10 Best Exosome Serum of 2025

Tested and Reviewed: Top 10 Exosome Serum deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

The INKEY List

The INKEY List Exosome Hydro-Glow Complex, Boosts Collagen Production, Rejuvanating Skincare, Advanced Hydration, Suitable For All Skin Types

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Editor's bottom line:

“This exosome serum is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

THAT JUST HAD A FACIAL GLOW - Bringing clinic-first Exosome technology direct to your skincare routine, this breakthrough serum delivers like skincare but performs like a daily professional facial. Packed with 3-million plant-derived Exosomes in every bottle, Exosome Hydro-Glow Complex is clinically proven to visibly boost glow, smooth and renew skin in just 14 days.
POWERFUL INGREDIENTS - At 300x smaller than a pore, our plant-based Exosomes are the start ingredient and act as targeted messengers working deeper within the skins surface. This breakthrough ingredient helps to boost collagen production by 300%, reduce inflammation by 55% and improve skin repair by 63% in 8 hours***. Supported by a powerful blend of Prickly Pear extract for gentle exfoliation and 1% Kollaren to increase firmness together with Hyaluronic Acid and Ectoin for barrier support and up to 12 hours of hydration**.
FOR ALL SKIN TYPES - The creamy, lightweight texture effortlessly sinks into the skin without tackiness and layers perfectly under other skincare and makeup. Suitable for use as part of the AM and PM routine.
HOW TO USE - Use twice daily, AM & PM. Always use as your first serum after cleansing. Apply a pea-sized amount to face and neck and follow with preferred treatments and moisturizer to seal the benefits into skin. Always finish with SPF for your AM routine.
THE INKEY LIST - We believe our products should be accessible to all, but we will never compromise on quality, ensuring only the best products reach you.

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Picked by 397 people today

9.5

Seraphime

Seraphime Exosome Multi-Peptide Serum – 2% Exosomes, Argireline, Copper Peptides (GHK-CU), Oligopeptide-1 (EGF) & Hyaluronic Acid – Advanced Anti Aging Skincare Stem Cell Serum with Multi Peptide

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Main Highlights

EXOSOME TECHNOLOGY FOR SKIN IMPROVEMENT: Powered by exosomes, the natural messengers derived from stem cell science, this advanced serum supports a smoother, refreshed, and radiant-looking complexion.
MULTI-PEPTIDE COMPLEX - ARGIRELINE & COPPER PEPTIDES: Features Argireline (Acetyl Hexapeptide-8), GHK-Cu copper peptides, and sh-Oligopeptide-1 (EGF serum) to help reduce the look of fine lines and support firmer-looking skin.
HYDRATION & BARRIER SUPPORT: With dual-weight Hyaluronic Acid, Niacinamide, Panthenol, and Allantoin, lightweight serum provides lasting hydration while helping skin feel soft, supple, and balanced.
BRIGHTER GLASS SKIN: Niacinamide, Vitamin E, and Green Tea Extract help visibly improve uneven tone and protect against the appearance of dullness for a more luminous, glass-skin glow.
SCIENCE BACKED LUXURY BEAUTY: A premium advanced skincare serum formulated with peptides, antioxidants, and exosome technology. Suitable for all skin types and daily use in any beauty routine. 1 fl oz (30ml) glass bottle

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9.5

medicube

medicube Exosome Shot Zero 2,000 PPM Spicule Facial Serum | Liquid Skin Booster Serum | Exosome, AHA+BHA+PHA | Pore Care, Dead Skin Cells, Skin Texture | Korean Skincare, 1.01 fl.oz

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Main Highlights

Viral product beloved by everyone - Transform your skin with the Exosome + Shot Booster. Featuring a micro-sized, needle-shaped design and enriched with 15M patented Exosome shots for precise treatment, this booster delivers active ingredients directly to your pores to tackle various skin issues.
Exosome-Coated Technology - Harness the next-generation skincare with Exosome-coated Spicule and Exosome, penetrating deep into the skin to deliver active ingredients effectively. Our advanced formula is designed to address a range of skin concerns, from pore care to enhancing skin vitality and energy.
Superior Absorption & Hydration - Achieve unmatched hydration and absorption rates with our formula, which enhances active ingredient uptake by 242% compared to standalone use. Ingredients like Niacinamide and Panthenol boost skin barrier and improve hydration levels, ensuring your skin remains supple and radiant.
Clinically Proven & Gentle on Skin - Enjoy peace of mind with our clinically validated Tingling Ampoule that is non-comedogenic, tested to be low-irritating, gluten-free, and free from artificial colors. Suitable for all skin types, including sensitive skin.
Easy to Integrate into Skincare Routine - Apply our Tingling Ampoule easily with a three-step routine, starting with a cleansing pad, followed by the Zero One Day Exosome Shot, and finish with a water-based moisturizer like Medicubes Collagen Jelly Cream. For an added boost, use after the "Air Shot Mode" of the AGE-R Booster Pro to maximize effects.

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9.2

medicube

medicube Exosome Shot Zero 7,500 PPM Spicule Facial Serum | Liquid Skin Booster Serum | Exosome, AHA+BHA+PHA | Pore Care, Dead Skin Cells, Skin Texture | Korean Skincare, 1.01 fl.oz

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Main Highlights

Viral product beloved by everyone - Transform your skin with the Exosome + Shot Booster. Featuring a micro-sized, needle-shaped design and enriched with 15M patented Exosome shots for precise treatment, this booster delivers active ingredients directly to your pores to tackle various skin issues.
Exosome-Coated Technology - Harness the next-generation skincare with Exosome-coated Spicule and Exosome, penetrating deep into the skin to deliver active ingredients effectively. Our advanced formula is designed to address a range of skin concerns, from pore care to enhancing skin vitality and energy.
Superior Absorption & Hydration - Achieve unmatched hydration and absorption rates with our formula, which enhances active ingredient uptake by 242% compared to standalone use. Ingredients like Niacinamide and Panthenol boost skin barrier and improve hydration levels, ensuring your skin remains supple and radiant.
Clinically Proven & Gentle on Skin - Enjoy peace of mind with our clinically validated Tingling Ampoule that is non-comedogenic, tested to be low-irritating, gluten-free, and free from artificial colors. Suitable for all skin types, including sensitive skin.
Easy to Integrate into Skincare Routine - Apply our Tingling Ampoule easily with a three-step routine, starting with a cleansing pad, followed by the Zero One Day Exosome Shot, and finish with a water-based moisturizer like Medicubes Collagen Jelly Cream. For an added boost, use after the "Air Shot Mode" of the AGE-R Booster Pro to maximize effects.

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9.0

medicube

medicube Exosome Shot PDRN Pink Collagen 7,500 PPM Spicule Facial Serum | Liquid Skin Booster | Exosome, Salmon DNA Spicules | Uneven Skin Tone, Pore Care, Skin Texture | Korean Skincare, 1.01 fl.oz

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Main Highlights

Korean Glass Glow Skin: medicube PDRN Pink Collagen Exosome serum targets textured, rough skin, helps to resurface the skin, and boosts elasticity while enhancing the skin's glow and resilience.
PDRN Collagen Exosome-Coated Formula: Experience next-generation skincare with Exosome-coated Spicules, Salmon PDRN, and Collagen, specially designed to deliver active ingredients effectively. Our advanced formula targets a range of skin concerns, from pore care to boosting skin vitality and energy.
Superior Absorption & Hydration: Infused with 7,500 PPM of spicules, these tingly agents enhance the delivery of the serum's benefits. Enriched with Niacinamide, Salmon PDRN, and Collagen, this formula boosts hydration, leaving your skin supple and radiant.
Salmon DNA PDRN: Salmon DNA PDRN is a form of DNA extracted from salmon. It is known for its beneficial properties, supporting skin vitality and contributing to a clearer, more luminous complexion. It helps promote a more even skin tone and a natural glow by enhancing overall skin health. *Based on raw material properties only
Hydrating, Lightweight Formula: The PDRN Pink Collagen Exosome Shot Serum is formulated with a lightweight and watery texture, offering a pleasant application experience. For first-time users of products containing spicules, it is recommended to start with a concentration of 2,000 PPM.

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8.8

SkinMedica

SkinMedica TNS Recovery Complex - Fibroblast-Derived Skincare Technology Containing Exosomes and Growth Factors to Visibly Improve Fine Lines, Wrinkles, NEW PACKAGING, 1 Oz

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Main Highlights

The first fibroblast-derived exosome product.
TNS Recovery Complex was the first fibroblast-derived skincare technology containing exosomes and growth factors.
Contains the highest concentration of a patented growth factor blend to help visibly minimize signs of aging.
Use TNS Recovery Complex as an exosome-powered boost when paired with TNS Advanced+ serum.

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8.6

Dr.nineteen

Dr.nineteen ReDRN Exosome AmpouleㅣBiome PDRN 750,000ppm + Retinol + ExosomeㅣFace Serum for Pore Tightening & FirmingㅣKorean Skin Care (0.50 fl.oz. X 2EA)

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Main Highlights

Clinically Inspired Pore Care: Inspired by professional Korean skincare treatments; provides targeted care to improve the appearance of pores and skin texture
High-Purity BIOME PDRN: Contains 750,000ppm of vegan PDRN complex; supports skin barrier function and helps improve skin elasticity
Triple Complex Formula: Features a combination of PDRN, exosome, and retinol; designed to improve the appearance of skin firmness and texture
Gentle and Vegan-Friendly: Formulated with ingredients suitable for all skin types; dermatologist-tested and free from animal-derived ingredients
SkinMagnet Technology: Uses positively charged delivery system designed to support absorption and improve skin feel; helps reduce stickiness and maximize product performance

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8.3

medicube

Medicube Exosome Cica Tea Tree Ampoule for Sensitive Skin with Centella Asiatica help reduce redness and breakouts. Low-irritating, Moisturizing & Soothing Serum | Korean Skincare | 30ml

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Main Highlights

POWERFUL YET GENTLE SOOTHING AMPOULE: Calm all skin troubles with exosomes containing Centella Asiatica delivering powerful soothing effects and smoothing the skin texture.
ENRICHED WITH INNOVATIVE INGREDIENT : Contains exosome cica, Nano-sized ingredient smaller than pores with 5.3 times more powerful soothing effect than general cica. *Clinical Trial Tested by 'ICBIO Co., Ltd'
SUITABLE FOR TROUBLED SKIN: Exosome Cica and Tea Tree Leaf Water help soothe and hydrate troubled, textured areas for glass glow skin.
LIGHTWEIGHT: Refreshing, fast-absorbing texture that locks in long-lasting hydration without greasiness.
FOR ALL SKIN TYPE : Low-irritating toner pad suitable for all skin type. Perfect daily serum ampoule for gentle & mild soothing care. Perfect for AM & PM use.

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8.1

VT COSMETICS

VT COSMETICS CICA Reedle Shot 300, Advanced Night Exosome, Microneedling Serum, Centella Asiatica, Hyaluronic Acid, Propolis, Soft Skin, Regeneration, Glass Skin, Korean Skin Booster 1.69Fl Oz (50ml)

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Main Highlights

* While using our Reedle Shot essence, you may feel a slight tingling sensation, which is completely normal and indicates skin improvement. Rest assured, it contains 'cica reedle' for soothing benefits. To minimize the tingling, try applying tone
[Step Zero] Reedle Shot is your 'Step Zero' in skincare. Keep your routine the same, but adding Reedle Shot as the first step will make a noticeable difference!
[Korean Glass Skin ] Support the skins natural renewal process, promoting the gentle release of accumulated impurities over time. No remnants remain.
[For All Skin Types ] Designed with the delicate balance even for sensitive skin to blemish skin. Its recommended to use Mild 50 and 100 can be used for the beginners
[Exosome Skin Care Booster] On a cleansed face, use Reedle Shot first, and then followed by VTs essence or cream. The Reedle Shot will enhance the absorption of nutrients, ensuring a more nourished and vibrant complexion.
[Effortless Home Skincare ] Reedle Shot's micro-needling mechanism promotes instant skin enhancement for a smoother, softer feel. It's easy to apply and boosts absorption for moisturizers, replacing cumbersome treatments with a convenient, at-home solution!

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8.1

VT COSMETICS

VT COSMETICS PDRN Cica Exosome Ampoule, Firming Serum with Peptide & Ceramide for Anti-Aging, Wrinkle Care, Plumping, Hydration & Radiant Glow, For All Skin Types, Korean Skincare (1.01 fl. oz.)

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Main Highlights

Intensive Firming & Anti-Aging Serum Combines PDRN, peptide, and ceramide to visibly reduce fine lines and improve skin elasticity for a youthful appearance.
Deep Hydration & Moisture Barrier Support Delivers long-lasting moisture while strengthening the skin barrier with ceramide and cica-derived ingredients.
Radiant Glow & Plumping Effect Enhances skin luminosity and provides a naturally plumped look, perfect for dull or tired skin.
Lightweight, Fast-Absorbing Formula Smooth, non-sticky ampoule texture absorbs quickly into the skin, making it ideal for daily use under makeup.
Suitable for All Skin Types, Including Sensitive Skin Gentle formulation offers calming benefits while delivering powerful anti-aging care.

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Our Best Overall Choice

Best Choice

9.7

The INKEY List

The INKEY List Exosome Hydro-Glow Complex, Boosts Collagen Production, Rejuvanating Skincare, Advanced Hydration, Suitable For All Skin Types

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

THAT JUST HAD A FACIAL GLOW - Bringing clinic-first Exosome technology direct to your skincare routine, this breakthrough serum delivers like skincare but performs like a daily professional facial. Packed with 3-million plant-derived Exosomes in every bottle, Exosome Hydro-Glow Complex is clinically proven to visibly boost glow, smooth and renew skin in just 14 days.
POWERFUL INGREDIENTS - At 300x smaller than a pore, our plant-based Exosomes are the start ingredient and act as targeted messengers working deeper within the skins surface. This breakthrough ingredient helps to boost collagen production by 300%, reduce inflammation by 55% and improve skin repair by 63% in 8 hours***. Supported by a powerful blend of Prickly Pear extract for gentle exfoliation and 1% Kollaren to increase firmness together with Hyaluronic Acid and Ectoin for barrier support and up to 12 hours of hydration**.
FOR ALL SKIN TYPES - The creamy, lightweight texture effortlessly sinks into the skin without tackiness and layers perfectly under other skincare and makeup. Suitable for use as part of the AM and PM routine.
HOW TO USE - Use twice daily, AM & PM. Always use as your first serum after cleansing. Apply a pea-sized amount to face and neck and follow with preferred treatments and moisturizer to seal the benefits into skin. Always finish with SPF for your AM routine.
THE INKEY LIST - We believe our products should be accessible to all, but we will never compromise on quality, ensuring only the best products reach you.

Show Price

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