10 Best Eye Drops Similasan Dry Eye Relief of 2025

Tested and Reviewed: Top 10 Eye Drops Similasan Dry Eye Relief deals with expert ratings from 8.1 to a perfect 10

October 2025 Edition

Editor's Choice

9.7

Optase

OPTASE HYLO Relief Dry Eye Drops - Fast-Acting Preservative Free Drops with Patented HYLO Delivery System - Artificial Tears for Mild to Moderate Dry Eye Relief - .33 Oz, 300 Doses

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Editor's bottom line:

“This eye drops similasan dry eye relief is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

PRESERVATIVE AND PHOSPHATE FREE FORMULA - Made with moisturizing hyaluronic acid and glycerin, OPTASE HYLO Relief uses a phosphate and preservative free artificial tears formula for dry eye relief
NO WASTED EYE DROPS - The innovative, one-click, multi-use bottle of OPTASE HYLO Relief dry eyes eye drops provides 300 calibrated doses, while maintaining sterility for 6 months after opening
MILD TO MODERATE DRY EYE RELIEF - OPTASE HYLO Relief drops provides comfortable relief from mild to moderate dry eye symptoms. Plus, it is contact lens safe for convenient use throughout the day
INNOVATIVE BOTTLE DESIGN OPTASE HYLO Reliefs unique bottle technology releases one drop of lubricating eye drops with just a press, with no waste simply grip, position, and click
PAIR WITH OPTASE HYLO NIGHT For optimal results, use OPTASE HYLO Relief moisturizing eye drops with OPTASE HYLO Relief Nighttime Eye Gel as part of the complete line of expert dry eye relief

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Picked by 150 people today

9.5

Systane

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

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Main Highlights

#1 Dr Recommended Brand of Artificial Tears*, packaging may vary
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief.Store at room temperature
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

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9.5

Save 17%

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

17% OffFree Shipping

Main Highlights

FAST-ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: Soothes and prevents further irritation
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
ON-THE-GO VIALS: 30 sterile single-use vials per carton that are easy and safe to use as often as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

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9.2

Save 6%

Refresh

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

6% OffFree Shipping

Main Highlights

IMMEDIATE DRY EYE RELIEF: Quickly alleviates dryness, irritation, and discomfort by replenishing moisture to the eyes.
MIMICS NATURAL TEARS: Formulated to closely resemble natural tears, providing soothing and effective hydration.
CONTACT LENS COMPATIBLE: Safe for use with contact lenses, making it convenient for individuals with corrective eyewear.
GENTLE DAILY FORMULA: Non-irritating and suitable for frequent use to maintain eye comfort throughout the day.
PROTECTIVE MOISTURE BARRIER: Helps shield eyes from further dryness and irritation caused by environmental factors.

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Best Value

9.0

Save 35%

TheraTears

TheraTears Extra Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, 0.5 fl oz Bottle, 2 Count(Pack of 1)

35% OffFree Shipping

Main Highlights

Get up to 12 Hours of Hydrating Comfort; TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops provide EXTRAordinary relief for dry eyes
Discover TheraTears eye drop; one-of-a-kind silky hydration for dry eyes
Lubricating eye drops for extra dry eyes rehydrate; protect against further irritation and support a natural tear pH level
TheraTears Extra Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 2 bottles of TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops, 0.5 fl oz
FSA- and HSA-eligible product in the U.S.

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8.8

Save 5%

Biotrue

Biotrue Hydration Boost Eye Drops, Preservative Free, Soft Contact Lens Friendly for Irritated and Dry Eyes from Bausch + Lomb, Naturally Inspired, 0.33 FL OZ (10 mL)

5% OffFree Shipping

Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
CONTACT LENS FRIENDLY: Biotrue Hydration Boost Eye Drops can be applied while wearing soft contact lenses.
INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced.
EYE DROPS and MORE: Bausch and Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, and ointments to help your eyes feel moisturized and protected.

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8.6

Save 29%

iVIZIA

iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz Bottle

29% OffFree Shipping

Main Highlights

iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz bottle.
Unique Formulation: Hydrating polymers form a protective matrix, moisturizing Hyaluronic Acid holds up to 1000x its weight in moisture, and Trehalose (synthetic ingredient also found in desert plants).
Free of Irritating Preservatives: Sterile, safe for use with contact lenses
Patented ABAK Bottle: preservative-free, dispenses drop-by-drop, and does not stream. The ergonomic bottle is easy to open, easy to hold and squeeze.
iVIZIA We See a Better Way: for healthy, comfortable eyes

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8.3

Save 18%

TheraTears

TheraTears Dry Eye Therapy Eye Drops for Dry Eyes, 0.5 Fl Oz

18% OffFree Shipping

Main Highlights

TheraTears Dry Eye Therapy - Lubricant Eye Drops provide immediate, long lasting relief of dry eye symptoms
Restores Eyes Natural Balance
Unique hypotonic and electrolyte balanced formula replicates healthy tears
Preservative free in the eye
Convenient, multi-use bottle

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8.1

Visine

Visine Multi-Symptom Eye Drops - Astringent, Lubricant & Redness Reliever for Irritated, Dry, Red Eyes - 0.5 fl. oz

Free Shipping

Main Highlights

0.5-fluid ounce bottle of Visine Red Eye Total Comfort All-In-One Multi-Symptom Astringent, Lubricant & Redness Reliever Eye Drops soothe and protect against further eye irritations
Sterile moisturizing eye drops provide relief for burning, watery, itchy, gritty, dry, irritated and red eyes and contain the active ingredients zinc sulfate, polyethylene glycol & tetrahydrozoline HCl
Soothing red eye drops temporarily relieve discomfort and red eye due to minor eye irritations
These moisturizing red eye drops protect against further eye irritations
Available in a convenient size allowing for portable on-the-go use. Provides up to 10 hours of comfort

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8.1

Save 16%

Systane

Systane Ultra Lubricant Eye Drops,0.14 Fl Oz (Pack of 1)

16% OffFree Shipping

Main Highlights

Dr Recommended Brand of Artificial Tears
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

Show Price

Our Best Overall Choice

Best Choice

9.7

Optase

OPTASE HYLO Relief Dry Eye Drops - Fast-Acting Preservative Free Drops with Patented HYLO Delivery System - Artificial Tears for Mild to Moderate Dry Eye Relief - .33 Oz, 300 Doses

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

PRESERVATIVE AND PHOSPHATE FREE FORMULA - Made with moisturizing hyaluronic acid and glycerin, OPTASE HYLO Relief uses a phosphate and preservative free artificial tears formula for dry eye relief
NO WASTED EYE DROPS - The innovative, one-click, multi-use bottle of OPTASE HYLO Relief dry eyes eye drops provides 300 calibrated doses, while maintaining sterility for 6 months after opening
MILD TO MODERATE DRY EYE RELIEF - OPTASE HYLO Relief drops provides comfortable relief from mild to moderate dry eye symptoms. Plus, it is contact lens safe for convenient use throughout the day
INNOVATIVE BOTTLE DESIGN OPTASE HYLO Reliefs unique bottle technology releases one drop of lubricating eye drops with just a press, with no waste simply grip, position, and click
PAIR WITH OPTASE HYLO NIGHT For optimal results, use OPTASE HYLO Relief moisturizing eye drops with OPTASE HYLO Relief Nighttime Eye Gel as part of the complete line of expert dry eye relief

Show Price

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