10 Best Enzyme Based Cleaners of 2025

Tested and Reviewed: Top 10 Enzyme Based Cleaners deals with expert ratings from 8.1 to a perfect 10

May 2026 Edition

Editor's Choice

9.7

Zeiff

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce - Fragrance Free

Editor's bottom line:

“This enzyme based cleaners is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Pro Grade Clean - Zeiff Pro-Grade Formulas are innovative, unique proprietary solutions, trusted by professionals and consumers for being the most effective cleaning products to get the job done. Whether youre a pro or just expect pro-grade results, Zeiff delivers Pro Grade Clean
Powerful Cleaning Performance - Our proprietary formulation breaks up complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease and grime without leaving any visible residue. Don't just expect clean, expect Zeiff Clean! You'll know it when you see it, clean you didn't even know exists
Multi-Purpose Enzyme Cleaner - The special blend of bacterial enzymes, detergent and deodorant, prevents clogging in drains, grease traps, septic tanks, drain lines and downpipes, and cleans stains, odors, carpets, floors, kitchen & bathroom surfaces, and much more. Ideal for Professional and Home use
Deodorizer & Odor Eliminator - Highly concentrated bacterial digestant for grease, stains, oils, & organic waste. Effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage and grease, leaves long-lasting freshness
Safe & Effective - Zeiff Pro Grade Formulas are safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and dyes, pH neutral, paraben-free, pet safe, cruelty-free. Proudly made in the USA

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Picked by 397 people today

9.5

Bioda

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Main Highlights

THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
MADE IN THE USA - 1 Gallon Bottle

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Best Value

9.5

Save 33%

Biokleen

Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

33% Off

Main Highlights

STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts

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9.2

GELEAN

Multi-Purpose Probiotic Enzyme Citrus Cleaner, 1/2 Gallon (64 oz.) - Pet Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, Made in USA

Main Highlights

MULTI-PURPOSE FORMULA: Professional-strength enzymatic cleaner designed for surfaces including floors, bathrooms, toilets, drains, and trash cans
PROBIOTIC TECHNOLOGY: Uses natural enzyme-producing probiotics to break down stains, grime, and organic matter at a microscopic level
ODOR ELIMINATION: Effectively neutralizes unpleasant smells including pet odors and waste-related smells rather than masking them
PROFESSIONAL STRENGTH: Concentrated gallon-size formula provides superior cleaning power for both commercial and residential applications
VERSATILE USE: Suitable for multiple surfaces including tile, porcelain, concrete, and sealed floors while being safe for regular use

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9.0

Rocco & Roxie Supply Co.

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

Main Highlights

Eliminates Stains, Odors, & Residue: If its gross, its gone; from blowouts, urine, vomit, and other organic spills; Rocco & Roxie stain & odor eliminator has a subtle Meyer lemon scent that quickly dissipates, leaving your space feeling fresher
Every Surface, Every Time: Our fast-acting carpet stain remover spray formula works great on floors, furniture, clothing, pet bedding, litter boxes, travel crates, hamster cages, cars, campers, and anywhere else major accidents happen
Minerals & Enzymes: The key is getting to the problem deep-down, so we added a mineral-based odor neutralizer to our bio-enzymatic formula; upon contact with tough stains & odors, this pet enzyme cleaner feasts on ammonia crystals and organic matter
Gentle & Safe Carpet Spray: Safe to use around pets and children, when used as directed; chlorine-free, color-safe with no hazardous propellants; Certified Safe for all carpets with the Seal of Approval by the trusted Carpet and Rug Institute (CRI)
Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this pet odor eliminator and stain remover, contact us; we are determined to make it right

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8.8

Black Diamond Stoneworks

Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)

Main Highlights

Powerful Enzymatic Action Breaks down stains and odors at the source - from pet accidents to everyday messes. Keep your home fresh, clean, and worry-free.
Eliminates Odors in Seconds Neutralizes dog, cat, and human urine smells from carpets, floors, drains, and more. Because lifes too short for lingering odors.
Multi-Surface Safe & Family-Friendly Gentle on carpets, hardwood, tile, upholstery, and more tough on messes, safe for pets and kids. Clean with confidence.
Perfect for Pet Accidents & Beyond Tackles stains, urine, vomit, and more from litter boxes to kennels to everyday spills. Freshness where you need it most.
Commercial Strength. Home Safe. Trusted by homeowners, vets, and cleaners alike biodegradable, non-toxic, and ready for the toughest jobs, big or small.

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8.6

Nature's Miracle

Nature’s Miracle Urine Destroyer Plus for Cats, Enzymatic Formula, Ready-to-Use, 32 oz

Main Highlights

FOR CAT URINE MESSES: Begins to break down and remove stains immediately on contact.
POWERFUL FORMULA: Just soak the affected area, allow to work for 15 minutes, then blot up stain with a clean cloth.
ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
TRUSTED BRAND: From the maker of Natures Miracle products, the pet stain and odor removing brand you trust because it works!
SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and in your home.

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8.3

Save 17%

Nature's Miracle

Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

17% Off

Main Highlights

SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.
ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
TRUSTED BRAND: From the maker of Natures Miracle products, the pet stain and odor removing brand you trust because it works!
SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.

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8.1

Eco Strong

Eco Strong Pet Stain and Odor Remover - Cat Urine Enzyme Cleaner Destroyer, Urine Destroyer for Dogs, Pet Urine Enzyme Cleaner - 128 Oz

Main Highlights

Enzymatic Cleaner for Dog Urine: Our natural Bio-Enzymatic formula breaks down and digests the odor and stain causing proteins in pet and people urine. We eliminate the problem and not simply mast the odor with perfumes. This multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments use on carpets, furniture, hardwood, tile, drains, liter boxes, garbage cans, RVs and more
Cat Litter Deodorizer: In between scooping you can quickly and easily eliminate get rid of lingering litter box smells. Simply spray liberally, over the litter and youll notice the odor will immediately disappear. Repeat anytime your cat leaves a particularly smelly deposit and you dont have the time to scoop. Also control odors by using to clean the litter box before filling with new litter.
Ultimate Enzyme Cleaner for Dog Urine and Poop in Carpet: When your puppy, kitten, cat or dog accidentally urinates on the carpet our Bio-Enzyme cleaner will break down and destroy the odor and stain causing proteins in; cat or dog pee, poop vomit, general pet smells, stains, grease from your carpet. This will also work on area rugs and can be used in carpet cleaner, check direction for best results.
My Pet Peed on My Bed: So often pet parents need a solution to the problem caused by pets, dogs or cats, young or old having accidents. Accidents can happen on bedding, sheets, towels, clean or dirty clothes. If an accident happens on something that washable, or you are washing your pets bed, add Eco Strong to the prewash cycle and the odors will be gone. Follow directions for best results.
Multi-Purpose Professional Strength, made in the USA, this multi-purpose product is Non-toxic, Non- corrosive, non-flammable, non-acidic, and non-caustic. Works on organic stains left by pets or people Eco Strong is tough on stains and gentle on surfaces.

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8.1

AmazonCommercial

AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack

Main Highlights

1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments
Breaks up complex organic proteins, pet smells and stains, hair, grease, oils, and more for effective results
Ideal for commercial properties, retail, and hospitality
Use as needed on stains and problem areas for spot cleaning carpet, surfaces, drains, toilets, grease traps, and more

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Our Best Overall Choice

Best Choice

9.7

Zeiff

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce - Fragrance Free

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Pro Grade Clean - Zeiff Pro-Grade Formulas are innovative, unique proprietary solutions, trusted by professionals and consumers for being the most effective cleaning products to get the job done. Whether youre a pro or just expect pro-grade results, Zeiff delivers Pro Grade Clean
Powerful Cleaning Performance - Our proprietary formulation breaks up complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease and grime without leaving any visible residue. Don't just expect clean, expect Zeiff Clean! You'll know it when you see it, clean you didn't even know exists
Multi-Purpose Enzyme Cleaner - The special blend of bacterial enzymes, detergent and deodorant, prevents clogging in drains, grease traps, septic tanks, drain lines and downpipes, and cleans stains, odors, carpets, floors, kitchen & bathroom surfaces, and much more. Ideal for Professional and Home use
Deodorizer & Odor Eliminator - Highly concentrated bacterial digestant for grease, stains, oils, & organic waste. Effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage and grease, leaves long-lasting freshness
Safe & Effective - Zeiff Pro Grade Formulas are safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and dyes, pH neutral, paraben-free, pet safe, cruelty-free. Proudly made in the USA

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