10 Best Eye Drops Chronic Dry Eyes of 2025

Tested and Reviewed: Top 10 Eye Drops Chronic Dry Eyes deals with expert ratings from 8.1 to a perfect 10

August 2025 Edition

Editor's Choice

9.7

Optase

OPTASE MGD Advanced Dry Eye Drops - Preservative Free Drops for Dry Eyes and MGD - Lipid-Based Artificial Tears - Demet Technology, Multidose Bottle, Contact Lens Safe - .33 fl oz, 300 Doses

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Editor's bottom line:

“This eye drops chronic dry eyes is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

INNOVATIVE DEMET TECHNOLOGY: OPTASE MGD Advanced Eye Drops offers a superior lubricating eye drops in an optically clear, non-blurry formula for relief from moderate to severe symptoms of MGD
LIPID BASED DRY EYE RELIEF: The advanced formulation of OPTASE MGD eye drops utilizes Sacha Inchi seed oil, a high quality, natural lipid with a balanced Omega 3 and Omega 6 ratio for maximum comfort
EFFECTIVELY MANAGE MGD SYMPTOMS: With an innovative lipid solution, OPTASE MGD strengthens, protects, and hydrates the tear film to help soothe symptoms of MGD and evaporative lipid deficiency
ADVANCED BOTTLE TECHNOLOGY: The multi-use bottle of OPTASE MGD Advanced offers 300 drops, maintains sterility over 3 months, and is preservative free and contact lens safe for convenience on the go
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, especially Meibomian Gland Dysfunction (MGD)
USE AS DIRECTED: Please note this product includes both a manufactured date and an expiration date. Always read the label, warnings, and instructions for use

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Picked by 299 people today

9.5

Optase

Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses

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Main Highlights

MOISTURIZE AND PROTECT: Made of glycerin and quality ingredients, Optase Dry Eye Intense Drops mix with the natural oils needed to protect your tears and hydrate your eyes to improve tear quality
PRESERVATIVE FREE: Optase Intense Eye Drops is the only product of its kind to provide a preservative free combination of ingredients designed to treat dry eye patients in a unique multi-dose bottle
MODERATE TO SEVERE DRY EYE RELIEF: The long lasting formulation of Optase Intense provides comfort for dry eye and post operative patients. And it is contact lens safe, providing relief when needed
ADVANCED BOTTLE TECHNOLOGY: A convenient multi-use drop bottle with advanced technology maintains sterility over 3 months without preservatives. Avoid the hassle of individual vials while on the go
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, Blepharitis and Meibomian Gland Dysfunction (MGD)

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9.5

Save 17%

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

17% OffFree Shipping

Main Highlights

FAST-ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: Soothes and prevents further irritation
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
ON-THE-GO VIALS: 30 sterile single-use vials per carton that are easy and safe to use as often as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

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9.2

Save 20%

Refresh

Refresh Optive GEL DROPS Lubricant Eye Gel Preserved Tears, 0.33 fl oz (10 mL)

20% OffFree Shipping

Main Highlights

Extended relief plus protection for dry, irritated eyes
Our most comprehensive gel formula
Anytime relief, day or night
Feels like a drop but works like a gel for lasting comfort
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
#1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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9.0

Save 9%

Systane

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

9% OffFree Shipping

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*, packaging may vary
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief.Store at room temperature
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

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Best Value

8.8

Save 35%

TheraTears

TheraTears Extra Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, 0.5 fl oz Bottle, 2 Count(Pack of 1)

35% OffFree Shipping

Main Highlights

Get up to 12 Hours of Hydrating Comfort; TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops provide EXTRAordinary relief for dry eyes
Discover TheraTears eye drop; one-of-a-kind silky hydration for dry eyes
Lubricating eye drops for extra dry eyes rehydrate; protect against further irritation and support a natural tear pH level
TheraTears Extra Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 2 bottles of TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops, 0.5 fl oz
FSA- and HSA-eligible product in the U.S.

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8.6

Save 5%

Biotrue

Biotrue Hydration Boost Eye Drops, Preservative Free, Soft Contact Lens Friendly for Irritated and Dry Eyes from Bausch + Lomb, Naturally Inspired, 0.33 FL OZ (10 mL)

5% OffFree Shipping

Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
CONTACT LENS FRIENDLY: Biotrue Hydration Boost Eye Drops can be applied while wearing soft contact lenses.
INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced.
EYE DROPS and MORE: Bausch and Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, and ointments to help your eyes feel moisturized and protected.

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8.3

Save 23%

BLINK

Blink GelTears Eye Drops for Dry Eyes, Gel Lubricating Eye Drops, Instantly Soothing, Moisturizing & Extra Long-Lasting Hydrating Eye Care for Moderate to Severe Dry Eye Symptom Relief, 0.34 fl oz

23% OffFree Shipping

Main Highlights

Relief with Every Blink: Experience immediate and long-lasting dry eye symptom relief with Blink GelTears eye drops for dry eyes. This thicker, more viscous lubricating formula is for enhanced comfort and great for daytime and nighttime use
Hydration Boost with Hyaluronate: Our gel lubricating eye drops for dry eyes instantly soothe and comfort. It contains our highest level of hyaluronate to provide longer lasting relief for moderate to severe dry eye symptoms
Day & Night Relief: Blink eye drops are formulated for daytime and nighttime use and provides superior end-of-day comfort (in an Ocular Lubricant questionnaire, comfort ratings were statistically significantly higher for Blink GelTears vs. Allergans Refresh Optive Liquid Gel after 7 days and 30 days).
Reduce Everyday Discomfort: These drops are an extra moisturizing gel for enhanced comfort. Work with every blink to restore your tears' natural balance and maximize hydration
Trusted Brand: Blink has a range of products to meet your eye and contact lens care needs, from drops for dry eyes to lock in moisture, to preservative-free formulas; and contact lens drops to keep your contacts clean and hydrated.

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8.1

Save 16%

Systane

Systane Ultra Lubricant Eye Drops,0.14 Fl Oz (Pack of 1)

16% OffFree Shipping

Main Highlights

Dr Recommended Brand of Artificial Tears
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

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Our Best Overall Choice

Best Choice

9.7

Optase

OPTASE MGD Advanced Dry Eye Drops - Preservative Free Drops for Dry Eyes and MGD - Lipid-Based Artificial Tears - Demet Technology, Multidose Bottle, Contact Lens Safe - .33 fl oz, 300 Doses

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

INNOVATIVE DEMET TECHNOLOGY: OPTASE MGD Advanced Eye Drops offers a superior lubricating eye drops in an optically clear, non-blurry formula for relief from moderate to severe symptoms of MGD
LIPID BASED DRY EYE RELIEF: The advanced formulation of OPTASE MGD eye drops utilizes Sacha Inchi seed oil, a high quality, natural lipid with a balanced Omega 3 and Omega 6 ratio for maximum comfort
EFFECTIVELY MANAGE MGD SYMPTOMS: With an innovative lipid solution, OPTASE MGD strengthens, protects, and hydrates the tear film to help soothe symptoms of MGD and evaporative lipid deficiency
ADVANCED BOTTLE TECHNOLOGY: The multi-use bottle of OPTASE MGD Advanced offers 300 drops, maintains sterility over 3 months, and is preservative free and contact lens safe for convenience on the go
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, especially Meibomian Gland Dysfunction (MGD)
USE AS DIRECTED: Please note this product includes both a manufactured date and an expiration date. Always read the label, warnings, and instructions for use

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