10 Best Best Spider Killer of 2025

Tested and Reviewed: Top 10 Best Spider Killer deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Ortho

Ortho Home Defense Insect Killer for Indoor and Perimeter2 with Comfort Wand, Controls Ants, Roaches, Spiders and More, 1.33 gal

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Editor's bottom line:

“This best spider killer is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Ortho Home Defense Insect Killer for Indoor & Perimeter2 kills the toughest home-invading insects, including ants, cockroaches, spiders, fleas, ticks, scorpions, earwigs, silverfish and periodical cicadas (as listed)
This insect killer spray provides a long-lasting bug barrier of up to 12 month protection against ants, roaches and spiders indoors on non-porous surfaces
Use this pest control spray indoors in kitchens and bathrooms or around doors and windows, and outdoors to the perimeter of foundations, patios, decks, garages or wherever insects are a recurring problem
Apply this bug killer anytime as a preventative treatment or after you see evidence of insect activity
This 1.33 gal. container of Ortho Home Defense Insect Killer for Indoor & Perimeter2 comes with a battery-powered Comfort Wand, which delivers a continuous spray for easy application

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Picked by 397 people today

9.5

Wet & Forget

Wet & Forget 803064 Miss Muffet's Revenge Indoor and Outdoor Spider Killer with Attached Sprayer, 64 Fluid Ounces, Ready to Use

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Main Highlights

Kills spiders and creates a barrier inside and outside the home to keep them away for up to 12 months with just one application
Attached sprayer for quick and easy application with a spray range of up to 10 feet for those hard to reach places
Treat all areas were spiders are found, spray until wet but not soaking and for long lasting results leave spray undisturbed
Apply in calm weather where rain is not expected for 24hrs and allow to dry completely before entering treated area
Miss Muffet's Revenge is ready to use and specially formulated for all spiders except Black Widow and Brown Recluse

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9.5

Terro

TERRO T2302 Spider, Ant, Roach, and Other Insects Killer Aerosol Spray – 2 Pack

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Main Highlights

2 spray bottles
Kills spiders (including Black widow, brown recluse and hobo spiders), ants, cockroaches, crickets, scorpions, and other insects
Kills on contact
Can be used indoors and outdoors

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9.2

HOT SHOT

Hot Shot Spider & Scorpion Killer (Aerosol), Kills Large Spiders and Scorpions in Seconds, Including Black Widow, Brown Recluse and Wolf Spiders, 16 Ounces

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Main Highlights

KILLS IN SECONDS: The fast-acting formula kills spiders, scorpions and other listed insects in seconds
KILLS FOR UP TO 4 MONTHS: Keeps killing ants (excluding harvester, pharaoh and fire ants), cockroaches and crickets for up to 4 months
KILLS BLACK WIDOW SPIDERS: Also kills black widow spiders as they hatch
UP TO 5-FT TARGETED SPRAY: Broad spray pattern ensures full coverage of treatment area
NO-MESS FORMULA: The water-based formula is non-staining and leaves no oily residue or lingering odor

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9.0

Maxguard

MaxGuard Spider + Insect Traps (12 pcs Box Trap) | Non-Toxic Extra Sticky Glue Traps, Kill Black Widow Hobo Brown Recluse Spiders and Other Crawling Bugs & Insects |

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Main Highlights

OPTIMAL SOLUTION: Keeping your house free of spiders is simple with our professional-grade Spider + Insect Traps. Our traps will capture and kill Hobo, Black Widow, Brown Recluse, American House, Yellow Sac, Wolf, and Jumping Spiders.
HOW THEY WORK: Unlike other chemical-based solutions, our traps utilize a non-toxic industrial-grade adhesive and feature a dark-colored interior to better attract, catch and kill all species of spiders.
NON-TOXIC & INSECTICIDE-FREE: Made with an industrial-grade super sticky adhesive that's 100% Non-toxic. Our traps are safe for usage throughout your home.
EASY, EFFECTIVE & LONG-LASTING: Just peel, fold and place the trap in your spider infested areas. Our traps are effective for up to 6 months.
WHAT YOU GET: Each box comes with 12 traps that are guaranteed to work. If you are not completely satisfied, simply contact us for an exchange or a full refund. No questions asked. EPA Est. No. 93048-CHN-1

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8.8

Ortho

Ortho Home Defense Max Indoor Insect Barrier with Extended Reach Comfort Wand, Kills Ants, Roaches, Spiders, Fleas and Ticks, 1 gal.

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Main Highlights

Start killing ants, roaches, spiders, fleas and ticks with Ortho Home Defense Max Indoor Insect Barrier
This insect control spray kills listed bugs and protects your home for 365 days against ants, roaches and spiders indoors on nonporous surfaces
Use this indoor insect spray in kitchens, bathrooms and basements, and around doors and windows; apply outdoors to foundations to create a barrier around your home
Create an insect barrier anytime as a preventative treatment or after you see evidence of insect activity
Apply Ortho Home Defense Max Indoor Insect Barrier using the Extended Reach Comfort Wand, which lets you spray without bending

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8.6

HARRIS

Harris Spider Killer, Liquid Spray with Odorless and Non-Staining Formula (32oz, 2-Pack)

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Main Highlights

Odorless Formula - Odorless and non-staining formula will not cause damage to fabrics when used according to label directions
EPA Registered - Registered with the Environmental Protection Agency (No. 3-11) for indoor residential use
Kills a Variety of Insects - Also effective for ants, roaches, asian lady beetles, crickets, silverfish & more
For Indoor/Outdoor Use - The spray can use used indoors and outdoors as long as it is applied according to label directions
Kills Spiders When Spray Dries - The spray will kill once completely dried

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8.3

Ortho

Ortho Home Defense Max Indoor Insect Barrier with Battery-Powered Sprayer, Kills Ants, Roaches, Spiders, Fleas and Ticks, 1.5 L.

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Main Highlights

Start killing ants, roaches, spiders, fleas and ticks with Ortho Home Defense Max Indoor Insect Barrier
This insect control spray kills listed bugs and protects your home for 365 days against ants, roaches and spiders indoors on nonporous surfaces
Use this indoor insect spray in kitchens, bathrooms and basements, and around doors and windows; apply outdoors to foundations to create a barrier around your home
Create an insect barrier anytime as a preventative treatment or after you see evidence of insect activity
Apply Ortho Home Defense Max Indoor Insect Barrier using the one-handed battery-powered sprayer for a continuous, no bending or pumping spray

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Our Best Overall Choice

Best Choice

9.7

Ortho

Ortho Home Defense Insect Killer for Indoor and Perimeter2 with Comfort Wand, Controls Ants, Roaches, Spiders and More, 1.33 gal

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Ortho Home Defense Insect Killer for Indoor & Perimeter2 kills the toughest home-invading insects, including ants, cockroaches, spiders, fleas, ticks, scorpions, earwigs, silverfish and periodical cicadas (as listed)
This insect killer spray provides a long-lasting bug barrier of up to 12 month protection against ants, roaches and spiders indoors on non-porous surfaces
Use this pest control spray indoors in kitchens and bathrooms or around doors and windows, and outdoors to the perimeter of foundations, patios, decks, garages or wherever insects are a recurring problem
Apply this bug killer anytime as a preventative treatment or after you see evidence of insect activity
This 1.33 gal. container of Ortho Home Defense Insect Killer for Indoor & Perimeter2 comes with a battery-powered Comfort Wand, which delivers a continuous spray for easy application

Show Price

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