10 Best Enzyme Based Laundry Detergent of 2025

Tested and Reviewed: Top 10 Enzyme Based Laundry Detergent deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

ACTIVE

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

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Editor's bottom line:

“This enzyme based laundry detergent is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Powerful Bio Enzymatic Cleaner: ACTIVE Laundry Odor Removers Boost your normal laundry detergent to effectively target Stains & Odors, not mask them like washing soda or in-wash scent boosters. It uses Lab-proven Biological Cleaning to remove laundry odor & strong smell
Heavy Duty Stain Remover for clothes: Our Enzyme Laundry Additive Powder is formulated for Stain Removal of dirty clothes, perfect for Funk, Grease, Armpit Sweat stain, Blood stain, Oil and more!
Gentle on All Fabrics: Our Fragrance Free Laundry Boost Plant-based Formula uses zero harsh chemicals. Natural enhancer for whites & colors. Even safe for pesky activewear fabrics
Value 64 Load Package: ACTIVE Enzyme Cleaner Concentrated 32-oz size is good for 64 Loads compared to other products with 1 lb or less
Compatible with all Washers & Detergents: Add Laundry Booster Powder to your usual detergent & cleaners! HE, Front & Top load Washer Approved. Also use as laundry soak pretreat powder in order to treat set-in stain

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Picked by 397 people today

9.5

ACTIVE

Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator - 64 Loads

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Main Highlights

Concentrated Powder Detergent: ACTIVE Pet Detergent is a Powerful, High Efficiency Compatible Odor Destroyer & Stain Eliminating Detergent. Every Scoop has a Natural Cleaning Power to Handle any Mess, Stain, or Smell left behind by your pet.
Suitable for all Pet Laundry: Including Pet Bed, Clothing, Leash, Harness, Blankets, Towels, Furniture Covers & More! ACTIVE is an All-in-One Laundry Detergent Compatible With All Fabric Types, Even Use on your own Clothing and Bedding that smells like your pet!
Bio Based Enzyme Cleaner: ACTIVE Enzyme Laundry Detergent is Formulated to Target Pesky Stains and Odors, Including Pet Urine, Cat & Dog Pee, Vomit, Slobber, Dirt, Grime, Oils and Protein Stains. ACTIVE Enzymes even get rid of Wet Dog Odor, and others stubborn scents
Natural & Fragrance Free: ACTIVE Pet Detergent is a Natural Laundry Stain Remover, Free of Harsh Chemicals and Gentle for Pets and Sensitive Skin. ACTIVE Actually Removes Odors rather than using scents to cover them up like some alternatives
Best Value 64 Loads: Compare ACTIVE Dog Laundry Detergent to liquids that take up more space with less uses. Our Value Pack Comes in a Bulk 2 Lb bag so you can Keep Your Pet Laundry Taken Care Of!
Instructions for Use: First, Add 1 to 2 Scoops of ACTIVE Pet Laundry Detergent to your washing machine. Then add your pet laundry or other articles you wish to wash. Finally, start the appropriate washer program for the items you are cleaning. Note: this detergent powder is suitable for all water temperature settings including cold water, but some fabrics may be cleaned more effectively using Warm or Hot water options
Troubleshooting Guide: Some heavily soiled laundry items with pet stains or odors present may require extra treatment. We recommend pre-soaking your items in a tub of water, along with 1-2 scoops of detergent, for at least 2 hours. After the pre-soak, simply run through the washing machine like normal. You may also use one scoop of this detergent alongside your preferred laundry detergent for an extra boost of cleaning performance.

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9.5

Nature's Miracle

Nature’s Miracle Laundry Boost In-Wash Stain and Odor Remover, 32 Ounces, Laundry Stain and Odor Removing Additive For All Machines

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Main Highlights

LAUNDRY BIO-ENZYMATIC FORMULA: Helps break down and destroy tough pet stains and odors, such as urine, feces, vomit, blood, grass and drool.
GENTLE ON FABRICS: Perfect for use on clothing, pet beds and morenot for use on specialty fabrics, including washable silk, khaki, fluorescents, wool, suede and leathers.
SAFE FOR PETS AND HOME: Formulated without phosphates, parabens, sulfates and bleach, this product is safe for use around pets and home, when used as directed.
ODORCAPTURE 360 TECHNOLOGY: An odor neutralizing system from Natures Miracle, the brand you trust because it works!
WORKS IN ALL MACHINES INCLUDING HE: Use in addition to your laundry detergent to help loosen and remove tough pet stains and odors.

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9.2

Dirty Labs

Dirty Labs | Murasaki Scent | Bio Enzyme Liquid Laundry Detergent | 32 Loads (8.6 fl oz) | Hyper-Concentrated | High Efficiency & Standard Washing | Nontoxic, Biodegradable | Stain & Odor Removal

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Main Highlights

GENTLE: Most cleaners today use technologies that were developed almost 100 years ago. In fact, many common deep-cleaning formulas still rely on harmful, petroleum-based chemicals. Dirty Labs is different. Consciously formulated with nontoxic, biobased ingredients, our formulas are safe for sensitive skin and all clothing types. Dirty Labs is cruelty-free, vegan, hypoallergenic, and safe for babies and pets.
EFFECTIVE: For us, dirty-free cleaning is not just about clean ingredients. We formulate to get the job done, and we put our products through rigorous testing to ensure theyre strong enough for those who like to get really dirty. Phytolase, our advanced enzyme cleaning technology targets stains and odors at their source while being extra gentle for you, your clothes, and the planet. But don't just take our word for it see what our customers are saying.
ENVIRONMENTALLY FRIENDLY: At Dirty Labs - Less is More. By creating hyper-concentrated formulas, we greatly reduce our package sizes (and thus, our carbon footprint). Our bottles are made of aluminum and can be infinitely recycled. Our ingredients are responsibly sourced and created through biorenewable manufacturing processes. We examine every aspect of our product life cycles in order to achieve the safest, most sustainable solutions.
DIRECTIONS: Follow your garment care label and washing machine instructions. Measure with Dirty Labs silicone beaker (washable & reusable) according to load size. For tough stains, pretreat directly to soil area and allow to sit for 5 minutes before washing. Our detergent is hyper-concentrated use as follows: 8ml for medium loads, 12ml for large loads, 16 ml for x-large loads.
SPECS: 8.6 fl oz = 32 loads. Murasaki Scent (Jasmine, Matcha, & Vetiver). Compatible with traditional and HE washers. Optimized for cold water. Certified EPA Safer Choice. No sulfates, dyes, parabens, preservatives, chlorine bleach, or CA Prop.65 Chemicals. Visit our store for more ingredients information.

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9.0

OxiClean

OxiClean Odor Blasters Versatile Odor and Laundry Stain Remover Powder, 5 lb

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Main Highlights

One 5 lb box of OxiClean Odor Blasters Versatile Odor Eliminator and Stain Remover Powder laundry booster to get out tough stains and stubborn smells
Oxygen-based, water-activated laundry booster gets out tough dirt, persistent spots and set-in stains, plus eliminates sweat, musty towel and body odors with OxiClean stain remover
Works with regular detergent as a clothes stain remover and odor neutralizer to get clothes extra clean. For best results, use as a presoak before washing
This OxiClean powder stain and laundry odor remover can be used as a kitchen cleaner, bathroom cleaner, and fabric odor eliminator for machine-washable fabrics so you are ready for any mess
Tough on stains yet gentle on fabric, this chlorine-free, color-safe, fabric stain remover formula removes odors and stains to help keep the clothes you love look newer, longer

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8.8

Lysol

Lysol Tough Odor Eliminator Laundry Sanitizer Additive, Sanitizing Liquid for Gym Clothes and Activewear, 0% Bleach, Eliminates Odor Causing Bacteria, 90oz

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Main Highlights

LAUNDRY DETERGENT ADDITIVE: Add Lysol Laundry Sanitizer to every wash, in the fabric softener drawer, to sanitize and deodorize smelly laundry. Lysol Laundry Sanitizer kills many bad odors that detergents leave behind.
COLOR SAFE BLEACH ALTERNATIVE: Lysol Laundry Sanitizer is a bleach alternative that effectively kills 99.9% of bacteria, without the harshness of bleach. It's gentle on fabrics, effective in cold water, and is safe to use on colors and whites.
LYSOL LAUNDRY SANITIZER: Better than in-wash scent boosters that just mask bad odors. Lysol Laundry Sanitizer kills the odor causing bacteria that laundry detergents alone can leave behind, even in cold water Can be used in standard and HE machines.
ODOR ELIMINATOR FOR STRONG ODOR: Say goodbye to stubborn odors with Lysol Laundry Sanitizer, an advanced formula designed to act as an effective odor eliminator for even the toughest smells, leaving your clothes smelling fresh after every wash.
HOUSEHOLD ESSENTIALS and CLEANING SUPPLIES: Lysol is a leader in disinfection. Shop our range of household cleaning supplies including disinfectant wipes, toilet bowl cleaners, air sanitizers, and disinfectant sprays. The best protection is prevention
Kills 99.9% of Staphylococcus aureus and Klebsiella pneumonia on laundry.

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8.6

Dirty Labs

Dirty Labs | Scent Free | Bio Enzyme Liquid Laundry Detergent | 80 Loads (21.6 fl oz) | Hyper-Concentrated | High Efficiency & Standard Machine Washing | Nontoxic, Biodegradable | Stain & Odor Removal

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Main Highlights

GENTLE: Most cleaners today use technologies that were developed almost 100 years ago. In fact, many common deep-cleaning formulas still rely on harmful, petroleum-based chemicals. Dirty Labs is different. Consciously formulated with nontoxic, biobased ingredients, our formulas are safe for sensitive skin and all clothing types. Dirty Labs is cruelty-free, vegan, hypoallergenic, and safe for babies and pets.
EFFECTIVE: For us, dirty-free cleaning is not just about clean ingredients. We formulate to get the job done, and we put our products through rigorous testing to ensure theyre strong enough for those who like to get really dirty. Phytolase, our advanced enzyme cleaning technology targets stains and odors at their source while being extra gentle for you, your clothes, and the planet. But don't just take our word for it see what our customers are saying.
ENVIRONMENTALLY FRIENDLY: At Dirty Labs - Less is More. By creating hyper-concentrated formulas, we greatly reduce our package sizes (and thus, our carbon footprint). Our bottles are made of aluminum and can be infinitely recycled. Our ingredients are responsibly sourced and created through biorenewable manufacturing processes. We examine every aspect of our product life cycles in order to achieve the safest, most sustainable solutions.
DIRECTIONS: Follow your garment care label and washing machine instructions. Measure with teaspoon or Dirty Labs silicone beaker (available separately, or with all 32 load bottles). For tough stains, pretreat directly to soil area and allow to sit for 5 minutes before washing. Our detergent is hyper-concentrated use as follows: 8ml for medium loads, 12ml for large loads, 16 ml for x-large loads.
SPECS: 21.6 fl oz = 80 loads. Free & Clear (Scent Free). Compatible with traditional and HE washers. Optimized for cold water. Certified EPA Safer Choice Partner. 97% USDA Biobased certified. No sulfates, dyes, parabens, preservatives, chlorine bleach, or CA Prop.65 Chemicals. Visit our store for more ingredients information.

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8.3

Dirty Labs

Dirty Labs | Scent Free | Bio Enzyme Laundry Booster | 48 Loads (1 lb) | Hyper Concentrated | High Efficiency & Standard Machine Washer | Nontoxic, Biodegradable | Stain & Odor Removal Enzyme Booster

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Main Highlights

GENTLE: Our formula is consciously formulated with 100% bio and mineral-based ingredients. We left out all the harsh chemicals, fillers, toxins, and pollutants commonly found in other boosters to create a hyperefficient, nontoxic, biodegradable formula. We only use the good stuff so your body and the environment are left as clean as your detergent.
EFFECTIVE: Our advanced 4-in-1 formula is the first laundry product in the US to feature a groundbreaking bioenzyme that breaks down tough-to-remove biological stains and odors caused by sweat, body grime, and blood. (Think ring around the collar, yellow pit stains, weird grey or yellow stains on your favorite white sheets, and other stains.)
ENVIRONMENTALLY FRIENDLY: At Dirty Labs - Less is More. By creating hyper-concentrated formulas, we greatly reduce our package sizes (and thus, our carbon footprint). Our packaging is made of recyclable cardboard. Our scoop is made from responsibly sourced schima superba wood. Our materials are responsibly sourced and extracted directly from nature. We examine every aspect of our product life cycles in order to achieve the safest, most sustainable solutions.
DIRECTIONS: Follow your washer and garment care label instructions. For best results, use with Dirty Labs Bio Laundry Detergents. For standard and HE machines. Septic Safe. 1) Use laundry detergent as you normally would. 2) Add Bio Laundry Booster to wash drum before adding clothes.
SPECS: 480 g = 48 loads. Free & Clear (Scent Free). Compatible with traditional and HE washers. Optimized for cold water. No synthetic ingredients. Biodegradable formula. Hypoallergenic and safe for sensitive skin. Safe for babies and pets. Cruelty-free. Vegan. No sulfates. No dyes. No parabens and preservatives. No optical brighteners. No chlorine bleach. No 1,4-dioxane. No fragrance. No CA Prop. 65 chemicals. Packaging and formula are BPA-free.

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8.1

ECOS

ECOS Laundry Detergent Liquid, 200 Loads - Dermatologist Tested Laundry Soap - Hypoallergenic, EPA Safer Choice Certified, Plant-Powered - Lavender, 100 Fl Oz (Pack of 2)

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Main Highlights

CLIMATE POSITIVE AND SUSTAINABLE - Not only is this laundry detergent formula effective and kind to sensitive skin, but it's also pH-balanced.
100% VEGAN Containing enough detergent for 200 loads of laundry, plant-powered ECOS Laundry Detergent is both cruelty-free and vegan, making it an ideal choice for planet-conscious households.
PARABEN AND PHOSPHATE FREE - Unlike most conventional laundry detergents, ECOS does not contain any harsh chemicals or ingredients that can pollute water when it enters the ecosystem.
DERMATOLOGIST-TESTED AND HYPOALLERGENIC - ECOS Laundry Detergent is an effective yet gentle cleaning solution for clothes that is suitable for families with skin allergies and sensitivities.
MADE IN USA - Proudly made in the USA with globally sourced ingredients
CLEAN FORMULAS WITH VISIBLE RESULTS - Since 1967, ECOS has created safer, powerful products by using enzymes found in nature. Our liquid laundry detergents are made in a carbon neutral, water neutral, TRUE Platinum Zero Waste factory using 100% renewable energy.
CERTIFIED SAFER CHOICE - Safer Choice certification means that the product perfoms well and contains ingredients that are safer for human health and the environment.
BLACK OWNED AND WOMAN LED - ECOS is a Black-owned and woman-led company

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8.1

Gain

Gain + Odor Defense Liquid Laundry Detergent, Super Fresh Blast Scent, 107 Loads, HE Compatible Washing Soap

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Main Highlights

SCENT ADVENTURE: Formula designed to take your nose on a scent focused adventure with Super Fresh Blast fragrance
3 IN 1 PERFORMANCE: Liquid detergent made to help eliminate tough odors in wear while providing a strong clean and lasting scent
MATCHES PLUS ODOR DEFENSE LINE: Liquid laundry detergent that matches with other Gain Plus Odor Defense products for one coordinated scent
UNIVERSAL MACHINE USE: Washing detergent that works in many machines and water temperatures when used as directed
SAFE ON ALL FABRICS: Laundry soap that is safe for use on all fabric types according to the label instructions
107 LOAD HOUSEHOLD SIZE: Bottle provides enough Gain Super Fresh Blast Odor Defense liquid laundry detergent for multiple loads of laundry

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Our Best Overall Choice

Best Choice

9.7

ACTIVE

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Powerful Bio Enzymatic Cleaner: ACTIVE Laundry Odor Removers Boost your normal laundry detergent to effectively target Stains & Odors, not mask them like washing soda or in-wash scent boosters. It uses Lab-proven Biological Cleaning to remove laundry odor & strong smell
Heavy Duty Stain Remover for clothes: Our Enzyme Laundry Additive Powder is formulated for Stain Removal of dirty clothes, perfect for Funk, Grease, Armpit Sweat stain, Blood stain, Oil and more!
Gentle on All Fabrics: Our Fragrance Free Laundry Boost Plant-based Formula uses zero harsh chemicals. Natural enhancer for whites & colors. Even safe for pesky activewear fabrics
Value 64 Load Package: ACTIVE Enzyme Cleaner Concentrated 32-oz size is good for 64 Loads compared to other products with 1 lb or less
Compatible with all Washers & Detergents: Add Laundry Booster Powder to your usual detergent & cleaners! HE, Front & Top load Washer Approved. Also use as laundry soak pretreat powder in order to treat set-in stain

Show Price

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