10 Best Hydroxyapatite With Fluoride Toothpaste of 2025

Tested and Reviewed: Top 10 Hydroxyapatite With Fluoride Toothpaste deals with expert ratings from 8.1 to a perfect 10

July 2025 Edition

Editor's Choice

9.7

Save 15%

Dr Jen

Dr. Jen Super Paste/Toothpaste with Fluoride +10% Nano-Hydroxyapatite Travel Toothpaste for Teeth Whitening & Sensitive Teeth Care (3.4 Ounce (Pack of 1), Cool Mint)

15% Off

Editor's bottom line:

“This hydroxyapatite with fluoride toothpaste is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Clinically Proven 10% Nano-Hydroxyapatite The Gold Standard for Maximum Mineral uptake. Formulated with the optimal 10% concentration of nano-Hydroxyapatite, shown to deliver the highest levels of calcium and phosphate uptake into enamel for unmatched cavity defense and enamel repair.
Premium-Grade Nano-Hydroxyapatite for Deep Repair Below the Surface. Our ultra-fine, medical-grade nano-Hydroxyapatite penetrates deep into enamel and dentin micro-channels, restoring mineral content where decay startsbeneath the surface.

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Picked by 263 people today

9.5

RiseWell

RiseWell Mineral Toothpaste - All Natural Toothpaste with Hydroxyapatite - Made in The USA, No Added Fluoride, SLS-Free - for a Stronger and Healthier Teeth, Wild Mint, 3.4 Oz

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Main Highlights

REMINERALIZE AND SHINE WITH EVERY BRUSH: Our SLS free toothpaste with no added fluoride has Hydroxyapatite that strengthens enamel, naturally whitens teeth without harsh abrasives, and helps remineralize teeth. This natural sensitive toothpaste reduces sensitivity while delivering effective remineralization.
SENSITIVE TEETH RELIEF: Experience natural protection with our clean toothpaste for sensitive teeth! Unlike other toothpastes, this hydroxyapatite toothpaste uses hydroxyapatite to reduce sensitivity while remineralizing tooth enamel. For a stronger and healthier smile, try our hydroxyapatite-toothpaste.
100% CLEAN & TRAVEL-READY: This travel toothpaste is TSA-approved at 3.4 oz toothpaste, making it easy to take anywhere. Formulated to remineralize teeth, this no added fluoride toothpaste is free from sulfates, parabens, and artificial additivespure, safe, and always ready remineralize toothpaste for your next trip!
LONG-LASTING NATURAL DENTIST TOOTHPASTE: This 3.4oz tube of remineralizing toothpaste with hydroxyapatite lasts approximately 3 months when used twice daily, a good toothpaste that provides continuous oral care without running out. Try RiseWell's hydroxyapatite whitening toothpaste!
MADE IN THE USA MINERAL TOOTHPASTE: RiseWell's hydroxyapatite whitening toothpaste is proudly manufactured in the USA. This natural whitening toothpaste is cruelty-free, vegan, and gluten free toothpaste. This made by dentist toothpaste offers a clean, ethical option for those who care about what goes into their oral health routine.

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9.5

CariFree

CariFree Gel 1100 (Mint) Anti-Cavity Fluoride Toothpaste with Nano Hydroxyapatite, Cavity Prevention and Enamel Protection, Dentist Recommended for Kids and Adults, 2.40 oz.

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Main Highlights

Dentist-Recommended Fluoride Toothpaste: CariFree Fluoride Gel is recommended by dentists to help prevent cavities and promote good dental health. Fluoride is a key ingredient that strengthens tooth enamel and helps protect against decay. By using this toothpaste regularly, you can give your teeth an added layer of protection against cavities.
Real Mint Flavor: CariFree uses genuine mint oil to create a real, fresh taste that is safe to use every day. Our Gel is also made with xylitol, a naturally occurring, sweet-tasting ingredient found in many types of plants that research shows may reduce your risk of dental cavities.
Nano Hydroxyapatite: CariFree Gel 1100 contains nanoXIM by FlUIDINOVA, the highest quality nano hydroxyapatite that's the same shape and size as the naturally occurring hydroxyapatite found in saliva. Our toothpaste is a low-abrasion tooth gel that combines proven anti-cavity benefits, including .24% fluoride, nano hydroxyapatite and our unique, patented pH+ technology to neutralize acidsrecommended for ages 3+
Fight Cavities and Promote Fresh Breath: CariFree Gel 1100 contains 0.24% sodium fluoride to fight cavities and help prevent tooth decay while also freshening your breath. With patented pH+ technology, CariFree toothpaste is designed to target the root cause of cavities while also leaving your breath minty fresh.
Proudly Made in the USA: CariFree products are meticulously formulated and produced in the USA, showcasing our commitment to domestic quality and local craftsmanship. Founded in Albany, Oregon, CariFree is committed to offering affordable, science-based solutions to common dental health concerns for the whole family.

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9.2

MILTODENT

MILTODENT Premium Hydroxyapatite Toothpaste – 15% Micro-Hydroxyapatite | Fluoride-Free, Best Taste, Foam-Free, Natural Mineralizing | Safe Alternative to Nano-Hydroxyapatite | SLS-Free & Natural 4oz

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Main Highlights

Ultra-Strength 15% Micro-Hydroxyapatite Formula: MILTODENT contains a powerful 15% concentration of micro-hydroxyapatitemore than most brandsfor superior enamel remineralization, cavity protection, and sensitivity relief. Unlike nano-particles, our micro-HA remains on the tooth surface, where it fills microscopic enamel defects, restoring natural strength and shine without the risk of systemic absorption.
Fluoride-Free & Dentist-Formulated for Safe, Natural Care: Developed by a dentist, this formula provides effective cavity defense without fluoride, making it safe for daily use by both adults and children. It uses all-natural, biocompatible ingredients derived from nature, offering a clean, science-backed alternative to conventional chemical-laden toothpastes.
Whitens Teeth Gently & Fights Plaque Build-Up: MILTODENT naturally polishes away stains using mineral action from hydroxyapatite, helping to brighten teeth over timewithout relying on peroxide or abrasives. Its antibacterial properties support cleaner teeth and gums, reducing plaque, odor, and the risk of gingivitis.
Foam-Free, SLS-Free Formula for Sensitive Mouths: Unlike most commercial toothpastes, MILTODENT is free from sodium lauryl sulfate (SLS), foaming agents, and surfactants that can irritate the mouth. It offers a smooth, non-foaming brushing experience thats gentle on soft tissues, making it ideal for those with dry mouth, mouth ulcers, or chemical sensitivity.
Nano-Free Mineral Particles for Peace of Mind: While nano-hydroxyapatite is common in other natural toothpastes, MILTODENT uses only micro-sized particles to eliminate concerns over nano absorption and bioaccumulation. Our formula delivers the same enamel-rebuilding powerwithout compromising long-term safety.
Clean, Natural Taste Without Artificial Additives: Crafted with natural mint flavor and no artificial sweeteners, dyes, parabens, or preservatives, MILTODENT provides a refreshing brushing experience that tastes greatencouraging consistent daily use. Its vegan, gluten-free, cruelty-free, and safe for both adults and children.

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9.0

Made by Dentists

Made by Dentists Professional Enamel Rebuilding Toothpaste - 2 Pack - Remineralizing Nano Hydroxyapatite Toothpaste with Sodium Fluoride, ADA Approved, Vegan, 2 x 4.2oz

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Main Highlights

Advanced Enamel Rebuilding: This hydroxyapatite toothpaste contains nano hydroxyapatite and fluoride to replenish and remineralize enamel, making teeth stronger and harder.
How It Works: Utilizes nano-sized Hydroxyapatite particles that penetrate deeply into the tooth to remineralize from within, restoring the natural strength of enamel.
Protects Against Sensitivity: This remineralizing toothpaste contains potassium nitrate to block sensitive pathways in your teeth, providing relief from discomfort while strengthening enamel.
ADA Approved: Officially recognized by the American Dental Association for its effectiveness in enamel restoration and cavity prevention.
Vegan, Cruelty-Free, & Eco-Friendly: A vegan-friendly formula that's also cruelty-free, with packaging made from 100% recyclable materials.

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Best Value

8.8

Save 19%

Boka

Boka Fluoride Free Toothpaste Nano Hydroxyapatite, Helps Remineralize, Appropriate for Sensitive Teeth, Whitening - for Adult, Kids Oral Care - Ela Mint Flavor, 4 Fl Oz 1Pk US Manufactured

19% OffFree Shipping

Main Highlights

APPROPRIATE FOR GUM HEALTH & ENAMEL REPAIR: A powerhouse next generation formula for gum health by harnessing the strength of Nano Hydroxyapatite (NHA)!
REMINERALIZES & WHITENS TEETH: Thanks to its innovative formula with Nano Hydroxyapatite (NHA), our toothpaste not only effectively cleans your teeth but also aids in the remineralization process. As a result, it improves your overall tooth enamel health and helps to brighten those pearly whites
BIOCOMPATIBLE: Free from Fluoride, Sulfates, Parabens & Artificial Flavors & Colors - we meticulously crafted our product to be 100% biocompatible, ensuring its safe for daily use and non-toxic when used as directed. A perfect way to take your oral hygiene routine to the next level!
APPROPRIATE FOR SENSITIVE TEETH: Gentle yet effective, it provides a soothing and refreshing experience for the whole family. Embrace an oral care routine designed for a luxurious experience
TASTE THE ELA MINT FUSION: A delightful fusion of refreshing mint, antioxidant-rich green tea, with a hint of cardamom. The invigorating mint leaves your breath feeling fresh & revitalized, with just a touch of cardamom adding a unique, yet welcome twist to your brushing experience. Say goodbye to the bland & mundane - say hello to a toothpaste flavor that excites your taste buds every time you brush

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8.6

Mouthology

Mouthology 10% Nano Hydroxyapatite Toothpaste (Fluoride Free), Whitening, Remineralizing, Natural, Sensitive Teeth, SLS Free, Xylitol Nano-Hydroxyapatite Toothpaste for Adults, Mint 4oz (USA Made)

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Main Highlights

NASA-INSPIRED ENAMEL REPAIR: Developed from NASA's space research, our 10% Nano Hydroxyapatite toothpaste restores and strengthens enamel, better than fluoride, without the harmful side effects. Achieve next-level protection and care for your teeth with every brush.
CLINICALLY PROVEN 10% NANO HYDROXYAPATITE: Unlike other brands that hide their Nano-Hydroxyapatite percentages, our toothpaste contains the full 10% Nano Hydroxyapatitethe clinically proven amount required for effective enamel restoration. Our nano-sized particles are precisely engineered to fill the microscopic pores in your teeth, delivering superior remineralization and protection.
NATURAL WHITENING, NO SENSITIVITY: Say goodbye to harsh bleaching agents. Our nano hydroxyapatite toothpaste smooths and whitens teeth by filling micro-lesions in the enamel, leaving you with a glossier, brighter smilewithout causing sensitivity.
FLUORIDE FREE & SAFE FOR ALL AGES: Our toothpaste is completely fluoride-free, offering a safe alternative for those looking to avoid the negative health impacts of fluoride. Our nHa toothpaste is made with biocompatible ingredients, safe if swallowed and recommended by dentists nation-wide.
MADE IN USA WITH CLEAN, NATURAL INGREDIENTS: Made in the USA with premium, natural ingredients. Our toothpaste is fluoride-free, SLS-free, with birch xylitol to promote oral health. No artificial colors or flavorsjust clean, gentle care for your mouth.

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8.3

Davids

Davids Hydroxi Fluoride Free Nano Hydroxyapatite Toothpaste for Remineralizing Enamel & Sensitive Relief, Whitening, Antiplaque, SLS Free, Natural Peppermint, 5.25oz, Made in USA

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Main Highlights

Features Hydroxi, our proprietary formulation of Nano Hydroxyapatite (n-HA) - the same ingredient that naturally makes up 97% of your teeth material, and carefully selected naturally sourced and naturally derived ingredients. We eliminated the fluoride and replaced it with this biocompatible ingredient to remineralize your enamel, reduce teeth sensitivity and naturally whiten.
Safe & Gentle Whitening micro polishing agents gently remove surface stains to safely whiten without causing the sensitivity normally found with peroxide or other bleaching agents. RDA (abrasive rating) of 101 to effectively remove plaque and surface stains while being enamel safe for daily brushing. Safe range per ADA (American Dental Association).
Bioactive Sensitive Relief - most sensitive toothpastes uses Potassium Nitrate (nerve numbing drug) to temporarily numb the tooth nerves. We use Hydroxyapatite (n-HA) to reduce sensitivity by remineralizing the enamel and passageways (tubules) to the nerves.
Clean & Safe Ingredients we use only premium ingredients derived from plants and the earth, with no animal by-products (vegan). Fluoride Free, Sulfate Free (no SLS), EWG VERIFIED. No Artificial Flavors, Colors, or Preservatives. Birch xylitol used to improve oral health.
Healthy Mouth formulated to restore a healthy PH balance and support your mouths natural oral microbiome. Plaque is the main enemy of teeth and Davids is designed to aggressively stop plaque from forming and reduce existing plaque buildup, while leaving your mouth feeling minty fresh and exceptionally clean. Healthy mouth for a healthy you.

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8.1

GuruNanda

GuruNanda Hydroxyapatite Toothpaste, SLS & Fluoride Free, Whitening Toothpaste - Freshens Breath, Fights Plaque - Natural CocoMint Jasmine Neem, 4.2oz

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Main Highlights

FLUORIDE-FREE, FORTIFYING FORMULA: GuruNanda toothpaste with Hydroxyapatite & Neem, aids in remineralization and deep cleans your teeth, enhancing enamel health and brightening your smile.
MULTIPLE BENEFITS FOR SENSITIVE TEETH: This hydroxyapatite toothpaste effectively helps remove plaque and debris, promotes happy gums, and supports overall oral hygiene for a healthier, brighter smile.
NATURAL INGREDIENTS: Made with natural ingredients, this toothpaste blends neem, jasmine, essential oils, and vitamins D3, K2, E with mineral-rich Celtic Sea Salt for a gentle, effective clean without harsh chemicals.
HOW TO USE: Brush your teeth twice daily with a pea-sized amount for 2 minutes (30 seconds in each quadrant). For best results, use our toothpaste after pulling oil with GuruNanda's range of oil-pulling products.
DENTIST RECOMMENDED: Non-GMO and made with clean, natural ingredients, our toothpaste is free from harsh chemicals like SLS, fluoride, parabens, artificial colors, flavors, and preservatives. Recommended by dentists, it provides a deep clean while being gentle on sensitive teeth and gums.

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8.1

ATTITUDE

ATTITUDE Toothpaste with Fluoride, Prevents Tooth Decay and Cavities, Vegan, Cruelty-Free and Sugar-Free, Whitening, Peppermint, 4.2 Oz

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Main Highlights

EWG VERIFIED: This toothpaste is certified EWG Verified and made with clean ingredients that meet the Environmental Working Group's strict health and safety standards so you can feel confident that it does not contain any potentially concerning ingredients.
CLEAN FORMULA: This EWG Verified toothpaste contains fluoride and is free from SLS, dyes, artificial sweeteners, and artificial flavors, for a worry-free experience.
WHITENING: This adult toothpaste removes plaque with regular brushing and whitens your teeth thanks to its formula with sodium fluoride, green tea extract, and hydroxyapatite.
PEPPERMINT: Bursting with a crisp peppery mint flavor that leaves your mouth feeling cool, clean, and refreshed after every brush.
VEGAN & SUSTAINABLE : This toothpaste is vegan and comes without cardboard packaging to reduce waste.

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Our Best Overall Choice

Best Choice

9.7

Dr Jen

Dr. Jen Super Paste/Toothpaste with Fluoride +10% Nano-Hydroxyapatite Travel Toothpaste for Teeth Whitening & Sensitive Teeth Care (3.4 Ounce (Pack of 1), Cool Mint)

15% Off

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Clinically Proven 10% Nano-Hydroxyapatite The Gold Standard for Maximum Mineral uptake. Formulated with the optimal 10% concentration of nano-Hydroxyapatite, shown to deliver the highest levels of calcium and phosphate uptake into enamel for unmatched cavity defense and enamel repair.
Premium-Grade Nano-Hydroxyapatite for Deep Repair Below the Surface. Our ultra-fine, medical-grade nano-Hydroxyapatite penetrates deep into enamel and dentin micro-channels, restoring mineral content where decay startsbeneath the surface.

Show Price

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