSTEM - Use this Leather Cleaner for car interiors to remove embedded dirt, then apply Leather Conditioner to hydrate and protect; achieve professional results at home or in your garage
TRUSTED FORMULA - Developed by the Chemical Guys for enthusiasts and professionals; perfect as a leather car seat cleaner, and for maintaining sofas, jackets, and accessories with a complete leather care solution

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8.1

Chemical Guys

Chemical Guys Sprayable Leather Cleaner and Conditioner in One - Cleans, Conditions, and Protects Leather, Vinyl, Faux & More, Safe for Cars, Furniture & Apparel - 16 oz

Main Highlights

SPRAYABLE LEATHER CLEANER & CONDITIONER (SPI_103_16SW) - Chemical Guys Leather Cleaner and Conditioner cleans, conditions, and protects leather surfaces in one step; restores a soft, supple feel with a classic scent
SAFE FOR MULTIPLE LEATHER TYPES - As a car interior cleaner, it works on natural leather, synthetic, faux, and interior surfaces without causing fading or damage
CLEAN AND NOURISH - This car leather cleaner and conditioner removes dirt and oils while replenishing essential smooth to help prevent cracking and drying
VERSATILE USE - A car leather conditioner that is perfect as a car interior car cleaner, or for use on furniture, apparel, boots, and more; safe for coated or protected leather finishes
EASY SPRAY APPLICATION - Spray Chemical Guys leather conditioner and cleaner directly onto the surface or applicator, work in evenly, and buff off any excess for a smooth, clean finish
BEYOND AUTOMOTIVE USES - The Chemical Guys leather car cleaner and conditioner is great for jackets, handbags, and home leather goods; maintains leather's look and feel in any setting

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8.1

Biokleen

Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

Main Highlights

STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts

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Our Best Overall Choice

Best Choice

9.7

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen enzyme cleaner for dog urine
Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen enzyme cleaner for dog urine
Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx

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