10 Best Immune Vitamin B12 Supplements of 2025

Tested and Reviewed: Top 10 Immune Vitamin B12 Supplements deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

EZ Melts

EZ Melts Dissolvable B12 2,500 mcg - Vitamin B12 for Energy & Immune Support - Non-GMO, Vegan & Gluten-Free - Red Cherry - 90 Sublingual Tablets (90 Servings)

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Editor's bottom line:

“This immune vitamin b12 supplements is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Vitamin B12 Supplement: EZ Melts B12 are dissolvable tablets that deliver 2,500 mcg of vitamin B12 per serving for easy metabolic energy support*
Energy Support Supplement: Supports healthy energy levels, cellular health, and natural energy production to support overall wellness*
Brain Health Supplement: Methylcobalamin B12 is essential to help maintain focus and cognitive function, so you can stay alert when it matters most*
Mood Support Supplement: Supports nervous system function, which helps maintain clarity*
Non-GMO & Vegan Supplement: EZ Melts makes it easier to take superior quality vitaminsfree from artificial flavors, gluten, dairy, soy, and sugar

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Picked by 397 people today

9.5

Nature Made

Nature Made Super B Complex with Vitamin C & Folic Acid, B Complex Vitamins for Women and Men, Dietary Supplement for Immune Support, 140 Tablets, 140 Day Supply

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Main Highlights

Immune support supplement: contains one 140 count value size bottle of Nature Made B Complex with Vitamin C and Folic Acid Tablets for a 140-day supply
Nature Made B Vitamin Complex supplement provides Vitamin C to help support the immune system
Super Vitamin B Complex supplement provides 8 B vitamins to support a healthy brain and nervous system
Provides all 8 essential B vitamins, including Folic Acid (B9), Biotin and Vitamin B12
Adults take one of these Vitamin B-complex supplements daily with water and a meal
Made with high-quality ingredients, this Super B-Complex Nature Made supplement is gluten free with no color added and no artificial flavors
United States Pharmacopeia (USP) Verified, #1 Pharmacist Recommended Vitamin & Supplement Brand*
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

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9.5

Amazon Basics

Amazon Basics Vitamin B12 3000 mcg Gummies, Normal Energy Production and Metabolism, Immune System Support, Raspberry, 100 Count (2 per Serving) (Previously Solimo)

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Main Highlights

Supports energy production by converting food to fuel and is essential for red blood cell formation. Promotes energy metabolism.*
Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
Supports normal brain function and cognition. Supports healthy immune function*
Raspberry flavor with other natural flavors; Soft pectin-based vegan gummy
100 gummies, a one-and-a half month supply (taken daily at listed serving size)
Gluten-free, no wheat, no dairy, no soy, no egg
An Amazon brand
During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

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9.2

Nature's Bounty

Nature's Bounty Vitamin B12, Supports Energy Metabolism and Nervous System Health, 500mcg, 100 Quick Dissolve Tablets

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Main Highlights

FOR ENERGY 100-count Vitamin B-12 500mcg Tablets; Natures Bounty Quick Dissolve B-12 vitamins play an important role in energy metabolism in the body(1); They help the body convert food into the fuel which is used to produce energy in the body(1)
FOR YOUR HEART Natures Bounty Vitamin B-12 is a commonly used vitamin taken to support the health of the cardiovascular and circulatory systems(1)
FOR YOUR NERVES Natures Bounty B-12 is an important vitamin for maintaining healthy nerve cells(1)
VEGETARIAN FORMULA Natures Bounty quick-dissolve Vitamin B-12 tablets are suitable for vegetarians; They are non-GMO gluten-free and sugar-free
FROM THE TRUSTED WELLNESS EXPERTS Natures Bounty Vitamin B-12 tablets are a product of 50 years of dedication to quality consistency and scientific research to make vitamins and nutritional supplements of unrivaled excellence

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9.0

Nature Made

Nature Made Maximum Strength Vitamin B12 5000 mcg, Dietary Supplement for Energy Metabolism Support, 60 Softgels, 60 Day Supply

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Main Highlights

Energy metabolism support supplement(1): contains one 60 count bottle of Nature Made Maximum Strength Vitamin B 12 5000 mcg Softgels for a 60-day supply
Vitamin B12 supplements help break down food into energy that your body can use all day long
Nature Made B12 Vitamins 5000 mcg helps support brain cell function and mood health(3)
Vitamin B12 is important for proper red blood cell formation and helps reduce fatigue for those low in B12 vitamins
Adults, take one Vitamin B-12 softgel daily with water and a meal
Made with high quality ingredients, these gluten free B12 Vitamins for women and men have no color added, no artificial flavors, and no preservatives
United States Pharmacopeia (USP) Verified, #1 Pharmacist Recommended Vitamin & Supplement Brand*
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

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8.8

AgeImmune

AgeImmune Vitamin B Complex with Vitamin D3 B12 B6 Magnesium Bisglycinate and Folate as Methylfolate - Doctor Formulated Methylated B Complex Supplement – 60 Capsules - Without Niacin

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Main Highlights

NEURO and BRAIN support with B6 as Pyridoxal-5-Phosphate 20mg, B12 as Methylcobalamin 1000mcg, D3 1000IU, Albion Magnesium Bisglycinate 26mg, Folate 600mcg DFE. Support Stamina, Mood, Energy production.
With VITAMIN D3 for Immune support. Vitamin B deficiency is often associated with Vitamin D deficiency. Magnesium regulates vitamin B and D3 absorption.
With FOLATE (Metafolin L-5-MTHF), not Folic Acid, for MTHFR gene expression, cognitive function support and best B Vitamins absorption.
With ALBION MAGNESIUM bisglycinate, the most bioavailable form of magnesium, which is not ionized in the gut and not causing intestinal distress. Controls Vitamins B and D absorption.
FORMULATED for people who feel fatigue or have low energy levels, with Vitamin B and D deficiency, methylation difficulties, MTHFR traits. Made in the USA without Magnesium Stearate, Silicon Dioxide or Titanium Dioxide.

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8.6

Nature Made

Nature Made Vitamin B12 1000 mcg, B12 Vitamins, Dietary Supplement for Energy Metabolism Support, 160 Time Release Tablets, 160 Day Supply

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Main Highlights

Energy metabolism support supplement(1): contains one 160 count bottle of Nature Made B12 1000mcg Time Release Tablets for a 160-day supply
Nature Made B12 1000 mcg dietary supplements provide B12 to help break down food into energy that your body can use all day long
B-12 vitamin helps support brain cell function and mood health (2)
Vitamin B12 is important for proper red blood cell formation and helps reduce fatigue for those low in vitamin B-12
Time release formula extends vitamin absorption by the body; Adults take one Nature Made B12 timed release tablet daily with water and a meal
Made with high quality ingredients, these NatureMade B12 1000 mcg tablets have no color added, no artificial flavors and no preservatives
#1 Pharmacist Recommended Vitamin & Supplement Brand*
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

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8.3

Nature's Bounty

Nature’s Bounty Vitamin B12 2500 mcg, Cellular Energy Support, for Energy Metabolism, Heart & Nervous System Health, 75 Quick Dissolve Tablets

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Main Highlights

HELPS FUEL YOUR BODY (1): Natures Bounty Vitamin B-12 supports energy metabolism by helping the body convert food into the cellular energy (1)
SUPPORTS HEART HEALTH (1): Taking a Vitamin B 12 supplement is a great way to support the health of your cardiovascular and circulatory systems (1)
SUPPORTS YOUR NERVOUS SYSTEM (1): Natures Bounty Vitamin B-12 helps to maintain healthy nerve cells, supporting nervous system health (1)
QUALITY IS OUR PRIORITY: Natures Bounty is committed to the safety of all of our supplements. Our quick dissolve Vitamin B-12 tablets are gluten free, sugar free, contain no artificial flavors or sweeteners, and are suitable for vegetarians
FROM THE TRUSTED WELLNESS EXPERTS: Natures Bounty Vitamin B-12 is a product of 50 years of dedication to quality, consistency and scientific research to make vitamins and nutritional supplements of unrivaled excellence

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8.1

Pure Encapsulations

Pure Encapsulations B12 Liquid | 1,000 mcg Vitamin B12 (Methylcobalamin) Supplement to Support Nerves, Immune Health, Energy, and Cognitive Function* | 1 fl. oz.

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Main Highlights

Cognitive Function: B12 is helps support nerve cell health and cognitive function.*
Cellular Energy Production: Vitamin B12 can also play an important role in contributing to energy production and maintaining a healthy immune system*
Immune Support: Vitamin B12 plays a role in immune system health and healthy homocysteine metabolism.*
Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

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8.1

Nature Made

Nature Made Vitamin B12 1000 mcg, Dietary Supplement for Energy Metabolism Support, B12 Vitamins 1000 mcg, 150 Softgels, 150 Day Supply

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Main Highlights

Energy metabolism support supplement(1): contains one 150 count bottle of Nature Made Vitamin B12 1000 mcg Softgels for a 150 day supply
These Nature Made B12 1000mcg softgels help break down food into energy that your body can use all day long
Vitamin B 12 helps support brain cell function and mood health (2)
Vitamin B12 is important for proper red blood cell formation and helps reduce fatigue for those low in B12 vitamins
Adults take one B 12 vitamin softgel daily with water and a meal
This gluten free Vitamin B12 supplement has no synthetic dyes and no artificial flavors
United States Pharmacopeia (USP) Verified, #1 Pharmacist Recommended Vitamin and Supplement Brand*
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

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Our Best Overall Choice

Best Choice

9.7

EZ Melts

EZ Melts Dissolvable B12 2,500 mcg - Vitamin B12 for Energy & Immune Support - Non-GMO, Vegan & Gluten-Free - Red Cherry - 90 Sublingual Tablets (90 Servings)

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Vitamin B12 Supplement: EZ Melts B12 are dissolvable tablets that deliver 2,500 mcg of vitamin B12 per serving for easy metabolic energy support*
Energy Support Supplement: Supports healthy energy levels, cellular health, and natural energy production to support overall wellness*
Brain Health Supplement: Methylcobalamin B12 is essential to help maintain focus and cognitive function, so you can stay alert when it matters most*
Mood Support Supplement: Supports nervous system function, which helps maintain clarity*
Non-GMO & Vegan Supplement: EZ Melts makes it easier to take superior quality vitaminsfree from artificial flavors, gluten, dairy, soy, and sugar

Show Price

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