10 Best Colt Python Holster 4 25 Inch of 2025

Tested and Reviewed: Top 10 Colt Python Holster 4 25 Inch deals with expert ratings from 8.1 to a perfect 10

July 2025 Edition

Editor's Choice

9.7

MASC

Premium Leather Vertical Shoulder Holster System with Double Speed Loader, Colt Python 357 Magnum Revolver 4.25" BBL, Right Hand Draw, Brown Color #1304#

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Editor's bottom line:

“This colt python holster 4 25 inch is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

KA1-SPL KOZA // Vertical Shoulder holster Made from Premium Genuine Leather. Hand-made molding for a perfect fit.
Note: THE HOLSTER IS UNASSEMBLED. The buyer needs to combine three parts (Holster, Leather Harness, Speed Loader ) and adjust the Leather Harness with the screw-rivet system to fit their body size.
The SHOULDER STRAPS are fits up to 48 chest.
Belt tie-down on the back side of the holster helps keep the holster firmly in place when drawing the gun. Sight rail space to protect the leather and muzzle sight. High concealment.
The retention strap helps keep the gun securely in place. It has a snap closure on the front of the holster, and a plastic tab on the holster strap provides fast pulls.
Double speed loader can be attached to the belt both from the holster and mag carrier for a more comfortable pistol carrying experience. It has adjustable tension screws for customized retention.
NOTE: The holster may appear to fit too tight at first and when holstering your gun the first time. This is for long usage of your holster, considering the fact that the leather will relax with use.
NOTE: if you are right-handed you will draw your gun from underneath your left arm.

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Picked by 251 people today

9.5

MASC

Premium Leather Three Slot Belt Holster with Retention Strap Fits Colt Python 357 Magnum 6” Barrel, R/H Draw, Brown Color #1306#

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Main Highlights

KM/USBR // Made from Premium Genuine Leather. Hand-made molding for a perfect fit.
The retention strap helps keep the gun securely in place. Retention strap has a snap closure on the front of the holster. A plastic tab on the holster strap provides fast pulls.
Three belt slots on the back provide different carriage styles. It can be worn Strong Side or Cross-Draw at the users discretion. Fits up to 1 3/4" wide belts.
Adjustable tension screw for customized retention. Sight rail space to protect the leather and muzzle sight.
High and tight carry. Effective concealment with maximum comfort.
PLEASE NOTE: The holster may appear to fit too tight at first and when holstering your gun the first time. This is for long usage of your holster, considering the fact that the leather will relax with use.

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9.5

MASC

Leather Paddle OWB Revolver Holster with Retention Strap Fits Colt Python 357 Magnum 6" Barrel, Right Hand Draw, Brown Color #1306#

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Main Highlights

USBR // Made from Premium Genuine Leather. Hand-made molding for a perfect fit.
The retention strap helps keep the gun securely in place. Retention strap has a snap closure on the front of the holster. A plastic tab on the holster strap provides fast pulls.
Adjustable tension screw for customized retention. Sight rail space to protect the leather and muzzle sight. High and tight carry. Effective concealment with maximum comfort.
Has a moving polymer paddle to adjust the carrying angle. Using 2 screws on the polymer paddle the holster can be rotated up to 45 degrees each way with a screwdriver.
It can be easily adjusted to wear on the Strong Side, Cross-Draw. Zero cant, forward cant, and rearward cant. Fits up to 1 3/4" wide belts.
PLEASE NOTE: The holster may appear to fit too tight at first and when holstering your gun the first time. This is for long usage of your holster, considering the fact that the leather will relax with use.

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9.2

DeSantis

DeSantis Speed Scabbard, Right, Black, COLT Python, Trooper 4", S&W L Frame 4", DAN Wesson 15/2,15/2V,15/2VH 4", Ruger GP100 4"

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Main Highlights

Fits Colt Python, Trooper 4" S&W L Frame 4"; Ruger Gp100 4" Dan Wesson 15/2,15/2V,15/2Vh 4"
For Right Hand
Black in color

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9.0

MASC

Premium Leather Paddle OWB Revolver Holster with Retention Strap Fits Colt Python 357 Magnum Revolver 4.25", Right Hand Draw, Brown Color #1304#

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Main Highlights

USBR // Made from Premium Genuine Leather. Hand-made molding for a perfect fit.
The retention strap helps keep the gun securely in place. Retention strap has a snap closure on the front of the holster. A plastic tab on the holster strap provides fast pulls.
Adjustable tension screw for customized retention. Sight rail space to protect the leather and muzzle sight. High and tight carry. Effective concealment with maximum comfort.
Has a moving polymer paddle to adjust the carrying angle. Using 2 screws on the polymer paddle the holster can be rotated up to 45 degrees each way with a screwdriver.
It can be easily adjusted to wear on the Strong Side, Cross-Draw. Zero cant, forward cant, and rearward cant. Fits up to 1 3/4" wide belts.
PLEASE NOTE: The holster may appear to fit too tight at first and when holstering your gun the first time. This is for long usage of your holster, considering the fact that the leather will relax with use.

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8.8

MASC

Premium Leather OWB Paddle Holster Open Top, Fits Colt Python 357 Magnum 4.25" Barrel, Right Hand Draw, Brown Color #1304#

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Main Highlights

LXGF-115 TUGCE // Made from Premium Genuine Leather. Hand-made molding for a perfect fit.
Open top for fast drawing. High and tight carry. Adjustable tension screw for customized retention. Sight rail space to protect the leather and muzzle sight.
Has a moving polymer paddle to adjust the carrying angle. Using 2 screws on the polymer paddle the holster can be rotated up to 45 degrees each way with a screwdriver.
It can be easily adjusted to wear on the Strong Side, Cross-Draw. Zero cant, forward cant, and rearward cant. Fits up to 1 3/4" wide belts.
PLEASE NOTE: The holster may appear to fit too tight at first and when holstering your gun the first time. This is for long usage of your holster, considering the fact that the leather will relax with use.

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8.6

DeSantis

Desantis Thumb Break Scabbard Holster fits 4-Inch Colt Python, Right Hand, Black

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Main Highlights

Features three belt slots so you can have either straight up or a forward draw
Most models feature a tension screw so it can be as tight or as loose as the user wishes
Comes with a thumb break
Rides high and tight to the body
High quality leather, extremely tough design and stitching

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8.3

DeSantis

Desantis Speed Scabbard Holster fits 4-Inch Colt Python, Trooper, Right Hand, Tan

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Main Highlights

Designed to fit the following firearms: COLT PYTHON, TROOPER 4", S&W L FRAME 4", DAN WESSON 15/2,15/2V,15/2VH 4", RUGER GP100 4"
Designed to meet the needs of plainclothes professionals preferring a holster without a thumb break while still providing firearm retention
Features precise molding and tension screw device on most models
Belt slots are 1.75 inch wide
Recommended carry position on hip or behind the hip

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8.1

Nehir Holster

Nehir Holster for Colt Python 4 inch Revolver Fast Draw Owb Leather Gun Holsters (Black Right Hand)

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Main Highlights

*Our covers are made of vegetal leather and processed without using any chemicals for your health.
**Protected with two layers of polish, it is not affected by water, moisture and sweat.
***You can easily use it with your trouser belts that are 1.57 inches (4 cm) wide and 0.39 inches (1 cm) thick.
****Our holsters have a hard structure and do not lose their hardness.

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8.1

EDS HOLSTER

EDS Holster Colt King Cobra - Colt Python 357 Magnum 4 inch Revolver OWB Leather Gun Holster (Brown)

Main Highlights

-Compatible Model: For Colt King Cobra - Colt Python 357 Magnum 4 inch Revolver
-Specifically molded to fist colt 4 inch Full Size Handguns for Concealed Carry (w/o rail or accessories).
-A new leather holster is supposed to be very snug fit for the intended for colt 4 inch at first so that it can provide good enough retention after the leather is broken-in. Wearing the holster with your (unloaded) firearm in it ensures the leather will break in nicely within a few days and become very comfortable
-It minimizes your gun for colt king cobra 4 inch to rust and be affected by sweat. We want your holster to be as valuable as your weapon. Do not risk your gun with synthetic and plastic sleeves. Feel the comfort of the skin with your gun.
-For Colt king cobra 4 inch Gun Holsters are designed for optimum performance, maximum comfort. It is a comfortable, durable, lightweight leather holster that you can carry all day. It is produced from 100% cow-hide leather with reinforced and double stitching at every stage with care.
-It has a structure suitable for fast draw. For Colt king cobra 4 inch molded a perfect fit. Barrel mouth is open. The retention strap helps keep the gun securely in place. It covers the trigger and the barrel completely. Thumb break constructed with top quality snap. Belt slots accommodate belts up to 1.8 (45 mm) wide and 0.16 (4 mm) thick.

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Our Best Overall Choice

Best Choice

9.7

MASC

Premium Leather Vertical Shoulder Holster System with Double Speed Loader, Colt Python 357 Magnum Revolver 4.25" BBL, Right Hand Draw, Brown Color #1304#

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

KA1-SPL KOZA // Vertical Shoulder holster Made from Premium Genuine Leather. Hand-made molding for a perfect fit.
Note: THE HOLSTER IS UNASSEMBLED. The buyer needs to combine three parts (Holster, Leather Harness, Speed Loader ) and adjust the Leather Harness with the screw-rivet system to fit their body size.
The SHOULDER STRAPS are fits up to 48 chest.
Belt tie-down on the back side of the holster helps keep the holster firmly in place when drawing the gun. Sight rail space to protect the leather and muzzle sight. High concealment.
The retention strap helps keep the gun securely in place. It has a snap closure on the front of the holster, and a plastic tab on the holster strap provides fast pulls.
Double speed loader can be attached to the belt both from the holster and mag carrier for a more comfortable pistol carrying experience. It has adjustable tension screws for customized retention.
NOTE: The holster may appear to fit too tight at first and when holstering your gun the first time. This is for long usage of your holster, considering the fact that the leather will relax with use.
NOTE: if you are right-handed you will draw your gun from underneath your left arm.

Show Price

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