10 Best Eye Drops Contacts Preservative Free of 2025

Tested and Reviewed: Top 10 Eye Drops Contacts Preservative Free deals with expert ratings from 8.1 to a perfect 10

May 2025 Edition

Editor's Choice

9.7

Systane

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

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Editor's bottom line:

“This eye drops contacts preservative free is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Hydrates fast and provides long-lasting relief for dry eyes
Preservative free eye drops
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses
Extra moisturizing eye drops for sensitive eyes

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Picked by 196 people today

9.5

Optase

Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses

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Main Highlights

MOISTURIZE AND PROTECT: Made of glycerin and quality ingredients, Optase Dry Eye Intense Drops mix with the natural oils needed to protect your tears and hydrate your eyes to improve tear quality
PRESERVATIVE FREE: Optase Intense Eye Drops is the only product of its kind to provide a preservative free combination of ingredients designed to treat dry eye patients in a unique multi-dose bottle
MODERATE TO SEVERE DRY EYE RELIEF: The long lasting formulation of Optase Intense provides comfort for dry eye and post operative patients. And it is contact lens safe, providing relief when needed
ADVANCED BOTTLE TECHNOLOGY: A convenient multi-use drop bottle with advanced technology maintains sterility over 3 months without preservatives. Avoid the hassle of individual vials while on the go
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, Blepharitis and Meibomian Gland Dysfunction (MGD)

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9.5

Save 24%

Refresh

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

24% OffFree Shipping

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
Value size. 50 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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Best Value

9.2

Save 31%

Alcon

Alcon Hydration Preservative-Free Lubricant Eye Drops, Transparent, 0.7 ml, 30 Count

31% OffFree Shipping

Main Highlights

Hydrates fast and provides long-lasting relief.
Doctor and pharmacist Recommended brand
Preservative free
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses

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9.0

Biotrue

Biotrue Hydration Boost Rehydrating Contact Lens Eye Drops from Bausch + Lomb, Hydrating, Preservative Free, Naturally Inspired, 0.33 FL Oz (10 mL)

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Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost for Contacts are enhanced with HA (Hyaluronan), Antioxidant (Protects HA from free radicals), and Electrolyte.
LASTING MOISTURE: For up to 8 hours of moisture (based on a laboratory study) and to help prevent deposit buildup.
REWETTING DROPS FOR CONTACT LENSES: Biotrue Hydration Boost for Contacts are the first preservative free multi-dose contact lens drops.
BIOTRUE CONTACT LENS DROPS: Not only are Biotrue Hydration Boost for Contacts free of preservatives but they are also pH balanced for comfort.
EYE DROPS and MORE: Bausch plus Lomb makes eye care products you can trust, from contact lens solutions to eye drops, vitamins, and ointments to help your contacts and eyes feel moisturized and protected.

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8.8

Biotrue

Biotrue Hydration Boost Eye Drops, Preservative Free, Soft Contact Lens Friendly for Irritated and Dry Eyes from Bausch + Lomb, Naturally Inspired, 0.33 FL OZ (10 mL)

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Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
CONTACT LENS FRIENDLY: Biotrue Hydration Boost Eye Drops can be applied while wearing soft contact lenses.
INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced.
EYE DROPS and MORE: Bausch and Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, and ointments to help your eyes feel moisturized and protected.

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8.6

Save 22%

Refresh

Refresh RELIEVA FOR CONTACTS Lubricant Eye Drops For Use with Contact Lenses, 0.27 fl oz (8 mL)

22% OffFree Shipping

Main Highlights

Innovative formula specially designed for contact lens wearers
Relieves mild to moderate symptoms of eye dryness, irritation, and discomfort associated with contact lens wear
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
You may keep your contacts in upon application
May also be used to lubricate and rewet soft and rigid gas permeable (RGP) contact lenses and to cushion lenses prior to application

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8.3

Save 15%

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

15% OffFree Shipping

Main Highlights

TheraTears Dry Eye Therapy Lubricant Eye Drops, Preservative Free, provide immediate, long-lasting relief of dry eye symptoms
Discover TheraTears eye drops, one-of-a-kind silky hydration for dry eyes
TheraTears Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Preservative free for sensitive eyes; the single-use vials come in a foil pouch to ensure freshness
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 1 box of TheraTears Dry Eye Therapy Lubricant Drops, Preservative Free, 30 vials
FSA- and HSA-eligible product in the U.S.

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8.1

Save 25%

iVIZIA

iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.16 fl oz Bottle Packaging May Vary

25% OffFree Shipping

Main Highlights

Your Dry Eyes Deserve Better: iVIZIA Dry Eye drops are scientifically formulated to moisturize and lubricate dry eyes and relieve discomfort and eye strain due to dryness.
Unique Formulation: Hydrating polymers form a protective matrix, moisturizing Hyaluronic Acid holds up to 1000x its weight in moisture, and Trehalose (synthetic ingredient also found in desert plants).
Free of Irritating Preservatives: Sterile, safe for use with contact lenses
Patented ABAK Bottle: preservative-free, dispenses drop-by-drop, and does not stream. The ergonomic bottle is easy to open, easy to hold and squeeze.
iVIZIA We See a Better Way: for healthy, comfortable eyes

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8.1

Save 18%

BLINK

Blink Contacts Lubricating Eye Drops for Soft & RGP Contact Lenses, Lubricant Eye Drops with Hyaluronate for Hydration, Moisturizing & Comforting Daily Eye Care, 0.34 fl oz

18% OffFree Shipping

Main Highlights

Relief with Every Blink: Blink Contacts Lubricating Eye Drops moisturize dry contact lenses to provide long-lasting comfort. These drops work with the eye's natural tears to help keep your contact lenses feeling fresh and comfortable all day
Hydration Boost with Hyaluronate: Our moisturizing eye drops instantly moisturize dry lenses. Our unique hyaluronate formulate works as a hydration booster to help contacts stay refreshed and comfortable through end of day
Comfort till End of Day: Blink Contacts Lubricating Eye Drops are formulated with beneficial electrolytes similar to those found in natural tears. Enjoy the freedom to wear your soft or RGP lenses while experiencing long-lasting comfort
Moisturizes Dry Lenses: The Blink Contacts Lubricating Eye Drops rewet and moisturize lenses before insertion and during wear, moisturizing and refreshing lenses. They reduce the feeling of contact lens dryness to help maintain comfort to the end of the day
Trusted Brand: Blink has a range of products to meet your eye and contact lens care needs, from drops for dry eyes to lock in moisture, to preservative-free formulas; and contact lens drops to keep your contacts clean and hydrated.

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Our Best Overall Choice

Best Choice

9.7

Systane

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Hydrates fast and provides long-lasting relief for dry eyes
Preservative free eye drops
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses
Extra moisturizing eye drops for sensitive eyes

Show Price

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Biotrue Hydration Boost Eye Drops for Irritated, Dry Eyes in Single Dose Vials from Bausch + Lomb, Instant Moisture, Preservative Free, pH Balanced, Naturally Inspired, Pack of 30 Vials

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Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses

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