10 Best Best Nighttime Eye Drops For Dry Eyes of 2025

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  Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve dry eye symptoms.
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  Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
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  Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for dry eye or nighttime use.
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  iVIZIA We See a Better Way: for healthy, comfortable eyes

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  #1 Dr Recommended Brand of Artificial Tears*
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  Provides nighttime relief of dry eye symptoms
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  Ointment soothes and protects against dry, irritated eyes
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  Forms long-lasting, protective layer on eyes while you sleep
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  Safe, preservative-free formula

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  Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms, 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
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  Instant hydration: TheraTears eye drops restore eyes natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
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  Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
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  Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
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  Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

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  EYE OINTMENT FOR DRY EYES AT NIGHT: Use Soothe Lubricant Eye Ointment to help moisturize & refresh severe dry eyes overnight for long-lasting relief & comfort. Soothing nighttime dry eye relief formula to help relieve dryness & prevent irritation
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  SEVERE DRY EYE RELIEF: This dry eye ointment contains two lubricants to help relieve dry and irritated eye symptoms. Soothe ointment is gentle enough for sensitive eyes and can be used as often as needed, but stop use and ask a doctor if condition worsens or persists more than 72 hours. Remove contact lenses before using
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  BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
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  EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
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  EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected

Main Highlights

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  Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms which may be better for people with sensitive eyes, with 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
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  Instant hydration: TheraTears eye drops restore eyes natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
• 
  Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
• 
  Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
• 
  Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

Main Highlights

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  Extended relief plus protection for dry, irritated eyes
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  Our most comprehensive gel formula
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  Anytime relief, day or night
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  Feels like a drop but works like a gel for lasting comfort
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  Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
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  #1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

Main Highlights

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  #1 Dr Recommended Brand of Artificial Tears*
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  Thicker eye drop formulation that creates a protective shield over your eyes.
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  Convenience of a drop with a protection of a gel.
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  For the temporary relief of burning and irritation due to dryness of the eye
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  NOTE: PRODUCT PACKAGING MAY VARY

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  Relief with Every Blink: Experience immediate and long-lasting dry eye symptom relief with Blink GelTears eye drops for dry eyes. This thicker, more viscous lubricating formula is for enhanced comfort and great for daytime and nighttime use
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  Hydration Boost with Hyaluronate: Our gel lubricating eye drops for dry eyes instantly soothe and comfort. It contains our highest level of hyaluronate to provide longer lasting relief for moderate to severe dry eye symptoms
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  Day & Night Relief: Blink eye drops are formulated for daytime and nighttime use and provides superior end-of-day comfort (in an Ocular Lubricant questionnaire, comfort ratings were statistically significantly higher for Blink GelTears vs. Allergans Refresh Optive Liquid Gel after 7 days and 30 days). These lubricant eye drops maximize hydration for enhanced comfort, in addition to instantly soothing & comforting
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  Reduce Everyday Discomfort: These drops are an extra moisturizing gel for enhanced comfort. Work with every blink to restore your tears' natural balance and maximize hydration
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  Trusted Brand: Blink has a range of products to meet your eye and contact lens care needs, from drops for dry eyes to lock in moisture, to preservative-free formulas; and contact lens drops to keep your contacts clean and hydrated. Blink products provide comfort and hydration, to help your eyes feel moisturized & protected

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  iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz bottle.
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  Free of Irritating Preservatives: Sterile, safe for use with contact lenses
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  Patented ABAK Bottle: preservative-free, dispenses drop-by-drop, and does not stream. The ergonomic bottle is easy to open, easy to hold and squeeze.
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  iVIZIA We See a Better Way: for healthy, comfortable eyes

Main Highlights