10 Best Best Sinus Decongestant of 2025

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  ULTIMATE SINUS RELIEF - Experience maximum strength nasal decongestion and sinus pressure relief from indoor or outdoor allergies or common cold symptoms. 10 mg of Phenylephrine HCl helps alleviate pressure in your nose, sinus, ears, and throat.
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  BREATHE EASIER - Lowering sinus pressure and eliminating congestion can help you breathe better and deeper during the day or night. This over the counter decongestant can help with common symptoms like runny nose or blocked nasal passages.
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  NON DROWSY FORMULA - GenCare Nasal Decongestion can be taken any time of day including the morning or daytime. Many decongestant treatments are only suitable for nighttime use and are therefore limited for active adults and kids who need relief all day long.
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  BULK SAVINGS BOTTLE - Stop worrying about constant refills with our value savings 300 tablet family size bottle. This is the perfect size for families or people who suffer from chronic congestion due to allergies or seasonal illness.
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  Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
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  Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
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  This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
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  Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
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  Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details

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  MAXIMUM STRENGTH MUCINEX SINUS-MAX DAY: Helps relieve pain, sinus pressure, headache, nasal and chest congestion and thins and loosens mucus
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  MAXIMUM STRENGTH MUCINEX SINUS-MAX NIGHT: Helps relieve pain, sinus pressure, nasal congestion, cough, and runny nose and sneezing
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  TRUSTED COLD and COUGH BRAND: Cold and Cough brand doctors trust
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  ACTIVE INGREDIENTS IN DAY: Contains Acetaminophen for pain relief, Dextromethorphan HBr for cough suppression, Guaifenesin as an expectorant and Phenylephrine HCl for nasal decongestion
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  ACTIVE INGREDIENTS IN NIGHT: Contains Acetaminophen for pain relief, Dextromethorphan HBr for cough suppression, Doxylamine Succinate as an Antihistamine and Phenylephrine HCl for nasal decongestion

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  SINUS PRESSURE & CONGESTION RELIEF: 36-count package of Sudafed PE Sinus Congestion, a maximum strength non-drowsy decongestant tablet for fast and powerful relief of sinus pressure and sinus and nasal congestion
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  NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus congestion and cold relief medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold for non-drowsy symptom relief
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  POWERFUL PHENYLEPHRINE FORMULA: Each sinus pressure relief tablet contains 10 mg of phenylephrine HCI, a nasal decongestant that provides fast and powerful symptom relief. The decongestant helps reduces nasal swelling to help you breathe easier
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  HOW TO USE: Sudafed PE sinus congestion tablets can be used by adults and children ages 12 and up. Take one nasal decongestant tablet every four hours; do not exceed six tablets within a 24 hour time period
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  FSA HSA APPROVED PRODUCT: Sinus pressure due to cold and allergies medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure is HSA & FSA eligible. Product eligibility may vary by plan

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  MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion.
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  #1 TRUSTED COLD AND COUGH BRAND: #1 Cold and Cough brand doctors trust*
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  PAIN RELIEVER: Contains Acetaminophen which relieves minor aches and pains
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  EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion
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  NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure

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  20-count of Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Medicine Tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
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  Each multi-pack contains 20 tablets of nasal decongestant, with 12 Daytime and 8 Nighttime tablets for powerful symptom relief throughout the day and while you sleep
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  Each daytime and nighttime dose contains 10 milligrams of the nasal decongestant phenylephrine HCl per tablet and each nighttime dose also contains 25 milligrams per tablet of the antihistamine diphenhydramine HCl
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  Both formulas help relieve sinus pressure and sinus congestion, and nasal congestion due to the common cold, hay fever, or upper respiratory allergies. Nighttime tablets also relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose
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  From the #1 pharmacist recommended brand among oral OTC decongestants, this maximum-strength formula can be used by adults and children 12 years and older for powerful symptom relief

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  24-count box of Sudafed PE Head Congestion + Mucus Tablets to provide non-drowsy relief from sinus pain and pressure, nasal & chest congestion, and excess mucus
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  Sinus relief medicine contains 5 mg of phenylephrine HCl, a decongestant, for congestion relief and 325 mg of acetaminophen for pain and fever reduction. Also has 200 mg of guaifenesin, an expectorant, for mucus reduction
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  Head congestion tablets temporary relieves symptoms associated with hay fever, upper respiratory allergies, and the common cold
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  Non-drowsy decongestant tablets provide relief of sinus pressure, headaches, nasal and chest congestion, excess mucus, and minor aches and pains
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  Head congestion relief medicine also helps loosen mucus to clear bronchial passageways and make coughs more productive. Get powerful head congestion relief from the #1 pharmacist recommended brand among oral OTC decongestants.

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  24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
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  Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
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  Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
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  The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
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  From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief