10 Best Best Over Counter Medicine For Sore Throat of 2025

Tested and Reviewed: Top 10 Best Over Counter Medicine For Sore Throat deals with expert ratings from 8.1 to a perfect 10

September 2025 Edition

Editor's Choice

9.7

Vicks

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

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Editor's bottom line:

“This best over counter medicine for sore throat is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesnt stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

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Picked by 200 people today

9.5

Vicks

VICKS NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Sneezing, Runny Nose, and Cough, 48 LiquiCaps

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Main Highlights

POWERFUL MULTI-SYMPTOM RELIEF for your headache, fever, sore throat, minor aches and pains, sneezing, runny nose, and cough.
EFFECTIVE NIGHTTIME COLD & FLU SYMPTOM RELIEF. NyQuil Cold & Flu Liquicaps temporarily relieves common cold & flu symptoms so you can get the rest you need
FAST RELIEF SO YOU CAN SLEEP. Don't let your cold keep you up. Just one dose of NyQuil starts working fast to provide effective cold & flu relief
POWER THROUGH YOUR WORST COLD & FLU SYMPTOMS. Life doesnt stop when you have a cold. NyQuil relieves bothersome symptoms such as cough and fever so that you can get the rest you need
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

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9.5

Save 7%

Mucinex

Mucinex Fast-Max Max Strength Cold and Flu Medicine for Adults, Daytime Cold Medicine, Over-The-Counter Medication with Acetaminophen, Dextromethorphan HBr, Guaifenesin, Phenylephrine HCl, 20 Caplets

7% OffFree Shipping

Main Highlights

1 Dose, 9 Symptom Relief, Maximum Strength Formula
Relieves Aches, Fever, & Sore Throat
Controls Cough
Relieves Nasal & Chest Congestion
Thins & Loosens Mucus

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9.2

Tylenol

Tylenol Extra Strength Severe Cough + Sore Throat Day & Night Caplets, Combo Pack for Powerful Multi-Symptom Relief for Painful Sore Throat & Cough, Acetaminophen Pain Reliever, 24 ct

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Main Highlights

24-count combo pack, 16 day & 8 night caplets, of Extra Strength Tylenol Severe Cough + Sore Throat Day & Night caplets with acetaminophen & dextromethorphan HBr for powerful, multi-symptom relief for your painful sore throat & cough all day & night
Extra strength pain reliever & fever reducer + cough suppressant caplets help temporarily relieve your daytime or nighttime cold symptoms like head & body aches, fever & sore throat, & painful coughs, plus, relief from your runny nose at night
The maximum-strength, multi-symptom cold & flu medicine is formulated with 500 mg of extra strength acetaminophen to help relieve aches & pains & reduce fever, plus, 15 mg of dextromethorphan HBr cough suppressant to help calm your severe cough
Say goodnight to your cough & sore throat. The nighttime cold medicine also contains chlorpheniramine maleate, a powerful antihistamine to help relieve your runny nose. Available over the counter, keep this combo pack with your sick care supplies
Get fast, multi-symptom cold and flu relief with the power of extra strength acetaminophen from Tylenol, the #1 doctor recommended pain relief brand. For adults & children 12 years and older, take two caplets every six hours while symptoms last

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9.0

Vicks

Vicks VapoCOOL Sore Throat Spray, Powerful Sore Throat Numbing Relief, Soothes Throat Pain, Fast-Acting, with Benzocaine & Menthol - Oral Anesthetics, Winterfrost Flavor, 6 FL OZ

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Main Highlights

VAPORIZE SORE THROAT PAIN: When you need something powerful that will knock out the pain right where you need it
FAST-ACTING AND NUMBING RELIEF: Powerful numbing agent, Benzocaine, tackles sore throat pain fast
COOLING POWER OF MENTHOL: Vicks VapoCOOL spray has cooling vapors and provides max-strength relief
RELIEVES PAINFUL SORE THROAT & MOUTH: Vicks VapoCool Sore Throat spray temporarily relieves occasional minor irritation and pain due to sore throat and sore mouth
DELIGHTFUL WINTERFROST FLAVOR: Enjoy the cool winterfrost flavor, For more sore throat relief, also try Vicks VapoCOOL SEVERE Drops and Lozenges in Winterfrost flavor

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Best Value

8.8

Save 34%

Mucinex

Mucinex Fast-Max Liquid Gels for Cold/Flu/Sore Throat, 16 Count

34% Off

Main Highlights

MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Fast-Max Cold, Flu & Sore Throat helps reduce fever, relieve cough, sore throat, stuffy nose, chest & nasal congestion, headache and minor aches and pains
#1 TRUSTED COUGH & COLD: #1 Cough & Cold Brand Doctors Trust* and #1 Pharmacist Recommended Brand
PAIN RELIEVER: Contains Acetaminophen which reduces fever and relieves minor aches and pains thereby relieving your sore throat pain
COUGH SUPPRESSANT: Contains Dextromethorphan HBr that helps relieve cough
EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion

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8.6

Save 27%

Boiron

Boiron ThroatCalm On The Go Travel Essential for Relief of Sore Throat, or Scratchy, Red or Dry Throat, and Hoarseness - 2 Count (160 Pellets)

27% OffFree Shipping

Main Highlights

Boiron ThroatCalm On the Go, Sore Throat Relief
No known interactions with other medications.
No drowsiness or sleeplessness, so they are great for day and nightime relief.
Recommended for everyone ages 3 and up.
Boiron products are HSA & FSA eligible in the U.S.

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8.3

Contac

Contac Non-Drowsy Day & Multi-Symptom Night Cold & Flu Medicine, Maximum Strength Relief for Fever, Sore Throat, Nasal Congestion, Head & Body Aches, Runny Nose, 28 Count, 16 Day, 12 Night Caplets

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Main Highlights

FAST-ACTING, MAXIMUM-STRENGTH RELIEF: Get 24-hour relief from common cold & flu symptoms, including nasal congestion, sinus congestion and pressure, sore throat, head & body aches and fever, runny nose, and sneezing
NON-DROWSY, DAYTIME RELIEF: Our severe cold & flu medicine provides symptom relief without making you drowsy; Stay alert and active throughout your day
NIGHTTIME COMFORT: Sleep better with our nighttime formula that eases symptoms for restful sleep
24-HOUR RELIEF: Feel better and stay alert by using our daytime formula with Phenylephrine HCI a nasal decongestant to ease congestion and acetaminophen a pain reliever/fever reducer to relieve minor aches, pains and sore throat; get some rest at night with our nighttime formula that also contains Chlorpheniramine maleate an antihistamine to ease your symptoms overnight
FIGHT THE FLU & COLD: Contac Cold + Flu tackles severe cold & flu symptoms for adults and children 12 years and older; FSA/HSA eligible, gluten-free and no artificial colors
TRUSTED BRAND: Contac has been trusted to relieve cold and flu symptoms for over 55 years - Choose one of our formulations depending on your cold, flu or cough symptoms: Contac Cold + Flu Daytime for non-drowsy relief, Contac Cold + Flu Day & Night for 24-hour relief, Contac Cough & Congestion to thin and loosen mucus and control your cough for 12 hours, and Contac Chest Congestion to thin and loosen mucus and make coughs more productive

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8.1

Save 26%

Boiron

Boiron Mercurius Corrosivus 9C for Sore Throat with Pain While Swallowing - 80 Pellets

26% OffFree Shipping

Main Highlights

PURE RELIEF: Mercurius Corrosivus is a homeopathic medicine that relieves sore throat with pain while swallowing.*
A BETTER WAY TO FEEL BETTER: This medicine has no known interactions with other medications, herbs, or supplements; no contraindications; and does not contain artificial colors, flavors, sweeteners, or preservatives
EASY TO TAKE: Pellets melt under the tongue, no food or water needed and great for on the go
A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are made to meet the highest standards of cGMP and HPUS for purity and quality
HSA & FSA eligible: Boiron homeopathic medicines are HSA & FSA eligible.

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8.1

Vicks

Vicks VapoCool Severe Medicated Sore Throat Drops, Max Strength Menthol, Soothes Sore Throat Pain, Cherry Flavor, 45ct

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Main Highlights

FAST SORE THROAT RELIEF. Simply let the Vicks VapoCOOL drop dissolve in your mouth for a powerful rush of Vicks Vapors
POWERFUL RELIEF. Its not your grandmas cough drop, its Vicks VapoCOOL Severe with intense cooling power that starts working in seconds.
VAPORIZE SORE THROAT PAIN. When you need something powerful to soothe your worst sore throat pain that mightve come from that terrible cough.
2X MORE MENTHOL per drop vs. the leading competitive [menthol] drop.
CHERRY FLAVORED. Vicks VapoCOOL SEVERE combines the cherry flavor, with a powerful rush of trusted Vicks Vapors
FOR MORE SORE THROAT RELIEF, also try Vicks VapoCOOL Lozenges and Sore Throat Spray in Winterfrost flavor.
Intended for use by Adults and Children Ages 12+

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Our Best Overall Choice

Best Choice

9.7

Vicks

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesnt stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

Show Price

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Vicks NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches and Pains, Sneezing, Runny Nose, and Cough, 24 Liquicaps

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Chloraseptic Sore Throat Spray, Menthol, 6 oz

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