10 Best Good Night Bed Bug Spray of 2025

Tested and Reviewed: Top 10 Good Night Bed Bug Spray deals with expert ratings from 8.1 to a perfect 10

May 2026 Edition

Editor's Choice

9.7

Sprayway

Good Night Bed Bug Spray, 16oz | Odorless, Water-Based, EPA Registered | Eliminates Bed Bugs, Lice, Ticks, Fleas, House Dust Mites | Ideal for Homes, Dormitories, Hotels

Editor's bottom line:

“This good night bed bug spray is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Eliminates bed bugs, lice, ticks, fleas, and dust mites
Odorless
Water-Based

Show Price

Picked by 397 people today

9.5

Sprayway

Good Night Bed Bug Spray, 16oz, Pack of 12 | Odorless, Water-Based, EPA Registered | Eliminates Bed Bugs, Lice, Ticks, Fleas, House Dust Mites | Ideal for Homes, Dormitories, Hotels

Main Highlights

Eliminates bed bugs, lice, ticks, fleas, and dust mites
Odorless
Water-Based

Show Price

9.5

EcoVenger

Bed Bug Killer 16 oz EcoVenger by EcoRaider, 100% Kill Efficacy, Bedbugs & Mites, Kills Eggs & The Resistant, Lasting Protection, USDA BIO-Certified, Plant Extract Based & Non-Toxic, Child & Pet Safe

Main Highlights

HIGHLY EFFECTIVE, PLANT-POWERED BED BUG KILLER: EcoVenger Bed Bug Killer uses a patented blend of botanical insecticidal compounds to combat tough insects. A published university study ranks it as the #1 most effective natural product against bed bugs among 12 products tested, outperforming traditional pesticides.
USDA FIELD-TESTED & PROVEN: Vetted through the USDA IR4 PHP Program and field-tested by research entomologists. Recommended for sensitive environments, it's a trusted solution for eliminating bed bugs in public housing and other vulnerable settings.
KILLS ALL STAGES, INCLUDING RESISTANT BED BUGS: This formula kills bed bug adults and nymphs on contact with 100% efficacy. It's also proven to eliminate bed bugs resistant to traditional pesticides and has the highest performance in destroying bed bug eggs.
EXTENDED DRY RESIDUAL PROTECTION: A university study demonstrates that EcoVenger's residual formula provides two weeks of extended protection against bed bugs, even after it has dried, offering long-term peace of mind.
NON-TOXIC, SAFE & ECO-FRIENDLY: Certified as a USDA BioBased insecticide and dermatologically safe. This product is child and pet-friendly, making it safe to use directly on mattresses and box springs without worry.
INGREDIENTS: Geraniol, Cedarwood oil, Sodium Lauryl Sulfate, Glyceryl dicaprylate, Silica hydrate, Glyceryl monooleate and water.
UNDERSTANDING PRODUCT BATCH IDS: You may see two different types of product IDs on products you receive. A "Manufacture Batch #" indicates the date the product was manufactured. A "Best Use Before" date suggests the optimal time frame for using the product for best performance. If you have any questions, please contact the seller directly.

Show Price

Best Value

9.2

Save 11%

Ortho

Ortho Home Defense Max Bed Bug Killer - Also Kills Fleas & Brown Dog Ticks, Spot Treatment, 18 oz

11% Off

Main Highlights

Kill even the toughest (pyrethroid-resistant) bed bugs and their eggs with the Ortho Home Defense Max Bed Bug Killer spray
KILLS FAST: The bed bug spray kills quickly and keeps on killing for up to 16 weeks on ceramic (non-porous) surfaces
EFFECTIVE CONTROL: This spray works on the toughest (pyrethroid-resistant) bed bugs and their eggs as well as fleas, brown dog ticks, stink bugs, earwigs, clothes moths, carpet beetles and other listed bugs
EASY TO USE: Once bed bugs have been detected, spray this bed bug killer around bed frames, headboards, floors, and carpeting as a spot treatment
A BED BUG SOLUTION SYSTEM: Use with Step 1 Ortho Home Defense Max Bed Bug trap to detect bed bugs, and Step 3 Ortho Home Defense Max Bed Bug & Flea Killer Powder to kill bed bugs on contact (sold separately)

Show Price

9.0

Ortho

Ortho Home Defense Max Bed Bug, Flea and Tick Killer with Comfort Wand, Bed Bug Spray, Kills Bed Bug Eggs, Fleas and Ticks, 1 gal.

Main Highlights

Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results

Show Price

8.8

Save 9%

HOT SHOT

Hot Shot Ready-to-Use Bed Bug Killer Spray, Kills Bed Bugs and Bed Bug Eggs, Kills Fleas and Dust Mites, 32 Ounce

9% Off

Main Highlights

BED BUG TREATMENT: Hot Shot Bed Bug Killer With Egg Kill kills bed bugs and bed bug eggs, adult and pre-adult (larvae) fleas and dust mites.
USE INDOORS: Spot treat mattress tufts, folds, vent holes, buttons, creases, indentations and seams do not use on pets.
WATER-BASED FORMULA: This non-staining formula leaves no odor.
APPLICATION: Spray intended use areas until damp, but do not saturate inspect the area and apply every two weeks while bed bugs are present.
TREAT BED BUGS AS PART OF A CYCLE: For best results, use this product as part of a comprehensive bed bug treatment plan treating bed bugs as part of a cycle is key to gaining control.

Show Price

8.6

RID

Rid Home Lice Bed Bug Dust Mite Spray Home Treatment Spray with Permethrin Kills Lice and Lice Eggs on Mattresses Furniture Car Interiors and Other Nonwashable Items Spray Can, 5 Ounce

Main Highlights

Trusted Brand : RID is trusted by families for killing lice and lice eggs. This permethrin lice killing spray also kills bedbugs and dust mites.
KILLS LICE AND THEIR EGGS: RID Home Lice, Bed Bug & Dust Mite Spray kills lice and their eggs on mattresses, furniture, car interiors, and other non-washable items.
EFFECTIVE AGAINST BEDBUGS AND DUST MITES: RID Home Lice, Bed Bug & Dust Mite Spray is also effective at killing bedbugs and dust mites on non-washable items.
WHERE TO USE: RID Home Lice, Bed Bug & Dust Mite Spray kills lice & their eggs on mattresses, furniture, car interiors, and other non-washable items.
EASY TO USE: Just diffuse RID Home Lice, Bed Bug & Dust Mite Spray with permethrin for 3 seconds and allow to dry. Spray only on non-washable items such as mattresses, furniture, car interiors, and other items that cannot be laundered.

Show Price

8.3

Eco Defense

Eco Defense Bed Bug Killer - Bed Bug Spray & Dust Mite Spray - Natural Treatment - 16 Oz

Main Highlights

KILLS ON CONTACT - Natural ingredients eliminate bed bugs on contact in all stages of life, Eggs, Nymphs, and Adults.
NON STAINING - Won't stain your bedding like some products on the market. Apply directly to sheets, mattress and cover to kill bed bugs on site.
SLEEP SECURE - Made of natural as well as plant-based ingredients. No worries of fumes or dangerous pesticides and chemicals coming in contact with you and your family
FASTEST TREATMENT - Eco Defense Bed Bug Killer Spray works extremely fast and is easy to use. Many customers have found it easier to use and more effective than other Bed Bug products including, Bed Bug Powders, Bed Bug Traps, and Bed Bug Foggers. Rest assured, Eco Defense is your #1 solution.

Show Price

8.1

EcoLogic

Ecologic Bed Bug Killer Aerosol, 14 Ounces, Aerosol Formula Made With Lemongrass Oil And Cornmint Oil For Use On Seams, Edges And Tufts Of Mattresses, Bed Frames, Suitcases And More

Main Highlights

KILLS BED BUGS BY CONTACT: Ecologic Bed Bug Killer Aerosol2 kills pyrethroid-resistant bed bugs & bed bug eggs by contact.
APPLY AS SPOT TREATMENT: Use this product on mattresses*, bed frames, suitcases and more.
MADE WITH MINDFUL INGREDIENTS: This product is formulated with lemongrass oil and cornmint oil.
TESTED TO ENSURE EFFECTIVENESS: Indoor defense you can feel confident using in & around your home.
SAFE AROUND KIDS AND PETS: When used and stored as directed.

Show Price

Our Best Overall Choice

Best Choice

9.7

Sprayway

Good Night Bed Bug Spray, 16oz | Odorless, Water-Based, EPA Registered | Eliminates Bed Bugs, Lice, Ticks, Fleas, House Dust Mites | Ideal for Homes, Dormitories, Hotels

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Eliminates bed bugs, lice, ticks, fleas, and dust mites
Odorless
Water-Based

Show Price

Deals are Live

Special Amazon deal ends in: