10 Best Ergonomic Computer Mice of 2025

Tested and Reviewed: Top 10 Ergonomic Computer Mice deals with expert ratings from 8.1 to a perfect 10

June 2025 Edition

Editor's Choice

9.7

Anker

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse For Work, Multi-Device Connectivity, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC - Black

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Editor's bottom line:

“This ergonomic computer mice is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.

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Picked by 189 people today

9.5

JYKEYMOUT

JYKEYMOUT Bluetooth and 2.4G (2-in-1) Rechargeable Wireless Mouse, Ergonomic Vertical Design, 1000/1200/1600 DPI, 6 Silent Buttons, for Laptop, Computer, PC, MacBook, Chromebook-Black

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Main Highlights

2-in-1 (Bluetooth & 2.4G) Dual ModeThe wireless PC mouse features both Bluetooth (5.2/3.0) and 2.4GHz USB modes. Opt for Bluetooth mode to connect to a laptop or tablet, saving a USB-A port. Especially convenient for MacBook Pro without USB port. Or choose the 2.4GHz USB mode, simply plug in the USB receiver for quick connection without the pairing process. Effortlessly switch between the two modes with the press of a button for flexible use according to your needs.
Simultaneous Connection to 2 DevicesOne JYKEYMOUT mouse could simultaneously connect to 2 devices. One device connects via Bluetooth, the other via USB. With just a simple press of a button, seamless switching between them. No need for repetitive USB plugging or Bluetooth pairing. Widely compatible with various devices and systems, including Windows/ Mac/ Chrome/ Linux/ Android/ laptop/ desktop/ smartphone.
Ergonomic DesignErgonomic vertical mouse promotes a neutral handshake position for the right hand, reducing wrist and arm pressure for lasting comfort. Optical tracking technology with 1000/1200/1600 DPI resolution ensures smooth and precise tracking on various surfaces.
Quiet Clicking - Quick BrowsingThe wireless computer mice features 6 silent buttons, ensuring nearly soundless clicks. Won't disturb family members' sleep or disrupt colleagues' work. The "Back" and "Forward" function buttons enable faster web browsing(not compatible with Mac OS). Especially suitable for home, office, library, conference room, airplane, and other places.
Rechargeable FeatureThe ergo mouse is built in a high-capacity rechargeable battery (Note: To protect the battery, please avoid using a fast charging adapter and refrain from charging for extended periods after reaching full charge). A full charge can be used for about 1-3 months (actual time depends on habits and frequency). It charges via a Type-C interface and comes with a charging cable, saving on battery replacement costs. After the mouse is idle for 10 minutes, it will enter power-saving mode, during which the cursor cannot be moved. Pressing any key will wake up the mouse, and the LED light will light up.

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Best Value

9.5

Save 41%

TECKNET

TECKNET Wireless Mouse, 2.4G Ergonomic Optical Mouse, Computer Mouse for Laptop, PC, Computer, Chromebook, Notebook, 6 Buttons, 24 Months Battery Life, 2600 DPI, 5 Adjustment Levels

41% OffFree Shipping

Main Highlights

Compact Design, Travel Friendly - With the dimension of 4.09*2.68*1.49 in, this compact mouse provides more portability and a better travel experience. Only compatible with USB-A Port Devices.
Ergonomic Design, Comfort Grip - The contoured shape of this mouse is ergonomically designed to fit the natural curve of your hand, ensuring lasting comfort and productivity. Featuring rubber side-grips, it offers added thumb support for a superior working experience.
Advanced Optical Tracking - Featuring 5-level adjustable DPI (800/1200/1600/2000/2600), this mouse provides high-performance precision and smart cursor control on most surfaces. ( Glass surface is Not included )
24 Months Battery Life - Combined with a power-saving mode and on/off switch, this efficiently engineered mouse grants you up to 24 months of battery life.
Plug and Play - Simply plug the USB-A mini-receiver into your Windows, Mac, Chrome OS, or Linux computer and enjoy seamless connectivity up to 49 feet.
Notice - Please be aware that the AAA batteries are not included. The USB receiver is stored at the back of the mouse.

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9.2

Save 15%

TECKNET

TECKNET Ergonomic Mouse Wireless, Rechargeable Mouse Wireless Silent for Carpal Tunnel Right Hand, 2.4GHz USB Vertical Mouse Wireless for Laptop, 5 Adjustable 4800 DPI, Computer, MacBook, Desktop

15% OffFree Shipping

Main Highlights

Ergonomic Design: This ergonomic mouse promotes a natural wrist and arm position, minimizing hand fatigue from prolonged use. With a vertical layout, the vertical mouse aids in maintaining a comfortable posture, reducing shoulder and neck strain.
Long-Lasting & Rapid Charging: Equipped with a 600mAh battery, the ergonomic mouse wireless fully charges in 1.5 hours via Type-C (cable included). The vertical mouse delivers a 2-month runtime per charge(depending on the actual frequency of use).
Stable Wireless Vertical Mouse: 2.4 GHz technology ensures reliable 10m connectivity with zero interference. Plug-and-play via nano USB receiver (no drivers required). Ergonomic design maintains seamless productivity for office/remote professionals.
Silent Ergonomic Mouse Wireless: Silent-click tech eliminates noise in shared spaces (libraries/offices/homes). The vertical mouse is perfect for mobile workers in noise-sensitive environments, blending ergonomic comfort with wireless convenience.
Adjustable DPI Vertical Mouse: 5-step 4800-800 DPI adapts to tasks/habits. Tru-Wave optical tracking surpasses traditional mice with enhanced sensitivity, ensuring precision on multiple surfaces (excluding glass). Professional-grade responsiveness for graphic design/office workflows.
Wide Compatibility: 2.4GHz ergonomic mouse wireless ensures stable connectivity with USB-A devices (desktops/laptops/PCs). The vertical mouse seamlessly fits most computer models featuring USB-A port interfaces but excludes USB-C.
Power Saving Mode: The ergonomic mouse wireless Features an automatic sleep mode that automatically turns off and saves power after 8 minutes of inactivityclick any button to reactivate the vertical mouse.

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9.0

Save 7%

ProtoArc

ProtoArc Ergonomic Vertical Mouse, EM11 NL Rechargeable Wireless Mouse Bluetooth, Ergo Mice with 3 Multi-Device for PC/Notebook/Laptop, 2.4GHz Optical Mice for Windows, Mac OS, Black

7% OffFree Shipping

Main Highlights

Connect up to 3 Devices: This ergonomic wireless mouse features dual BT 5.0 and 2.4G USB connectivity modes for simultaneous connection of up to 3 different devices, and is compatible with Windows 8, Windows 10 or higher, Mac OS X 10.12 or higher, and Android 4.3 or higher
Rechargeable Ergonomic Mouse: The Bluetooth Vertical Mouse has a built-in 500mAh Li-Ion battery that can be conveniently recharged using the included Type-C cable
Ergonomic Vertical Design: The ergonomic mouse wireless keeps your wrist naturally straight, putting your forearm and wrist in a more natural and relaxed position, which can reduce overall fatigue compared to a standard mouse. Warm tips: We encourage you to relax your palm and hold the mouse naturally when using a vertical mouse
Warm tips: Since it takes a learning curve to get used to the shape when using our ergonomic mouse for the first time, it may cause inconvenience to your mouse grip, We recommend that you take 1-2 weeks to get used to it, as many users find that it will help reduce the pressure and pain on your wrist caused by long-term use of the mouse and improve comfort
Notes: We recommend that small to medium hands use our ergonomic vertical mouse. Please measure the size before ordering for a better fit and more comfort
Adjustable Dpi & High Performance: 1000/1600/2400 DPI levels provide higher sensitivity than standard optical mice for precise optical tracking; with the back and forward buttons, you can easily navigate websites and increase work efficiency. Note: All buttons are not programmable and the forward and back buttons are not compatible with Mac OS systems
Silent Clicking Sound: Our vertical mouse's whisper-quiet clicking helps you focus on what's important without any noise distractions. Therefore, it is perfect for shared workspaces such as offices or libraries

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8.8

Save 38%

Lekvey

Lekvey Ergonomic Mouse, Vertical Wireless Mouse - Rechargeable 2.4GHz Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Levels 6 Buttons, for Laptop, PC, Computer, Desktop, Notebook etc, Black

38% OffFree Shipping

Main Highlights

Ergonomic, Sleek and Rechargeable Design: Scientific ergonomic design encourages healthy neutral " handshake " wrist and arm positions for smoother movement and less overall strain
Multifunction and Convenient: Advanced " Page Back " and " Page Forward " functionality buttons provide convenience when web page browsing. 800 /1200/1600 DPI Levels -- Easily adjusts the sensitivity of the mouse
High-Capacity Rechargeable Battery: Built-in rechargeable battery. You no longer need to buy batteries, very convenient !! Easy To Use -- One nano USB receiver at the bottom of the mouse, Just Plug and Play
Widely Compatible: Widely compatible with Windows 2000 / XP / Vista / 7 / 8 / 10 / Linux. ** Note: Not compatible with Mac OS, Apple Products. ** Once you get used to the ergonomic mouse, you will love it so much
Lekvey Wireless Ergonomic Mouse: Revolutionize your work experience! Are you tired of using traditional mice that strain your wrist? Say goodbye to discomfort and hello to the Lekvey wireless carpal tunnel mouse! Designed with your ergonomic needs in mind, this innovative vertical ergonomic mouse offers a whole different level of comfort and efficiency

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8.6

Save 21%

TECKNET

TECKNET Ergonomic Mouse, Wireless Bluetooth Vertical Mouse, 4800 DPI Optical Tracking, 6 Adjustable DPI, Quiet Clicks, 2.4GHz with USB A Receiver, 6 Buttons, Wide Compatibility - Black

21% OffFree Shipping

Main Highlights

Seamless Switching Between Three DevicesThe ergonomic mouse features Bluetooth (5.0/3.0) and 2.4GHz USB A modes for connectivity. When connected via Bluetooth, The vertical mouse can effectively reduces the usage of your USB-A port (Bluetooth mode can connect to two devices simultaneously), which is convenient for devices without USB ports. To switch to 2.4GHz mode, simply plug in the USB receiver for quick connection without the need for additional software installation. With just a press of a button, you can easily switch between these two modes, enhancing your work efficiency (Note: The 2.4GHz receiver is built into the bottom of the mouse).
Higher DPI & 6 Adjustable LevelsThis vertical ergonomic mouse is equipped with a high-performance chip and features 6 adjustable DPI levels (4800/3200/2400/1600/1200/800) to meet your daily needs. wireless mouse upgraded technology allows this ergonomic mouse to operate smoothly on different types of surfaces. When changing the DPI, the light will flash, with the number of flashes corresponding to the DPI level.
Silent MouseThis computer mouse operates quietly, allowing for usage even in quiet environments like libraries. Additionally, the vertical mouse provides nearly silent clicks, helping avoid disturbances to others and ensuring your work or study remains undisturbed (Note: Only the left and right click buttons of the mouse are silent; other function buttons are not silent).
Ergonomic DesignThe wireless mouse's ergonomic design offers ultimate comfort by placing your palm at a near-vertical angle on the desktop, reducing pressure and pain on your wrist caused by prolonged inverted mouse usage (Note: Mouse is designed for right-handed use only).
Broad Compatibility and Low Battery WarningThe wireless computer mouse is compatible with various devices, including Windows, Mac, Chrome, and Linux laptops (side buttons are not compatible with macOS). Additionally, the bluetooth mouse for laptops enters power-saving mode (completely cutting off power) after being idle for about 8 minutes; you can awake it by pressing the right or left button. Note: We recommend using branded batteries to ensure the mouse's longevity. When the battery is low, the LED light will blink (2 AAA batteries not included).
36 MONTHS WARRANTYIf you encounter any problems in using the product, please feel free to contact our professional customer service team, enjoying TECKNET 36 Months Warranty (Registered Only).

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8.3

Save 24%

Logitech

Logitech M575 Ergonomic Wireless Trackball USB Mouse, Black (910-005869)

24% OffFree Shipping

Main Highlights

Ergonomic comfort design, relaxed hand and arm: The comfortable, sculpted ergonomic shape naturally fits your hand.
Smooth thumb control, precise tracking: Great cursor control on any surface. Adjust the cursor speed with Logitech Options software.
Perfect for tight workspaces: Because the trackball doesnt move, its perfect for tight workspaces and busy desks.
2 ways to connect and multi-OS: Connect simply with Bluetooth or the USB receiver and never worry about drop-offs or lag up to a 33 ft (10m) range. Nominal value: 400 dpi
Plastic parts in ERGO M575 include post consumer recycled plastic (Graphite/Black: 50%, Off-White: 21%). Uses FSC-certified paper for responsible packaging.

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8.1

Save 6%

Logitech

Logitech Lift Vertical Ergonomic Mouse, Wireless, Bluetooth or Logi Bolt USB receiver, Quiet clicks, 4 buttons, compatible with Windows/macOS/iPadOS, Laptop, PC - Graphite

6% OffFree Shipping

Main Highlights

Lift yourself up: When the desk life gets you down, lift yourself up with Logitech Lift Vertical Ergonomic Mouse - a great fit for small to medium right hands
Raise your hand into comfort: Rest on Lift upright mouse throughout the day, with a softly textured grip and snug thumb rest for level-above coziness
57 degrees of sooooothe: Lifts vertical shape helps wrists feel like ahhh at work, and promotes a more natural posture in the forearm, for day-long comfort and productivity
Relax into focus: Settle into work with a wireless computer mouse featuring easy-to-reach customizable buttons, whisper-quiet clicks, and a SmartWheel for smooth, seamless scrolling
Ergo-certified: Lift wireless vertical mouse has been designed, developed, tested, and approved according to criteria set out by leading ergonomists
Connect your way: Connect via Bluetooth Low Energy or Logi Bolt USB to Windows, macOS, iPadOS, Chrome OS, or Linux, and enjoy up to 2 years battery life
Plastic parts in Lift include certified post consumer recycled plastic (Graphite: 70%, Off-White and Rose: 54%(6)).

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8.1

Save 16%

Logitech

Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite

16% OffFree Shipping

Main Highlights

Logitech MX Vertical Wireless Ergonomic Mouse is a great fit for medium to large size right hands
NATURAL HANDSHAKE POSITION: MX Verticals natural handshake position reduces muscular activity by 10 percent compared to a standard mouse without any loss in overall performance
57° VERTICAL ANGLE FOR IMPROVED WRIST POSTURE: MX Verticals unique 57° vertical angle reduces the pressure on your wrist, while your thumb is positioned comfortably on the thumb rest
USER TESTED. ERGONOMIST-APPROVED: MX Vertical has been designed and tested with criteria set out by leading ergonomists improve posture, lower muscle strain, and reduce wrist pressure
ADVANCED OPTICAL TRACKING WITH CURSOR SPEED SWITCH: The 4000 DPI high-precision sensor results in 4x less hand movement and reduces fatigue. The cursor speed switch instantly adjusts DPI speed and accuracy with the touch of a button
COMFORT FORM WITH TEXTURED SURFACE: MX Vertical is shaped for the human hand and smooth to the touch. Its unique form fits a variety of hand shapes and sizes, and the textured rubber surface assures a natural grip
Uses FSC-certified paper for responsible packaging

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Our Best Overall Choice

Best Choice

9.7

Anker

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse For Work, Multi-Device Connectivity, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC - Black

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.

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