10 Best Folate L Methylfolate of 2025

Tested and Reviewed: Top 10 Folate L Methylfolate deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Nutricost

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO (Methylated Folate)

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Editor's bottom line:

“This folate l methylfolate is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

120 Capsules MethylFolate (120 Servings)
1,000mcg MethylFolate Per Serving
Vegetarian Capsules
Non-GMO & Gluten Free & 3rd Party Tested
Made in an NSF Certified, GMP Compliant, FDA Registered Facility.

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Picked by 397 people today

9.5

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

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Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

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9.5

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

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Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

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9.2

NatureBell

NatureBell Methyl Folate 15mg - 240 Capsules - 5-MTHF with Methyl B12-15mg L-Methylfolate & 1,000mcg Vitamin B12 - Energy & Cognitive Support Supplement* - Gluten-Free & Non-GMO

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Main Highlights

Folate Supplement: NatureBell Methyl Folate is expertly formulated with 15mg L-methylfolate, an easily absorbed active folic acid, for energy level support and effective folate support*
Dual-Action Energy & Focus Formula: Each capsule combines easily absorbed methylfolate and vitamin B12 for cognitive health and fatigue support*
Prenatal Health & Support Vitamin: These B12 capsules are ideal for daily prenatal health, MTHF support, and energy support*
Third-Party Tested: These vegetarian capsules are third-party tested for quality and potency; they are also non-GMO, gluten-free, dairy-free, soy-free, and egg-free
Pure, High-Quality Ingredients: At NatureBell, we use only the finest ingredients to help support you on your health and wellness journey

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9.0

Nutricost

Nutricost L-Methylfolate 15mg, 120 Capsules (5-MTHF) - Vegan, Non-GMO, Gluten Free

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Main Highlights

Nutrient Support for Well-Being: Nutricost's L-Methylfolate delivers this nutrient in a convenient and customizable way to support your wellness.
120 Capsules per Bottle: With 120 capsules in each bottle, you receive an extended supply to seamlessly incorporate this essential nutrient into your daily routine.
15mg Per Serving: Each serving packs a robust 15mg of methylfolate, delivering a concentrated dose to meet your nutritional needs.
GMP Compliant Manufacturing: Crafted in an NSF Certified GMP Compliant facility, Nutricost upholds the highest manufacturing standards, ensuring you receive a premium product aligned with your health-conscious choices.
Third-Party Quality Assurance: Rigorous third-party testing by independent ISO-accredited laboratories guarantees the quality and purity of every batch, instilling confidence in the effectiveness of Nutricost's L-Methylfolate. Embrace the balance your body deserves with Nutricost's commitment to excellence.

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8.8

Life Extension

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

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Main Highlights

Get a brain boost Stay proactive about your brain health and support optimal cognitive function with this folate supplement. This 1700 mcg vitamin B formula helps maintain healthy cognitionespecially as you age.
Pump up the heart health This 5-MTHF supplement is a cardiovascular health superstar! Folate helps maintain already-normal homocysteine levels, an important cardiovascular health marker. Folate is a great way to keep heart health in check.
Metabolically active form 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folates 5-MTHF form.
Ingredients matter We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USAand a Certificate of Analysis is available for every one.
Live your healthiest life We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. Thats why so many of our formulas feature specific ingredients and amounts based on scientific studies.

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8.6

THORNE

THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg

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Main Highlights

Healthy Methylation: Provides essential nutritional support in the form of bioactive, methylated folate (vitamin B9) to support the body's methylation cycle*
Cognitive Support: Enhances the production of key neurotransmitters like serotonin, melatonin, dopamine, and other natural brain chemicals that regulate brain function and mood*
Nerves & Circulation: Supports healthy blood vessel and nerve function, and supports healthy fetal brain development during pregnancy*
4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

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8.3

Carlyle

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free Supplement | Methyl Folate, 5-MTHF | by Opti-Folate

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Main Highlights

L-METHYLFOLATE: A metabolically active form of Folic Acid, also known as Folate or B-9 Vitamin!
COMPLETE FORMULA: Quick-release capsules deliver 25,000 mcg Folate (15 mg L-METHYLFOLATE)
ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living.
CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
NATURALLY FREE OF: Gluten, Wheat, Yeast, Lactose, Soy, Artificial Flavor, Preservatives and Non-GMO

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8.1

Carlyle

Carlyle L Methylfolate 1000mcg | 200 Capsules | Value Size | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

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Main Highlights

Gluten Free, Non-GMO; Free Of Wheat, Yeast, Milk, Lactose, Soy, Artificial Color, Artificial Flavor
Each L-Methylfolate capsule provides you with 1000 mcg of this bioavailable form of folic acid
Folate, also referred to as Folic Acid, is a fully active B complex vitamin
Our professional formula is backed by our commitment to purity and potency
Manufactured in a facility that is GMP certified.

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8.1

Life Extension

Life Extension Optimized Folate (L-Methylfolate) 1700 mcg DFE, 180 Veg Tablets

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Main Highlights

Life Extension Optimized Folate (L-Methylfolate) 1700 mcg DFE, 180 Vegetarian Tablets
Life Extension's Optimized Folate formula promotes both cardiovascular and cognitive health with 1,700 mcg of folate in the form of 5-MTHF, the metabolically active form of folic acid.
Metabolically active form 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folates 5-MTHF form.
Ingredients matter We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USAand a Certificate of Analysis is available for every one.
Live your healthiest life We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there.

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Our Best Overall Choice

Best Choice

9.7

Nutricost

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO (Methylated Folate)

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

120 Capsules MethylFolate (120 Servings)
1,000mcg MethylFolate Per Serving
Vegetarian Capsules
Non-GMO & Gluten Free & 3rd Party Tested
Made in an NSF Certified, GMP Compliant, FDA Registered Facility.

Show Price

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