10 Best Enzyme Cleaners of 2025

Tested and Reviewed: Top 10 Enzyme Cleaners deals with expert ratings from 8.1 to a perfect 10

August 2025 Edition

Editor's Choice

9.7

Pestco Products

Enz-O-Matic Enzyme Drain Cleaner - Organic Enzyme-Based Waste Degrader And Odor Neutralizer - 1 Gallon Bottle 128 Fl Oz - Multi-Purpose Enzyme Cleaner - Clean Fresh Scent - Bathroom Accessories

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Editor's bottom line:

“This enzyme cleaners is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Organic Waste Degrader - Helps prevent build up of organic waste and matter, including food particles, grease, soap scum, urine salts and other organic waste residues, reducing unpleasant odors.
Advanced Biological Enzyme Action Formulate - Utilizes a specialized blend of natural biological enzyme-acting bacteria to accelerate the degradation process, ensuring thorough waste breakdown.
Safe And Eco-Friendly - Formulated with environmentally friendly ingredients, this waste degrader is non-toxic, making it safe for use around people, pets and ecosystems.
Versatile Applications - Ideal for homes and businesses, addressing waste and odor issues in drain lines, floor drains, grease traps, garbage disposals, sinks, toilet bowls, urinals, septic systems and more.
Long-Lasting Results - A gallon-sized bottle offers ample supply for extended use, providing ongoing waste management and odor control with each application.
Pleasant Fragrance And Effective Odor Control - With its pleasant Kleenaire fresh laundry scent and odor neutralizing ingredients, Enz-O-Matic smells great and is ideal to deodorize all types of odors.
Additional Details - Contains over 200 billion live bacterial cultures per gallon of concentrate. Its non-pathogenic, live bacteria cultures produce enzyme-action to rapidly degrade all forms of organic wastes.

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Picked by 204 people today

9.5

Simple Solution

Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz

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Main Highlights

PET STAIN AND ODOR REMOVER: Things can get a little messy when your pet is involved - thats where we come in; This extra-strength cleaning solution is specially formulated to tackle the toughest smells & dirtiest spots left behind by your beloved pets.
EXTREME ENZYMATIC CLEANER: This professional strength spray consists of a powerful enzyme formula three times stronger than our regular formula, specialized for breaking down, eliminating, and permanently neutralizing both new and old stains and odors.
FOR DOGS AND CATS: Say goodbye to bad messes - This dog and cat-specific cleaning spray is the best thing for cleaning up after urine, feces, vomit, and all the stains and smells that accompany them; It is a pet-safe and family-friendly cleaning option
MULTIFUNCTION SPRAY: This cleaner can be used for carpets, upholstery, bedding, fabric toys, clothing, & other water-safe surfaces in your home; It uses a patented 3-in-1 nozzle with mist, foam, and stream features so you can pick the best way to clean up
SIMPLE SOLUTION: its just thata simple solution to all of your pets messes wherever they may be; We offer easy-to-use, no-hassle products that will effectively help you keep your home clean and sparkling; In short - pet parenting made easy.

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9.5

Nanoskin

Nanoskin ENZYME Multi-Purpose Cleaner & Odor Eliminator 16 Oz. - Removes Complex Organic Stains, Dirt, Grease, and Grime from Multi Surfaces | For Automotive, Floor, Kitchen, Bathroom, Plumbing

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Main Highlights

COMBAT ORGANIC MESSES : Enzyme cleaner emits enzymes to break down molecules found in organic material like grass, blood, urine, vomit feces, and food. Once it breaks the molecules down into smaller pieces, the raising agent swoops in to consume those molecules.
MULTI-PURPOSE: Proprietary blend of enzymes breaks up complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease, and grime without leaving any visible residue. Don't just expect clean, expect Enzyme Clean!
MULTI-SURFACE: Nanoskin Enzyme has a special blend of beneficial enzymes, detergent, and deodorant, prevents clogging in drains, grease traps, septic tanks, drain lines, and downpipes and cleans stains, odors, carpets, floors, kitchen & bathroom surfaces, and much more. Ideal for professional detailer and home use.
ELIMINATE FOUL ODORS: Effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage, and grease and leaves long-lasting freshness. Nanoskin Enzyme is fragrance free with no artificial fragrance to cover the odor. Safe to use around pets and children.
EASY & SAFE TO USE: Ready-to-Use formula. Nanoskin Enzyme is formulated to be safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and staining dyes, pH neutral, paraben-free. Unique proprietary solutions, trusted by professionals and consumers.

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9.2

Resolve

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

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Main Highlights

DESTOYS URINE ODORS THE FIRST TIME: Urine elimination technology neutralizes and removes odors on contact for immediate freshness
REMOVES PET STAINS AND MORE: Effectively tackles pet stains, food stains, and other tough messes
HELPS PREVENT REMARKING: Discourages pets from returning to make a mess in the same spot
SUITABLE FOR USE AROUND PETS: Suitable for use around pets when used as directed
MULTIPURPOSE USE: Effective on most carpets, fabrics and hard surfaces for versatile cleaning
FROM THE #1 PET MESS CLEANING BRAND: Trusted by pet owners for superior cleaning performance.

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Best Value

9.0

Save 17%

Nature's Miracle

Nature's Miracle Dog Stain and Odor Remover, Everyday Mess Enzymatic Formula, 32 fl oz

17% OffFree Shipping

Main Highlights

SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.
ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
TRUSTED BRAND: From the maker of Natures Miracle products, the pet stain and odor removing brand you trust because it works!
SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.

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8.8

Aviano

Aviano Botanicals Multi-Purpose Enzyme Cleaner, Made in USA – (1 Gallon) Safe, Pet & People Friendly, Eco-Friendly Solution for Pet Mess, Odor, Carpet, Upholstery, Drain, Bathroom & Floor Cleaning

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Main Highlights

Delivers powerful cleaning as enzyme cleaner for dog urine and poop carpet and enzymatic cleaner for tough pet stains.
Effectively eliminates messes using enzyme cleaner for cat urine and urine enzyme cleaner, leaving surfaces fresh.
Engineered to work as drain enzyme cleaner and enzyme carpet cleaner, breaking down clogs and stubborn stains.
Offers proven performance as cat pee enzyme cleaner and cat urine enzyme cleaner to neutralize odors.
Versatile action as dog urine enzyme cleaner, pet enzyme cleaner, and cat enzyme urine cleaner for complete home care.

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8.6

ACTIVE

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

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Main Highlights

Powerful Bio Enzymatic Cleaner: ACTIVE Laundry Odor Removers Boost your normal laundry detergent to effectively target Stains & Odors, not mask them like washing soda or in-wash scent boosters. It uses Lab-proven Biological Cleaning to remove laundry odor & strong smell
Heavy Duty Stain Remover for clothes: Our Enzyme Laundry Additive Powder is formulated for Stain Removal of dirty clothes, perfect for Funk, Grease, Armpit Sweat stain, Blood stain, Oil and more!
Gentle on All Fabrics: Our Fragrance Free Laundry Boost Plant-based Formula uses zero harsh chemicals. Natural enhancer for whites & colors. Even safe for pesky activewear fabrics
Value 64 Load Package: ACTIVE Enzyme Cleaner Concentrated 32-oz size is good for 64 Loads compared to other products with 1 lb or less
Compatible with all Washers & Detergents: Add Laundry Booster Powder to your usual detergent & cleaners! HE, Front & Top load Washer Approved. Also use as laundry soak pretreat powder in order to treat set-in stain

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8.3

Bioda

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

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Main Highlights

THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
MADE IN THE USA - 1 Gallon Bottle

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8.1

AmazonCommercial

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

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Main Highlights

1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments
Breaks up complex organic proteins, pet smells and stains, hair, grease, oils, and more for effective results
Ideal for commercial properties, retail, and hospitality
Use as needed on stains and problem areas for spot cleaning carpet, surfaces, drains, toilets, grease traps, and more

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8.1

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Odor Eliminator for Strong Odor - Enzyme Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Enzymatic Cat Urine Destroyer - Carpet Cleaner Spray

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Main Highlights

Certified Gentle And Safe: Chlorine free and color safe; Safe to use around pets and children; No hazardous propellants, no residue left behind. So gentle its been Certified Safe for all carpets, earning the Seal of Approval by the trusted Carpet and Rug Institute (cri)
Eliminates Stains, Odors and Residue: If its gross, its gone; Not just the stain, but the stink; From stinky yellow pet urine and feces to vomit and other organic spills, our professional strength formula tackles them all
Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areasanywhere stains happen
Enzyme Activated: The key is getting to the problem deep-down; This spray contains natural enzymes that are activated on contact with odors and stains, feeding on ammonia crystals and organic matter until they are completely eliminated
Buy With Confidence: You want the best for your best friend; We do, too; If you are not satisfied with the performance of this product, contact us; We are determined to make it right

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Our Best Overall Choice

Best Choice

9.7

Pestco Products

Enz-O-Matic Enzyme Drain Cleaner - Organic Enzyme-Based Waste Degrader And Odor Neutralizer - 1 Gallon Bottle 128 Fl Oz - Multi-Purpose Enzyme Cleaner - Clean Fresh Scent - Bathroom Accessories

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Organic Waste Degrader - Helps prevent build up of organic waste and matter, including food particles, grease, soap scum, urine salts and other organic waste residues, reducing unpleasant odors.
Advanced Biological Enzyme Action Formulate - Utilizes a specialized blend of natural biological enzyme-acting bacteria to accelerate the degradation process, ensuring thorough waste breakdown.
Safe And Eco-Friendly - Formulated with environmentally friendly ingredients, this waste degrader is non-toxic, making it safe for use around people, pets and ecosystems.
Versatile Applications - Ideal for homes and businesses, addressing waste and odor issues in drain lines, floor drains, grease traps, garbage disposals, sinks, toilet bowls, urinals, septic systems and more.
Long-Lasting Results - A gallon-sized bottle offers ample supply for extended use, providing ongoing waste management and odor control with each application.
Pleasant Fragrance And Effective Odor Control - With its pleasant Kleenaire fresh laundry scent and odor neutralizing ingredients, Enz-O-Matic smells great and is ideal to deodorize all types of odors.
Additional Details - Contains over 200 billion live bacterial cultures per gallon of concentrate. Its non-pathogenic, live bacteria cultures produce enzyme-action to rapidly degrade all forms of organic wastes.

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