10 Best Eye Drops Preservative Free Gel of 2025

Tested and Reviewed: Top 10 Eye Drops Preservative Free Gel deals with expert ratings from 8.1 to a perfect 10

June 2025 Edition

Editor's Choice

9.7

Save 8%

TheraTears

TheraTears Liquid Gel Nighttime Lubricating Eye Drops for Dry Eyes, Single-Use Vials, 30 Count

8% OffFree Shipping

Editor's bottom line:

“This eye drops preservative free gel is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

TheraTears Liquid Gel Nighttime Dry Eye Therapy Lubricant Eye Gel provides soothing overnight relief and protection for dry eyes
Discover TheraTears eye drops, one-of-a-kind silky hydration for dry eyes
TheraTears Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Preservative free for sensitive eyes; the single-use vials come in a foil pouch to ensure freshness
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 1 box of TheraTears Liquid Gel Nighttime Dry Eye Therapy Lubricant Eye Drops, 30 vials
FSA- and HSA-eligible product in the U.S.

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Picked by 213 people today

9.5

Save 17%

Refresh

Refresh Liquigel Lubricant Eye Gel Drops, 0.5 Fl Oz Sterile

17% OffFree Shipping

Main Highlights

Original strength gel formula
Relieves dry, burning, irritated eyes
Alleviates discomfort
Keeps eyes feeling better longer
Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun

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9.5

Save 10%

Systane

Systane Lubricant Eye Gel Drops, 10-mL (Packaging May Vary)

10% OffFree Shipping

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*
Thicker eye drop formulation that creates a protective shield over your eyes.
Convenience of a drop with a protection of a gel.
For the temporary relief of burning and irritation due to dryness of the eye
NOTE: PRODUCT PACKAGING MAY VARY

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9.2

Systane

Systane Nighttime Lubricant Eye Ointment 3.5g Tube

Free Shipping

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*
Provides nighttime relief of dry eye symptoms
Ointment soothes and protects against dry, irritated eyes
Forms long-lasting, protective layer on eyes while you sleep
Safe, preservative-free formula

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9.0

Save 31%

Refresh

Refresh Celluvisc Lubricant Eye Gel Drops, Single-Use Containers, 30 Count (Pack of 1)

31% OffFree Shipping

Main Highlights

Original strength gel formula
Relieves dry, burning, irritated eyes
Alleviates discomfort
Keeps eyes feeling better longer
#1 doctor recommended with over 30 years of experience.* *REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey

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8.8

Save 20%

Refresh

Refresh Optive GEL DROPS Lubricant Eye Gel Preserved Tears, 0.33 fl oz (10 mL)

20% OffFree Shipping

Main Highlights

Extended relief plus protection for dry, irritated eyes
Our most comprehensive gel formula
Anytime relief, day or night
Feels like a drop but works like a gel for lasting comfort
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
#1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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8.6

Save 26%

Refresh

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

26% OffFree Shipping

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
Value size. 50 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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8.3

iVIZIA

iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary

Free Shipping

Main Highlights

Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
Unique Formulation: Hydrating polymers form a protective matrix, moisturizing Hyaluronic Acid holds up to 1000x its weight in moisture, and Trehalose (synthetic ingredient also found in desert plants).
Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
iVIZIA We See a Better Way: for healthy, comfortable eyelids

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Best Value

8.1

Save 39%

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

39% OffFree Shipping

Main Highlights

Fast acting hydration for sensitive eyes
Preservative free tear evaporation protection
Nano droplets for better coverage

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8.1

Save 35%

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

35% OffFree Shipping

Main Highlights

FAST-ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: Soothes and prevents further irritation
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

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Our Best Overall Choice

Best Choice

9.7

TheraTears

TheraTears Liquid Gel Nighttime Lubricating Eye Drops for Dry Eyes, Single-Use Vials, 30 Count

8% OffFree Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

TheraTears Liquid Gel Nighttime Dry Eye Therapy Lubricant Eye Gel provides soothing overnight relief and protection for dry eyes
Discover TheraTears eye drops, one-of-a-kind silky hydration for dry eyes
TheraTears Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Preservative free for sensitive eyes; the single-use vials come in a foil pouch to ensure freshness
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 1 box of TheraTears Liquid Gel Nighttime Dry Eye Therapy Lubricant Eye Drops, 30 vials
FSA- and HSA-eligible product in the U.S.

Show Price

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