10 Best Drops For Dry Eyes Fda Approved Preservative Free of 2025

Tested and Reviewed: Top 10 Drops For Dry Eyes Fda Approved Preservative Free deals with expert ratings from 8.1 to a perfect 10

June 2025 Edition

Editor's Choice

9.7

Optase

Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses

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Editor's bottom line:

“This drops for dry eyes fda approved preservative free is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

MOISTURIZE AND PROTECT: Made of glycerin and quality ingredients, Optase Dry Eye Intense Drops mix with the natural oils needed to protect your tears and hydrate your eyes to improve tear quality
PRESERVATIVE FREE: Optase Intense Eye Drops is the only product of its kind to provide a preservative free combination of ingredients designed to treat dry eye patients in a unique multi-dose bottle
MODERATE TO SEVERE DRY EYE RELIEF: The long lasting formulation of Optase Intense provides comfort for dry eye and post operative patients. And it is contact lens safe, providing relief when needed
ADVANCED BOTTLE TECHNOLOGY: A convenient multi-use drop bottle with advanced technology maintains sterility over 3 months without preservatives. Avoid the hassle of individual vials while on the go
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, Blepharitis and Meibomian Gland Dysfunction (MGD)

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Picked by 254 people today

Best Value

9.5

Save 40%

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

40% OffFree Shipping

Main Highlights

Fast acting hydration for sensitive eyes
Preservative free tear evaporation protection
Nano droplets for better coverage

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9.5

Save 9%

Systane

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

9% OffFree Shipping

Main Highlights

Hydrates fast and provides long-lasting relief for dry eyes
Preservative free eye drops
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses
Extra moisturizing eye drops for sensitive eyes

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9.2

Systane

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

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Main Highlights

#1 Dr Recommended Brand of Artificial Tears*, packaging may vary
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief.Store at room temperature
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

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9.0

Save 25%

Refresh

Refresh Optive Advanced Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 30 Count

25% OffFree Shipping

Main Highlights

Preservative-free triple-action relief drop
Lubricants and hydrates dry, burning, irritated eyes
Helps prevent tears from evaporating
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
Recommended for sensitive eyes
On-the-go single use vials
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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8.8

Save 35%

TheraTears

TheraTears Extra Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, 0.5 fl oz Bottle, 2 Count(Pack of 1)

35% OffFree Shipping

Main Highlights

Get up to 12 Hours of Hydrating Comfort; TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops provide EXTRAordinary relief for dry eyes
Discover TheraTears eye drop; one-of-a-kind silky hydration for dry eyes
Lubricating eye drops for extra dry eyes rehydrate; protect against further irritation and support a natural tear pH level
TheraTears Extra Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 2 bottles of TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops, 0.5 fl oz
FSA- and HSA-eligible product in the U.S.

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8.6

Save 17%

BLINK

Blink Eye Drops for Dry Eyes, Triple Care Lubricant Eye Drops, Instantly Soothing, Moisturizing & Extra Long-Lasting Hydrating Eye Care for Moderate to Severe Dry Eye Symptom Relief, 0.34 fl oz

17% OffFree Shipping

Main Highlights

Relief with every Blink: Experience extended dry eye symptom relief with Blink Triple Care Lubricating Eye Drops. This 3-in-1 formula instantly soothes, gives extra long-lasting hydration, and seals in moisture.
Dry Eye Lubricant: Discover what makes Blink Triple Care Lubricating Eye Drops different from other eye drops. Our drops for dry eyes have a dual-action moisture seal to lock in moisture for instant, long-lasting relief.
Long-Lasting Hydration: Blink Triple Care Lubricating Eye Drops are formulated with hyaluronate - also found in your eyes - to boost hydration. Hydrate like your tears for extra long-lasting comfort
Reduce Everyday Discomfort: These dops for dry eyes deliver extended relief for moderate to severe dry eye symptoms
Trusted Brand: Blink has a range of products to meet your eye and contact lens care needs, from drops for dry eyes to lock in moisture, to preservative-free formulas; and contact lens drops to keep your contacts clean and hydrated.

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8.3

Save 29%

iVIZIA

iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz Bottle

29% OffFree Shipping

Main Highlights

iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz bottle.
Unique Formulation: Hydrating polymers form a protective matrix, moisturizing Hyaluronic Acid holds up to 1000x its weight in moisture, and Trehalose (synthetic ingredient also found in desert plants).
Free of Irritating Preservatives: Sterile, safe for use with contact lenses
Patented ABAK Bottle: preservative-free, dispenses drop-by-drop, and does not stream. The ergonomic bottle is easy to open, easy to hold and squeeze.
iVIZIA We See a Better Way: for healthy, comfortable eyes

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8.1

Save 15%

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

15% OffFree Shipping

Main Highlights

TheraTears Dry Eye Therapy Lubricant Eye Drops, Preservative Free, provide immediate, long-lasting relief of dry eye symptoms
Discover TheraTears eye drops, one-of-a-kind silky hydration for dry eyes
TheraTears Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Preservative free for sensitive eyes; the single-use vials come in a foil pouch to ensure freshness
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 1 box of TheraTears Dry Eye Therapy Lubricant Drops, Preservative Free, 30 vials
FSA- and HSA-eligible product in the U.S.

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Our Best Overall Choice

Best Choice

9.7

Optase

Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

MOISTURIZE AND PROTECT: Made of glycerin and quality ingredients, Optase Dry Eye Intense Drops mix with the natural oils needed to protect your tears and hydrate your eyes to improve tear quality
PRESERVATIVE FREE: Optase Intense Eye Drops is the only product of its kind to provide a preservative free combination of ingredients designed to treat dry eye patients in a unique multi-dose bottle
MODERATE TO SEVERE DRY EYE RELIEF: The long lasting formulation of Optase Intense provides comfort for dry eye and post operative patients. And it is contact lens safe, providing relief when needed
ADVANCED BOTTLE TECHNOLOGY: A convenient multi-use drop bottle with advanced technology maintains sterility over 3 months without preservatives. Avoid the hassle of individual vials while on the go
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, Blepharitis and Meibomian Gland Dysfunction (MGD)

Show Price

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