10 Best Enzyme Cleaners of 2025

Tested and Reviewed: Top 10 Enzyme Cleaners deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

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Editor's bottom line:

“This enzyme cleaners is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen enzyme cleaner for dog urine
Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen enzyme cleaner for dog urine
Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx

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Picked by 397 people today

9.5

Zeiff

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Pet Stain and Odor Remover, Drain Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce

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Main Highlights

Pro Grade Clean - Zeiff Pro-Grade Formulas are innovative, unique proprietary solutions, trusted by professionals and consumers for being the most effective cleaning products to get the job done. Whether youre a pro or just expect pro-grade results, Zeiff delivers Pro Grade Clean
Powerful Cleaning Performance - Our super strength proprietary formulation breaks up and digests complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease and grime without leaving any visible residue. Don't just expect clean, expect Zeiff Clean! You'll know it when you see it, clean you didn't even know exists
Multi-Purpose Enzyme Cleaner - The drain odor eliminator is a special blend of powerful bacterial enzymes, detergent and deodorant, that prevents clogging in drains, garbage disposals, grease traps, sinks, toilets, urinals, septic tanks, drain lines and downpipes. The floor and carpet stain remover cleans stains, odors, carpets, upholstery, fabric, laundry, floors, hardwood, laminate, kitchen & bathroom surfaces, and much more. Ideal for Professional and Home use
Deodorizer & Odor Eliminator - The dog enzyme cleaner and pet odor eliminator for home is a highly concentrated bacterial digestant for grease, stains, oils, & organic waste. The pet urine enzyme cleaner effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage and grease, leaves long-lasting freshness, with a subtle fresh breeze that instantly refreshes any space with a pleasant aroma, great pet enzyme urine cleaner and cat odor eliminator
Safe & Effective - Zeiff Pro Grade Formulas are safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and dyes, pH neutral, paraben-free, pet safe, cruelty-free. Proudly made in the USA

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9.5

ACTIVE

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

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Main Highlights

Powerful Bio Enzymatic Cleaner: ACTIVE Laundry Odor Removers Boost your normal laundry detergent to effectively target Stains & Odors, not mask them like washing soda or in-wash scent boosters. It uses Lab-proven Biological Cleaning to remove laundry odor & strong smell
Heavy Duty Stain Remover for clothes: Our Enzyme Laundry Additive Powder is formulated for Stain Removal of dirty clothes, perfect for Funk, Grease, Armpit Sweat stain, Blood stain, Oil and more!
Gentle on All Fabrics: Our Fragrance Free Laundry Boost Plant-based Formula uses zero harsh chemicals. Natural enhancer for whites & colors. Even safe for pesky activewear fabrics
Value 64 Load Package: ACTIVE Enzyme Cleaner Concentrated 32-oz size is good for 64 Loads compared to other products with 1 lb or less
Compatible with all Washers & Detergents: Add Laundry Booster Powder to your usual detergent & cleaners! HE, Front & Top load Washer Approved. Also use as laundry soak pretreat powder in order to treat set-in stain

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9.2

Bioda

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

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Main Highlights

THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
MADE IN THE USA - 1 Gallon Bottle

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9.0

Nature's Miracle

Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

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Main Highlights

SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.
ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
TRUSTED BRAND: From the maker of Natures Miracle products, the pet stain and odor removing brand you trust because it works!
SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.

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8.8

GELEAN

GELEAN Multi-Purpose Probiotic Enzyme Citrus Cleaner, 64oz - Pet Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, Made in USA

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Main Highlights

MULTI-PURPOSE FORMULA: Professional-strength enzymatic cleaner designed for surfaces including floors, bathrooms, toilets, drains, and trash cans
PROBIOTIC TECHNOLOGY: Uses natural enzyme-producing probiotics to break down stains, grime, and organic matter at a microscopic level
ODOR ELIMINATION: Effectively neutralizes unpleasant smells including pet odors and waste-related smells rather than masking them
PROFESSIONAL STRENGTH: Concentrated gallon-size formula provides superior cleaning power for both commercial and residential applications
VERSATILE USE: Suitable for multiple surfaces including tile, porcelain, concrete, and sealed floors while being safe for regular use

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8.6

Biokleen

Biokleen Bac-Out Enzyme Cleaner Spray and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 32 Ounces

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Main Highlights

Destroys stains and odors safely and naturally with an unique blend of live enzyme cultures, botanicals, and plant-based surfactants
Full Strength Formula is ready to use - No diluting required
Eco-Friendly, Non-Toxic, Plant-Based, No Artificial Fragrance, Colors or Preservatives
Great on pet accidents, wine, diapers, laundry, drains, carpets, and much more
Kind to those with chemical sensitivities and allergies
Preferred by commercial carpet cleaners nationwide
No negative effects on rivers, streams, plants or wildlife
Made in the USA

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8.3

Biokleen

Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

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Main Highlights

STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts

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8.1

Resolve

Resolve Pet Expert Stain and Odor Remover, Carpet Cleaner, Pet Stain and Odor Remover, Carpet & Upholstery Cleaner - Removes Stains and Odors, 22 oz

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Main Highlights

1. DESTROYS URINE ODORS THE FIRST TIME Urine elimination technology neutralizes and removes odors on contact for immediate freshness
2. REMOVES PET STAINS AND MORE Penetrates deep to lift and remove tough pet stains like feces, vomit, dirt and their odors
3. HELPS PREVENT REMARKING Discourages pets from returning to make a mess in the same spot
4. SAFE FOR ALL SOFT SURFACE AREAS Effective of carpets, upholstery, and area rugs for versatile cleaning.
5. FROM THE #1 PET MESS CLEANING BRAND*: Trusted by pet owners for superior cleaning performance. *Based on unit sales of pet mess cleaning products ending latest 52 weeks 6/15/24
6. SUITABLE TO USE AROUND PETS: Suitable for Use Around Pets: Suitable for use around cats & dogs when used as directed

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8.1

AmazonCommercial

AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack

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Main Highlights

1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments
Breaks up complex organic proteins, pet smells and stains, hair, grease, oils, and more for effective results
Ideal for commercial properties, retail, and hospitality
Use as needed on stains and problem areas for spot cleaning carpet, surfaces, drains, toilets, grease traps, and more

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Our Best Overall Choice

Best Choice

9.7

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen enzyme cleaner for dog urine
Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen enzyme cleaner for dog urine
Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx

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