10 Best Lactose Free Infant Formula of 2025

Tested and Reviewed: Top 10 Lactose Free Infant Formula deals with expert ratings from 8.1 to a perfect 10

April 2026 Edition

Editor's Choice

9.7

Enfamil

Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 12.6 Oz Can

Editor's bottom line:

“This lactose free infant formula is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Fast relief NOW. Fewer allergy challenges LATER
Starts to manage colic in as early as the first feeding, with 90% of infants improving within 48 hours*+
Clinically demonstrated to help reduce future allergy challenges
Helps babies return to consuming milk protein without an allergic response

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Picked by 397 people today

9.5

Good Start

Good Start | Dr. Brown's Soy-ease Pro Baby Formula Powder, for Sensitive Tummies, Dairy Free and Lactose Free for Fussiness and Gas, Non-GMO, 20 Oz

Main Highlights

COMPLETE NUTRITION SPECIALLY FORMULATED FOR SENSITIVE TUMMIES: Good Start | Dr. Brown's Soy-ease Pro Infant Formula provides a milk and lactose free alternative for your baby to help with fussiness and gas caused by sensitivity to milk-based formulas.
100% PLANT BASED PROTEINS: Gentle on tiny tummies with milk or lactose sensitivity.
MILK AND LACTOSE FREE: For fussiness and gas caused by sensitivity to milk or lactose.
DHA: Helps support brain and eye development.
GROWTH AND DEVELOPMENT: Made with 100% plant-based soy proteins, Good Start | Dr. Brown's Soy-ease Pro infant formula provides complete nutrition for babies with fussiness and gas caused by sensitivity to milk-based formulas. This baby formula is gentle on tiny tummies with milk or lactose sensitivity. Soy-ease Pro is for infants aged 0-12 months.

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9.5

Enfamil

Enfamil Prosobee Plant based Baby Formula, for Sensitive Tummies, Soy-based Plant Sourced Protein, Vitamins for Immune Support, Lactose-free, Milk free, Gluten free, 20.9 Oz Can

Main Highlights

DAIRY-FREE FORMULA: Enfamil ProSobee baby formula powder is a completely lactose and dairy free, soy formula alternative to milk-based baby formula
POWDER FORMULA FOR MILK SENSITIVITY: Dairy free formula helps ease fussiness, gas & colic caused by sensitivity to milk-based formulas, with plant-based protein that is naturally easy on sensitive tummies
COMPLETE NUTRITION: Gentle formula tailored for your baby through their first 12 months
KOSHER AND VEGETARIAN: Enfamil Prosobee Soy Infant Formula is great for following special dietary guidelines, like families who require vegetarian or Kosher diets
SUPPORTS COGNITIVE-BRAIN DEVELOPMENT: Enfamil ProSobee has the same brain-nourishing DHA levels as Enfamil routine formula to foster cognitive brain development
#1 TRUSTED BRAND: Enfamil is the #1 Trusted Brand for Brain-building & Immune Support
PEDIATRICIAN RECOMMENDED: Enfamil is the #1 infant formula brand recommended by pediatricians
SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits
SUBSCRIBE & SAVE: Choose Subscribe and Save for additional savings and convenience

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9.2

Similac

Similac Sensitive Infant Formula, for Fussiness & Gas Due to Lactose Sensitivity, Baby Formula Powder, 29.8-oz Value Can

Main Highlights

GET MORE REWARDS POINTS: Scan the MySimilac QR code on select products to earn points toward a Reward
DESIGNED FOR BABYS FUSSINESS & GAS: Our sensitive formula for babies is specially designed for fussiness and gas due to lactose sensitivity
SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk
NO PALM OLEIN OIL: Designed to support excellent calcium absorption
NO ARTIFICIAL GROWTH HORMONES: Similac was the first leading infant formula brand with no artificial growth hormones
CERTIFIED KOSHER AND HALAL: Similac Sensitive infant formula is kosher and halal
SIMILAC IS THE #1 INFANT FORMULA BRAND FED IN HOSPITALS

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9.0

Enfamil

Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 19.8 Oz Can

Main Highlights

HELPS TO EASE COLIC: Delivers Clinically-Proven Relief when managing colic due to cows milk allergy for a happier, better-rested baby & mom.Amino acid-based
FAST RELIEF NOW: As early as the first feeding, with 90% of infants improving within 48 hours
INCLUDES LGG: The most extensively studied probiotic for allergy management and supporting the digestive health of your baby
BRAIN SUPPORT: Nutramigen is a gentle, lactose free baby formula that has important nutrients found in breast milk such as Omega-3 DHA, ARA, and Choline that provide brain support
IMMUNE SUPPORT: Helps support baby's immune system to return to consuming traditional milk protein formula without an allergic response

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8.8

Similac

Similac 360 Total Care Sensitive Infant Formula for Fussiness & Gas Due to Lactose Sensitivity, Has 5 HMO Prebiotics, Baby Formula Powder, 20.1-oz Tub

Main Highlights

GET MORE REWARDS POINTS: Scan the MySimilac QR code on select products to earn points toward a bonus offer
HAS OUR CLOSEST PREBIOTIC BLEND TO THAT IN BREAST MILK: Our biggest formula breakthrough for sensitive tummies, Similac 360 Total Care Sensitive has an exclusive blend of 5 HMO prebiotics structurally identical to those in breast milk
DESIGNED FOR FUSSINESS AND GAS: Gentle nutrition designed to ease common tummy troubles like fussiness and gas due to lactose sensitivity
360 WHOLE-BABY SUPPORT: Nutrition designed to help support the immune system, brain development, and digestive health
SIMILAC IS THE #1 INFANT FORMULA BRAND FED IN HOSPITALS
NO ARTIFICIAL GROWTH HORMONES & NON-GMO: Similac was the first leading infant formula brand with no artificial growth hormones. Similac 360 Total Care Sensitive contains ingredients that are not genetically engineered
joining MySimilac Rewards and choosing digital savings

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8.6

NUTRICIA PEPTICATE

Pepticate Baby Formula, Hypoallergenic Powdered Infant Formula for Cow Milk Allergy, with Omega 3 DHA, ARA, Iron & Prebiotics, 13.2oz

Main Highlights

HYPOALLERGENIC INFANT FORMULA: Pepticate is the leading extensively hydrolyzed infant formula (eHF) in Europe with over 30 years of experience in managing infants with cow milk allergy (CMA)
COW MILK ALLERGY SYMPTOM MANAGEMENT: Clinically shown to be effective in the nutritional management of CMA. Helps to provide relief from symptoms of CMA, such as eczema and colic
INSPIRED BY BREAST MILK: Pepticate is inspired by key components found in breast milk, including prebiotic oligosaccharides to support infant digestive health and immune system development, nucleotides to help support the immune system, and DHA and ARA to promote brain and eye development
MADE IN EUROPE: Nutritionally complete, safe, and well tolerated formula sold in over 75 countries
#1 EXTENSIVELY HYDROLYZED FORMULA (eHF) in Europe: Pepticate is the #1 eHF recommended by UK pediatricians (Most recommended brand on a 2022 survey of UK GPs, pediatricians, and dieticians: n =206)

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8.3

Similac

Similac 360 Total Care Sensitive Infant Formula for Fussiness & Gas Due to Lactose Sensitivity, Has 5 HMO Prebiotics, Baby Formula, Ready to Feed, 2-fl-oz Bottle, Pack of 12

Main Highlights

Kosher
Halal
Gluten Free
Hormone Free/No Hormones/No Added Hormones/No Synthetic Hormones

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8.1

Enfamil

Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 27.8 Oz Can

Main Highlights

HELPS TO EASE COLIC: Delivers Clinically-Proven Relief when managing colic due to cows milk allergy for a happier, better-rested baby & mom.Amino acid-based
FAST RELIEF NOW: As early as the first feeding, with 90% of infants improving within 48 hours
INCLUDES LGG: The most extensively studied probiotic for allergy management and supporting the digestive health of your baby
BRAIN SUPPORT: Nutramigen is a gentle, lactose free baby formula that has important nutrients found in breast milk such as Omega-3 DHA, ARA, and Choline that provide brain support
IMMUNE SUPPORT: Helps support baby's immune system to return to consuming traditional milk protein formula without an allergic response

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8.1

Mama Bear

Amazon Brand - Mama Bear Soy Based Powder Infant Formula with Iron, for Fussiness & Gas, Lactose-Free, 22 ounce (Pack of 1)

Main Highlights

LACTOSE-FREE: Lactose-free Mama Bear Soy Baby Formula is suitable for babies who may be sensitive to lactose in milk-based infant formulas. Compare to Similac Soy Isomil & Enfamil ProSobee*.
LESS GAS, LESS FUSSY: Mama Bear Soy Baby Formula reduces fussiness and gas so your lactose-sensitive baby can be more comfortable. Complete soy nutrition for babies from birth to 12 months, lactose-free, and gluten-free.
COMPLETE NUTRITION: Mama Bear Soy Baby Formula contains complete soy nutrition for the first year of life. Vitamin E, lutein and DHA, an omega-3 fatty acid, iron & 100% soy protein, plus over 25 vitamins and minerals to fuel baby's growth and development.
WITH PREBIOTICS: Prebiotics support healthy bacteria in the digestive system, crucial to immune support system development

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Our Best Overall Choice

Best Choice

9.7

Enfamil

Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 12.6 Oz Can

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Fast relief NOW. Fewer allergy challenges LATER
Starts to manage colic in as early as the first feeding, with 90% of infants improving within 48 hours*+
Clinically demonstrated to help reduce future allergy challenges
Helps babies return to consuming milk protein without an allergic response

Show Price

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